Madrigal's MGL-3196 shows sustained benefit in mid-stage NASH study; shares up 40% premarket

A Phase 2 clinical trial assessing Madrigal Pharmaceuticals' (NASDAQ:MDGL) MGL-3196 in patients with non-alcoholic steatohepatitis (NASH) met the primary endpoint at week 12 and demonstrated a sustained treatment benefit at week 36.

39% of the responders at week 12 experienced complete resolution of NASH at week 36 compared to 6% for placebo (p=0.001). Fibrosis was resolved in half the patients.

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Mean liver fat reduction was 37.0% in the treatment group compared to 8.9% for placebo.

No new safety signals were observed.

A larger Phase 3 with a longer treatment period is next up.

May 31, 2018

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