Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

Pfizer-Lilly pain drug meets late-stage trial goals

An experimental osteoarthritis drug developed by Pfizer Inc and Eli Lilly and Co achieved its main goal of lowering pain in a late stage trial, the companies said on Wednesday, potentially offering a safer alternative to opioids.

The treatment, tanezumab, belongs to an investigational category of pain medications that target nerve growth factor, a protein involved in the growth of nerve cells, and is also being evaluated to treat chronic lower back and cancer pain.

U.S. regulators in 2015 lifted a hold on trials of medicines targeting the protein due to concerns they could worsen osteoarthritis in a small percentage of patients.

Pfizer’s shares were marginally up at $37.79 in premarket trade. Eli Lilly shares rose 1 percent to $90.50.

FILE PHOTO: The logo of Lilly is seen on a wall of the Lilly France company unit, part of the Eli Lilly and Co drugmaker group, in Fegersheim near Strasbourg, France, February 1, 2018. Picture taken February 1, 2018. REUTERS/Vincent Kessler

The study showed that patients who received two doses of the drug, tanezumab, showed a statistically significant improvement in physical function and an assessment of osteoarthritis by the patients, when compared to placebo, meeting all three goals of the study.

Preliminary safety data showed that the drug was generally well-tolerated in these patients, with only about 1 percent of patients discontinuing treatment due to adverse effects.

“Safety concerns have been an overhang on the tanezumab opportunity. The data today should alleviate some of those concerns, in our opinion,” Cantor Fitzgerald analyst Louis Chen said.

Pfizer and Lilly, in a $1.8 billion deal, agreed in 2013 to jointly develop and sell tanezumab for several pain-related conditions, with the companies equally sharing development expenses and future sales.

The drug’s sales are expected to reach $283 million for Pfizer by 2020, according to Thomson Reuters’ data.

Osteoarthritis is the most common form of arthritis, affecting about 20 million people in the United States alone.

Due to the lack of effective alternatives, patients with painful conditions like osteoarthritis and cancer turn to opioids for managing their symptoms. On average, 115 Americans die every day from opioid overdose.

JULY 18, 2018


0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies