Lazertinib
Chemical Structure Depiction of
Lazertinib
Lazertinib
Compound characteristics
| Compound ID: | CE04-5538 |
| Compound Name: | Lazertinib |
| Molecular Weight: | 554.65 |
| Molecular Formula: | C30 H34 N8 O3 |
| CAS Number: | 1903008-80-9 |
| Smiles: | CN(C)Cc1cn(c2ccnc(Nc3cc(c(cc3OC)N3CCOCC3)NC(C=C)=O)n2)nc1c1ccccc1 |
| InChI Key: | RRMJMHOQSALEJJ-UHFFFAOYSA-N |
| Short Description: | Lazertinib (GNS-1480) is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild ty pe EGFR respectively. |
| Pathway: | Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors |
| Target: | EGFR |
| Type of molecule: | Clinical |
| Alias: | Lazertinib (YH25448) , GNS-1480 , YH25448 |
| Stock amount: | 5857 |