SC-10914
Chemical Structure Depiction of
SC-10914
SC-10914
Compound characteristics
| Compound ID: | CE05-5248 |
| Compound Name: | SC-10914 |
| Molecular Weight: | 241.29 |
| Molecular Formula: | C15 H15 N O2 |
| CAS Number: | 76985-08-5 |
| Smiles: | C(C(C(O)=O)N)c1ccc(cc1)c1ccccc1 |
| InChI Key: | JCZLABDVDPYLRZ-AWEZNQCLSA-N |
| Short Description: | SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 muM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacok inetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers. |
| Stock amount: | 100 |