MK-0159
Chemical Structure Depiction of
MK-0159
MK-0159
Compound characteristics
| Compound ID: | CE04-8834 |
| Compound Name: | MK-0159 |
| Molecular Weight: | 400.5 |
| Molecular Formula: | C20 H24 N4 O3 S |
| CAS Number: | 2641484-61-7 |
| Smiles: | COCCO[C@H]1CC[C@@H](CC1)NC(c1cc(c2cncs2)nc2c1cc[nH]2)=O |
| InChI Key: | JUVJFMVGYBBDKN-UHFFFAOYSA-N |
| Short Description: | MK-0159 (compound 37) is a CD38 inhibitor with oral activity and selectivity. MK-0159 can inhibit CD38 in humans, mice and rats, with IC50 of 22, 3 and 70 nM respectively. MK-0159 showed good stabilit y in human and rodent liver microsomes. MK-0159 can increase heart and whole blood NAD+(nicotinamide adenine dinucleotide) and reduce ADPR (adenosine diphosphate ribose). |
| Stock amount: | 10 |