Noberastine citrate
Chemical Structure Depiction of
Noberastine citrate
Noberastine citrate
Compound characteristics
| Compound ID: | CE05-4353 |
| Compound Name: | Noberastine citrate |
| Molecular Weight: | 503.51 |
| Molecular Formula: | C17 H21 N5 O.C6 H8 O7 |
| CAS Number: | 139751-07-8 |
| Smiles: | Cc1ccc(Cn2c(NC3CCNCC3)nc3cccnc23)o1.C(C(O)=O)C(CC(O)=O)(C(O)=O)O |
| InChI Key: | VXIJMTRTCJNTMW-UHFFFAOYSA-N |
| Short Description: | Noberastine citrate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack central nervous system effects. After subacute (steady-state) administration of noberastine, there was inc reasing inhibition of weal and flare formation with higher doses of the drug. The 30 mg daily dose showed maximum antihistaminic effects. |
| Stock amount: | 100 |