ChemDiv in Publications and Patents
Haiping Zhang; Hongjie Fan; Jixia Wang; Tao Hou; Konda Mani Saravanan; Wei Xia; Hei Wun Kan; Junxin Li; John Z H Zhang; Xinmiao Liang; Yang Chen
PMC ID: PMC11167311 | DOI: 10.1093/bib/bbae281 | ISSN: 1467-5463 | Journal: Briefings in Bioinformatics, 25(1) | Publisher: Oxford University Press | Publication date: 2024-06-12
Original document: PMC | Score: 8.431637 | Text size: 73184 | Find: similar documents
We performed virtual screening against the ChemDiv database using the DeepGPCR_BC, DeepGPCR_RG and Schrödinger docking with Q9HC97 (GPR35) and GLP_1R serving as representative examples. ... The Chemdiv database, provided by ChemDiv company (https://www.chemdiv.com/), contains approximately 1 500 000 compounds, most of which are purchasable from ChemDiv Company. ... The ChemDiv database was screened using the DeepGPCR_BC, DeepGPCR_RG and Schrödinger docking. ... Chemdiv ID ... Chemdiv ID
Carbenoid-involved reactions integrated with scaffold-based screening generates a Nav1.7 inhibitor
Jirong Shu; Yuwei Wang; Weijie Guo; Tao Liu; Song Cai; Taoda Shi; Wenhao Hu
PMC ID: PMC11169417 | DOI: 10.1038/s42004-024-01213-3 | Journal: Communications Chemistry, 7(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-06-12
Original document: PMC | Score: 8.117959 | Text size: 60496 | Find: similar documents
The chemical space of the OREAL library was compared with 3 different commercial compound libraries, compounds with sodium channel inhibitory activity included in ChEMBL49–51, AN4500 Ion Channel library from ASINEX and Voltage-Gated Ion Channel-Targeted Library from ChemDiv(www.chemdiv.com), by using Principal Moment of Inertia (PMI)52 analysis and Principal Component Analysis (PCA)53,54 To explore the characteristics of shapes of virtual compounds, a PMI analysis was taken to visualize the 3D shape diversity of our OREAL. ... A Principal Moment of Inertia (PMI) analysis of four libraries: OREAL (Blue), ChEMBL (Red), ChemDiv (yellow) and ASINEX (green).
PMC ID: PMC11127438 | DOI: 10.1186/s13321-024-00845-w | Journal: Journal of Cheminformatics, 16(1) | Publisher: Springer International Publishing | Publication date: 2024-05-24
Original document: PMC | Score: 6.12045 | Text size: 83907 | Find: similar documents
Two groups of synthetic compounds were obtained from the ZINC Clean Leads [15, 16], and 11 commercially available vendors (BIONET, Chembridge, ChemDiv, Enamine, IBS, LifeChemical, Maybridge, MolPort, Specs, TargetMol, and VitasM).
Katja Stefan; Vigneshwaran Namasivayam; Sven Marcel Stefan
PMC ID: PMC11116543 | DOI: 10.1038/s41597-024-03343-8 | Journal: Scientific Data, 11(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-05-23
Original document: PMC | Score: 6.3167486 | Text size: 63189 | Find: similar documents
Many vendors are available providing different(ly focused) virtual compound libraries [e.g., ChemDiv (https://www.chemdiv.com), ChemSpace (https://chem-space.com), Enamine (https://enamine.net), MolPort (https://www.molport.com), ZINC (https://zinc20.docking.org), etc];
High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors
Suman Khan; Efrat Ozer Partuk; Jeanne Chiaravalli; Noga Kozer; Khriesto A. Shurrush; Yael Elbaz-Alon; Nadav Scher; Emilie Giraud; Jaouen Tran-Rajau; Fabrice Agou; Haim Michael Barr; Ori Avinoam
PMC ID: PMC11176637 | DOI: 10.1016/j.isci.2024.110019 | Journal: iScience, 27(1) | Publisher: Elsevier | Publication date: 2024-05-17
Original document: PMC | Score: 7.3305492 | Text size: 78673 | Find: similar documents
ChemDiv ... The composition of the screening set was 0.7% Bioactive Screening Libraries (Selleck Chemicals, USA), 7.6% HitFinder Collection (Maybridge, USA), 10.8% Drug-Like Set (Enamine, Ukraine), 26.8% DIVERset-CL (Chembridge, USA), 54.1% Diversity Library (ChemDiv, USA).
Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16
Kejue Wu; Yinfeng Guo; Tiefeng Xu; Weifeng Huang; Deyin Guo; Liu Cao; Jinping Lei; Shijun Zhong
PMC ID: PMC11124212 | DOI: 10.3390/molecules29102312 | Journal: Molecules, 29(1) | Publisher: MDPI | Publication date: 2024-05-15
Original document: PMC | Score: 8.134724 | Text size: 53352 | Find: similar documents
A total of 349,000 compounds from the ZINC15 database and 100,000 compounds from the ChemDiv database were collected and screened by filtering steps of the virtual screening workflow (HTVS, SP, XP) of Schrödinger software. ... Additionally, we selected an extra dataset of 100,000 molecules from ChemDiv ( ... https://www.chemdiv.com/catalog/diversity-libraries ... The virtual screening workflow (HTVS, SP, XP) in Schrödinger software combined with visual inspection of the binding interactions were used for our screening of 349,000 compounds from the ZINC database and 100,000 compounds from the ChemDiv database.
Discovering allatostatin type-C receptor specific agonists
Kübra Kahveci; Mustafa Barbaros Düzgün; Abdullah Emre Atis; Abdullah Yılmaz; Aida Shahraki; Basak Coskun; Serdar Durdagi; Necla Birgul Iyison
PMC ID: PMC11087482 | DOI: 10.1038/s41467-024-48156-w | Journal: Nature Communications, 15(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-05-10
Original document: PMC | Score: 7.8062797 | Text size: 74446 | Find: similar documents
ChemDiv GPCR-Targeted (64515 compounds) and Peptidomimetic (61518 compounds) libraries were used in virtual screening, targeting the orthosteric pocket of the AlstR-C. ... Peptidomimetic70 and GPCR-Targeted71 libraries from ChemDiv were prepared with LigPrep module of Maestro molecular modeling package using OPLS3e72 force field. ... All the finally selected compounds with at least 95% purity were ordered from ChemDiv (https://www.chemdiv.com/).
Tony Eight Lin; Dyan Yen; Wei‐Chun HuangFu; Yi‐Wen Wu; Jui‐Yi Hsu; Shih‐Chung Yen; Tzu‐Ying Sung; Jui‐Hua Hsieh; Shiow‐Lin Pan; Chia‐Ron Yang; Wei‐Jan Huang; Kai‐Cheng Hsu
PMC ID: PMC11081523 | DOI: 10.1002/pro.5007 | ISSN: 0961-8368 | Journal: Protein Science : A Publication of the Protein Society, 33(1) | Publisher: John Wiley & Sons, Inc. | Publication date: 2024-05-09
Original document: PMC | Score: 6.440691 | Text size: 52408 | Find: similar documents
The screening library (1.6 million compounds) was obtained from ChemDiv (https://www.chemdiv.com).
Alexandra M. D’Ordine; Gerwald Jogl; John M. Sedivy
PMC ID: PMC11078990 | DOI: 10.1038/s41467-024-48066-x | Journal: Nature Communications, 15(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-05-08
Original document: PMC | Score: 8.151964 | Text size: 83546 | Find: similar documents
The following EN inhibitors were obtained from the listed suppliers through Molport: AD2/ZINC89469886/NSC89640 (Alinda IBS-L0127235), AD3/ZINC100299612 (ChemBridge 5151622), AD5/ZINC100499350 (ChemDiv 1440-2881), AD7/ZINC254379081 (Enamine Z56821059), AD9/ZINC20677610 (ChemDiv K784-1448),
Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective
Naomi Scarano; Chiara Brullo; Francesca Musumeci; Enrico Millo; Santina Bruzzone; Silvia Schenone; Elena Cichero; George Mihai Nitulescu; Dragos Mihai
PMC ID: PMC11123952 | DOI: 10.3390/ph17050601 | Journal: Pharmaceuticals, 17(1) | Publisher: MDPI | Publication date: 2024-05-08
Original document: PMC | Score: 7.5663624 | Text size: 136419 | Find: similar documents
In particular, the ROC-AUC associated with preliminary screening and an annotated database was reported, and the best performing conformation (PDB ID: 5Y5N) [20] was chosen to perform a VS of a CNS-focused library from ChemDIV (22,000 compounds). ... The selected computational protocol was applied for the search of putative SIRT2Is based on the ChemDIV library (22, 000 compounds), thereby leading to L407-0319 as a modest inhibitor (see previous Table 5, Entry 6). ... ChemDIV (22,000)
Xiaodie Chen; Zhen Lu; Jin Xiao; Wei Xia; Yi Pan; Houjun Xia; Youhai H. Chen; Haiping Zhang; Alexander E. Kalyuzhny; David Qian
PMC ID: PMC11082981 | DOI: 10.3390/cells13090771 | Journal: Cells, 13(1) | Publisher: MDPI | Publication date: 2024-04-30
Original document: PMC | Score: 6.2764883 | Text size: 60410 | Find: similar documents
Our screening encompassed the ZINC database (version 2019), and this methodology could be applied to subsequent versions of ZINC or other popular databases like ChemDiv or the Natural Product Database.
Illuminating Dark Chemical Matter Using the Cell Painting Assay
Axel Pahl; Jie Liu; Sohan Patil; Soheila Rezaei Adariani; Beate Schölermann; Jens Warmers; Jana Bonowski; Sandra Koska; Yasemin Akbulut; Carina Seitz; Sonja Sievers; Slava Ziegler; Herbert Waldmann
PMC ID: PMC11181314 | DOI: 10.1021/acs.jmedchem.4c00160 | ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 67(1) pp. 8862-8876 | Publisher: American Chemical Society | Publication date: 2024-04-30
Original document: PMC | Score: 8.441963 | Text size: 61732 | Find: similar documents
ChemDiv offers a DCM library17 that represents the overlap of the 140,000 DCM compounds published by Wassermann et al. and the ChemDiv compound stock. ... The structural overlap of the full ChemDiv data set with our internal compound database (“COMAS DB”, 194,832 compounds) was determined by InChIKey to be 2818 compounds (Figure 1A). ... The full ChemDiv DCM data set was filtered for compounds with sufficient availability (“available” ≥ 2 mg), leaving 18,411 compounds. ... The PAINS filter by Saubern et al. was used to detect problematic moieties.44 All tested compounds were obtained from commercial sources, mostly from ChemDiv.
Data-balanced transformer for accelerated ionizable lipid nanoparticles screening in mRNA delivery
Kun Wu; Xiulong Yang; Zixu Wang; Na Li; Jialu Zhang; Lizhuang Liu
PMC ID: PMC11052633 | DOI: 10.1093/bib/bbae186 | ISSN: 1467-5463 | Journal: Briefings in Bioinformatics, 25(1) | Publisher: Oxford University Press | Publication date: 2024-04-25
Original document: PMC | Score: 6.440691 | Text size: 61365 | Find: similar documents
Firstly, the pre-training dataset is derived from previous work [44], consisting of 19 datasets.(The 19 datasets include Targetmol (link), Chemdiv (link), Enamine (link), Chembridge (link), Life Chemical (link), Specs (link), Vitas-M (link), InterBioScreen (link), Maybridge (link), Bionet-Key Organics (link), Asinex (link), UkrOrgSynthesis (link), Eximed (link), HTS Biochemie Innovationen (link), Princeton BioMolecular (link), Otava (link), Alinda Chemical (link), Analyticon (link), ZINC (link) and ChemBL (link).) The dataset comprises 19 million molecules, with each molecule randomly generating 11 conformations, resulting in a total of 209 million conformations.
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
Stephane Ferretti; Jacques Hamon; Ruben de Kanter; Clemens Scheufler; Rita Andraos-Rey; Stephanie Barbe; Elisabeth Bechter; Jutta Blank; Vincent Bordas; Ernesta Dammassa; Andrea Decker; Noemi Di Nanni; Marion Dourdoigne; Elena Gavioli; Marc Hattenberger; Alisa Heuser; Christelle Hemmerlin; Jürgen Hinrichs; Grainne Kerr; Laurent Laborde; Isabel Jaco; Eloísa Jiménez Núñez; Hans-Joerg Martus; Cornelia Quadt; Markus Reschke; Vincent Romanet; Fanny Schaeffer; Joseph Schoepfer; Maxime Schrapp; Ross Strang; Hans Voshol; Markus Wartmann; Sarah Welly; Frédéric Zécri; Francesco Hofmann; Henrik Möbitz; Marta Cortés-Cros
PMC ID: PMC11078746 | DOI: 10.1038/s41586-024-07350-y | ISSN: 0028-0836 | Journal: Nature, 629(1) pp. 443-449 | Publisher: Nature Publishing Group UK | Publication date: 2024-04-24 | Print publication date: 2024
Original document: PMC | Score: 5.762312 | Text size: 95858 | Find: similar documents
Compound 1 (ZINC21803075, D475-1631) was purchased from ChemDiv, and the synthesis of compounds 2–6 is described in the Supplementary Information.
Matthew R. Freidel; Pratiti A. Vakhariya; Shalinder K. Sardarni; Roger S. Armen; Chaoping Chen; Andreas Jekle
PMC ID: PMC11054727 | DOI: 10.3390/v16040640 | Journal: Viruses, 16(1) | Publisher: MDPI | Publication date: 2024-04-20
Original document: PMC | Score: 6.197487 | Text size: 72058 | Find: similar documents
Samples of Arbidol 1 and derivatives were purchased from ChemDiv, including 1 (1635-0087), 1b (8015-5742) and 1c (H027-0218C) and 1d (H027-0205C).
Loïc Deblais; Mary Drozd; Anand Kumar; Janet Antwi; James Fuchs; Rahul Khupse; Yosra A. Helmy; Gireesh Rajashekara
PMC ID: PMC11061419 | DOI: 10.3389/fmicb.2024.1342573 | Journal: Frontiers in Microbiology, 15(1) | Publisher: Frontiers Media S.A. | Publication date: 2024-04-17
Original document: PMC | Score: 6.0453043 | Text size: 83854 | Find: similar documents
However, known bioactive collection (Biomol 4, MSDiscovery 1, Microsource 1, and MIH Clinical Collection 1 and 2) displayed higher hit rate (approximately 3.54%) than commercial libraries (Asinex, Chembridge 3, Chemdiv 4, Enamine 2, Lifechemicals 1, and Maybridge 5; approximately 1.20%), suggesting that each library might be composed of SM with distinct chemical structures (Supplementary Table S2).
Awwad A. Radwan; Fars Alanazi; Abdullah Al-Dhfyan; Wagdy Mohamed Eldehna
PMC ID: PMC11020408 | DOI: 10.1371/journal.pone.0298326 | Journal: PLOS ONE, 19(1) | Publisher: Public Library of Science | Publication date: 2024-04-16
Original document: PMC | Score: 8.431431 | Text size: 42199 | Find: similar documents
In our study we used the ChemDiv diversity database for receptor-based virtual screening to secure EGFR-TK inhibitors chemotherapeutics. ... In our study, we applied the VS study using EGFR-TK receptor-gefitinib complex structure against a diversity set of 350,000 small-molecule compounds (ChemDiv Library DC0, accessed Sep 08, 2022) in order to identify new EGFR inhibitors as potential anti-cancer agents. ... The structures of the screening library of 350,000 compounds were obtained from the ChemDiv (https://www.chemdiv.com/) (accessed on 1-Jan-2022) online collection using the publicly available discovery chemistry (DC01).
Shane M. Carey; Destiny M. O’Neill; Garrett B. Conner; Julian Sherman; Ana Rodriguez; Edward L. D’Antonio; Bernhard Biersack
PMC ID: PMC11050443 | DOI: 10.3390/ijms25084319 | Journal: International Journal of Molecular Sciences, 25(1) | Publisher: MDPI | Publication date: 2024-04-13
Original document: PMC | Score: 6.3167486 | Text size: 57713 | Find: similar documents
For the 3-nitro-2-phenyl-2H-chromene analogues, compounds 1–7 were purchased from TimTec, LLC (Tampa, FL, USA), while compounds 8–13 were purchased from ChemDiv, Inc.
Yanling He; Xinyuan Zhang; Weijun Pan; Jiebiao Zhang; Weiliang Zhu; Jian Zhang; Jian Shi
PMC ID: PMC11077371 | DOI: 10.7150/ijbs.87442 | Journal: International Journal of Biological Sciences, 20(1) pp. 2403-2421 | Publisher: Ivyspring International Publisher | Publication date: 2024-04-08
Original document: PMC | Score: 6.0453043 | Text size: 65419 | Find: similar documents
Based on Chemdiv library, we screened the compounds which have high affinity to CILK1 and relatively low affinity to CDK1 protein, by virtual screening and molecular docking.
The gasdermin family: emerging therapeutic targets in diseases
Chenglong Zhu; Sheng Xu; Ruoyu Jiang; Yizhi Yu; Jinjun Bian; Zui Zou
PMC ID: PMC10999458 | DOI: 10.1038/s41392-024-01801-8 | ISSN: 2095-9907 | Journal: Signal Transduction and Targeted Therapy, 9(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-04-08
Original document: PMC | Score: 4.853503 | Text size: 262585 | Find: similar documents
A virtual screen of ChemDiv compounds conducted by Cao et al. revealed that C202-2729 potently inhibits inflammation, manifesting robust anti-inflammatory activity in mouse models of endotoxin shock and EAE.503 C202-2729 does not affect either the cleavage of GSDMD or the initiation of inflammasome activation upstream.
Frances M. Bashore; Vittorio L. Katis; Yuhong Du; Arunima Sikdar; Dongxue Wang; William J. Bradshaw; Karolina A. Rygiel; Tina M. Leisner; Rod Chalk; Swati Mishra; C. Andrew Williams; Opher Gileadi; Paul E. Brennan; Jesse C. Wiley; Jake Gockley; Gregory A. Cary; Gregory W. Carter; Jessica E. Young; Kenneth H. Pearce; Haian Fu; Alison D. Axtman; Yanlin Yu
PMC ID: PMC10868801 | DOI: 10.1371/journal.pone.0293548 | Journal: PLOS ONE, 19(1) | Publisher: Public Library of Science | Publication date: 2024-02-15
Original document: PMC | Score: 7.276384 | Text size: 75386 | Find: similar documents
A total of 138,214 compounds from two chemical diversity libraries (ChemDiv and Asinex) at Emory Chemical Biology Discovery Center (ECBDC) have been screened. ... Compounds 2–41 were purchased from ChemDiv, ChemBridge, Vitascreen, LifeChemicals, and Enamine.
Targeting MYC at the intersection between cancer metabolism and oncoimmunology
Simran Venkatraman; Brinda Balasubramanian; Chanitra Thuwajit; Jaroslaw Meller; Rutaiwan Tohtong; Somchai Chutipongtanate
PMC ID: PMC10881682 | DOI: 10.3389/fimmu.2024.1324045 | Journal: Frontiers in Immunology, 15(1) | Publisher: Frontiers Media S.A. | Publication date: 2024-02-08
Original document: PMC | Score: 6.197487 | Text size: 79361 | Find: similar documents
The novel inhibitor was identified using the drug database ChemDiv and molecularly docked to the crystallized structure of the MYC-MAX heterodimer complexed with DNA (PDB ID: 1NKP) (176).
Screening Techniques for Drug Discovery in Alzheimer’s Disease
Sandra Maniam; Subashani Maniam
PMC ID: PMC10870277 | DOI: 10.1021/acsomega.3c07046 | Journal: ACS Omega, 9(1) pp. 6059-6073 | Publisher: American Chemical Society | Publication date: 2024-02-05
Original document: PMC | Score: 5.971982 | Text size: 84447 | Find: similar documents
Virtual screening through ROCS was used to identify inhibitors of BChE (Figure 9a).65 Biochemical evaluations were conducted on Chemdiv database which contains over a million compounds.
Identification of New EGFR Inhibitors by Structure-Based Virtual Screening and Biological Evaluation
Shuyi Wang; Xiaotian Xu; Chuxin Pan; Qian Guo; Qinlan Li; Shanhe Wan; Zhonghuang Li; Jiajie Zhang; Xiaoyun Wu; Elena Levantini
PMC ID: PMC10856253 | DOI: 10.3390/ijms25031887 | Journal: International Journal of Molecular Sciences, 25(1) | Publisher: MDPI | Publication date: 2024-02-04
Original document: PMC | Score: 8.419415 | Text size: 43566 | Find: similar documents
To identify potential inhibitors, molecular docking-based virtual screening was conducted on ChemDiv and Enamine commercial databases using the Glide program. ... Molecular docking was conducted on ChemDiv and Enamine commercial databases. ... Two databases, Chemdiv and Enamine, were rationally selected according to the structural diversity and commercial availability of the compounds. ... First, ChemDiv and Enamine databases were downloaded from the ZINC website [18,19], prepared using the Ligprep module, and filtered using Lipinski’s rule of five to improve compound drug-likeness [20]. ... Commercially available compounds of the ChemDiv (about 1,400,000 compounds) and Enamine (about 1,800,000 compounds) databases were downloaded from the ZINC website.
