Thiocarlide
Chemical Structure Depiction of
Thiocarlide
Thiocarlide
Compound characteristics
| Compound ID: | CE04-2193 |
| Compound Name: | Thiocarlide |
| Molecular Weight: | 400.58 |
| Molecular Formula: | C23 H32 N2 O2 S |
| CAS Number: | 910-86-1 |
| Smiles: | CC(C)CCOc1ccc(cc1)NC(Nc1ccc(cc1)OCCC(C)C)=S |
| InChI Key: | BWBONKHPVHMQHE-UHFFFAOYSA-N |
| Short Description: | Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi -drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml. [1] [2] At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure whi ch is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.[2] |
| Alias: | Isoxyl |
| Stock amount: | 500 |