Takeda and NsGene Partner to Perform Research in Cell Encapsulation Therapies for Parkinson's Disease

Osaka, Japan, January 8, 2016, and Providence, RI; January 7, 2016 – Takeda Pharmaceutical Company Limited (TSE: 4502) and NsGene, Inc. today announced a research agreement to develop encapsulated cell therapies for the potential treatment of Parkinson’s disease. The partnership will focus on the delivery of recombinant Glial Cell Line-Derived Neurotrophic Factor (GDNF) to affected brain regions by way of implanted, encapsulated cell therapy devices.

GDNF has been pursued as a neuro-regenerative growth factor that holds promise in the treatment of Parkinson’s disease, but has met problems in delivery of drug to the affected portions of the diseased brain. This collaboration will explore the potential of surgically implanted recombinant cells housed within a device to directly secrete GDNF on site to promote neuron survival and regeneration.

NsGene has developed the experimental technology that originated at Brown University into a clinically applicable cell therapy platform. The device contains genetically engineered cells encased in an immune-shielding capsule that can continuously produce therapeutic levels of biotherapeutics for an extended time after implantation. GDNF is a neurotrophic factor that has been shown in preclinical systems to promote axon growth and protect dopaminergic neurons when delivered directly to the diseased cells for an extended duration.

NsGene will receive funding from Takeda for technology development that enables NsGene to complete critical scientific milestones needed for clinical trials and further constructive partnering. Further details of the agreement were not disclosed.

Takeda is considering regenerative medicine as a potential new modality to treat diseases and is committed to supporting such research. The research collaboration with NsGene marks one of Takeda’s efforts to explore a novel biologics modality and implantable drug delivery system that could potentially make an impact in the lives of many patients.

About NsGene

NsGene, Inc. is a privately held clinical stage biotechnology company based in Providence, Rhode Island developing the Encapsulated Cell Therapy platform. The company works with industrial and academic partners to develop products with applications in neurological disorders and sensorineural hearing loss. The company has successfully applied its technology in initial clinical studies for the treatment of Alzheimer’s disease.

About Takeda

Located in Osaka, Japan, Takeda (TSE: 4502) is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for people worldwide through leading innovation in medicine. Additional information about Takeda is available through its corporate website, www.takeda.com.

Source: http://www.takeda.com/news

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