Molecular fragmentation as a crucial step in the AI-based drug development pathway
Shao Jinsong; Jia Qifeng; Chen Xing; Yajie Hao; Li Wang
PMC ID: PMC10834946 | DOI: 10.1038/s42004-024-01109-2 | Journal: Communications Chemistry, 7(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-02-01
Original document: PMC | Score: 6.3988395 | Text size: 50714 | Find: similar documents
ChemDiv
Filipa Lynce; Laura E. Stevens; Zheqi Li; Jane E. Brock; Anushree Gulvady; Ying Huang; Faina Nakhlis; Ashka Patel; Jeremy M. Force; Tufia C. Haddad; Naoto Ueno; Vered Stearns; Antonio C. Wolff; Amy S. Clark; Jennifer R. Bellon; Edward T. Richardson; Justin M. Balko; Ian E. Krop; Eric P. Winer; Paulina Lange; E. Shelley Hwang; Tari A. King; Sara M. Tolaney; Alastair Thompson; Gaorav P. Gupta; Elizabeth A. Mittendorf; Meredith M. Regan; Beth Overmoyer; Kornelia Polyak
PMC ID: PMC10829369 | DOI: 10.1186/s13058-024-01774-0 | ISSN: 1465-5411 | Journal: Breast Cancer Research : BCR, 26(1) | Publisher: BioMed Central | Publication date: 2024-01-31 | Print publication date: 2024
Original document: PMC | Score: 7.3305492 | Text size: 59286 | Find: similar documents
N.U. is a consultant for AstraZeneca plc, Bayer AG, Pfizer Inc., Gilead Sciences, Inc., Chugai Pharmaceutical Co., CytoDyn Inc., Daiichi Sankyo, Inc., DynaMed, LLC, Eisai Co., Ltd., KeChow Pharma, Inc., Lavender Health Ltd., OBI Pharma Inc., OncoCyte Co., Ourotech, Inc., DBA Pear Bio, Kirilys Therapeutics, Inc., Peptilogics, Inc., Phoenix Molecular Designs, Preferred Medicine, Inc., Puma Biotechnology, Inc., Sumitomo Dainippon Pharma, Inc., Sysmex Co. Ltd., Takeda Pharmaceuticals, Ltd., Unitech Medical, Inc., CARNA Biosciences, Inc., ChemDiv, Inc., DualityBio, LARVOL, Oncolys BioPharma Inc., Rakuten Medical, Inc., Merck Co.
Identification of Triazolopyrimidinyl Scaffold SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitor
Sebastjan Kralj; Marko Jukič; Miha Bahun; Luka Kranjc; Anja Kolarič; Milan Hodošček; Nataša Poklar Ulrih; Urban Bren; Bingfang Yan
PMC ID: PMC10893172 | DOI: 10.3390/pharmaceutics16020169 | Journal: Pharmaceutics, 16(1) | Publisher: MDPI | Publication date: 2024-01-25
Original document: PMC | Score: 6.4830923 | Text size: 44717 | Find: similar documents
We collected commercially available libraries marketed as protease inhibitor libraries (APExBIO (Houston, TX, USA), Asinex (Winston-Salem, NC, USA), ChemDiv (San Diego, CA, USA), Enamine (Cincinnati, OH, USA), Life Chemicals (Kyiv, Ukraine), Otava (Ann Arbor, MI, USA), Selleckchem (Houston, TX, USA), TargetMol (Boston, MA, USA)) and expanded the database with all cysteine protease inhibitors and all viral proteases available in the ChEMBL dataset using SQLite.
Deepti Mudaliar; Rachel H. Mansky; Angel White; Grace Baudhuin; Jon Hawkinson; Henry Wong; Michael A. Walters; Rocio Gomez-Pastor
PMC ID: PMC10849513 | DOI: 10.1101/2024.01.18.576328 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2024-01-22
Original document: PMC | Score: 8.504611 | Text size: 61533 | Find: similar documents
With this promising potential binding pocket as our target, we performed a screen of a commercial library of ~29,000 allosteric kinase inhibitor-like compounds (The ChemDiv Allosteric Kinase Inhibitor (CDAKI) Library) using a CK2α’ activity-dependent ADP-GloTM Kinase assay. ... To identify new CK2α’ hits that could potentially target this Type IV allosteric site, we decided to screen a commercial library of 28,812 allosteric-kinase-inhibitor-like compounds (The ChemDiv Allosteric Kinase Inhibitor (CDAKI) Library). ... The optimized ADP GloTM standard HTS assay was used to screen 28,812 compounds of the ChemDiv Allosteric Kinase Inhibitor (CDAKI) Library (ChemDiv, Inc) (Fig. 3).
Si Min Zhang; Cynthia B.J. Paulin; Huazhang Shu; Miriam Yagüe-Capilla; Maurice Michel; Petra Marttila; Florian Ortis; Henri Colyn Bwanika; Christopher Dirks; Rajagopal Papagudi Venkatram; Elisée Wiita; Ann-Sofie Jemth; Ingrid Almlöf; Olga Loseva; Femke M. Hormann; Tobias Koolmeister; Erika Linde; Sun Lee; Sabin Llona-Minguez; Martin Haraldsson; Hanna Axelsson; Kia Strömberg; Evert J. Homan; Martin Scobie; Thomas Lundbäck; Thomas Helleday; Sean G. Rudd
PMC ID: PMC10839966 | DOI: 10.1016/j.isci.2024.108907 | Journal: iScience, 27(1) | Publisher: Elsevier | Publication date: 2024-01-13
Original document: PMC | Score: 5.971982 | Text size: 103523 | Find: similar documents
We initiated this study with one of the largest reported biochemical screening campaigns against SAMHD1, composed of 17,656 diverse chemical entities of both commercial (Enamine, TimTec, Maybridge, and ChemDiv) and/or in-house origins (donation from Biovitrum).
Numan Yousaf; Rima D Alharthy; Maryam; Iqra Kamal; Muhammad Saleem; Muhammad Muddassar
PMC ID: PMC10084823 | DOI: 10.7717/peerj.14936 | ISSN: 2167-8359 | Journal: PeerJ, 11 | Publication date: 2023 | Print publication date: 2023
Original document: Medline | Score: 10.21365 | Text size: 2227 | Find: similar documents
The best query model was then employed for performing shape, color, and electrostatics complementarity-based virtual screening of the ChemDiv database.
Identification of a novel small-molecule inhibitor targeting TIM-3 for cancer immunotherapy
Menghan Wu; Aijun Wu; Xiangrui Zhang; Yang Li; Beibei Li; Shengzhe Jin; Qingyu Dong; Xiaoshuang Niu; Lihan Zhang; Xiaowen Zhou; Jiangfeng Du; Yahong Wu; Wenjie Zhai; Xiuman Zhou; Lu Qiu; Yanfeng Gao; Wenshan Zhao
DOI: 10.1016/j.bcp.2023.115583 | ISSN: 1873-2968 | Journal: Biochemical pharmacology, 212 pp. 115583-115583 | Publisher: Elsevier Science | Publication date: 2023-05-04 | Print publication date: 2023-05-04
Original document: Medline | Score: 12.223339 | Text size: 1396 | Find: similar documents
Here, to identify small molecule inhibitors targeting TIM-3, the docking pocket in TIM-3 was analyzed by Molecular Operating Environment (MOE) and the Chemdiv compound database was screened.
Exploring allosteric hits of the NS2B-NS3 protease of DENV2 by structure-guided screening
Aditi Gangopadhyay; Achintya Saha
DOI: 10.1016/j.compbiolchem.2023.107876 | ISSN: 1476-928X | Journal: Computational biology and chemistry, 104 pp. 107876-107876 | Publisher: Elsevier | Publication date: 2023-04-29 | Print publication date: 2023-04-29
Original document: Medline | Score: 10.21365 | Text size: 2227 | Find: similar documents
This study aimed to identify serotype-specific hits against the allosteric site in the NS2B-NS3 protease of DENV serotype 2 (DENV2) from the Enamine, Selleck, and ChemDiv antiviral libraries.
Tong Qin; Xuefeng Gao; Lei Lei; Jing Feng; Wenxuan Zhang; Yuhua Hu; Zhufang Shen; Zhenming Liu; Yi Huan; Song Wu; Jie Xia; Liangren Zhang
DOI: 10.1016/j.ejmech.2023.115307 | ISSN: 1768-3254 | Journal: European journal of medicinal chemistry, 252 pp. 115307-115307 | Publisher: Editions Scientifiques Elsevier | Publication date: 2023-03-27 | Print publication date: 2023-04-05
Original document: Medline | Score: 14.456684 | Text size: 2581 | Find: similar documents
To this end, we developed a multi-stage computational workflow to screen the Specs and ChemDiv chemical library for FXR agonists, which consisted of machine learning (ML)-based classifiers, shape-based and electrostatic-based models, a FRED-based molecular docking protocol, an ADMET prediction protocol and substructure search. ... As a result, we identified a novel chemotype that has never been reported before, with compound XJ02862 (ChemDiv ID: Y020-6413) as the representative.
Yu-Bin Bai; Xiao-Rong Yang; Bing Li; Xu-Zheng Zhou; Wei-Wei Wang; Fu-Sheng Cheng; Ji-Yu Zhang
PMC ID: PMC10100900 | DOI: 10.1128/spectrum.03502-22 | ISSN: 2165-0497 | Journal: Microbiology spectrum | Publisher: ASM Press | Publication date: 2023-02-21 | Print publication date: 2023-02-21
Original document: Medline | Score: 8.771491 | Text size: 2730 | Find: similar documents
High-affinity inhibitors were screened from the ChemDiv database (1,535,478 compounds) using LuxS as a ligand.
Leah Amod; Roxanne Mohunlal; Nicole Teixeira; Timothy J Egan; Kathryn J Wicht
PMC ID: PMC9929333 | DOI: 10.1038/s41598-023-29273-w | ISSN: 2045-2322 | Journal: Scientific reports, 13(1) pp. 2648-2648 | Publisher: Nature Publishing Group | Publication date: 2023-02-14 | Print publication date: 2023-02-14
Original document: Medline | Score: 13.557122 | Text size: 1349 | Find: similar documents
In this study, molecular docking and machine learning techniques, including Bayesian and support vector machine classifiers, were used in sequence to screen the in silico ChemDiv 300k Representative Compounds library for inhibitors of βH with retained activity against P. falciparum.
Hongshan Jin; Chengjun Wu; Rui Su; Tiemin Sun; Xingzhou Li; Chun Guo
PMC ID: PMC9862751 | DOI: 10.3390/molecules28020527 | ISSN: 1420-3049 | Journal: Molecules (Basel, Switzerland), 28(2) | Publisher: MDPI | Publication date: 2023-01-05 | Print publication date: 2023-01-05
Original document: Medline | Score: 9.682976 | Text size: 2444 | Find: similar documents
All molecules in the ChemDiv library (>1,500,000) were narrowed down to a final set of 37 molecules for the binding assays.
PMC ID: PMC9820117 | DOI: 10.3390/ijms24010339 | ISSN: 1422-0067 | Journal: International journal of molecular sciences, 24(1) | Publisher: MDPI | Publication date: 2022-12-25 | Print publication date: 2022-12-25
Original document: Medline | Score: 10.8058605 | Text size: 2040 | Find: similar documents
The ligand-based models-including the pharmacophore model, 3D QSAR, AutoQSAR, and ADME/T calculation-were integrated and used in the following virtual screening of the ChemDiv PPI database.
Yueyan Li; Xuan Huang; Jing Tang
DOI: 10.1016/j.ejphar.2022.175471 | ISSN: 1879-0712 | Journal: European journal of pharmacology, 940 pp. 175471-175471 | Publisher: Elsevier Science | Publication date: 2022-12-19 | Print publication date: 2023-02-05
Original document: Medline | Score: 9.682976 | Text size: 2238 | Find: similar documents
A docking virtual assay on the Chemdiv database was used to screen La binders, and their affinity were measured by surface plasmon resonance (SPR).
Ajay Mili; Subham Das; Krishnadas Nandakumar; Richard Lobo
DOI: 10.1080/07391102.2022.2141885 | ISSN: 1538-0254 | Journal: Journal of biomolecular structure & dynamics, pp. 1-18 | Publisher: Taylor & Francis | Publication date: 2022-11-03 | Print publication date: 2022-11-03
Original document: Medline | Score: 10.8058605 | Text size: 2007 | Find: similar documents
Acquiring and preparing the KEAP1-NRF2 Protein (PDB: 4L7D) with Schrodinger Suite was followed by developing a ligand library (Anti-inflammatory library downloaded from ChemDiv database).
Computational investigation of peptidomimetics as potential inhibitors of SARS-CoV-2 spike protein
PMC ID: PMC9971351 | DOI: 10.1080/07391102.2022.2116601 | ISSN: 1538-0254 | Journal: Journal of biomolecular structure & dynamics, pp. 1-14 | Publisher: Taylor & Francis | Publication date: 2022-08-29 | Print publication date: 2022-08-29
Original document: Medline | Score: 15.672428 | Text size: 1864 | Find: similar documents
Virtual screening of two different peptidomimetics databases, ChEMBL and ChemDiv databases, was carried out against both S1 and S2 subunits. ... Multi-layered filtration, based on physicochemical properties and docking scores, of nearly 114,000 compounds found in the ChEMBL database and nearly 14,000 compounds in the ChemDiv database was employed.
Prediction of novel and potent inhibitors of lanosterol 14-α demethylase
Mohd Waseem; Jitendra K Thakur; Naidu Subbarao
DOI: 10.1080/07391102.2022.2096116 | ISSN: 1538-0254 | Journal: Journal of biomolecular structure & dynamics, pp. 1-13 | Publisher: Taylor & Francis | Publication date: 2022-07-09 | Print publication date: 2022-07-09
Original document: Medline | Score: 11.470976 | Text size: 1619 | Find: similar documents
In this study, we have screened a large number of small molecules from different chemical databases (ZINC, DrugBank, ChEMBL, and ChemDiv) to find out novel and potential inhibitors of LDM.
Tanaporn Uengwetwanit; Nopporn Chutiwitoonchai; Kanin Wichapong; Nitsara Karoonuthaisiri
PMC ID: PMC8813674 | DOI: 10.1016/j.csbj.2022.02.001 | ISSN: 2001-0370 | Journal: Computational and structural biotechnology journal, 20 pp. 882-890 | Publication date: 2022 | Print publication date: 2022
Original document: Medline | Score: 12.223339 | Text size: 1549 | Find: similar documents
Molecular docking was employed to screen inhibitors of SARS-CoV-2 from the ZINC ChemDiv database.
Ziyi Wang; Xuesong Wang; Zhe Guo; Haiyan Liao; Yan Chai; Ziwen Wang; Zhong Wang
PMC ID: PMC9792167 | DOI: 10.3389/fcimb.2022.1050497 | ISSN: 2235-2988 | Journal: Frontiers in cellular and infection microbiology, 12 pp. 1050497-1050497 | Publisher: Frontiers Media SA | Publication date: 2022 | Print publication date: 2022
Original document: Medline | Score: 13.9169035 | Text size: 2549 | Find: similar documents
The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database (https://www.chemdiv.com/complete-list/) and use the system to screen for AKT1 activation agents, which may provide clues for the research and development of new drugs to treat SALI. ... Based on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency.
Gbolahan O Oduselu; Rufus Afolabi; Ibitayo Ademuwagun; Ashley Vaughan; Ezekiel Adebiyi
PMC ID: PMC9877529 | DOI: 10.3389/fmed.2022.1022429 | ISSN: 2296-858X | Journal: Frontiers in medicine, 9 pp. 1022429-1022429 | Publication date: 2022 | Print publication date: 2022
Original document: Medline | Score: 10.8058605 | Text size: 2191 | Find: similar documents
The best model of the tertiary structure of Pf 5-ALAS was obtained using MolProbity, while the following databases were explored for the pharmacophore-based virtual screening: CHEMBL, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC databases.
Sathya Babu; Santhosh Kumar Nagarajan; Sruthy Sathish; Vir Singh Negi; Honglae Sohn; Thirumurthy Madhavan
PMC ID: PMC9068899 | DOI: 10.3389/fphar.2022.837369 | ISSN: 1663-9812 | Journal: Frontiers in pharmacology, 13 pp. 837369-837369 | Publication date: 2022 | Print publication date: 2022
Original document: Medline | Score: 9.204724 | Text size: 2774 | Find: similar documents
Based on the validation results, the best pharmacophore models ADHRRR, DDHRRR, DDRRR, DPRRR, DHRRR, ADRRR, DDHRR, and ADPRR were selected and taken for virtual screening against the Maybridge, Asinex, Chemdiv, Enamine, Lifechemicals, and Zinc database to identify the new molecules with novel scaffold that can bind to JAK1.
Danfeng Shi; Qianqian Pang; Qianyu Qin; Xinsheng Yao; Xiaojun Yao; Yang Yu
PMC ID: PMC9638114 | DOI: 10.3389/fphar.2022.1026306 | ISSN: 1663-9812 | Journal: Frontiers in pharmacology, 13 pp. 1026306-1026306 | Publication date: 2022 | Print publication date: 2022
Original document: Medline | Score: 10.8058605 | Text size: 1952 | Find: similar documents
Four compounds (Chemdiv codes: 8012-0567, 8018-6529, 8018-7168, 8018-7603) were proved with above 40% inhibitory ratio targeting PARP-1 under 20 μM, and further performed binding mode prediction and dynamic effect evaluation by molecular dynamics simulation.
Farzan Nabati; Ayshin Kamyabiamineh; Ramin Kosari; Faezeh Ghasemi; Seyedehmasoumeh Seyedebrahimi; Sobhan Mohammadi; Mohammad Moradi
PMC ID: PMC9652154 | DOI: 10.1016/j.imu.2022.101134 | ISSN: 2352-9148 | Journal: Informatics in medicine unlocked, 35 pp. 101134-101134 | Publication date: 2022 | Print publication date: 2022
Original document: Medline | Score: 10.8058605 | Text size: 1947 | Find: similar documents
We performed structure-based virtual screening (SBVS) of a library that was built from ChemDiv and PubChem databases against four SARS-CoV-2 target proteins: S-protein (spike), main protease (MPro), RNA-dependent RNA polymerase, and PLpro.
Jyoti Verma; Abdul Hasan; Sujatha Sunil; Naidu Subbarao
DOI: 10.1007/s10822-022-00463-4 | ISSN: 1573-4951 | Journal: Journal of computer-aided molecular design, 36(7) pp. 521-536 | Publisher: Springer | Publication date: 2022-07 | Print publication date: 2022-07
Original document: Medline | Score: 17.851965 | Text size: 2218 | Find: similar documents
Another potential inhibitor with ID ChemDiv 8015-3006 binds at both the target sites and shows anti-CHIKV activity at EC50 = 41 μM. ... The results show dose-dependent inhibitory effects of Taxifolin, Rutin and ChemDiv 8015-3006 against the CHIKV with minimal cytotoxicity. ... In conclusion, our study reports Taxifolin, Rutin and ChemDiv 8015-3006 as potential inhibitors of the CHIKV entry.
Yaodong Liu; Sibtain Ahmed; Yaowei Fang; Meng Chen; Jia An; Guang Yang; Xiaoyue Hou; Jing Lu; Qinwen Ye; Rongjun Zhu; Qitong Liu; Shu Liu
PMC ID: PMC9628821 | DOI: 10.4014/jmb.2201.01009 | ISSN: 1738-8872 | Journal: Journal of microbiology and biotechnology, 32(4) pp. 504-513 | Publisher: Korean Society for Microbiology and Biotechnology | Publication date: 2022-04-28 | Print publication date: 2022-04-28
Original document: Medline | Score: 12.637784 | Text size: 1540 | Find: similar documents
In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening.
Olanrewaju Ayodeji Durojaye; Nkwachukwu Oziamara Okoro; Arome Solomon Odiba; Bennett Chima Nwanguma
PMC ID: PMC10141821 | DOI: 10.1038/s41598-023-33024-2 | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-04-28
Original document: PMC | Score: 9.797036 | Text size: 76768 | Find: similar documents
The chemical compound databases screened (based on pharmacophore-matching) include the CHEMBL30, ChemDiv, ChemSpace, Mcule, Mcule-ultimate, MolPort, NCI Open Chemical Repository, WuXi LabNetwork, and the ZINC databases. ... ChemDiv
Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors
Francesca Curreli; Kent Chau; Thanh-Thuy Tran; Isabella Nicolau; Shahad Ahmed; Pujita Das; Christopher D. Hillyer; Mary Premenko-Lanier; Asim K. Debnath; Yinzhong Shen
PMC ID: PMC10141620 | DOI: 10.3390/v15041001 | Journal: Viruses, 15(1) | Publisher: MDPI | Publication date: 2023-04-19
Original document: PMC | Score: 7.26731 | Text size: 59967 | Find: similar documents
We screened a set of twenty-two small molecules, of which NBCoV35-37 were purchased from Chembridge Corporation (San Diego, CA, USA) and NBCoV62-82 were purchased from ChemDiv, Inc.
Yunfan Shi; Liting Dong; Zhuang Ju; Qiufu Li; Yanru Cui; Yiran Liu; Jiaoyu He; Xianping Ding
PMC ID: PMC10100623 | DOI: 10.1007/s00894-023-05534-3 | ISSN: 1610-2940 | Journal: Journal of Molecular Modeling, 29(1) | Publisher: Springer Berlin Heidelberg | Publication date: 2023-04-13 | Print publication date: 2023
Original document: PMC | Score: 13.953599 | Text size: 38164 | Find: similar documents
ChemDiv ID ... ChemDiv ID ... The database are from TargetMol and the compound files are from ChemDiv.
Numan Yousaf; Rima D. Alharthy; Maryam; Iqra Kamal; Muhammad Saleem; Muhammad Muddassar; Pedro Silva
PMC ID: PMC10084823 | DOI: 10.7717/peerj.14936 | Journal: PeerJ, 11(1) | Publisher: PeerJ Inc. | Publication date: 2023-04-07
Original document: PMC | Score: 15.234975 | Text size: 50044 | Find: similar documents
The best query model was then employed for performing shape, color, and electrostatics complementarity-based virtual screening of the ChemDiv database. ... Chemdiv database was prepared by implementing drug like filter criteria to remove unwanted chemical structures, duplicates and salts. ... Toxicological and pharmacokinetics studies were conducted on virtually screened compounds mined from Chemdiv database by using online tool PreADMETv.2.0 (https://preadmet.bmdrc.kr/adme/) (Lee et al., 2004; Lee et al., 2003). ... After generating optimized query model, the Chemdiv database was screened by matching the query features with its compounds.
