PLX8394
Chemical Structure Depiction of
PLX8394
PLX8394
Compound characteristics
| Compound ID: | CE04-0132 |
| Compound Name: | PLX8394 |
| Molecular Weight: | 542.54 |
| Molecular Formula: | C25 H21 F3 N6 O3 S |
| CAS Number: | 1393466-87-9 |
| Smiles: | C1CC1c1ncc(cn1)c1cc2c(c[nH]c2nc1)C(c1c(ccc(c1F)NS(N1CC[C@H](C1)F)(=O)=O)F)=O |
| InChI Key: | YYACLQUDUDXAPA-INIZCTEOSA-N |
| Short Description: | PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, the n inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be effective against tumors that express multiple mutated forms of the kinase and may be an effective therapeutic agent for tumors that are resistant to other BRAF inhibitor therapies that are specific for the BRAF V600E mutant. |
| Pathway: | MAPK |
| Target: | Raf |
| Type of molecule: | Clinical |
| Stock amount: | 760 |