Kinases
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2000 compounds
Library of Immunomodulatory imide drugs (IMiD) like compounds . Targeting several known E3 ligase - warhead interactions . IMiD small molecule library Both PROTACs and Molecular Glues are the hot topics in drug discovery because they make possible to pharmacologically address targets previously deemed “undruggable”.
8,436 compounds
The DarkKinome refers to a subset of protein kinases that are less studied compared to their more prominent counterparts.
958 compounds
Ubiquitin-specific-processing protease 7 . Based on docking scores and conformation overlays, structures were selected to form the final library
24,000 compounds
RNA’s as targets are generally tougher than proteins, but the expected payoff is also significant. In particular, messenger and non-coding RNAs contain highly structured elements, and evidence suggests that many of these structures are important for function. Targeting these RNAs with small molecules offers opportunities to therapeutically modulate numerous cellular processes, including those linked to ‘undruggable’ protein targets
36,324 compounds
Protein Kinases Inhibitors Library is modulators that are used in cancer and inflammation treatment.
2,081 compounds
Proline Kinase Library is a set of kinase inhibitors. These kinases play a crucial role in diverse cellular processes and human diseases.
19,000 compounds
PI3K-Targeted Library is a set of small-molecule inhibitors of PI3K signaling pathway. They can be used in effective inhibiting tumor progression.
17,880 compounds
"Molecular Glue"-like small molecule commercial compounds for HTS
3,856 compounds
Lysine-specific histone demethylases (KDM) Library
16,000 compounds
KRAS-Targeted Library is a set of novel KRAS-active compounds.
15,080 compounds
Molecules from c-Met Library target receptor tyrosine kinase. It prevents binding hepatocyte growth factor with c-Met which can lead to cancer.
10,000 compounds
Set of small-molecule serine/threonine kinases family inhibitors.
26,000 compounds
Small‐molecule allosteric kinase modulators that target allosteric pockets of kinases outside the conserved ATP‐binding pocket.
23,000 compounds
We assembled a library of potential tTG inhibitors using as a seed a combination of known ChEMBL tTG ligands, which were expanded in several iterations, using chemoinformatics techniques and molecular docking, thus expanding the chemical space of reversible tTG ligands. The resulting molecules were grouped into the medicinal chemistry forming series with reasonable diversity within each group, thus facilitating hit-to-lead transition for early hits.
25,000 compounds
Molecular glue compounds that are capable of regulating cereblon (CRBN) conformation is the next generation in pharmaceutically targeting proteasomal degradation of a specific protein, building on top of and extending the IMiD, PROTAC and general molecular glue directions.
16,846 compounds
The library of Aryl Hydrocarbon Receptor (AhR) modulators represents a sophisticated collection of compounds designed to interact with a critical regulatory protein involved in various physiological and pathological processes.
8,000 compounds
Type II Kinase Inhibitors Library is a set of non-ATP site inhibitors or activators that bind to an extended ATP site including a back pocket.
12,000 compounds
Diacylglycerol kinase Inhibitors Library is a set of small-molecules that can inhibit the progression of cancer and innate cytotoxic immunocytes.
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Custom ChemistryNovel Scaffolds and Discovery LibrariesCustom Building Blocks for DNA Encoded LibrariesScale up SynthesisMacrocycle CompoundsIn silico Drug Design (CADD)PROTACADME, DMPKMedicinal ChemistryDNA Encoded Libraries-CDI-CapabilitiesDiscovery BiologyAssay DevelopmentHigh Throughput Screening (HTS)Animal ModelsToxicology and SafetyChemistry, Manufacturing and ControlsPre-Plated SetRepresentative CompoundsNatural-Product3D-PharmacophoreMCE-18RepresentativeSoluble DiversityTargeted DiversitySmartTMAntiviralGPCR3DPhenotypic ScreeningCNS activityTranscription FactorsDrugs LibraryTarget ActivityTherapeutical DiversityCNSIon ChannelsProteases HumanKinases HumanPhosphatases HumanReceptors HumanOpportunistic PathogensCancerCardiovascularMetabolicImmune systemInfectionsMusculoskeletalDigestive systemRespiratory tractOtorhinolaryngologicNervous systemEyeMaleFemaleHemic and lymphaticCongenitalSkinEndocrineAnimalWoundsKinasesProteasesPhosphatasesNuclear receptorsOthersPPI modulatorsReceptor's ligandsEpigeneticMimeticsCyclic compoundsFragmentsPoolChemical classes AgroAllosteric Inhibitors