VSFlow: an open-source ligand-based virtual screening tool
Sascha Jung; Helge Vatheuer; Paul Czodrowski
PMC ID: PMC10064649 | DOI: 10.1186/s13321-023-00703-1 | Journal: Journal of Cheminformatics, 15(1) | Publisher: Springer International Publishing | Publication date: 2023-03-31
Original document: PMC | Score: 10.434273 | Text size: 24957 | Find: similar documents
The web tool SwissSimilarity allows for the 2D fingerprint and 3D shape screening of common public databases and compound libraries of most commercial vendors such as Enamine or ChemDiv [15, 16].
Patrícia S. Sobral; Vanessa C. C. Luz; João M. G. C. F. Almeida; Paula A. Videira; Florbela Pereira; Jean Christopher Chamcheu; Jean Fotie
PMC ID: PMC10054797 | DOI: 10.3390/ijms24065908 | Journal: International Journal of Molecular Sciences, 24(1) | Publisher: MDPI | Publication date: 2023-03-21
Original document: PMC | Score: 5.9023848 | Text size: 87828 | Find: similar documents
Lyu et al. [85] aimed to identify novel inhibitors by using a structure-based virtual screening approach, retrieving about 500 molecules with a high binding affinity from the Chemdiv-Plus database.
Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface
Hassina Massudi; Jie-Si Luo; Jessica K. Holien; Satyanarayana Gadde; Sukriti Krishan; Mika Herath; Jessica Koach; Brendan W. Stevenson; Michael A. Gorman; Pooja Venkat; Chelsea Mayoh; Xue-Qun Luo; Michael W. Parker; Belamy B. Cheung; Glenn M. Marshall; Vladimir Spiegelman
PMC ID: PMC10046377 | DOI: 10.3390/cancers15061822 | Journal: Cancers, 15(1) | Publisher: MDPI | Publication date: 2023-03-17
Original document: PMC | Score: 7.26731 | Text size: 60232 | Find: similar documents
All compounds were purchased from Chemdiv (
Beatrice Balboni; Francesco Rinaldi; Viola Previtali; Andrea Ciamarone; Stefania Girotto; Andrea Cavalli; John J. Turchi
PMC ID: PMC10046612 | DOI: 10.3390/cancers15061817 | Journal: Cancers, 15(1) | Publisher: MDPI | Publication date: 2023-03-17
Original document: PMC | Score: 8.771591 | Text size: 94741 | Find: similar documents
Virtual screening (docking – PDB: 5JRB ssDNA groove: 47,737 cpds Targeted Diversity Library (TDL) – Chemdiv database, DOCK6.5 software) ... Virtual screening (docking – PDB: 5JRB self-association pocket: 66,608 cpds - Chemdiv database, DOCK6.5 software)
PMC ID: PMC9993391 | DOI: 10.1007/s11224-023-02148-6 | ISSN: 1040-0400 | Journal: Structural Chemistry, pp. 1-19 | Publisher: Springer US | Publication date: 2023-03-08
Original document: PMC | Score: 7.26731 | Text size: 59496 | Find: similar documents
In this study, 8722 chemical entities were collected from Asinex-Antiviral Library, 3700 compounds were collected from Enamine-Antiviral Library, and 67,470 molecules were taken from ChemDiv-Antiviral Library.
Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer
Weitao Fu; Hao Yang; Chenxian Hu; Jianing Liao; Zhou Gong; Minkui Zhang; Shuai Yang; Shangxiang Ye; Yixuan Lei; Rong Sheng; Zhiguo Zhang; Xiaojun Yao; Chun Tang; Dan Li; Tingjun Hou
PMC ID: PMC10141604 | DOI: 10.1021/acscentsci.2c01548 | ISSN: 2374-7943 | Journal: ACS Central Science, 9(1) pp. 675-684 | Publisher: American Chemical Society | Publication date: 2023-03-08
Original document: PMC | Score: 9.110828 | Text size: 35835 | Find: similar documents
Through compound library filtering using Lipinski’s rule-of-five, cascade molecular docking, and structural clustering, a total of 476 structurally diverse compounds were screened out from the ChemDiv database (∼1.6 million compounds) and submitted for AR transcriptional activity assay.
Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis
Zachariah P. Schuurs; John P. McDonald; Laura V. Croft; Derek J. Richard; Roger Woodgate; Neha S. Gandhi
PMC ID: PMC10020695 | DOI: 10.3389/fcimb.2023.1051602 | Journal: Frontiers in Cellular and Infection Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2023-03-03
Original document: PMC | Score: 17.08099 | Text size: 69792 | Find: similar documents
A structure-based virtual screening was performed with the ChemDiv library peptidomimetics of β-turn motifs (ChemDiv, 2019). ... The top 53 compounds were subsequently ordered from ChemDiv to test in vitro. ... The ChemDiv libraries Covalent Generic and Smart Inhibitors (ChemDiv, 2020) was docked to the WT LexA using the CovDock (Toledo Warshaviak et al., 2014; Zhu et al., 2014) workflow in the Schrödinger Maestro suite 2019-4. ... The 80 top scoring compounds were ordered from ChemDiv (San Diego, CA). ... A total of 133 compounds from the two screens were ordered from ChemDiv (San Diego, CA), which consisted of 80 molecules from the covalent screen, and 53 molecules from the β-turn library. ... ChemDiv. ... ChemDiv.
Ibitayo Abigail Ademuwagun; Gbolahan Oladipupo Oduselu; Solomon Oladapo Rotimi; Ezekiel Adebiyi
PMC ID: PMC9989394 | DOI: 10.1177/11779322231158254 | Journal: Bioinformatics and Biology Insights, 17(1) | Publisher: SAGE Publications | Publication date: 2023-03-02
Original document: PMC | Score: 8.495119 | Text size: 43363 | Find: similar documents
The Pharmit web server was configured to include best hits from the following databases: PubChem, MCULE, ZINC database, MolPort, CHEMBL30, ChemDiv, ChemSpace, MCULE-ULTIMATE, NCI Open Chemical Repository, and LabNetwork.13 Specifically, the following features were used as thresholds to filter databases in accordance with Lipinski rule of 5, Veber, Ghose, Egan, and Muegge rules.14-17 These include molecular weight ⩽ 500 g, number of rotable bonds ⩽ 10, logP (octanol-water partition coefficient) value ⩽ 5, topological polar surface area (TPSA) ⩽ 140 Å, hydrogen bonds acceptor ⩽ 10, hydrogen bonds donor ⩽ 5, and number of aromatics ⩽ 2.17
Sheli R. Radoshitzky; Patrick Iversen; Xianghan Lu; Jing Zou; Suzanne J. F. Kaptein; Kelly S. Stuthman; Sean A. Van Tongeren; Jesse Steffens; Ruoyu Gong; Hoa Truong; Annapurna A. Sapre; Huiling Yang; Xiaodong Xie; Jia Jun Chia; Zhijuan J. Song; Stacey M. Leventhal; Josolyn Chan; Alex Shornikov; Xin Zhang; David Cowfer; Helen Yu; Travis Warren; Tomas Cihlar; Danielle P. Porter; Johan Neyts; Pei-Yong Shi; Jay Wells; John P. Bilello; Joy Y. Feng
PMC ID: PMC9950143 | DOI: 10.1038/s41598-023-29517-9 | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-02-23
Original document: PMC | Score: 6.8701305 | Text size: 70342 | Find: similar documents
E864-0360 was purchased from ChemDiv (San Diego, CA).
Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay
Anice Sabag-Daigle; Erin F. Boulanger; Pankajavalli Thirugnanasambantham; Jamison D. Law; Alex J. Bogard; Edward J. Behrman; Venkat Gopalan; Brian M. M. Ahmer; Carlos J. Blondel
PMC ID: PMC10100877 | DOI: 10.1128/spectrum.04606-22 | Journal: Microbiology Spectrum, 11(1) | Publisher: American Society for Microbiology | Publication date: 2023-02-21
Original document: PMC | Score: 13.455724 | Text size: 46886 | Find: similar documents
ChemDiv ... ChemDiv ... ChemDiv
Yu-Bin Bai; Xiao-Rong Yang; Bing Li; Xu-Zheng Zhou; Wei-Wei Wang; Fu-Sheng Cheng; Ji-Yu Zhang; Livnat Afriat-Jurnou
PMC ID: PMC10100900 | DOI: 10.1128/spectrum.03502-22 | Journal: Microbiology Spectrum, 11(1) | Publisher: American Society for Microbiology | Publication date: 2023-02-21
Original document: PMC | Score: 15.859128 | Text size: 58848 | Find: similar documents
High-affinity inhibitors were screened from the ChemDiv database (1,535,478 compounds) using LuxS as a ligand. ... The present study screened quorum-sensing inhibitors (QSIs) from the ChemDiv database (1,535,478 compounds). ... A virtual screening was performed using the FRED software, where multiple conformations of each compound from the ChemDiv database (1,535,478 compounds, version 2019; ChemDiv, San Diego, CA) were docked to the LuxS pocket. ... Through the rigid docking strategy, 682 compounds with high affinity were screened from the ChemDiv database. ... The ChemDiv database, a commercially available small-molecule database from Shanghai TopScience Biotechnology Co. with more than 1 million compounds, was used as the screening library.
Phosphomevalonate Kinase Controls β‐Catenin Signaling via the Metabolite 5‐Diphosphomevalonate
Zhiqiang Chen; Xinyi Zhou; Xiaojun Zhou; Yi Tang; Mingzhu Lu; Jianhong Zhao; Chenhui Tian; Mingzhi Wu; Yanliang Liu; Edward V. Prochownik; Fubing Wang; Youjun Li
PMC ID: PMC10131864 | DOI: 10.1002/advs.202204909 | Journal: Advanced Science, 10(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2023-02-21
Original document: PMC | Score: 12.559463 | Text size: 63715 | Find: similar documents
Using a virtual screen, we identified the putative PMVK inhibitor top 5 (PMVKi5) (C24H23ClN2O6,N‐[(E)‐[3‐[(4‐chloro‐3,5‐dimethylphenoxy)methyl]‐4‐methoxyphenyl]methylideneamino]‐3,4,5‐trihydroxybenzamide) from a library of 1.7 million ChemDiv small molecule compounds (Figure 7A). ... The PMVK‐based crystal structure (PDB: 3CH4) was used for computer‐based virtual docking of 1.7 million small molecules from the ChemDiv database. ... Small molecules were downloaded from the ChemDiv database (https://www.chemdiv.com).
Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development
Chia-Ju Hsieh; Sam Giannakoulias; E. James Petersson; Robert H. Mach; Irina Velikyan
PMC ID: PMC9964981 | DOI: 10.3390/ph16020317 | Journal: Pharmaceuticals, 16(1) | Publisher: MDPI | Publication date: 2023-02-18
Original document: PMC | Score: 11.418604 | Text size: 78038 | Find: similar documents
[62,63], WuXi AppTec [64], ChemDiv Inc. ... ChemDiv Compound Libraries ... 1.5 M/ChemDiv
Leah Amod; Roxanne Mohunlal; Nicole Teixeira; Timothy J. Egan; Kathryn J. Wicht
PMC ID: PMC9929333 | DOI: 10.1038/s41598-023-29273-w | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-02-14
Original document: PMC | Score: 17.088491 | Text size: 40062 | Find: similar documents
In this study, molecular docking and machine learning techniques, including Bayesian and support vector machine classifiers, were used in sequence to screen the in silico ChemDiv 300k Representative Compounds library for inhibitors of βH with retained activity against P. falciparum. ... The ChemDiv 300k Representative Compounds library was initially filtered for druglikeness using Lipinski’s Rule of Five and OSIRIS DataWarrior’s24 inhouse score. ... Virtual screening of the ChemDiv 300k Representative Compounds library and prioritisation of in-silico hits for purchasing and experimental testing against βH and whole-cell cultures of Pf. ... 40.ChemDiv Inc. http://www.chemdiv.com/. ... (ChemDiv Inc.).
Melissa L. Sykes; Emily K. Kennedy; Vicky M. Avery; Katharine Carter
PMC ID: PMC9967867 | DOI: 10.3390/microorganisms11020476 | Journal: Microorganisms, 11(1) | Publisher: MDPI | Publication date: 2023-02-14
Original document: PMC | Score: 6.1931806 | Text size: 80014 | Find: similar documents
Ethyl oxo{[2-(4-phenyl-1-piperazinyl)-2-(3-pyridinyl)ethyl]amino} acetate: 20 mM (E155-0206; Chemdiv, San Diego, CA, USA).
Qing Wang; Fanhao Meng; Yuting Xie; Wei Wang; Yumin Meng; Linjie Li; Tao Liu; Jianxun Qi; Xiaodan Ni; Sanduo Zheng; Jianhui Huang; Niu Huang
PMC ID: PMC9924089 | DOI: 10.1021/acscentsci.2c01190 | ISSN: 2374-7943 | Journal: ACS Central Science | Publisher: American Chemical Society | Publication date: 2023-02-08
Original document: PMC | Score: 6.8701305 | Text size: 64011 | Find: similar documents
Our in-house compound library for virtual screening was constructed from the ChemDiv database (
Sorafenib/2800Z Co-Loaded into Cholesterol and PEG Grafted Polylysine NPs for Liver Cancer Treatment
Chen Zhang; Wu Zhong; Ying Cao; Bohao Liu; Xiaojun Tao; Zhuan Li; Silviya Zustiak
PMC ID: PMC9865580 | DOI: 10.3390/ph16010119 | Journal: Pharmaceuticals, 16(1) | Publisher: MDPI | Publication date: 2023-01-13
Original document: PMC | Score: 7.957362 | Text size: 50224 | Find: similar documents
Sorafenib (BAY 43–9006) was purchased from Selleck Chemicals (Shanghai, China), and 2800Z was purchased from Chemdiv (San Diego, CA, USA).
Opportunities and challenges in application of artificial intelligence in pharmacology
Mandeep Kumar; T. P. Nhung Nguyen; Jasleen Kaur; Thakur Gurjeet Singh; Divya Soni; Randhir Singh; Puneet Kumar
PMC ID: PMC9838466 | DOI: 10.1007/s43440-022-00445-1 | ISSN: 1734-1140 | Journal: Pharmacological Reports, pp. 1-16 | Publisher: Springer International Publishing | Publication date: 2023-01-09
Original document: PMC | Score: 6.5141163 | Text size: 77691 | Find: similar documents
It is built on six datasets collected from the ChEMBL database (EGFR inhibitors); the DNN model also obtained high performance in comparison with the RF method by cross-validation or screening a large compound library (PubChem, ChemDiv database) [87].
Hongshan Jin; Chengjun Wu; Rui Su; Tiemin Sun; Xingzhou Li; Chun Guo; Dmitri B. Kireev
PMC ID: PMC9862751 | DOI: 10.3390/molecules28020527 | Journal: Molecules, 28(1) | Publisher: MDPI | Publication date: 2023-01-05
Original document: PMC | Score: 15.354868 | Text size: 59245 | Find: similar documents
All molecules in the ChemDiv library (>1,500,000) were narrowed down to a final set of 37 molecules for the binding assays. ... The molecules in the ChemDiv compound database (consisting of 1,535,478 compounds at the time this study was initiated) were analyzed by molecular docking using the AutoDock Vina package in short-searching mode. ... Bioinformatics software, such as AutoDock Vina [10], Schrödinger [25], and Pymol [26] and online resources, such as the National Center for Biotechnology Information [27] and ChemDiv Database ( ... ChemDiv in-stock diverse collection database (downloaded from ... Parametric ChemDiv compounds (recorded in PDBQT files) were docked to the ligand-binding site of D3R with AutoDock Vina using the short docking mode and other conFigureurations described in Section 2.1.3.
Targeting SOST using a small-molecule compound retards breast cancer bone metastasis
Lisha Sun; Yixiao Zhang; Guanglei Chen; Yaoting Ji; Qingtian Ma; Xinbo Qiao; Sijin Wu; Lin Zhou; Jiawen Bu; Xudong Zhu; Xiaoying Zhang; Xiaofan Jiang; Chao Liu; Xinnan Li; Yang Liu; Yongliang Yang; Caigang Liu
PMC ID: PMC9798707 | DOI: 10.1186/s12943-022-01697-4 | Journal: Molecular Cancer, 21(1) | Publisher: BioMed Central | Publication date: 2022-12-29
Original document: PMC | Score: 7.26731 | Text size: 57449 | Find: similar documents
S6 (C29H24N6O2S, molecular weight 520.62, Chemdiv, USA) was dissolved in PBS and adjusted to different concentrations for BLI.
Huanglongbing Pandemic: Current Challenges and Emerging Management Strategies
Dilip Ghosh; Sunil Kokane; Brajesh Kumar Savita; Pranav Kumar; Ashwani Kumar Sharma; Ali Ozcan; Amol Kokane; Swadeshmukul Santra; Subhas Hajeri; Madhurababu Kunta
PMC ID: PMC9824665 | DOI: 10.3390/plants12010160 | Journal: Plants, 12(1) | Publisher: MDPI | Publication date: 2022-12-29
Original document: PMC | Score: 3.1194367 | Text size: 225215 | Find: similar documents
The identified compound ChemDiv C549-0604 specifically inhibits the activity of CLas transcription regulator VisN [161,162,163,164,165], which suggests that the small lead molecules that target transcription regulators of CLas can potentially mitigate HLB.
Swati Kumari; Sayan Chakraborty; Mohammed Ahmad; Varun Kumar; Prafullakumar B. Tailor; Bichitra K. Biswal
PMC ID: PMC9794403 | DOI: 10.1016/j.ijbiomac.2022.12.252 | ISSN: 0141-8130 | Journal: International Journal of Biological Macromolecules | Publisher: Elsevier B.V. | Publication date: 2022-12-28
Original document: PMC | Score: 11.093979 | Text size: 53650 | Find: similar documents
To identify MPXV DPol specific inhibitors, we screened two compound libraries: drug-like molecules (available at ZINC database [41]) and the antiviral annotated library (ChemDiv, available at https://www.chemdiv.com/catalog/sets/Antiviral annotated-library/). ... In this study, about 7.5 million drug-like compounds from the ZINC database and 21,667 antiviral annotated compounds from ChemDiv Library were virtually screened for identifying the molecule with potential drug-like features.
Jiqing Ye; Xiao Yang; Cong Ma; Giulio Vistoli
PMC ID: PMC9820117 | DOI: 10.3390/ijms24010339 | Journal: International Journal of Molecular Sciences, 24(1) | Publisher: MDPI | Publication date: 2022-12-25
Original document: PMC | Score: 11.093979 | Text size: 52980 | Find: similar documents
The ligand-based models—including the pharmacophore model, 3D QSAR, AutoQSAR, and ADME/T calculation—were integrated and used in the following virtual screening of the ChemDiv PPI database. ... The selected pharmacophore model was used for pharmacophore-based virtual screening of a focused compounds library from ChemDiv containing 222,447 molecules.
Anti-tuberculosis drug development via targeting the cell envelope of Mycobacterium tuberculosis
Xinyue Xu; Baoyu Dong; Lijun Peng; Chao Gao; Zhiqun He; Chuan Wang; Jumei Zeng
PMC ID: PMC9810820 | DOI: 10.3389/fmicb.2022.1056608 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-21
Original document: PMC | Score: 7.26731 | Text size: 59469 | Find: similar documents
Kumar et al. (2020) analyzed two peptide compound libraries (Asinex and ChemDiv) based on the structure of MurA, and they found that four compounds have acceptable pharmacokinetic properties.
Linhui Li; Pengfei She; Shasha Liu; Yimin Li; Zehao Li; Yifan Yang; Linying Zhou; Yong Wu
PMC ID: PMC9800007 | DOI: 10.3389/fmicb.2022.1078318 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-15
Original document: PMC | Score: 7.713231 | Text size: 53444 | Find: similar documents
The MINI Scaffold library contains a total of 5,033 molecules with its own scaffold based on more than 16,000,000 drug-like small molecules from ChemDiv.
Hui Zhu; Yulin Zhang; Wei Li; Niu Huang; Alexandre G. de Brevern
PMC ID: PMC9781938 | DOI: 10.3390/ijms232415961 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-12-15
Original document: PMC | Score: 7.26731 | Text size: 64384 | Find: similar documents
1/15/n.a. (SPECS and Chemdiv libraries)
Ziyi Wang; Xuesong Wang; Zhe Guo; Haiyan Liao; Yan Chai; Ziwen Wang; Zhong Wang
PMC ID: PMC9792167 | DOI: 10.3389/fcimb.2022.1050497 | Journal: Frontiers in Cellular and Infection Microbiology, 12(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-12
Original document: PMC | Score: 17.515972 | Text size: 46829 | Find: similar documents
The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database ( ... Based on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency. ... The pharmacophore model of SC79 was used to match the ChemDiv pharmacophore database model. ... The original ChemDiv Database contained 2091084 compounds, and after preprocessing, it contained 2465124 compounds. ... ChemDiv pharmacophore database model was constructed by using each molecule of ChemDiv database to generate pharmacophore model.
Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth
Karthiga Santhana Kumar; Cyrill Brunner; Matthias Schuster; Levi Luca Kopp; Alexandre Gries; Shen Yan; Simon Jurt; Kerstin Moehle; Dominique Bruns; Michael Grotzer; Oliver Zerbe; Gisbert Schneider; Martin Baumgartner
PMC ID: PMC10060354 | DOI: 10.1007/s13402-022-00753-x | ISSN: 2211-3428 | Journal: Cellular Oncology (Dordrecht), 46(1) pp. 331-356 | Publisher: Springer Netherlands | Publication date: 2022-12-10 | Print publication date: 2023
Original document: PMC | Score: 8.19944 | Text size: 109900 | Find: similar documents
Collection of commercially available fast-delivery compounds of the suppliers Asinex Corp., ChemBridge Corp., ChemDiv, Enamine, Specs, UkrOrgSyntez Ltd. ... The generated pharmacophore was run against a database containing all fast-delivery compounds of the suppliers Asinex Corp., ChemBridge Corp., ChemDiv, Enamine, Specs, UkrOrgSyntez Ltd.
DrugCentral 2023 extends human clinical data and integrates veterinary drugs
Sorin Avram; Thomas B Wilson; Ramona Curpan; Liliana Halip; Ana Borota; Alina Bora; Cristian G Bologa; Jayme Holmes; Jeffrey Knockel; Jeremy J Yang; Tudor I Oprea
PMC ID: PMC9825566 | DOI: 10.1093/nar/gkac1085 | ISSN: 0305-1048 | Journal: Nucleic Acids Research, 51(1) pp. D1276-D1287 | Publisher: Oxford University Press | Publication date: 2022-12-09
Original document: PMC | Score: 7.713231 | Text size: 56955 | Find: similar documents
He served on the Scientific Advisory Board of ChemDiv Inc. and InSilico Medicine.
Christopher J. S. Hart; Andrew G. Riches; Snigdha Tiash; Erin Clapper; Soumya Ramu; Johannes Zuegg; John H. Ryan; Tina S. Skinner-Adams; Péter Mátyus
PMC ID: PMC9775191 | DOI: 10.3390/biomedicines10123182 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-12-08
Original document: PMC | Score: 12.167842 | Text size: 44268 | Find: similar documents
SN00797640 (M013-0086) and SN00776497 (ZZ22822646) were repurchased from ChemDiv (San Diego, CA, USA) and Enamine (Kyiv, Ukraine) respectively for additional activity assays. ... However, the set are a series of regioisomeric 7-acylamides (ChemDiv personal communication and [22]).
Ngoc Minh Nguyen; Tatiana Merle; Florence Broders-Bondon; Anne-Christine Brunet; Aude Battistella; Emelie Britt Linnea Land; Florian Sarron; Aditya Jha; Jean-Luc Gennisson; Eric Röttinger; María Elena Fernández-Sánchez; Emmanuel Farge
PMC ID: PMC9754125 | DOI: 10.3389/fcell.2022.992371 | Journal: Frontiers in Cell and Developmental Biology, 10(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-01
Original document: PMC | Score: 9.088693 | Text size: 94365 | Find: similar documents
The S381-0393 small molecule (https://www.chemdiv.com/search-element.php?q=S381-0393) has been selected in silico by ChemDiv upon request from in silico-designed inhibitors of βcat signaling targeting all of the βcat reactive and protein interacting site (https://www.chemdiv.com/catalog/focused-and-targeted-libraries/inhibitors-of-beta-catenin-signaling/?sphrase-id=40485). ... The S381-0393 was selected by ChemDiv as a specific inhibitor of Y654-βcat phosphorylation by mimicking best the α-helix subdomain of E-cadherin that includes I657, A656, and D665 and interacts with Y654 βcat to dock Y654-bcat and thus prevent its phosphorylation.
Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex
Yongmei Feng; Stefan Grotegut; Predrag Jovanovic; Valentina Gandin; Steven H. Olson; Rabi Murad; Anne Beall; Sharon Colayco; Paul De-Jesus; Sumit Chanda; Brian P. English; Robert H. Singer; Michael Jackson; Ivan Topisirovic; Ze’ev A. Ronai
PMC ID: PMC9751428 | DOI: 10.3389/fphar.2022.1029093 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-01
Original document: PMC | Score: 6.5141163 | Text size: 73068 | Find: similar documents
We used a large library of approximately 320,000 compounds selected from a pool of over three million compounds from five chemical vendors (ChemBridge, Asinex, Enamine, Life Chemicals, and ChemDiv).
Evaluation of action of steroid molecules on SARS-CoV-2 by inhibiting NSP-15, an endoribonuclease
Anantha Krishnan Dhanabalan; Sriram Srinivasa Raghavan; Selvakumar Rajendran; Velavan Ramasamy; Shaik Abdul Azeez Abdul; Nandhagopal Narayanasamy; Gunasekaran Krishnasamy
PMC ID: PMC9715282 | DOI: 10.1007/s11030-022-10576-5 | ISSN: 1381-1991 | Journal: Molecular Diversity, pp. 1-14 | Publisher: Springer International Publishing | Publication date: 2022-12-01
Original document: PMC | Score: 16.647287 | Text size: 29129 | Find: similar documents
A total of 533 steroid like compounds were retrieved from ChemDiv database and eight steroid compounds with anti-viral activity as reported [2] were chosen for the structure based virtual screening against NSP-15 protein target. ... To identify a suitable steroid like ligand against NSP-15, ChemDiv DB chemical database was used and SBVS protocol was employed. ... The library of 533 steroids compounds from ChemDIV database was screened against NSP-15 through structure based docking using glide XP module. ... From these analysis, three compounds from ChemDIV (0449-0045, N001-0004, N006-0008) and two compounds (Dexamethasone and Cortisone) from tested compounds were identified as potential compounds based on glide scoring function and ligand–protein interaction profiles.
Discovery of novel DNA‐damaging agents through phenotypic screening for DNA double‐strand break
Doudou Zhang; Takashi Shimokawa; Qianqian Guo; Shingo Dan; Yoshio Miki; Shigeaki Sunada
PMC ID: PMC9986057 | DOI: 10.1111/cas.15659 | ISSN: 1347-9032 | Journal: Cancer Science, 114(1) pp. 1108-1117 | Publisher: John Wiley and Sons Inc. | Publication date: 2022-11-30
Original document: PMC | Score: 9.822761 | Text size: 30966 | Find: similar documents
DDA‐1 was obtained from Enamine; analogue numbers 1, 4, 6, 7, 8, and 9 were from Pharmeks, 2 and 5 were from ChemDiv, 3 and 11 from Vitas‐M, and 10 from Life Chemicals.
Matic Proj; Martina Hrast; Gregor Bajc; Rok Frlan; Anže Meden; Matej Butala; Stanislav Gobec
PMC ID: PMC9718554 | DOI: 10.1080/14756366.2022.2149745 | ISSN: 1475-6366 | Journal: Journal of Enzyme Inhibition and Medicinal Chemistry, 38(1) pp. 387-397 | Publisher: Taylor & Francis | Publication date: 2022-11-29
Original document: PMC | Score: 14.207614 | Text size: 54004 | Find: similar documents
For fragment library preparation, we selected compounds from more than 4500 in-house chemicals and more than 1.57 million compounds available for cherry-picking from ChemDiv (the database was downloaded on 05 October 2020). ... Compound were purchased from several vendors (ChemBridge Corporation, ChemDiv, Enamine, Maybridge, Vitas-M Laboratory, and Wuxi LabNetwork) and used as received. ... (2-Ethoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)(pyridin-2-yl)methanone (6, ChemDiv, S422-0111) ... 7–(4-Chlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (12, ChemDiv, C201-1701)
Pharos 2023: an integrated resource for the understudied human proteome
Keith J Kelleher; Timothy K Sheils; Stephen L Mathias; Jeremy J Yang; Vincent T Metzger; Vishal B Siramshetty; Dac-Trung Nguyen; Lars Juhl Jensen; Dušica Vidović; Stephan C Schürer; Jayme Holmes; Karlie R Sharma; Ajay Pillai; Cristian G Bologa; Jeremy S Edwards; Ewy A Mathé; Tudor I Oprea
PMC ID: PMC9825581 | DOI: 10.1093/nar/gkac1033 | ISSN: 0305-1048 | Journal: Nucleic Acids Research, 51(1) pp. D1405-D1416 | Publisher: Oxford University Press | Publication date: 2022-11-29
Original document: PMC | Score: 7.713231 | Text size: 55875 | Find: similar documents
He served on the scientific advisory board of ChemDiv Inc. and InSilico Medicine.
Danfeng Shi; Qianqian Pang; Qianyu Qin; Xinsheng Yao; Xiaojun Yao; Yang Yu
PMC ID: PMC9638114 | DOI: 10.3389/fphar.2022.1026306 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-10-24
Original document: PMC | Score: 15.052543 | Text size: 57102 | Find: similar documents
Four compounds (Chemdiv codes: 8012-0567, 8018-6529, 8018-7168, 8018-7603) were proved with above 40% inhibitory ratio targeting PARP-1 under 20 μM, and further performed binding mode prediction and dynamic effect evaluation by molecular dynamics simulation. ... Then, a protocol of virtual screening workflow is evaluated and designed for the discovery of novel scaffolds of PARP-1 inhibitors, and 20 compounds were purchased from the Chemdiv database for in vitro assays. ... The Chemdiv database (https://www.chemdiv.com/) that contains over 1.5 million compounds was applied for the screening of PARP-1 inhibitors.
Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence
Theresa Noonan; Katrin Denzinger; Valerij Talagayev; Yu Chen; Kristina Puls; Clemens Alexander Wolf; Sijie Liu; Trung Ngoc Nguyen; Gerhard Wolber; Pavel Polishchuk; Thomas Seidel
PMC ID: PMC9695541 | DOI: 10.3390/ph15111304 | Journal: Pharmaceuticals, 15(1) | Publisher: MDPI | Publication date: 2022-10-22
Original document: PMC | Score: 7.697359 | Text size: 125521 | Find: similar documents
The optimized model was then used as the first VS step filtering the ChemDiv library with 1,492,362 compounds yielding 141,916 compounds. ... The DNN and CNN classification models were then used to screen the ChemDiv library (1178506 compounds).
Alessia Caputo; Sara Sartini; Elisabetta Levati; Ilaria Minato; Gian Marco Elisi; Adriana Di Stasi; Catherine Guillou; Peter G. Goekjian; Pierre Garcia; David Gueyrard; Stéphane Bach; Arnaud Comte; Simone Ottonello; Silvia Rivara; Barbara Montanini; Florie Desriac; Yannick Fleury
PMC ID: PMC9598883 | DOI: 10.3390/antibiotics11101449 | Journal: Antibiotics, 11(1) | Publisher: MDPI | Publication date: 2022-10-21
Original document: PMC | Score: 7.713231 | Text size: 53659 | Find: similar documents
Compound 4 was purchased from ChemDiv (San Diego, CA, USA).
Amy Lewis; Saray Sánchez; Giulio Berti; Belen Pan-Castillo; Anke Nijhuis; Shameer Mehta; Liliane Eleid; Hannah Gordon; Radha Gadhok; Christopher Kimberley; Annamaria Minicozzi; Joanne Chin-Aleong; Roger Feakins; Robert Kypta; James Oliver Lindsay; Andrew Silver
PMC ID: PMC9583737 | DOI: 10.1042/CS20210889 | ISSN: 0143-5221 | Journal: Clinical Science (London, England : 1979), 136(1) pp. 1405-1423 | Publisher: Portland Press Ltd. | Publication date: 2022-10-14 | Print publication date: 2022-10
Original document: PMC | Score: 6.8701305 | Text size: 72844 | Find: similar documents
For all cell treatments, cells were serum starved overnight prior to 48 h treatment with 10 μM ICG-001 dissolved in DMSO, or 100 nM porcupine inhibitor Wnt-C59 (Selleckchem S7037), or 10 μM FZD8 inhibitor 3235-0367 (C1, ChemDiv), alone or in combination with 10 ng/mL-recombinant human TGFβ1 (R&D Systems).
Radwa E. Mahgoub; Feda E. Mohamed; Lara Alzyoud; Bassam R. Ali; Juliana Ferreira; Wael M. Rabeh; Shaikha S. AlNeyadi; Noor Atatreh; Mohammad A. Ghattas; Dmitri B. Kireev
PMC ID: PMC9572942 | DOI: 10.3390/molecules27196710 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-10-09
Original document: PMC | Score: 10.625123 | Text size: 61128 | Find: similar documents
A total of 178 compounds from all the screened libraries (i.e., TimTec: 59, ChEMBL: 48, and ChemDiv: 60) were further investigated using MD simulation and MM-GBSA scoring. ... Four libraries were initially downloaded for virtual screening: NCI [40], TimTec [41], ChEMBL [42], and ChemDiv [43].
Identification of a novel specific small-molecule melanocortin-2-receptor antagonist
Rachel Forfar; Mashal Hussain; Puneet Khurana; Jennifer Cook; Steve Lewis; Dillon Popat; David Jackson; Ed McIver; Jeff Jerman; Debra Taylor; Adrian JL Clark; Li F Chan
PMC ID: PMC9641778 | DOI: 10.1530/EC-22-0338 | Journal: Endocrine Connections, 11(1) | Publisher: Bioscientifica Ltd | Publication date: 2022-10-06
Original document: PMC | Score: 9.822761 | Text size: 30319 | Find: similar documents
The eight chemical libraries used in our screening were as follows: LOPAC1280 (Sigma-Aldrich), HitFinder (Maybridge, Cornwall, UK), bioactive compounds (InterBioScreen, Moscow, Russia), BBP-2080 library (BioBiopha, Kunming, China), MEGxm and MEGxp (Analy-Ticon Discovery, Potsdam, Germany), Prestwick chemical library (Prestwick, Illkirch, France), Tocriscreen Total (Tocris, Bristol, UK), and GPCR-targeted library (ChemDiv, San Diego, CA, USA).
Discovery of novel SARS-CoV-2 3CL protease covalent inhibitors using deep learning-based screen
Liying Wang; Zhongtian Yu; Shiwei Wang; Zheng Guo; Qi Sun; Luhua Lai
PMC ID: PMC9528019 | DOI: 10.1016/j.ejmech.2022.114803 | ISSN: 0223-5234 | Journal: European Journal of Medicinal Chemistry | Publisher: Elsevier Masson SAS. | Publication date: 2022-10-03
Original document: PMC | Score: 7.713231 | Text size: 50048 | Find: similar documents
Cysteine Targeted Covalent Library from ChemDiv (https://www.chemdiv.com) contains 39, 301 compounds that have specific warheads, which were designed to react with cysteine.
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
Yi Zang; Mingbo Su; Qingxing Wang; Xi Cheng; Wenru Zhang; Yao Zhao; Tong Chen; Yingyan Jiang; Qiang Shen; Juan Du; Qiuxiang Tan; Peipei Wang; Lixin Gao; Zhenming Jin; Mengmeng Zhang; Cong Li; Ya Zhu; Bo Feng; Bixi Tang; Han Xie; Ming-Wei Wang; Mingyue Zheng; Xiaoyan Pan; Haitao Yang; Yechun Xu; Beili Wu; Leike Zhang; Zihe Rao; Xiuna Yang; Hualiang Jiang; Gengfu Xiao; Qiang Zhao; Jia Li
PMC ID: PMC9871955 | DOI: 10.1093/procel/pwac016 | ISSN: 1674-800X | Journal: Protein & Cell, 14(1) pp. 17-27 | Publisher: Oxford University Press | Publication date: 2022-09-28
Original document: PMC | Score: 7.713231 | Text size: 54823 | Find: similar documents
The ~1,800,000 compounds of CNCL bought from ChemDiv (USA), ChemBridge (USA), Life Chemicals (Canada), Specs (Holland) and donated by NovoNordisk (Denmark) were primarily screened against Mpro and PLpro at the concentration of 10 and 8 μg/mL respectively.
Lin28 Regulates Cancer Cell Stemness for Tumour Progression
Zhuohui Lin; Mariia Radaeva; Artem Cherkasov; Xuesen Dong; Kavita Shah
PMC ID: PMC9564245 | DOI: 10.3390/cancers14194640 | Journal: Cancers, 14(1) | Publisher: MDPI | Publication date: 2022-09-24
Original document: PMC | Score: 5.6376715 | Text size: 87902 | Find: similar documents
127,007 compounds from LOPAC, Prestwick, Maybridge, ChemDiv, and UMich libraries
Gregory Gauthier-Coles; Angelika Bröer; Malcolm Donald McLeod; Amee J. George; Ross D. Hannan; Stefan Bröer
PMC ID: PMC9532951 | DOI: 10.3389/fphar.2022.963066 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-21
Original document: PMC | Score: 18.556135 | Text size: 77822 | Find: similar documents
ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv
Highly multiplexed selection of RNA aptamers against a small molecule library
Brent Townshend; Matias Kaplan; Christina D. Smolke; Floyd Romesberg
PMC ID: PMC9477273 | DOI: 10.1371/journal.pone.0273381 | Journal: PLoS ONE, 17(1) | Publisher: Public Library of Science | Publication date: 2022-09-15
Original document: PMC | Score: 12.764881 | Text size: 80266 | Find: similar documents
The target compound library comprises 5,120 small molecule compounds randomly selected from a ChemDiv representative diversity library obtained via the Stanford High-Throughput Bioscience Center [22]. ... However, the second-sourced sample of CDIQ165-N09 showed a clear peak with an m/z corresponding to an M+H adduct of the expected chemical whereas the ChemDiv sample showed no corresponding peak. ... Thus, the difference in observed responses is likely due to the expected chemical not being present in the ChemDiv sample at the expected concentration, possibly caused by degradation or handling of the library prior to our work.
Asma Sellami; Manon Réau; Matthieu Montes; Nathalie Lagarde
PMC ID: PMC9513233 | DOI: 10.3389/fendo.2022.986016 | Journal: Frontiers in Endocrinology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-13
Original document: PMC | Score: 4.780143 | Text size: 122095 | Find: similar documents
ChemDiv database (7476 compounds) for prospective screening
Enrique Crisman; Pablo Duarte; Esteban Dauden; Antonio Cuadrado; María Isabel Rodríguez‐Franco; Manuela G. López; Rafael León
PMC ID: PMC10087726 | DOI: 10.1002/med.21925 | ISSN: 0198-6325 | Journal: Medicinal Research Reviews, 43(1) pp. 237-287 | Publisher: John Wiley and Sons Inc. | Publication date: 2022-09-10 | Print publication date: 2023-01
Original document: PMC | Score: 3.892117 | Text size: 165955 | Find: similar documents
Kim et al. 136 identified compound 53 (Table 2) after performing a virtual screening of Asinex and Chemdiv chemical libraries using a ligand‐based pharmacophore, structure‐based pharmacophore, and docking combination strategy.
Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening
Chujiao Hu; Zhirui Zeng; Dan Ma; Zhixin Yin; Shanshan Zhao; Tengxiang Chen; Lei Tang; Shi Zuo
PMC ID: PMC9491111 | DOI: 10.3389/fphar.2022.982375 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-07
Original document: PMC | Score: 13.219877 | Text size: 50053 | Find: similar documents
ChemDiv (2019 version) database with more than 1.5 million molecules was used for the virtual screening. ... ChemDiv, a sub-database of the ZINC15 database, was used as the virtual screening library. ... In summary, the study identified a potent IDH1-R132C inhibitor based on molecular docking-based virtual screening using the ChemDiv database and cellular assays.
Bingwu Wang; Jian Gao; Zhongjun Zhao; Xuefei Zhong; Hao Cui; Hui Hou; Yanping Zhang; Junnian Zheng; Jiehui Di; Yong Liu
PMC ID: PMC9450376 | DOI: 10.1186/s10020-022-00537-x | ISSN: 1076-1551 | Journal: Molecular Medicine, 28(1) | Publisher: BioMed Central | Publication date: 2022-09-07
Original document: PMC | Score: 7.713231 | Text size: 49706 | Find: similar documents
The small molecule database used as the screening library was the ChemDiv database (commercially available) from TopScience Co. (Shanghai, China), which comprises more than 1 million compounds.
Small molecule SJ572946 activates BAK to initiate apoptosis
Giridhar Sekar; Geetika Singh; Xingping Qin; Cristina D. Guibao; Brittany Schwam; Zintis Inde; Christy R. Grace; Weixing Zhang; P. Jake Slavish; Wenwei Lin; Taosheng Chen; Richard E. Lee; Zoran Rankovic; Kristopher Sarosiek; Tudor Moldoveanu
PMC ID: PMC9485059 | DOI: 10.1016/j.isci.2022.105064 | Journal: iScience, 25(1) | Publisher: Elsevier | Publication date: 2022-09-06
Original document: PMC | Score: 5.6376715 | Text size: 89818 | Find: similar documents
ChemDiv
Tiffany S. Dwyer; Joseph B. O’Brien; Christopher P. Ptak; Justin E. LaVigne; Daniel P. Flaherty; Val J. Watts; David L. Roman
PMC ID: PMC9486168 | DOI: 10.3389/fphar.2022.977742 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-06
Original document: PMC | Score: 16.915955 | Text size: 84849 | Find: similar documents
ChemDiv CNS targeted library FP screen ... For the ChemDiv CNS targeted library (ChemDiv, San Diego, CA) of compounds, the protocol is the same as that outlined for the FDA-approved library, with minor differences as the MMSP and ChemBridge DIVERSet libraries. ... The test plate’s final ChemDiv CNS targeted compounds’ concentration was 14.64 μM (0.147% DMSO). ... The ChemDiv CNS targeted library (CDI, ChemDiv, San Diego, CA) is comprised of compounds selected for CNS protein targets (98 protein sub-families/unit targets) based on literature searches (ranging from 2014-present) as well as novel X-ray and Cryo-EM structures deposited in the PDB.
