Caricotamide
Chemical Structure Depiction of
Caricotamide
Caricotamide
Compound characteristics
| Compound ID: | CE05-2431 |
| Compound Name: | Caricotamide |
| Molecular Weight: | 181.19 |
| Molecular Formula: | C8 H11 N3 O2 |
| CAS Number: | 64881-21-6 |
| Smiles: | C1C=CN(CC(N)=O)C=C1C(N)=O |
| InChI Key: | WEJRSYKFMCUCRQ-UHFFFAOYSA-N |
| Short Description: | Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simulta neously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over-expressed in cancers such as hepatocellular carcinoma (HCC), colorectal and ovarian cancers. |
| Stock amount: | 100 |