Burger line Burger line Burger line
Logo Logo Logo
Burger line Burger line Burger line
Sign in
Sign in

FDA Updates Safety Labeling and Prescribing Information for Opioid Pain Meds

FDA Updates Safety Labeling and Prescribing Information for Opioid Pain Meds

Prometheus’s PRA023 is being developed to treat Crohn’s disease, ulcerative colitis and other autoimmune conditions.

Merck reached an agreement to buy Prometheus Biosciences to strengthen its immunology pipeline. 

Merck has signed a definitive agreement to buy clinical-stage biotechnology firm Prometheus Biosciences for $10.8bn, strengthening its immunology pipeline.

The company will buy all of Prometheus Biosciences’ outstanding shares for $200 a share through a subsidiary.

Prometheus Biosciences uses precision medicine to discover, develop and commercialise new therapeutic and companion diagnostic products to treat immune-mediated diseases.

PRA023, Prometheus’s lead candidate, is a humanised monoclonal antibody (mAb) targeting tumour necrosis factor (TNF)-like ligand 1A (TL1A).

TL1A is implicated in intestinal inflammation and fibrosis.

PRA023, which binds human TL1A with high affinity and specificity, is being developed to treat autoimmune conditions including Crohn’s disease (CD) and ulcerative colitis (UC).

Merck chairman and CEO Robert Davis stated: “At Merck, we are committed to delivering on our purpose to save and improve lives and continue to identify and secure opportunities where compelling science and value creation align.

“The agreement with Prometheus will accelerate our growing presence in immunology where there remains substantial unmet patient need.

“This transaction adds diversity to our overall portfolio and is an important building block as we strengthen the sustainable innovation engine that will drive our growth well into the next decade.”

Prometheus reported positive data from a placebo-controlled Phase II ARTEMIS-UC trial of PRA023 conducted in moderate to severely active UC patients, and a Phase IIA APOLLO-CD trial in moderate to severe CD patients in December 2022.

The company intends to advance the mAb into Phase III trials for UC and CD in 2023.

Subject to the approval of Prometheus Biosciences’ shareholders and other stated conditions, the transaction should be concluded in the third quarter of 2023.

April 17, 2023


0
Cart Subtotal:
Go to cart
You will be able to Pay Online or Request a Quote

We use "cookies*  to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:

Recognising you when you sign-in to use our services. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
Keeping track of your specified preferences. You may set your preferences through Your Account..
Keeping track of items stored in your shopping basket and personal cabinet.
Conducting research and diagnostics to improve ChemDiv’s content, products, and services.
Delivering content, including ads, relevant to your interests on ChemDiv’s site
Reporting. This allows us to measure and analyse the performance of our services.

By  cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy.

Accept all cookies