Virtual Screening in the Identification of Sirtuins’ Activity Modulators
Elena Abbotto; Naomi Scarano; Francesco Piacente; Enrico Millo; Elena Cichero; Santina Bruzzone; Dmitri B. Kireev
PMC ID: PMC9457788 | DOI: 10.3390/molecules27175641 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-09-01
Original document: PMC | Score: 12.4384985 | Text size: 182466 | Find: similar documents
They were merged together to form a single dynamic pharmacophore model, which was then used to screen the CHEMDIV database [258]. ... Maybridge (60,000), Chembridge (50,000), NCI (200,000), and ChemDiv (700 000) ... CHEMDIV database (700 000) ... Specs, ChemDiv, Selleck, and MedChemExpress and in-house database ... Chemdiv database (939319) ... More recently, in 2020, compound Hit20 was also discovered as SIRT-6 activator, thanks to molecular docking adopted to screen commercial chemical databases including Specs, ChemDiv, Selleck, and MedChemExpress, as well as an in-house database (see Section 2.6.1) [173]. ... Subsequent VS screening was carried out by Autodock Vina [301] by taking into account the Chemdiv database [258] containing 939,319 structurally diverse compounds.
Valeria Napolitano; Charlotte A. Softley; Artur Blat; Vishal C. Kalel; Kenji Schorpp; Till Siebenmorgen; Kamyar Hadian; Ralf Erdmann; Michael Sattler; Grzegorz M. Popowicz; Grzegorz Dubin
PMC ID: PMC9424529 | DOI: 10.1038/s41598-022-18841-1 | Journal: Scientific Reports, 12(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-08-29
Original document: PMC | Score: 9.45341 | Text size: 34007 | Find: similar documents
An in-house 30,000 molecules diversity set (ChemBridge, ChemDiv, Enamine, PPI) and FDA-approved drug library were used in high throughput screening.
Ana Mitrović; Emanuela Senjor; Marko Jukić; Lara Bolčina; Mateja Prunk; Matic Proj; Milica Perišić Nanut; Stanislav Gobec; Janko Kos
PMC ID: PMC9459403 | DOI: 10.1016/j.csbj.2022.08.046 | Journal: Computational and Structural Biotechnology Journal, 20(1) pp. 4667-4687 | Publisher: Research Network of Computational and Structural Biotechnology | Publication date: 2022-08-28
Original document: PMC | Score: 5.6376715 | Text size: 90683 | Find: similar documents
Compounds were obtained from various sources (Life Chemicals, ENAMINE, Vitas-M, ChemDiv, UkrOrgSynthesis, Otava ltd in InterBioScreen) and used as received.
Guangjian Zhao; Xiaochun Liu; Suyun Wang; Zhongyue Bai; Siyu Zhang; Yifan Wang; Haibo Yu; Ximing Xu
PMC ID: PMC9349924 | DOI: 10.1111/cbdd.14115 | ISSN: 1747-0277 | Journal: Chemical Biology & Drug Design | Publisher: John Wiley and Sons Inc. | Publication date: 2022-07-26
Original document: PMC | Score: 8.217452 | Text size: 46817 | Find: similar documents
The ligand library is taken from “TargetMol, USA” (ChemDiv and “Bioactive Compound Library”).
Debojyoti Halder; Subham Das; Aiswarya R.; Jeyaprakash R. S.
PMC ID: PMC9346375 | DOI: 10.1039/d2ra03451d | Journal: RSC Advances, 12(1) pp. 21452-21467 | Publisher: The Royal Society of Chemistry | Publication date: 2022-07-21
Original document: PMC | Score: 13.219877 | Text size: 49098 | Find: similar documents
In this research work, a specific biological target PI3Kα, which has a pan and a selective inhibitor, was selected and a kinase inhibitor database of 36 324 molecules from ChemDiv was chosen for the structure-based virtual screening to obtain the top ten hits, for further MMGBSA free binding energy analysis, ADMET predictions, IFD (induced fit docking) analysis and MD (molecular dynamics) simulations for the optimization of the kinase inhibitors for pan and selective inhibition of PI3Kα in the treatment of NSCLC squamous carcinoma. ... PI3K is a kind of kinase enzyme which readily mutates in squamous cell carcinoma in NSCLC, and therefore, the kinase inhibitor library from ChemDiv was chosen for the virtual screening.
Paul Andrei Negru; Denisa Claudia Miculas; Tapan Behl; Alexa Florina Bungau; Ruxandra-Cristina Marin; Simona Gabriela Bungau
PMC ID: PMC9289048 | DOI: 10.1016/j.biopha.2022.113432 | ISSN: 0753-3322 | Journal: Biomedicine & Pharmacotherapy | Publisher: The Author(s). Published by Elsevier Masson SAS. | Publication date: 2022-07-18
Original document: PMC | Score: 6.1931806 | Text size: 81496 | Find: similar documents
ChemDiv
Daniela G. Dengler; Qing Sun; Kaleeckal G. Harikumar; Laurence J. Miller; Eduard A. Sergienko
PMC ID: PMC9580343 | DOI: 10.1016/j.slasd.2022.07.001 | ISSN: 2472-5552 | Journal: SLAS discovery : advancing life sciences R & D, 27(1) pp. 384-394 | Publication date: 2022-07-16 | Print publication date: 2022-10
Original document: PMC | Score: 7.26731 | Text size: 59423 | Find: similar documents
(Camelford, Cornwall, UK), ChemBridge Corporation (San Diego, CA, USA), ChemDiv, Inc.
A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
Vaishnavi Muralikrishnan; Fang Fang; Tyler C. Given; Ram Podicheti; Mikhail Chtcherbinine; Tara X. Metcalfe; Shruthi Sriramkumar; Heather M. O’Hagan; Thomas D. Hurley; Kenneth P. Nephew; Christina M. Annunziata; Adam R. Karpf
PMC ID: PMC9318275 | DOI: 10.3390/cancers14143437 | Journal: Cancers, 14(1) | Publisher: MDPI | Publication date: 2022-07-15
Original document: PMC | Score: 11.093979 | Text size: 59259 | Find: similar documents
Compounds purchased from ChemDiv Corporation (San Diego, CA, USA) and ChemBridge Corporation (San Diego, CA, USA) were >95% pure based on vendor specifications (NMR spectra for the compounds can be found in the ). ... To avoid the potential off-target effects due to the structure of CM38, 974 was chosen amongst the ALDH1A1 inhibitors with high structural similarity to CM38 from commercial sources (ChemDiv Corporation and ChemBridge Corporation, San Diego, CA, USA).
Aliakbar Khalili Yazdi; Paknoosh Pakarian; Sumera Perveen; Taraneh Hajian; Vijayaratnam Santhakumar; Albina Bolotokova; Fengling Li; Masoud Vedadi
PMC ID: PMC9305828 | DOI: 10.1021/acsinfecdis.2c00165 | Journal: ACS Infectious Diseases | Publisher: American Chemical Society | Publication date: 2022-07-13
Original document: PMC | Score: 11.093979 | Text size: 51452 | Find: similar documents
SARS-CoV-2 nsp13 was screened against a library of potential kinase inhibitors containing 5000 small molecules (ChemDiv Kinase Library) at 50 μM using the optimized ssDNA+ ATPase assay. ... Protein expression and purification details, ChemDiv catalogue numbers for selected eight reproducible hits, detection of nsp13 ATPase activities using the bioluminescence assays, SARS-CoV-2 nsp13 purification, assay optimization, tests of the top eight hits in a counter screen, and dose-response analysis of six hits from the original in-house samples (PDF)
Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells
Katherine Chew; Branden Lee; Simon D. van Haren; Etsuro Nanishi; Timothy O’Meara; Jennifer B. Splaine; Maria DeLeon; Dheeraj Soni; Hyuk-Soo Seo; Sirano Dhe-Paganon; Al Ozonoff; Jennifer A. Smith; Ofer Levy; David J. Dowling
PMC ID: PMC9298130 | DOI: 10.1101/2022.06.17.496630 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2022-07-11
Original document: PMC | Score: 6.8701305 | Text size: 70072 | Find: similar documents
704 molecules were chosen for known activity toward PBMCs; these molecules filled up two library plates and originated from the ChemDiv6 library (ChemDiv Inc, San Diego, CA).
CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction
Woo Dae Jang; Mi Young Lee; Jihye Mun; Gyutae Lim; Kwang-Seok Oh; Seungho Baek
PMC ID: PMC9313426 | DOI: 10.3390/biomedicines10071671 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-07-11
Original document: PMC | Score: 8.217452 | Text size: 46289 | Find: similar documents
CDI (CAT#, NO75-0015) was obtained from ChemDiv (San Diego, CA, USA).
Fragment‐based drug discovery—the importance of high‐quality molecule libraries
Marta Bon; Alan Bilsland; Justin Bower; Kirsten McAulay
PMC ID: PMC9627785 | DOI: 10.1002/1878-0261.13277 | ISSN: 1574-7891 | Journal: Molecular Oncology, 16(1) pp. 3761-3777 | Publisher: John Wiley and Sons Inc. | Publication date: 2022-07-10 | Print publication date: 2022-11
Original document: PMC | Score: 9.797036 | Text size: 78283 | Find: similar documents
(A) General fragment sets were obtained from Maybridge (30 061 compounds), Life Chemicals (50 597 compounds), Enamine (172 689 compounds) and ChemDiv (11 269 compounds). ... High Fidelity Library (1920 compounds); Life Chemicals, General Fragment Library (50 607 compounds); ChemDiv, Fragments Library (11 269 compounds); Bionet, 2nd Generation Premium Library (1166 compounds).
Characterization of Dense Granule Metalloproteinase INS-16 in Cryptosporidium parvum
Hao Cui; Rui Xu; Yu Li; Yaqiong Guo; Ziding Zhang; Lihua Xiao; Yaoyu Feng; Na Li; Cristina Sánchez-Camacho
PMC ID: PMC9315855 | DOI: 10.3390/ijms23147617 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-07-10
Original document: PMC | Score: 12.167842 | Text size: 41216 | Find: similar documents
Although we failed to obtain the full INS-16 protein with enzymatic activity, based on the structure of human IDE together with known inhibitors, we were able to simulate the active structure of INS-16, leading to the identification of 48 potential inhibitors from the ChemDiv database through molecular docking. ... A total of 48 compounds were selected from the ChemDiv database through the molecular docking of INS-16 as described previously [30] (Table 1).
Modulating mitofusins to control mitochondrial function and signaling
Emmanouil Zacharioudakis; Bogos Agianian; Vasantha Kumar MV; Nikolaos Biris; Thomas P. Garner; Inna Rabinovich-Nikitin; Amanda T. Ouchida; Victoria Margulets; Lars Ulrik Nordstrøm; Joel S. Riley; Igor Dolgalev; Yun Chen; Andre J. H. Wittig; Ryan Pekson; Chris Mathew; Peter Wei; Aristotelis Tsirigos; Stephen W. G. Tait; Lorrie A. Kirshenbaum; Richard N. Kitsis; Evripidis Gavathiotis
PMC ID: PMC9262907 | DOI: 10.1038/s41467-022-31324-1 | Journal: Nature Communications, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-07-07
Original document: PMC | Score: 8.19944 | Text size: 107705 | Find: similar documents
Screened MASMs were purchased from Enamine, ChemBridge and ChemDiv. ... The rest of the screened MFIs were purchased from Enamine, ChemBridge, ChemDiv, Vitas M, and UORSY.
Glioblastoma: Current Status, Emerging Targets, and Recent Advances
Amandeep Thakur; Chetna Faujdar; Ram Sharma; Sachin Sharma; Basant Malik; Kunal Nepali; Jing Ping Liou
PMC ID: PMC9297300 | DOI: 10.1021/acs.jmedchem.1c01946 | ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 65(1) pp. 8596-8685 | Publisher: American Chemical Society | Publication date: 2022-07-05 | Print publication date: 2022-07-14
Original document: PMC | Score: 2.2328758 | Text size: 332970 | Find: similar documents
To establish the SAR, a total of 89 compounds from the Chemdiv library and NCI development program were tested using the PDI reductase assay.
Gbolahan O. Oduselu; Rufus Afolabi; Ibitayo Ademuwagun; Ashley Vaughan; Ezekiel Adebiyi
PMC ID: PMC9877529 | DOI: 10.3389/fmed.2022.1022429 | Journal: Frontiers in Medicine, 9(1) | Publisher: Frontiers Media S.A. | Publication date: 2022
Original document: PMC | Score: 15.052543 | Text size: 54985 | Find: similar documents
The best model of the tertiary structure of Pf 5-ALAS was obtained using MolProbity, while the following databases were explored for the pharmacophore-based virtual screening: CHEMBL, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC databases. ... The pharmacophore-based screening of the different databases (CHEMBL30, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC) gave rise to 2,755 hits (Table 4). ... The total number of hits obtained from the databases are in the order: ChemSpace > ZINC > MCULE > MolPort > CHEMBL30 > ChemDiv > LabNetwork > NCI Open Chemical Repository > MCULE-ULTIMATE.
Karel Miettinen; Nattawat Leelahakorn; Aldo Almeida; Yong Zhao; Lukas R. Hansen; Iben E. Nikolajsen; Jens B. Andersen; Michael Givskov; Dan Staerk; Søren Bak; Sotirios C. Kampranis
PMC ID: PMC9237071 | DOI: 10.1038/s41467-022-31357-6 | Journal: Nature Communications, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-06-27
Original document: PMC | Score: 5.9023848 | Text size: 90076 | Find: similar documents
ANT4 (#3888-1206) and ANT5 (#3909-7498) were bought from ChemDiv, US.
Said Moshawih; Ai Fern Lim; Chrismawan Ardianto; Khang Wen Goh; Nurolaini Kifli; Hui Poh Goh; Qais Jarrar; Long Chiau Ming; Supriyo Bhattacharya; Xiaolin Cheng
PMC ID: PMC9312989 | DOI: 10.3390/biom12070878 | Journal: Biomolecules, 12(1) | Publisher: MDPI | Publication date: 2022-06-23
Original document: PMC | Score: 4.780143 | Text size: 125484 | Find: similar documents
Commercially available protein-protein interaction small molecules from ChemDiv
Discovery and Characterization of Multiple Classes of Human CatSper Blockers
Erick J. Carlson; Rawle Francis; Yutong Liu; Ping Li; Maximilian Lyon; Celia M. Santi; Derek J. Hook; Jon E. Hawkinson; Gunda I. Georg
PMC ID: PMC9378630 | DOI: 10.1002/cmdc.202000499 | ISSN: 1860-7179 | Journal: Chemmedchem, 17(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2022-06-14 | Print publication date: 2022-08-03
Original document: PMC | Score: 10.19429 | Text size: 65842 | Find: similar documents
Over 72,000 compounds from the following libraries were tested in the primary screen at 10 μM: the National Cancer Institute set, the ChemDiv Peptidomimetic and Kinase libraries, the TOCRIS Tocriscreen Complete and Kinase Inhibitor Library, the ChemBridge MicroFormat Library, the LOPAC library, the NIH Clinical Library, the Prestwick Chemical Library, and the MicroSource Spectrum Collection. ... [43] Hits 1 a and 2 a were identified from the LOPAC library, hits 3 a, 4 a, and 5 a came from the ChemBridge library, 6 a from the MicroSource library and compound 7 a from the ChemDiv kinase library.
Yukari Endo; Linda Groom; Alper Celik; Natalia Kraeva; Chang Seok Lee; Sung Yun Jung; Lois Gardner; Marie-Anne Shaw; Susan L. Hamilton; Philip M. Hopkins; Robert T. Dirksen; Sheila Riazi; James J. Dowling
PMC ID: PMC9192596 | DOI: 10.1038/s41467-022-31088-8 | Journal: Nature Communications, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-06-13
Original document: PMC | Score: 6.5141163 | Text size: 73965 | Find: similar documents
To assess the motor function, 3-dpf fish were individually transferred to a 96-well plate and incubated with 10 μM optovin 6b8 (ChemDiv) at 28.5 °C for 5 min as previously described59.
Beatrice Mercorelli; Jenny Desantis; Marta Celegato; Alessandro Bazzacco; Lydia Siragusa; Paolo Benedetti; Michela Eleuteri; Federico Croci; Gabriele Cruciani; Laura Goracci; Arianna Loregian
PMC ID: PMC9172283 | DOI: 10.1016/j.antiviral.2022.105350 | ISSN: 0166-3542 | Journal: Antiviral Research, 204(1) pp. 105350-105350 | Publisher: Elsevier B.V. | Publication date: 2022-06-07 | Print publication date: 2022-08
Original document: PMC | Score: 12.154662 | Text size: 61716 | Find: similar documents
In approaches (1-1) and (1–2) (Fig. 1B), a database of small molecules composed of structures from Specs and ChemDiv vendors (overall 793,212 compounds) was generated by applying the following filters: molecular weight range = 150–500; logP >5; protonation state = most abundant protomer at pH = 7.4; up to 50 conformers with RMSD >0.1. ... Compounds 1–5 were purchased from ChemDiv, compounds 6–8 from Specs, compounds 9–20 from Vitas-M, compound 21 from Fluorochem, and compounds 22–24 from Sigma Aldrich (more details in Dataset S1). ... First, we performed LBVS campaigns on N3 and 13b using a dataset of commercially available compounds (almost 800,000 small molecules from Specs and ChemDiv) employing the FLAP software (Baroni et al., 2007) (Fig. 1B, approaches 1-1 and 1–2).
Xiaodong Dou; Qi Sun; Guofeng Xu; Yameng Liu; Caifang Zhang; Bingding Wang; Yangbin Lu; Zheng Guo; Lingyu Su; Tongyu Huo; Xinyi Zhao; Chen Wang; Zhongtian Yu; Song Song; Liangren Zhang; Zhenming Liu; Luhua Lai; Ning Jiao
PMC ID: PMC9162962 | DOI: 10.1016/j.ejmech.2022.114508 | ISSN: 0223-5234 | Journal: European Journal of Medicinal Chemistry | Publisher: Published by Elsevier Masson SAS. | Publication date: 2022-06-03
Original document: PMC | Score: 9.42958 | Text size: 73278 | Find: similar documents
A total of 70 compounds were captured and purchased from the ChemDiv and SPECS commercial databases. ... Compounds used for SARS-CoV-2 Mpro inhibitors screening were purchased from ChemDiv (https://www.chemdiv.com/) and SPECS (https://www.specs.net/) commercial databases.
Valerio Ciccone; Erika Terzuoli; Emma Ristori; Arianna Filippelli; Marina Ziche; Lucia Morbidelli; Sandra Donnini
PMC ID: PMC9186295 | DOI: 10.3892/ijmm.2022.5155 | ISSN: 1107-3756 | Journal: International Journal of Molecular Medicine, 50(1) | Publisher: D.A. Spandidos | Publication date: 2022-06-02
Original document: PMC | Score: 6.1931806 | Text size: 79064 | Find: similar documents
The ALDH1A1 inhibitor CM037 was from ChemDiv Inc.
Fanfan Shu; Yu Li; Wenlun Chu; Xuehua Chen; Ziding Zhang; Yaqiong Guo; Yaoyu Feng; Lihua Xiao; Na Li
PMC ID: PMC9090282 | DOI: 10.3389/fmicb.2022.883674 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-25
Original document: PMC | Score: 11.880346 | Text size: 45180 | Find: similar documents
Using molecular docking of the simulated CpCDPK2A structure, small molecules were selected from the ChemDiv database. ... A total of 50 compounds were selected from the ChemDiv core database according to the scores from molecular docking of CpCDPK2A (Table 1).
Novel Inhibitors of 2′-O-Methyltransferase of the SARS-CoV-2 Coronavirus
Alexey Sulimov; Danil Kutov; Ivan Ilin; Yibei Xiao; Sheng Jiang; Vladimir Sulimov; Athina Geronikaki
PMC ID: PMC9100384 | DOI: 10.3390/molecules27092721 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-04-23
Original document: PMC | Score: 16.607422 | Text size: 42506 | Find: similar documents
Here, we performed high-throughput docking into the SAM-binding site of nsp16 for almost 40 thousand structures, prepared for compounds from three libraries: Enamine Coronavirus Library, Enamine Nucleoside Mimetics Library, and Chemdiv Nucleoside Analogue Library. ... The results of calculations for the best ligands and their structures are presented in Table 6 and Figure 8 (ligands selected from the Enamine Coronavirus Library) and Figure 9 (ligands selected from the Chemdiv Nucleoside Analogue Library), respectively. ... Similarly to sinefungin and SAM, three of the four top compounds from the Chemdiv Nucleoside Analogue Library belong to purines.
Sathya Babu; Santhosh Kumar Nagarajan; Sruthy Sathish; Vir Singh Negi; Honglae Sohn; Thirumurthy Madhavan
PMC ID: PMC9068899 | DOI: 10.3389/fphar.2022.837369 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-21
Original document: PMC | Score: 13.442831 | Text size: 85497 | Find: similar documents
Based on the validation results, the best pharmacophore models ADHRRR, DDHRRR, DDRRR, DPRRR, DHRRR, ADRRR, DDHRR, and ADPRR were selected and taken for virtual screening against the Maybridge, Asinex, Chemdiv, Enamine, Lifechemicals, and Zinc database to identify the new molecules with novel scaffold that can bind to JAK1. ... The selected pharmacophore models were screened against Maybridge, Lifechemicals, Enamine, Chemdiv, Asinex, and Zinc (chemical and natural) databases for the identification of new hits. ... The fitness score was set to >1.5 for the Maybridge, Asinex, Chemdiv, Lifechemicals, and Enamine databases, whereas for the Zinc database, the fitness score was set to >2 because of high number of molecules retrieved from the Zinc database.
Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry
Chongyun Cheng; Miaomiao Liu; Xiaoqin Gao; Dong Wu; Mengchen Pu; Jun Ma; Ronald J. Quinn; Zhicheng Xiao; Zhijie Liu
PMC ID: PMC9088906 | DOI: 10.1021/acsomega.2c00340 | Journal: ACS Omega, 7(1) pp. 13925-13931 | Publisher: American Chemical Society | Publication date: 2022-04-14
Original document: PMC | Score: 9.110828 | Text size: 35916 | Find: similar documents
The compounds were purchased from ChemDiv and Enamine.
Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy
Zheyuan Shen; Weihao Zhuang; Kang Li; Yu Guo; Bingxue Qu; Sikang Chen; Jian Gao; Jing Liu; Lei Xu; Xiaowu Dong; Jinxin Che; Qimeng Li; Dmitri B. Kireev
PMC ID: PMC9024667 | DOI: 10.3390/molecules27082543 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-04-14
Original document: PMC | Score: 9.822761 | Text size: 33395 | Find: similar documents
To ensure the molecular diversity of our covalent compound library, compounds from ChemDiv compound libraries and TargetMol with well-developed skeleton diversities were initially included.
A Small Molecule Promoting Neural Differentiation Suppresses Cancer Stem Cells in Colorectal Cancer
Jung Kyu Choi; Ihn-Sil Kwak; Sae-Bom Yoon; Heeyeong Cho; Byoung-San Moon; Massimo Moro; Luca Falzone
PMC ID: PMC9025482 | DOI: 10.3390/biomedicines10040859 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-04-06
Original document: PMC | Score: 8.792208 | Text size: 41016 | Find: similar documents
Specifically, we used a 2000-compound ChemDiv drug screening library platform to identify compounds that would decrease TOP-flash reporter activity in the HEK293 TCF/LEF cell line.
Targeting papain-like protease for broad-spectrum coronavirus inhibition
Shuofeng Yuan; Xiaopan Gao; Kaiming Tang; Jian-Piao Cai; Menglong Hu; Peng Luo; Lei Wen; Zi-Wei Ye; Cuiting Luo; Jessica Oi-Ling Tsang; Chris Chun-Yiu Chan; Yaoqiang Huang; Jianli Cao; Ronghui Liang; Zhenzhi Qin; Bo Qin; Feifei Yin; Hin Chu; Dong-Yan Jin; Ren Sun; Jasper Fuk-Woo Chan; Sheng Cui; Kwok-Yung Yuen
PMC ID: PMC8983325 | DOI: 10.1007/s13238-022-00909-3 | ISSN: 1674-800X | Journal: Protein & Cell, pp. 1-14 | Publisher: Higher Education Press | Publication date: 2022-04-06
Original document: PMC | Score: 7.713231 | Text size: 55754 | Find: similar documents
The SmartTM chemical library was purchased from Chemdiv (San Diego, USA), which contains 50,080 small-molecule compounds with enhanced diversity and drug-like properties.
Hong Zhou; Wei-Jian Ni; Wei Huang; Zhen Wang; Ming Cai; Yan-Cai Sun
PMC ID: PMC9016159 | DOI: 10.3389/fimmu.2022.834942 | Journal: Frontiers in Immunology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-05
Original document: PMC | Score: 3.892117 | Text size: 156041 | Find: similar documents
Virtual screening: High-throughput screening is carried out to identify possible lead compounds from existing compound databases, such as ZINC, DrugBank, or ChemDiv, on the basis of structural biology and homology modeling analysis of protein structure.
Jinyeong Heo; Dahae Koh; Minjeong Woo; Doyoon Kwon; Virgínia Carla de Almeida Falcão; Connor Wood; Honggun Lee; Kideok Kim; Inhee Choi; Jichan Jang; Priscille Brodin; David Shum; Vincent Delorme
PMC ID: PMC8980009 | DOI: 10.1038/s41598-022-08209-w | Journal: Scientific Reports, 12(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-04-04
Original document: PMC | Score: 7.26731 | Text size: 57782 | Find: similar documents
A total of 104,783 small molecules were assembled, including 51,406 compounds from Enamine and 53,377 compounds from various suppliers: ChemDiv (12,270), ChemBridge (11,709), Life Chemicals (7917), Vitas-M (5000), Princeton BioMolecular Research (4751), InterBioScreen (3436), Otava Chemicals (3366), Thermo Fisher Scientific (Maybridge collection, 2951) and Specs (1977).
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
Irene Brusa; Elvira Sondo; Federico Falchi; Nicoletta Pedemonte; Marinella Roberti; Andrea Cavalli
PMC ID: PMC9014417 | DOI: 10.1021/acs.jmedchem.1c01897 | ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 65(1) pp. 5212-5243 | Publisher: American Chemical Society | Publication date: 2022-04-04 | Print publication date: 2022-04-14
Original document: PMC | Score: 3.4632015 | Text size: 180864 | Find: similar documents
In a different proof-of-principle study, Buchner and co-workers showed that a drug-like small molecule could specifically interfere with the catalytic function of the cochaperone Aha1, without affecting complex formation with Hsp90 (Figure 9, panel 3).113 For that, they screened a library of ∼15,000 chemical compounds from ChemDiv by a FRET-based assay that monitored the interaction between Hsp90 and Aha1 and identified nearly 40 compounds as possible modulators.
STAT3 pathway in cancers: Past, present, and future
Han‐Qi Wang; Qi‐Wen Man; Fang‐Yi Huo; Xin Gao; Hao Lin; Su‐Ran Li; Jing Wang; Fu‐Chuan Su; Lulu Cai,; Yi Shi; Bing Liu,; Lin‐Lin Bu
PMC ID: PMC8942302 | DOI: 10.1002/mco2.124 | Journal: MedComm, 3(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2022-03-23
Original document: PMC | Score: 4.4422913 | Text size: 144025 | Find: similar documents
Moreover, to prevent off‐target side effects, inS3‐54 analogs were searched in the virtual Chemdiv database, and analog A18 was demonstrated to specifically bind to the DBD of STAT3 and inhibit its activity.
Matic Proj; Steven De Jonghe; Tom Van Loy; Marko Jukič; Anže Meden; Luka Ciber; Črtomir Podlipnik; Uroš Grošelj; Janez Konc; Dominique Schols; Stanislav Gobec
PMC ID: PMC8972196 | DOI: 10.3389/fphar.2022.855653 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-18
Original document: PMC | Score: 7.713231 | Text size: 54897 | Find: similar documents
The third library used for pharmacophore-based screening contained 1.1 million compounds based on curated diversity sets from Asinex, ChemBridge, ChemDiv, Enamine, KeyOrganics, and Pharmeks.
Yuanyuan Yan; Miao He; Lin Zhao; Huizhe Wu; Yanyun Zhao; Li Han; Binbin Wei; Dongman Ye; Xuemei Lv; Yan Wang; Weifan Yao; Haishan Zhao; Bo Chen; Zining Jin; Jian Wen; Yan Zhu; Tao Yu; Feng Jin; Minjie Wei
PMC ID: PMC9433403 | DOI: 10.1038/s41418-022-00963-8 | ISSN: 1350-9047 | Journal: Cell Death and Differentiation, 29(1) pp. 1769-1789 | Publisher: Nature Publishing Group UK | Publication date: 2022-03-17 | Print publication date: 2022-09
Original document: PMC | Score: 8.475872 | Text size: 93408 | Find: similar documents
Recombinant human SOD2 (Abcam, ab93946), Paclitaxel (Sigma, T7402), Doxorubicin, (Sigma, D1515), Mitoxantrone (Sigma, M2305000), Cisplatin (Sigma, P4394), Docetaxel (Sigma, 01885), Mito TEMPO (Sigma, SML0737), PDI inhibitor 16F16 (Sigma, SML0021), YQ-0629 (Topscience, chemdiv diversity discovery library), (3-Aminopropyl) triethoxysilane (sigma, A3648), Glutaraldehyde solution (sigma, G7651). ... The chemical library was from chemdiv diversity discovery library (Topscience Co., Ltd).
Kate R. Fortney; Sara N. Smith; Julia J. van Rensburg; Julie A. Brothwell; Jessi J. Gardner; Barry P. Katz; Nagib Ahsan; Adam S. Duerfeldt; Harry L. T. Mobley; Stanley M. Spinola; Bonnie Chase Prokesch
PMC ID: PMC9045377 | DOI: 10.1128/spectrum.02430-21 | Journal: Microbiology Spectrum, 10(1) | Publisher: American Society for Microbiology | Publication date: 2022-03-17
Original document: PMC | Score: 7.26731 | Text size: 59485 | Find: similar documents
Compounds 1 and 6 were purchased from ChemDiv and Aurum Pharmatech, respectively (31, 32).
Hiroko Masuda; Kenichi Harano; Sakiko Miura; Ying Wang; Yuko Hirota; Oi Harada; Mohit Kumar Jolly; Yuki Matsunaga; Bora Lim; Anita L. Wood; Napa Parinyanitikul; Hee Jin Lee; Gyungyub Gong; Jason T. George; Herbert Levine; Jangsoon Lee; Xiaoping Wang; Anthony Lucci; Arvind Rao; Brock L. Schweitzer; O. Rayne Lawrence; Robert S. Seitz; Stephan W. Morris; David R. Hout; Seigo Nakamura; Savitri Krishnamurthy; Naoto T. Ueno
PMC ID: PMC8939918 | DOI: 10.1200/PO.20.00368 | Journal: JCO Precision Oncology, 6(1) | Publisher: Wolters Kluwer Health | Publication date: 2022-03-16
Original document: PMC | Score: 12.167842 | Text size: 41233 | Find: similar documents
Jangsoon Lee Research Funding: AnHeart Therapeutics, CytoDyn, ChemDiv ... Jangsoon Lee Research Funding: AnHeart Therapeutics, CytoDyn, ChemDiv
Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening
Huizhen Ge; Lizeng Peng; Zhou Sun; Huanxiang Liu; Yulin Shen; Xiaojun Yao
PMC ID: PMC8967249 | DOI: 10.3389/fphar.2022.850855 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-14
Original document: PMC | Score: 13.700139 | Text size: 41700 | Find: similar documents
About 1.5 million molecules from the ChemDiv database (version 2019) were used for virtual screening. ... About 1.5 million molecules in the ChemDiv (version 2019) database were used as the screening source. ... In this study, the Glide docking-based virtual screening and kinase inhibition assay were conducted to discover HPK1 inhibitors from the ChemDiv database.
Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer
Yixiao Zhang; Lisha Sun; Haonan Li; Liping Ai; Qingtian Ma; Xinbo Qiao; Jie Yang; Hao Zhang; Xunyan Ou; Yining Wang; Guanglei Chen; Jinqi Xue; Xudong Zhu; Yu Zhao; Yongliang Yang; Caigang Liu; Renata Pasqualini; Mone Zaidi
PMC ID: PMC8937232 | DOI: 10.7554/eLife.68481 | Journal: eLife, 11(1) | Publisher: eLife Sciences Publications, Ltd | Publication date: 2022-03-14
Original document: PMC | Score: 9.797036 | Text size: 73390 | Find: similar documents
Chemdiv Compond, San Diego, CA ... The results showed that C67399 (C38H48O5, 584.79 Da, 4903–2135, Chemdiv Compond, San Diego, CA) could obviously inhibit the cell viability of MDA-MB-231 cells (Figure 5—figure supplement 1C).
PMC ID: PMC8982080 | DOI: 10.3389/fmicb.2022.850588 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-10
Original document: PMC | Score: 9.42958 | Text size: 85779 | Find: similar documents
Bortezomib, Chemdiv C549-0604, and Chemdiv D244-0326 etc.
Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors
Ekaterina Ilgova; Simon Galkin; Maria Khrenova; Marina Serebryakova; Marina Gottikh; Andrey Anisenko; Nuno Taveira
PMC ID: PMC8951179 | DOI: 10.3390/ijms23062908 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-03-08
Original document: PMC | Score: 12.154662 | Text size: 65386 | Find: similar documents
To select such compounds, the representative Diversity Library containing 50,000 compounds with high diversity scoring (ChemDiv, Moscow, Russia) was used for docking into the Ku heterodimer pocket (PDB ID: 1JEQ). ... A total of 50,000 molecules from ChemDiv Diversity Library were selected for structure-based virtual screening against HIV-1 integrase putative binding site of Ku heterodimer. ... All compounds in ChemDiv diversity dataset were filtered for PAINS [58].
Carmine Varricchio; Gregory Mathez; Laurent Kaiser; Caroline Tapparel; Andrea Brancale; Valeria Cagno
PMC ID: PMC8923105 | DOI: 10.1101/2022.03.08.483429 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2022-03-08
Original document: PMC | Score: 11.3442745 | Text size: 50145 | Find: similar documents
A library of commercially available RNA-targeting compounds was downloaded from Enamine and ChemDiv website. ... To test the druggability of the binding site, we screened an RNA targeted library (Enamine, ChemDIV), which contains 44520 commercially available RNA-binding compounds, against site
Yang Yang; Yu Yan; Jiaxin Yin; Jie Hu; Xuefei Cai; Jieli Hu; Jie Xia; Kai Wang; Ni Tang; Luyi Huang; Koichi Watashi
PMC ID: PMC8876525 | DOI: 10.3390/v14020348 | Journal: Viruses, 14(1) | Publisher: MDPI | Publication date: 2022-02-08
Original document: PMC | Score: 11.093979 | Text size: 54984 | Find: similar documents
Compounds for screening were obtained from Chemdiv Inc. ... Small molecules from ChemDiv and Vitas-M libraries were prepared using Open Babel [42] and were docked into the SBA binding site using AutoDock Vina [43].
Yaodong Liu; Sibtain Ahmed; Yaowei Fang; Meng Chen; Jia An; Guang Yang; Xiaoyue Hou; Jing Lu; Qinwen Ye; Rongjun Zhu; Qitong Liu; Shu Liu
PMC ID: PMC9628821 | DOI: 10.4014/jmb.2201.01009 | ISSN: 1017-7825 | Journal: Journal of Microbiology and Biotechnology, 32(1) pp. 504-513 | Publisher: The Korean Society for Microbiology and Biotechnology | Publication date: 2022-02-05 | Print publication date: 2022-04-28
Original document: PMC | Score: 17.81079 | Text size: 35511 | Find: similar documents
In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. ... In this study, the 3D structure of AnCDA (pdb code: 2Y8U) was applied as the most reliable docking structure and used to screen the ChemDiv library through the SBVS method. ... The top-ranked 30 compounds derived from the ChemDiv database by structure-based pharmacophore virtual screening were purchased from ChemDiv, Inc. ... Representative molecular properties and key parameters identified in docking-based VS of the 23 purchased compounds from ChemDiv database. ... The compound number labeled in the ChemDiv database. ... According to the purity statements, the purity of all compounds purchased from the ChemDiv database is higher than 95%.
Tanaporn Uengwetwanit; Nopporn Chutiwitoonchai; Kanin Wichapong; Nitsara Karoonuthaisiri
PMC ID: PMC8813674 | DOI: 10.1016/j.csbj.2022.02.001 | Journal: Computational and Structural Biotechnology Journal | Publisher: The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. | Publication date: 2022-02-04
Original document: PMC | Score: 13.953599 | Text size: 39315 | Find: similar documents
Molecular docking was employed to screen inhibitors of SARS-CoV-2 from the ZINC ChemDiv database. ... To discover candidate inhibitors that can bind SARS-CoV-2 RdRp, molecular docking was carried out to screen for potential hit compounds from the Zinc (purchasable ChemDiv library) which contain diverse scaffolds [26]. ... Compounds from the purchasable Zinc ChemDiv library were docked into the binding pocket of the SARS-CoV-2 RdRp structure to predict the binding affinity.
Jin-ping Pang; Xue-ping Hu; Yun-xia Wang; Jia-ning Liao; Xin Chai; Xu-wen Wang; Chao Shen; Jia-jia Wang; Lu-lu Zhang; Xin-yue Wang; Feng Zhu; Qin-jie Weng; Lei Xu; Ting-jun Hou; Dan Li
PMC ID: PMC8809242 | DOI: 10.1038/s41401-021-00855-6 | ISSN: 1671-4083 | Journal: Acta Pharmacologica Sinica, pp. 1-10 | Publisher: Springer Singapore | Publication date: 2022-02-02
Original document: PMC | Score: 14.207614 | Text size: 52284 | Find: similar documents
By screening the ChemDiv chemical library, 54 potential compounds were identified and submitted to bioassays. ... Before molecule docking, the small molecules in the ChemDiv chemical library were prepared using the LigPrep module in Schrödinger, and filtered by the Lipinski’s rule-of-five [32] and Oprea’s [33] rules. ... We evaluated the toxicity of the compounds purchased from Chemdiv.
Jiayuan Su; Yiting Shen; Na Li; Yu Li; Ziding Zhang; Lihua Xiao; Yaqiong Guo; Yaoyu Feng; Eric Viscogliosi; Gabriela Certad; Magali Chabé
PMC ID: PMC8875172 | DOI: 10.3390/microorganisms10020333 | Journal: Microorganisms, 10(1) | Publisher: MDPI | Publication date: 2022-02-01
Original document: PMC | Score: 8.217452 | Text size: 47108 | Find: similar documents
These small molecules were selected based on the factors of molecular weight, ligand efficiency, coulomb energy, and H-bond energy in molecular docking of CpCDPK1 and CpCDPK9 in the ChemDiv database.
Cristina V. Iancu; Giovanni Bocci; Mohd Ishtikhar; Moumita Khamrai; Mislav Oreb; Tudor I. Oprea; Jun-yong Choe
PMC ID: PMC8791944 | DOI: 10.1038/s41598-022-05383-9 | Journal: Scientific Reports, 12(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-01-26
Original document: PMC | Score: 7.26731 | Text size: 62641 | Find: similar documents
He is on the Scientific Advisory Board of ChemDiv Inc. and Insilico Medicine.
Andrey A. Poloznikov; Sergey V. Nikulin; Dmitry M. Hushpulian; Anna Yu. Khristichenko; Andrey I. Osipyants; Andrey F. Asachenko; Olga V. Shurupova; Svyatoslav S. Savin; Sue H. Lee; Irina N. Gaisina; Gregory R. J. Thatcher; Anthony Narciso; Eric P. Chang; Sergey V. Kazakov; Nancy Krucher; Vladimir I. Tishkov; Bobby Thomas; Irina G. Gazaryan; Stanley Omaye
PMC ID: PMC8868400 | DOI: 10.3390/antiox11020220 | Journal: Antioxidants, 11(1) | Publisher: MDPI | Publication date: 2022-01-24
Original document: PMC | Score: 13.455724 | Text size: 47541 | Find: similar documents
Branched-tail oxyquinolines were purchased from ChemDiv (Moscow, Russia) or synthesized using the established protocol [9]; the minimum purity guaranteed by the supplier was 90%, and all purchased compounds were provided with NMR spectra. ... All compounds are commercially available from ChemDiv (Skolkovo, Russia). ... Other compounds are commercially available from ChemDiv (Skolkovo, Russia).
In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease
Muya Xiong; Tianqing Nie; Qiang Shao; Minjun Li; Haixia Su; Yechun Xu
PMC ID: PMC8783839 | DOI: 10.1016/j.ejmech.2022.114130 | ISSN: 0223-5234 | Journal: European Journal of Medicinal Chemistry | Publisher: Published by Elsevier Masson SAS. | Publication date: 2022-01-23
Original document: PMC | Score: 13.953599 | Text size: 38116 | Find: similar documents
In this work, we collected covalent warheads observed among the known peptidomimetic inhibitors of the SARS-CoV-2 3CLpro and used them as reference to pick up the potential covalent binders from the list resulting from the virtual screening on ChemDiv database. ... Our protocol for in silico screening consisted of two stages: a large-scale non-covalent virtual screening of compounds from ChemDiv database, which was followed by a covalent docking of the compounds containing the warheads shown in Fig. 1 . ... ChemDiv ID
Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors
Arup R. Chakraborty; Alex Vassilev; Sushil K. Jaiswal; Constandina E. O'Connell; John F. Ahrens; Barbara S. Mallon; Martin F. Pera; Melvin L. DePamphilis
PMC ID: PMC8828683 | DOI: 10.1016/j.stemcr.2021.12.013 | Journal: Stem Cell Reports, 17(1) pp. 397-412 | Publisher: Elsevier | Publication date: 2022-01-20
Original document: PMC | Score: 7.26731 | Text size: 60240 | Find: similar documents
WX8 (Specs, ChemDiv), Apilimod (Selleck Chemicals), and Adriamycin (MilliporeSigma) were purchased.
Luca Murer; Romain Volle; Vardan Andriasyan; Anthony Petkidis; Alfonso Gomez-Gonzalez; Liliane Yang; Nicole Meili; Maarit Suomalainen; Michael Bauer; Daniela Sequeira; Dominik Olszewski; Fanny Georgi; Fabien Kuttler; Gerardo Turcatti; Urs F. Greber
PMC ID: PMC8760634 | DOI: 10.1016/j.crviro.2022.100019 | Journal: Current Research in Virological Science | Publisher: Published by Elsevier B.V. | Publication date: 2022-01-15
Original document: PMC | Score: 5.173614 | Text size: 106219 | Find: similar documents
The remaining compounds were purchased from abcr GmbH, AK Scientific, Inc., Abcam plc., Acros Organics, AdipoGen Life Sciences, Inc., Advanced ChemBlocks Inc., Alinda Chemical Trade Company Ltd., Angene, Apollo Scientific Ltd., Axon Medchem, BIOTREND Chemikalien GmbH, BLD Pharmatech Ltd., Biosynth Carbosynth, Cayman Chemical Company, ChemBridge Corporation, ChemDiv Inc., Chemodex Ltd., Cohesion Biosciences Ltd., Combi-Blocks, Inc., Enamine Ltd.
