Transcription Factors annotated library

• Transcription Factors are proteins that regulate gene reading from DNA sequences

• A direct modulation of a Transcription Factor activity by small molecules can be achieved through

- Mimetics of peptide motifs that bind at either activation domain (AD) or signal-sensing domain (SSD)

- Mimetics of DNA motifs that bind at a DNA-binding domain (DBD)

• Transcription Factors are promising therapeutic targets for

- Oncology, e.g. immunological response modulators, tumor suppressors, oncogenes regulators

- Metabolic diseases, e.g. diabetes, osteoporosis, high-density lipoproteins (HDL) regulation

- Cardiovascular system, e.g. atherosclerosis, thrombosis

- Inflammation, e.g. autoimmune diseases, immune response suppression

A unique collection of small molecule compounds with annotated activities for Transcription Factors targets