Protein–protein interactions (PPIs) play a central role in many cellular processes and are involved in numerous pathways, including different stages of cancer development, host–pathogen interactions, and other diseases.
PPIs have shown increasing potential as new therapeutic targets over the last 10 years.
Modulators of these original interactions are likely to lead to the next generation of highly innovative drugs that should reach the market in the next decade.
α-helices are one of the key recognition elements of protein secondary structure.
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