NS309
Chemical Structure Depiction of
NS309
NS309
Compound characteristics
| Compound ID: | CE04-5666 |
| Compound Name: | NS309 |
| Molecular Weight: | 231.03 |
| Molecular Formula: | C8 H4 Cl2 N2 O2 |
| CAS Number: | 18711-16-5 |
| Smiles: | c1cc(c(c2c1\C(C(N2)=O)=N/O)[Cl])[Cl] |
| InChI Key: | CVOUSAVHMDXCKG-UHFFFAOYSA-N |
| Short Description: | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 muM for SK channels and 10-90 nM for IK channels) . It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 muM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancin g SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 sub types. |
| Pathway: | JAK/STAT signaling|||Membrane transporter/Ion channel|||Tyrosine Kinase/Adaptors|||Angiogenesis |
| Target: | HER|||Potassium Channel|||EGFR |
| Type of molecule: | Preclinical |
| Stock amount: | 1315 |