Epitranscriptome Focused library
Within the field of molecular biology, the epitranscriptome includes all the biochemical modifications of the RNA (the transcriptome) within a cell. Epitranscriptomics involves all functionally relevant changes to the transcriptome that do not involve a change in the ribonucleotide sequence. Thus, the epitranscriptome can be defined as the ensemble of such functionally relevant changes.
Epitranscriptomics
• A variety of abundant RNA modifications have been shown playing a critical role in gene regulation.
• “Writers”, “readers”, and “erasers” : RNA-binding proteins that perform post-transcriptional modifications and support cellular processes vital for RNA homeostasis.
• Aberrant RNA modifications are therapeutically relevant for the immune system and the central nervous system:
➢ Prompt the growth of acute myeloid leukemia cells.
➢ Associated with various neurodevelopmental and neuronal disorders – autism, epilepsy, brain development abnormalities, obesity, microcephaly, Prader-Willi syndrome, fragile X syndrome, major depressive disorder, etc.
➢ A regulatory mechanism of brain development and function.
Epitranscriptomics
• A variety of abundant RNA modifications have been shown playing a critical role in gene regulation.
• “Writers”, “readers”, and “erasers” : RNA-binding proteins that perform post-transcriptional modifications and support cellular processes vital for RNA homeostasis.
• Aberrant RNA modifications are therapeutically relevant for the immune system and the central nervous system:
➢ Prompt the growth of acute myeloid leukemia cells.
➢ Associated with various neurodevelopmental and neuronal disorders – autism, epilepsy, brain development abnormalities, obesity, microcephaly, Prader-Willi syndrome, fragile X syndrome, major depressive disorder, etc.
➢ A regulatory mechanism of brain development and function.