Biomea Fusion

Biomea Fusion Presents Data Demonstrating Enhanced Preclinical Activity of Icovamenib in Combination with Semaglutide in Type 2 Diabetes (T2D) Animal Model at the 61st EASD Annual Meeting and Provides Additional Corporate Update

SAN CARLOS, Calif., -- Biomea Fusion, Inc., a clinical-stage diabetes and obesity medicines company, today announced the presentation of preclinical data from its investigational menin inhibitor icovamenib in combination with semaglutide in a T2D animal model.  Biomea Fusion presented promising preclinical data for its menin inhibitor icovamenib in combination with semaglutide at the 61st EASD Annual Meeting. The combination therapy demonstrated significant improvements in a Type 2 Diabetes animal model, including a 60% reduction in fasting blood glucose and 50% lower glucose AUC compared to semaglutide alone.

Key findings showed the combination achieved greater body weight reduction (-12.5% vs -3.4%) while preserving lean mass, and improved beta cell function. Additionally, Biomea announced FDA clearance of their IND for BMF-650, their oral GLP-1 receptor agonist, with Phase I obesity trial data expected in H1 2026. The company plans to advance clinical evaluation of icovamenib with GLP-1 therapies in a Phase II study starting in H2 2025.

The oral presentation titled “Icovamenib and Semaglutide Combination Therapy Enhances Body Weight Loss and Glycemic Control While Preserving Lean Mass in a Type 2 Diabetes Animal Model” (Presentation #66), was presented at the 61st European Association for the Study of Diabetes (EASD) Annual Meeting, which takes place September 15 - 19, 2025, in Vienna, Austria.

The Biomea presentation highlighted icovamenib’s therapeutic potential across key dimensions of T2D pathophysiology, including its impact on beta cell function, and synergy with GLP-1 RAs to promote metabolic health and muscle-sparing body weight reduction.

“We are very encouraged by these preclinical results, which show that icovamenib combined with semaglutide not only improved glycemic control but also enhanced weight loss while preserving lean mass,” said Mick Hitchcock, Interim CEO of Biomea Fusion. “This growing body of evidence reinforces icovamenib’s unique mechanism of action in beta cell regeneration and highlights the potential of combining icovamenib with GLP-1 receptor agonists to deliver meaningful benefits for patients with type 2 diabetes.”