MS-177
Chemical Structure Depiction of
MS-177
MS-177
Compound characteristics
| Compound ID: | CE05-3180 |
| Compound Name: | MS-177 |
| Molecular Weight: | 914.04 |
| Molecular Formula: | C48 H55 N11 O8 |
| CAS Number: | 2225938-86-1 |
| Smiles: | CC(C)n1c2cc(cc(C(NCC3=C(C)C=C(C)NC3=O)=O)c2cn1)c1ccc(nc1)N1CCN(CCNC(CCOCCNc2cccc3C(N(C4CCC(NC4=O)=O)C(c23)=O)=O)=O)CC1 |
| InChI Key: | LRMNSTSNSCJHGZ-LHEWISCISA-N |
| Short Description: | MS177, a potent and rapid EZH2 degrader, functions as a PROTAC comprised of a CRBN ligand, linker, and a powerful enzymatic EZH2 inhibitor C24 (C24 IC50: 12 nM). It successfully targets and depletes b oth canonical EZH2-PRC2 and noncanonical EZH2-cMyc complexes. Furthermore, MS177 inhibits leukemia cell growth, induces apoptosis, and arrests cell cycle progression. |
| Stock amount: | 100 |