Maiia E. Bragina; Antoine Daina; Marta A. S. Perez; Olivier Michielin; Vincent Zoete; Bruno Pagano
PMC ID: PMC8776004 | DOI: 10.3390/ijms23020811 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-01-12
Original document: PMC | Score: 12.786698 | Text size: 36135 | Find: similar documents
Enamine, ChemBridge, Maybridge, Asinex, AsisChem, Otava, SPECS, TimTec, Vitas, Life Chemicals, ChemDiv, Innovapharm. ... In particular, on top of ZINC (drug-like, lead-like, and fragments), it is possible to screen compounds in the following commercially available chemical libraries: Enamine, ChemBridge, Maybridge, Asinex, AsisChem, Otava, SPECS, TimTec, Vitas, Life Chemicals, ChemDiv, and Innovapharm.
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes‐Associated Breast Cancer
Qiongyu Hao; Zhimin Huang; Qun Li; Dingxie Liu; Piwen Wang; Kun Wang; Jieqing Li; Wei Cao; Wenhong Deng; Ke Wu; Rui Su; Zhongmin Liu; Jay Vadgama; Yong Wu
PMC ID: PMC8867195 | DOI: 10.1002/advs.202102303 | Journal: Advanced Science, 9(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2022-01-12
Original document: PMC | Score: 11.3442745 | Text size: 50770 | Find: similar documents
A total of 237 (113 from enamine; 84 from chemdiv, 40 from Chembridge) potential hits were identified using the docking‐based virtual screening. ... We then virtually screened seven commercial compound libraries (ChemBridge, ChemDiv, Enamine, InterBioScreen, Life Chemicals, Maybridge and SPECS), including more than 5 million compounds, targeting the binding pocket.
John M. SEDIVY [US]; Gerwald JOGL [US]; Alexandra D'ORDINE [US]
Publication date: 2023-05-04 | Patent publication No.: US-20230139684-A1 | Assignees: Brown University [US] | IPC: A61K31/4741; A61K31/198; A61K31/366; A61K31/145; A61K31/17; A61K31/4192; A61K31/445; A61K31/166; A61K31/167; A61K31/64; A61K31/4035; A61K31/505; A61K31/423; A61K31/381; A61K31/53; A61K31/635 | Oldest priority date: 2019-11-22 | Publication date: 2023-05-04
Score: 12.352504 | Text size: 114680 | Find: similar documents
Compounds were obtained from the following sources: AD1 (National Cancer Institute), AD2 (Alinda), AD3 (ChemBridge), AD4 (AK Scientific), AD5 (ChemDiv), AD6 (ChemBridge), AD7 (Enamine), AD8 (Sigma), AD9 (ChemDiv), AD10 (ChemBridge), AD11 (ChemDiv), AD12 (Sigma), AD13 (Specs), AD14 (Specs), AD15 (TargetMol), AD16 (Vitas), AD17 (Vitas), AD18 (UkrOrgSynthesis), AD19 (TimTec), AD20 (Vitas).
INHIBITORS OF VIRAL HELICASES BINDING TO A NOVEL ALLOSTERIC BINDING SITE
MENZER, William M. [DE]; KNOBLOCH, Gunnar [DE]; SCHOMBURG, Adrian [DE]; LIELEG, Corinna [DE]; SENNHENN, Peter [DE]
Publication date: 2023-05-04 | Patent publication No.: WO-2023073222-A1 | Assignees: EISBACH BIO GMBH [DE] | IPC: A61K31/4155; A61K31/433; A61K31/517; A61P31/12; C07D231/00 | Oldest priority date: 2021-10-29 | Publication date: 2023-05-04
Score: 4.3235645 | Text size: 213643 | Find: similar documents
All compounds that have been rationally designed as described in Example 1 were ordered from the manufacturers Enamine (Riga, Latvia), ChemDiv (San Diego CA, USA), or Intonation Research Laboratories (Hyderabad, India) under CDA as shown in the table in Fig. 20.
Rudolf Schindler [DE]; Hans-Joachim Lankau [DE]; Norbert Höfgen [DE]; Christian Grunwald [DE]; Ute Egerland [DE]; Barbara Langen [DE]; Rita Dost [DE]; Thorsten Hage [DE]; Simon Ward [GB]
Publication date: 2023-05-02 | Patent publication No.: US-RE049517-E1 | Assignees: JANSSEN PHARMACEUTICALS, INC. [US] | IPC: C07D231/12; A61K31/4155; A61K31/03; C07D403/06 | Oldest priority date: 2014-08-15 | Publication date: 2023-05-02
Score: 12.433797 | Text size: 179865 | Find: similar documents
4-(chloroethyl)-3,5-dimethyl-1H-pyrazole, available from ChemDiv, order ID: BB01-4360 ... 3-(chloromethyl)-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB20-2557 ... 4-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB57-1549 ... 5-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB57-3435 ... The reaction mixture was stirred at room temperature for 20 minutes, then 4-(2-chloro-ethyl)-3,5-dimethyl-1H-pyrazole (159 mg, 1.0 mmol) (ChemDiv, BB01-4360) was added.
USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE
David J. Dowling [US]; Ofer Levy [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]
Publication date: 2023-04-27 | Patent publication No.: US-20230132397-A9 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2023-04-27
Score: 4.9277406 | Text size: 385657 | Find: similar documents
The chemical libraries screened included known bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... The chemical libraries screened included known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).
Small molecule antiviral drug treatment for human papillomavirus infections
Elliot J. Androphy [US]; Samy Meroueh [US]; Zhijian Lu [US]
Publication date: 2023-04-18 | Patent publication No.: US-11628158-B2 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS, INC. [US] | IPC: A61K31/381; A61P31/20; A61K9/00; C07D215/06; C07D487/04; C07D495/04; A61K38/10 | Oldest priority date: 2020-04-17 | Publication date: 2023-04-18
Score: 6.3513765 | Text size: 110204 | Find: similar documents
EIN-116(cat #V008-7329), EIN-117(cat #V008-7342), EIN-118(cat #V009-0689), EIN-119(cat #V009-0721), EIN-120(cat #V009-8145), EIN-121(cat #V013-5084), EIN-123(cat #V009-3346), EIN-124(cat #V001-3096), EIN-125(cat #V001-3172), EIN-126(cat #V002-4119), EIN-127(cat #V002-4126), EIN-128(cat #V002-4718), EIN-129(cat #V012-2359), EIN-130(cat #V031-2694), and EIN-131(cat #V031-2717) were each purchased from ChemDiv.
Zakia Belaid-Choucair [FR]; Olivier Hermine [FR]; Carmen Garrido-Fleury [FR]; Claude Cochet [FR]; Odile Filhol-Cochet [FR]; Renaud Seigneuric [FR]
Publication date: 2023-04-18 | Patent publication No.: US-11629192-B2 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) [FR]; UNIVERSITÉ PARIS CITÉ [FR]; FONDATION IMAGINE [FR]; ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]; UNIVERSITE GRENOBLE ALPES [FR]; COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES [FR]; UNIVERSITE DE BOURGOGNE [FR] | IPC: A61K31/00; A61K39/00; C07K16/28; A61K38/17; A61K31/4745; A61K31/7105; A61K31/713; A61K39/395; A61K45/06; C12N15/113; G01N33/566 | Oldest priority date: 2014-02-18 | Publication date: 2023-04-18
Score: 5.952544 | Text size: 141168 | Find: similar documents
Starting materials useful for preparing compounds of the invention and intermediates thereof are commercially available from sources, such as Aldrich Chemical Co. (Milwaukee, Wis.), Sigma Chemical Co. (St. Louis, Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (San Diego, Calif.), ChemDiv (San Diego, Calif.), SPECS (Delft, The Netherlands), Timtec (Newark, Del.), or alternatively can be prepared by well-known synthetic methods (see, e.g., Harrison et al., “Compendium of Synthetic Organic Methods”, Vols.
TLR8 AGONIST FOR MODULATING IMMUNE RESPONSE
DOWLING, David, J. [US]; LEVY, Ofer [US]; VAN HAREN, Simon, D. [US]; CHEW, Katherine [US]; SONI, Dheeraj [US]; DE LEON, Maria [US]
Publication date: 2023-04-06 | Patent publication No.: WO-2023056337-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4184; A01N43/52; A61P31/04; A61P35/00; C07D235/04; C07D235/20 | Oldest priority date: 2021-09-30 | Publication date: 2023-04-06
Score: 4.530187 | Text size: 212389 | Find: similar documents
These molecules originated from various bioactive and commercial libraries such as ChemDiv, ChemB ridge, and Asinex.
TLR4 AGONIST FOR MODULATING IMMUNE RESPONSE
LEVY, Ofer [US]; DOWLING, David, J. [US]; VAN HAREN, Simon, D. [US]; CHEW, Katherine [US]; SAITO, Yoshine [US]
Publication date: 2023-04-06 | Patent publication No.: WO-2023056334-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61P31/04; A61P31/12 | Oldest priority date: 2021-09-30 | Publication date: 2023-04-06
Score: 4.530187 | Text size: 206951 | Find: similar documents
These molecules originated from various bioactive and commercial libraries such as ChemDiv, ChemBridge, and Asinex.
Identification of Stabilizers of Multimeric Proteins
Isabella A. Graef [US]; Mamoun M. Alhamadsheh [US]
Publication date: 2023-04-06 | Patent publication No.: US-20230105307-A1 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; A61K31/4196; A61K31/428; A61K31/433; C07D231/12; C07D487/04; A61K31/519; A61K31/166 | Oldest priority date: 2010-05-07 | Publication date: 2023-04-06
Score: 5.952544 | Text size: 136723 | Find: similar documents
Approximately 120,000 compounds from the Stanford HTBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS. and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from Sigma).
PHARMACEUTICAL COMPOSITIONS FOR USE IN PREVENTION AND/OR TREATMENT AND/OR CURE OF HEPATITIS B VIRUS
The designation of the inventor has not yet been filed
Publication date: 2023-04-05 | Patent publication No.: EP-4159213-A1 | Assignees: Katholieke Universiteit Leuven [BE] | IPC: A61K31/4422; A61P31/20 | Oldest priority date: 2021-10-01 | Publication date: 2023-04-05
Score: 12.252368 | Text size: 69943 | Find: similar documents
An additional compound library consisting of 556 analogues was purchased from ChemDiv Inc. ... The inhibitory potential of all compounds of the Spectrum Collection (n = 2000) and the ChemDiv library (n = 556) were determined at equimolar concentrations with 3 μM tauro-nor-THCA-24-DBD.
MYCOBACTERIUM ABSCESSUS GROWTH INHIBITOR AND MODEL
GRÜBER, Gerhard [SG]; SHIN, Joon [SG]; AMARAVADHI, Venkata Krishna Harikishore [SG]; WONG, Chui Fann [SG]; RAGUNATHAN, Priya [SG]
Publication date: 2023-03-30 | Patent publication No.: WO-2023048641-A2 | Assignees: NANYANG TECHNOLOGICAL UNIVERSITY [SG] | Oldest priority date: 2021-09-21 | Publication date: 2023-03-30
Score: 10.849978 | Text size: 88143 | Find: similar documents
ChemDiv vendor library was employed using the default settings in Phase ligand preparation (Schrodinger release (2020-4) phase. New York, NY: Schrodinger, LLC; 2019; and Dixon, S. L. et al., J. Comput. ... Database screening with this pharmacophore model yielded about 30,000 molecules from the 1.3 million ChemDiv commercial library (San Diego, CA, USA) for further virtual screening studies.
David Kevin Wood [US]; Jonathan N. Sachs [US]; Nagamani Vunnam [US]; Chih Hung Lo [SG]
Publication date: 2023-03-30 | Patent publication No.: US-20230095509-A1 | Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US] | IPC: G01N33/72; G01N21/64 | Oldest priority date: 2021-09-27 | Publication date: 2023-03-30
Score: 7.9492164 | Text size: 80817 | Find: similar documents
Small molecule libraries are available, and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library, LOPAC 1280TH, MicroSource Spectrum Collection, Pharmakon, The Prestwick Chemical Library®, SPECS, NIH Clinical Collection, Chiral Centers Diversity Library.
Kailash SINGH [CN]; Billy Kwok Chong CHOW [CN]
Publication date: 2023-03-30 | Patent publication No.: US-20230099367-A1 | Assignees: VERSITECH LIMITED [CN] | IPC: A61K31/5377; A61P9/12 | Oldest priority date: 2019-04-16 | Publication date: 2023-03-30
Score: 10.262654 | Text size: 113338 | Find: similar documents
Publicly available small molecule libraries used include, but not limited to, PubChem, CHEMBL, MolProt, ChemDiv, ChemSpace, NCI open and ZINC. ... Hits from both the pharmacophore searches were combined together and a total of 1,03,555 small compounds were selected as hits (CHEMBL-11010hits; ChemDiv-330 hits; ChemSpace-8173, Molprot-5,163 hits; NCI open-422; PubChem-71,630; ZINC-6,827) via Pharmit tools.
COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES
LU, Boxun [CN]; FU, Yuhua [CN]; DING, Yu [CN]
Publication date: 2023-03-29 | Patent publication No.: EP-4155294-A1 | Assignees: Fudan University [CN] | IPC: C07D209/34; C07D403/06; C07D311/16; C07D239/88; C07D403/12; C07D487/04; C07D401/12; C07D513/04; C07D409/14; C07D239/70; C07J9/00; A61P3/00; A61P3/04; A61P3/10; A61P1/16; A61P35/00; A61P9/10; A61P25/28; A61K31/352; A61K31/404 | Oldest priority date: 2020-04-23 | Publication date: 2023-03-29
Score: 6.047818 | Text size: 409246 | Find: similar documents
Compound A4: commercially purchased from ChemDiv, CAS No. 779-27-1; ... Compound A5: also numbered AN2, PubChem CID 5398649, commercially purchased from ChemDiv, catalog number D715-2435; ... Compound A7: commercially purchased from ChemDiv;
SMALL MOLECULE INHIBITORS OF VOLTAGE-GATED SODIUM CHANNEL 1.7 AND METHODS OF USING SAME
Andrey BORTSOV [US]; Sharat CHANDRA [US]; Ru-Rong JI [US]
Publication date: 2023-03-23 | Patent publication No.: US-20230090372-A1 | Assignees: Duke University [US] | IPC: A61K31/4045; A61P17/04; A61K9/00 | Oldest priority date: 2019-12-11 | Publication date: 2023-03-23
Score: 14.708862 | Text size: 132748 | Find: similar documents
For virtual screening, a database of 1.5 million compounds was downloaded from the Chemdiv website (chemdiv.com, ChemDiv Inc., San Diego, Calif.). ... A similarity threshold value of 0.5 against the compounds from the Chemdiv database was used to screen for potential Nav1.7 inhibitors. ... Similarity search of the ChemDiv database (ChemDiv Inc, San Diego, Calif.) containing 1.5 million pre-synthetized compounds yielded a set of 2000 compounds structurally similar to the query molecules—known inhibitors of Nav1.7. ... Of those, 9 compounds with unique scaffolds and sufficient quantity (1 mg or more) available in stock were selected and purchased from ChemDiv for in vitro and in vivo activity assessment.
COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY
Nigel RAMSDEN [GB]; David John FOX [GB]; James Andrew HUNTINGTON [GB]; James Michael TOMLINSON [GB]
Publication date: 2023-03-23 | Patent publication No.: US-20230089087-A1 | Assignees: Z Factor Limited [GB] | IPC: A61K31/451; A61K31/4709; A61K31/4015; A61P1/16; A61P11/00 | Oldest priority date: 2019-12-13 | Publication date: 2023-03-23
Score: 10.621242 | Text size: 39504 | Find: similar documents
This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.
Leucine-Rich Repeat Kinase 2 Allosteric Modulators
Wim Versées [BE]; Ranjan Kumar Singh [BE]; Arjan Kortholt [NL]; Christian-Johannes Gloeckner [DE]
Publication date: 2023-03-23 | Patent publication No.: US-20230087785-A1 | Assignees: VIB VZW [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE]; RIJKSUNIVERSITEIT GRONINGEN [NL]; DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E.V. [DE] | IPC: C07K16/40; G01N33/68 | Oldest priority date: 2020-02-25 | Publication date: 2023-03-23
Score: 4.3235645 | Text size: 232358 | Find: similar documents
Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).
Eli Chapman [US]; Andrew J. Ambrose [US]; Taoda Shi [US]
Publication date: 2023-03-23 | Patent publication No.: US-20230091297-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US] | IPC: A61K31/426; A61K31/427; A61K31/428; A61P35/00 | Oldest priority date: 2020-03-13 | Publication date: 2023-03-23
Score: 6.3513765 | Text size: 120208 | Find: similar documents
Compound 1, N-(3-methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)thiophene-2-carboxamide, was purchased from ChemDIV Inc.
INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF
Jinah JEONG [KR]; Hyunjung KWAK [KR]; Gunhee KIM [KR]; Jeongeun KIM [KR]; Sanghwan LEE [KR]; Seolhee LEE [KR]; Jinhee LEE [KR]; Jihye CHOI [KR]; Hongchul YOON [KR]; Joontae PARK [KR]; Kyungmi AN [KR]; Jungwoo LEE [KR]; Eunjung LEE [KR]
Publication date: 2023-03-16 | Patent publication No.: US-20230080054-A1 | Assignees: ILDONG PHARMACEUTICAL CO., LTD. [KR] | IPC: C07D405/12; C07D307/52; C07D405/14; C07D237/20; C07D401/12; C07D403/12; C07D409/12; C07C237/30; C07D241/20; C07D239/42; C07D413/14; C07D409/14; C07D471/08; C07D213/74; C07D417/12; C07D271/07; C07D213/38; C07D239/26; C07D241/12; C07D211/98 | Oldest priority date: 2021-01-22 | Publication date: 2023-03-16
Score: 19.20178 | Text size: 404586 | Find: similar documents
Chemdiv, Inc ... ChemDiv, Inc. ... ChemDiv, Inc. ... ChemDiv, Inc. ...
COMPOSITIONS AND APPLICATIONS THEREOF
Todor A. Popov [BG]; Peter David Josling [GB]
Publication date: 2023-03-09 | Patent publication No.: US-20230075885-A1 | Assignees: Nasaleze Patents Limited [GB] | IPC: A61K9/16; A61K47/46; A61K31/675; A61K31/352; A61K41/00; A61K38/21; A61K31/215; A61K31/7056; A61K31/513; A61K36/16; A61K31/07; A61K31/375; A61K31/355; A61K36/258; A61K36/82; A61K31/522; A61K31/122; A61K36/23 | Oldest priority date: 2020-02-12 | Publication date: 2023-03-09
Score: 12.913415 | Text size: 93700 | Find: similar documents
A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl) benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370). ... A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370). ... A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370).
DIRECT REPROGRAMMING OF SOMATIC CELLS INTO MYOGENIC CELLS
Konrad HOCHEDLINGER [US]; Ori BAR-NUR [US]
Publication date: 2023-02-09 | Patent publication No.: US-20230042917-A1 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N5/077; C12N15/85; C12Q1/6883; A61K35/34 | Oldest priority date: 2016-04-06 | Publication date: 2023-02-09
Score: 5.2883806 | Text size: 164100 | Find: similar documents
Compound libraries can be obtained commercially, for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
Compositions and methods of treatment using nicotinamide mononucleotide
Shin-ichiro Imai [US]; Alessia Grozio [US]
Publication date: 2023-01-31 | Patent publication No.: US-11564936-B2 | Assignees: Washington University [US] | IPC: A61K31/706; A61P3/04; A61K45/06; A61K48/00; C12N15/86; G01N33/50; G01N33/68 | Oldest priority date: 2017-08-10 | Publication date: 2023-01-31
Score: 5.2883806 | Text size: 156540 | Find: similar documents
For experiments with Sirt1 and Sirt6 inhibitors, the ilea from 24-month-old female B6 mice were pre-incubated for 2 h at 37° C. in 500 μl of secretion media contending 0.2% DMSO (vehicle), 20 M EX527 (Cayman chemical, MI) or 20 M STK665401 (ChemDiv, cat #8018-9378; Sociali, G. et al., Eur. J. Med.
METHODS FOR IDENTIFYING ADAR1 INHIBITORS, AND COMPOSITIONS AND METHODS OF USE IN TREATING CANCER
Publication date: 2023-01-26 | Patent publication No.: WO-2023004342-A2 | Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US] | IPC: C12Q1/6883; G16B20/00 | Oldest priority date: 2021-07-20 | Publication date: 2023-01-26
Score: 4.530187 | Text size: 202787 | Find: similar documents
It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.), Fluka Chemika-Biochemica-Analytika (Buchs Switzerland) and the like.
METHODS FOR IDENTIFYING ADAR1 INHIBITORS, AND COMPOSITIONS AND METHODS OF USE IN TREATING CANCER
Publication date: 2023-01-26 | Patent publication No.: WO-2023004342-A9 | Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US] | IPC: C12Q1/68; C12N9/22 | Oldest priority date: 2021-07-20 | Publication date: 2023-01-26
Score: 4.530187 | Text size: 202941 | Find: similar documents
It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.), Fluka Chemika-Biochemica-Analytika (Buchs Switzerland) and the like.
CRYSTAL STRUCTURES OF ALK AND LTK RECEPTOR TYROSINE KINASES AND THEIR LIGANDS
SAVVIDES, Savvas [BE]; DE MUNCK, Steven [BE]
Publication date: 2023-01-12 | Patent publication No.: WO-2023280766-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE] | IPC: C12N9/12; C07K16/40; C07K14/52; C07K14/715; C30B29/58; G16B15/30 | Oldest priority date: 2021-07-07 | Publication date: 2023-01-12
Score: 6.3513765 | Text size: 123298 | Find: similar documents
Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands).
ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY
Rushdia Yusuf [US]; Shrikanta Chattopadhyay [US]; David T. Scadden [US]; Nick Van Gastel [BE]; Azeem S. Sharda [US]; Borja Saez [ES]; Vasanthi S. Viswanathan [US]
Publication date: 2023-01-05 | Patent publication No.: US-20230000896-A1 | Assignees: Rushdia Yusuf [US]; Shrikanta Chattopadhyay [US]; President and Fellows of Harvard College [US]; The Broad Institute, Inc. [US]; The General Hospital Corporation [US] | IPC: A61K31/713; A61P35/00; A61K31/381; A61K31/437; A61K31/496 | Oldest priority date: 2019-12-09 | Publication date: 2023-01-05
Score: 4.530187 | Text size: 205906 | Find: similar documents
The initial screen will be performed on the ChemDiv 6 library, a select set of 44,000 public domain compounds.
TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA) SMALL MOLECULE INHIBITOR
Sang Dun CHOI [KR]; Mahesh Chandra PATRA [KR]; Nasir JAVAID [KR]; Maria BATOOL [KR]; Dae-Hyun HAHM [KR]
Publication date: 2023-01-05 | Patent publication No.: US-20230000861-A1 | Assignees: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]; UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY [KR] | IPC: A61K31/502; A61P29/00; A61P37/00; C07D417/14; C07D417/12 | Oldest priority date: 2019-11-05 | Publication date: 2023-01-05
Score: 11.169593 | Text size: 89229 | Find: similar documents
SPD304 (MolPort ID: MolPort-042-665-817; ChemDiv catalog #4031-0592), C87 (Tocris Cookson, Bristol, UK), rhTNF-α (Miltenyi Biotec, Auburn, Calif., USA), rhTNF-α (Miltenyi Biotec), act-D (Thermo Fisher Scientific, Inc.), and BS3 (Thermo Fisher Scientific, Inc.) were purchased from the respective companies, noted in parentheses above. ... ChemDiv
COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY
RAMSDEN, Nigel [GB]; FOX, David John [GB]
Publication date: 2022-12-22 | Patent publication No.: WO-2022263817-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: C07D211/96; A61P1/16; A61P11/00; A61P35/00; A61K31/445 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22
Score: 13.446067 | Text size: 15363 | Find: similar documents
This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.
COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY
RAMSDEN, Nigel [GB]; FOX, David John [GB]; HUNTINGTON, James Andrew [GB]
Publication date: 2022-12-22 | Patent publication No.: WO-2022263816-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61K31/445; A61P11/00 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22
Score: 10.057776 | Text size: 43695 | Find: similar documents
This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.
COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY
RAMSDEN, Nigel [GB]; FOX, David John [GB]
Publication date: 2022-12-22 | Patent publication No.: WO-2022263820-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D241/04; C07D265/30; A61K31/495; A61K31/5375 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22
Score: 12.766966 | Text size: 19482 | Find: similar documents
This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.
COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY
RAMSDEN, Nigel [GB]; FOX, David John [GB]
Publication date: 2022-12-22 | Patent publication No.: WO-2022263819-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D211/96; A61K31/445 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22
Score: 13.446067 | Text size: 14861 | Find: similar documents
This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.
E3 LIGASE INHIBITORS AND METHODS OF USE THEREOF
RAPE, Michael [US]; SCHALETZKY, Julia Sabine [US]; WEHRI, Edward Eric [US]; MANFORD, Andrew Garrett [US]
Publication date: 2022-12-22 | Patent publication No.: WO-2022266321-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/42; A61K31/4164; A61P35/00; A61K31/423; A61K31/4709 | Oldest priority date: 2021-06-17 | Publication date: 2022-12-22
Score: 7.061031 | Text size: 104533 | Find: similar documents
Diversity and Antibacterial chemical libraries containing 100,000 and 15,000 small molecule compounds, respectively, were purchased from (Chemdiv, San Diego, CA) with same storage conditions.
RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHODS OF USING SAME
Anna Marie Pyle [US]; David Rawling [US]; Erik G. Jagdmann [US]; Olga Potapova [US]
Publication date: 2022-12-15 | Patent publication No.: US-20220395487-A1 | Assignees: YALE UNIVERSITY [US] | IPC: A61K31/403; A61K31/4184; A61P37/00 | Oldest priority date: 2019-11-04 | Publication date: 2022-12-15
Score: 6.3513765 | Text size: 123176 | Find: similar documents
Using this assay, a library of over 11,000 compounds spanning 11 libraries, including the ChemBridge, Enzo Kinase Inhibitor, Enzo Phosphatase Inhibitor, ChemDiv and Nuclear Receptor Libraries, was screened.
SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF
Susan Stevens [US]; Mary Stenzel-Poore [US]; Marie Foss [US]; Aaron Nilsen [US]; Haihong Jin [US]
Publication date: 2022-12-15 | Patent publication No.: US-20220395500-A1 | Assignees: Neuralexo, Inc. [US] | IPC: A61K31/496; A61P9/10; A61K31/167; A61K31/519; A61K31/5377; A61K31/341; A61K31/381; A61K31/423; A61K31/428; A61K31/427; A61K31/4365; A61K31/437; A61K31/4439; A61K31/4245; A61K31/4178; A61K31/55 | Oldest priority date: 2020-05-04 | Publication date: 2022-12-15
Score: 3.3945959 | Text size: 288502 | Find: similar documents
This library was purchased from SIGA Technologies in 2014 and is made up of compounds from the ChemBridge DIVERSetTM-CL library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv.
COMPOUNDS THAT BIND NON-CANONICAL G-QUADRUPLEX STRUCTURES AND METHODS OF MAKING AND USING THE SAME
SCHNEEKLOTH, John S. [US]; YANG, Mo [US]; LIANG, Xiao [US]; FULLENKAMP, Christopher [US]
Publication date: 2022-12-15 | Patent publication No.: WO-2022261296-A1 | Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: C07D413/04; C07D413/14; A61P35/00; A61K31/501 | Oldest priority date: 2021-06-09 | Publication date: 2022-12-15
Score: 8.120042 | Text size: 273393 | Find: similar documents
Other sequences of DNA/RNA samples used for binding specificity study are summarized in FIGS.1-2: Hit compounds for binding validation were purchased from ChemDiv and Chembridge. ... In these examples, compounds for SAR study were either purchased from ChemDiv (MY-1, MY-2, MY-3, MY-4, MY-9, MY-10, MY-11, MY-12) or synthesized in the lab (MY-5, MY-6, MY-7, MY-8, MY-13, MY-14). ... Briefly, ~15,000 compounds (10 mM in DMSO) from ChemDiv and Chembridge libraries as well as control dyes (Alexa Fluor 647 and 488, 10 μM in DMSO) were prepared in 384 well plates (Arrayjet JetstarTM).
Ehud GAZIT [IL]; Dana LAOR [IL]; Dorin SADE YAZDI [IL]
Publication date: 2022-12-08 | Patent publication No.: US-20220390471-A1 | Assignees: Ramot at Tel-Aviv University Ltd. [IL] | IPC: G01N33/68 | Oldest priority date: 2021-06-03 | Publication date: 2022-12-08
Score: 3.3945959 | Text size: 318328 | Find: similar documents
Compound libraries are commercially available from a number of companies including but not limited to Maybridge Chemical Co. (Trevillet, Cornwall, UK), Comgenex (Princeton, N.J.), Microsource (New Milford, Conn.), Aldrich (Milwaukee, Wis.), AKos Consulting and Solutions GmbH (Basel, Switzerland), Ambinter (Paris, France), Asinex (Moscow, Russia), Aurora (Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.), Chemical Block Lt, (Moscow, Russia).
Byeong Cheol AHN [KR]; Ji Min OH [KR]
Publication date: 2022-12-01 | Patent publication No.: US-20220378796-A1 | Assignees: Kyungpook National University Industry-Academic Cooperation Foundation [KR] | IPC: A61K31/519; A61P35/04 | Oldest priority date: 2017-10-20 | Publication date: 2022-12-01
Score: 10.621242 | Text size: 41046 | Find: similar documents
Among the TKI candidates, TKI-0266 was selected, purchased from Chemdiv (USA), dissolved in DMSO, and then stored at −80° C.
Kang-Yell CHOI [KR]; Minguen YOON [KR]; Soung-Hoon LEE [KR]
Publication date: 2022-12-01 | Patent publication No.: US-20220378741-A1 | Assignees: CK Regeon Inc. [KR] | IPC: A61K31/404; A61P25/28; A61P25/16 | Oldest priority date: 2019-11-04 | Publication date: 2022-12-01
Score: 10.548147 | Text size: 102776 | Find: similar documents
To initially identify small molecules that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280
WHITTINGHAM, William Guy [GB]; SCUTT, James Nicholas [GB]; HENNESSY, Alan Joseph [GB]; FRYE, Elizabeth Catherine [GB]; DALE, Suzanna [GB]; ASPINALL, Ian Henry [GB]
Publication date: 2022-11-24 | Patent publication No.: WO-2022243155-A1 | Assignees: SYNGENTA CROP PROTECTION AG [CH] | IPC: A01N37/10; C07C69/614 | Oldest priority date: 2021-05-19 | Publication date: 2022-11-24
Score: 7.061031 | Text size: 97018 | Find: similar documents
1-186, 1-6, 1-2 and 1-473 are obtainable as of the priority date of the present application from commercial sources, such as Enamine, Accela and ChemDiv.
SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1
MCKENNA, Charles E. [US]; PETOSA, Carlo [FR]; GOVIN, Jerome [FR]; KASHEMIROV, Boris A. [US]; FERRI, Elena [US]; MIETTON, Flore [FR]
Publication date: 2022-11-23 | Patent publication No.: EP-3490552-B1 | Assignees: University of Southern California [US]; CNRS [FR]; Université Grenoble Alpes [FR]; Inserm [FR]; Commissariat à l'Energie Atomique et aux Energies Alternatives [FR] | IPC: A61K31/554; A61K31/437; A61K31/454; C07D281/14; C07D417/12; C07D417/14; C07D471/04; C07D513/04; A61P31/10 | Oldest priority date: 2016-07-26 | Publication date: 2022-11-23
Score: 13.495927 | Text size: 145215 | Find: similar documents
DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; chemcats: ChemDiv Inc: XP002799331, Database accession no. 1358915-86-2 ... DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 March 2002 (2002-03-02), chemcats: ChemDiv Inco: "7-(5-(3-furanyl)-1,2,4-oxadiazol-3-yl)10- (1-methylethyl)-dibenzo(b,f)(1,4)thiazepin e-11(10H)-one", XP002799332, Database accession no. 1359492-68-4 ... DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 March 2002 (2002-03-02), chemcats: chemdiv inc: "N-(10-cyclopropyl-10,11,dihydro-11-oxodib enzo[b,f][1,4]thiazepin-7-yl)-2-pyridineca rboxamide", XP002799334, Database accession no. 1359492-28-6
Anti-cancer compounds targeting Ral GTPases and methods of using the same
Dan Theodorescu [US]; Michael Fitzpatrick Wempe [US]; David Ross [US]; Chao Yan [US]; Phillip Reigan [US]
Publication date: 2022-10-18 | Patent publication No.: US-11472812-B2 | Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US] | IPC: C07D491/052; A61K31/4162; A61P35/04; A61K45/06 | Oldest priority date: 2014-07-10 | Publication date: 2022-10-18
Score: 5.0089407 | Text size: 164417 | Find: similar documents
The ChemDiv library [v2006.5, 500,000 compounds excluding those possessing reactive groups, known ADME/toxicity, physicochemical properties lie outside drug-likeness' parameters (Lipinski's rule of 5 and Veber's Rule of 2) at pH 7] was downloaded from ZINC database and docked into the identified site on RalA-GDP using rigid docking protocols.
Autophagy modulators for use in treating cancer
Melvin L. DePamphilis [US]; Gaurav Sharma [IN]; Juan Jose Marugan [US]; Marc Ferrer [US]; Ajit Roy [US]
Publication date: 2022-10-18 | Patent publication No.: US-11471460-B2 | Assignees: The United States of Americans represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/53; A61P35/00; A61K31/506; C07D239/50; C07D251/54; C07D403/12 | Oldest priority date: 2017-12-01 | Publication date: 2022-10-18
Score: 5.952544 | Text size: 133677 | Find: similar documents
Compounds 1, 4, 5, 3, and 2 (Specs, ChemDiv, Life Chemicals) and Rapamycin (S1039, Selleck Chemicals) were dissolved in dimethyl sulfoxide (DMSO) at 20 mM concentrations and stored at −20° C. Compound 1 family compounds (FIG. 1) were assayed for purity by high pressure liquid chromatography and their identity confirmed by Mass spectroscopy.
Catherine TACHDJIAN [US]; Andrew P. PATRON [US]; Sara L. ADAMSKI-WERNER [US]; Farid BAKIR [US]; Qing CHEN [US]; Vincent DARMOHUSODO [US]; Stephen Terrence HOBSON [US]; Xiaodong LI [US]; Ming QI [CN]; Daniel H. ROGERS [US]; Marketa RINNOVA [US]; Guy SERVANT [US]; Xiao-Qing TANG [US]; Mark ZOLLER [US]; David WALLACE [US]; Amy XING [US]; Klaus GUBERNATOR [US]
Publication date: 2022-10-13 | Patent publication No.: US-20220326230-A1 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00 | Oldest priority date: 2003-08-06 | Publication date: 2022-10-13
Score: 2.9692738 | Text size: 326033 | Find: similar documents
USA and their subsidiaries Fluka and Riedel-de Haën, at their various other worldwide offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif., Asinex of Moscow Russia, SPECS/BIOSPECS of the Netherlands, Maybridge of Cornwall England, Acros, TimTec of Russia, Comgenex of South San Francisco Calif. and ASDI Biosciences of Newark Del.
CO-POTENTIATORS FOR THERAPY OF CYSTIC FIBROSIS CAUSED BY MINIMAL FUNCTION CFTR MUTANTS
Alan S. VERKMAN [US]; Puay-Wah PHUAN [US]; Peter M. HAGGIE [US]
Publication date: 2022-10-13 | Patent publication No.: US-20220323425-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/438; A61K31/47; A61K45/06; A61K31/4245 | Oldest priority date: 2019-08-28 | Publication date: 2022-10-13
Score: 7.629327 | Text size: 87877 | Find: similar documents
For screening, 120,000 diverse drug-like synthetic compounds (i.e., Structures (A), (B), (C), and (D); ChemDiv Inc., San Diego, Calif.) were tested.
CFTR REGULATORS AND METHODS OF USE THEREOF
VERKMAN, Alan [US]; LEVIN, Marc, H [US]; CIL, Onur [US]; KURTH, Mark, J [US]
Publication date: 2022-10-12 | Patent publication No.: EP-4071140-A1 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; A61K31/502; A61P11/00; A61P27/02 | Oldest priority date: 2016-08-18 | Publication date: 2022-10-12
Score: 6.2266536 | Text size: 717013 | Find: similar documents
High-throughput screening was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. ... For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... High-throughput screening was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. ... For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... Commercial analogs were purchased from ChemDiv (San Diego, CA).
NOVEL SULFONAMIDE SERIES OF QR2 INHIBITORS TO TACKLE OXIDATIVE STRESS AND COGNITIVE DECLINE
ROSENBLUM, Kobi [IL]; GOULD, Natheniel [IL]; EDRI, Efrat [IL]
Publication date: 2022-10-06 | Patent publication No.: WO-2022208499-A1 | Assignees: CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. [IL] | IPC: A61K31/40; C07D403/12; A61P25/00 | Oldest priority date: 2021-03-30 | Publication date: 2022-10-06
Score: 4.3235645 | Text size: 209193 | Find: similar documents
The chemical libraries used were Selleck Chemicals Bioactives, the Drug-like set from Enamine, HitFinder collection from Maybridge, Spectrum Collection from Microsource, Lopac from Sigma- Aldrich and the diversity sets from ChemDiv and ChemBridge.
Roger Cone [US]; Patrick Sweeney [US]
Publication date: 2022-10-06 | Patent publication No.: US-20220313789-A1 | Assignees: The Regents of the University of Michigan [US] | IPC: A61K38/34; A61K38/26; A61K31/485; A61K45/06; A61P25/24; A61P3/04 | Oldest priority date: 2019-06-19 | Publication date: 2022-10-06
Score: 5.2883806 | Text size: 165300 | Find: similar documents
A screen was performed with a series of 4160 samples from the ChemDiv 100,000 compound diversity set maintained at CCG (FIG. 2D-F).
Hakon Hakonarson [US]; Patrick Sleiman [US]
Publication date: 2022-10-06 | Patent publication No.: US-20220316008-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61P11/06; A61K31/5585; A61K31/135 | Oldest priority date: 2019-09-09 | Publication date: 2022-10-06
Score: 7.9492164 | Text size: 85748 | Find: similar documents
In addition, compound libraries are commercially available from a number of companies including but not limited to Maybridge Chemical Co. (Trevillet, Cornwall, UK), Comgenex (Princeton, N.J.), Microsource (New Milford, Conn.), Aldrich (Milwaukee, Wis.), AKos Consulting and Solutions GmbH (Basel, Switzerland), Ambinter (Paris, France), Asinex (Moscow, Russia), Aurora (Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive Chemistry, Ltd (Obninsk, Russia), Enamine (Kiev, Ukraine), Evotec (Hamburg, Germany), Indofine (Hillsborough, N.J.), Interbioscreen (Moscow, Russia), Interchim (Montlucon, France), Life Chemicals, Inc.
Autotaxin inhibitory compounds
Martin Lee Stockley [GB]; Ellen Catherine Macdonald [GB]; Pritom Shah [GB]; Allan Jordan [GB]; James Hitchin [GB]; Niall Hamilton [GB]
Publication date: 2022-09-27 | Patent publication No.: US-11453666-B2 | Assignees: Cancer Research Technology Limited [GB] | IPC: A61P1/00; A61P1/16; A61P29/00; A61P31/20; A61P31/14; A61P31/12; A61P3/10; A61P7/12; A61P17/00; A61P17/04; A61P17/02; A61P35/00; A61P35/02; A61P7/04; A61P7/02; A61P13/02; A61P13/12; A61P9/12; A61P9/00; A61P43/00; A61P19/04; A61K31/5025; A61K31/444; A61K31/4545; A61K31/5377; A61K31/404; A61K31/551; A61K31/55; A61K31/496; A61K31/4184; A61K45/06; C07D235/02; C07D471/04; A61K31/437 | Oldest priority date: 2015-02-06 | Publication date: 2022-09-27
Score: 6.047818 | Text size: 397678 | Find: similar documents
XP-002756982; ChemDiv Screening Collection, “C614-0971”, Database CHEMCATS, Database accession No. 2058888426, May 13, 2015. ... XP-002756983; ChemDiv Screening Collection, “C614-0943”, Database CHEMCATS, Database accession No. 1904759099, May 13, 2015. ... XP-002756988; ChemDiv Screening Collection, “C614-0930”, Database CHEMCATS, Database accession No. 0674250759, May 13, 2015.
Ali Shilatifard [US]; Kaiwei Liang [US]; Edwin R. Smith [US]; Gary E. Schiltz [US]; Rama K. Mishra [US]; Kristen Stoltz [US]
Publication date: 2022-09-27 | Patent publication No.: US-11453640-B2 | Assignees: Northwestern University [US] | IPC: C07C235/74; A61P35/00; C07C235/78; C07D213/40; C07D213/75; C07D231/14; C07D239/36; C07D239/42; C07D241/20; C07D257/06; C07D261/18; C07D271/07; C07D277/46 | Oldest priority date: 2018-03-21 | Publication date: 2022-09-27
Score: 7.161399 | Text size: 203009 | Find: similar documents
Based on the structure of KL-1 (FIG. 1C), we performed a KL-1 similarity search with ChemDiv compounds and tested the top 32 most similar compounds. ... The candidate chemicals from the in silico screening were purchased from the vendors ChemDiv, ChemBridge and Enamine.
INHIBITORS OF ANO6 AND THEIR USES THEREOF
OH, Changmok [KR]; KWON, Sungwook [KR]; LIM, Dami [KR]; LEE, Eunjung [KR]; LEE, Seolhee [KR]; YOON, Hongchul [KR]; AN, Kyung Mi [KR]; PARK, Joontae [KR]; CHO, Sung Min [KR]; CHOI, Won Gu [KR]; LEE, Min Goo [KR]; LEE, Jae Myun [KR]; NAMKUNG, Wan [KR]; LEE, JUNGWOO [KR]
Publication date: 2022-09-22 | Patent publication No.: WO-2022195522-A1 | Assignees: ILDONG PHARMACEUTICAL CO., LTD. [KR]; UIF (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY [KR] | IPC: A61K31/50; A61K31/505; A61K31/44; A61K31/506; A61K31/501; A61P31/14; C07D237/20; C07D239/42; C07D213/74; C07D405/04 | Oldest priority date: 2021-03-17 | Publication date: 2022-09-22
Score: 6.047818 | Text size: 388308 | Find: similar documents
Compound A24 (ChemDiv; Cat# F575-0482, 3-{[l-benzyl-2-(thiophen-2-yl)-lH-indol- 3-yl]methyl}-l-[(oxolan-2-yl)methyl]urea), Compound A24 (ChemDiv; Cat# F474-2423, ethyl 8-methyl-4-((4-(methylthio)benzyl)amino)-2-oxo-l,2-dihydroquinoline-3-carboxylate), abamectin (Cayman Chemical, Ann Arbor, MI, USA), ivermectin (Sigma-Aldrich, St. Louis, MO, USA), camostat mesylate (Sigma-Aldrich, #SML0057), BAPTA-AM (Sigma-Aldrich, #A1076), amphotericin B solution (Sigma-Aldrich, #A2942), and trypsin (Sigma-Aldrich, #T6567) were purchased commercially. ... For the high-throughput screening of a library of 54,000 drug like small-molecule compounds (Chemdiv, San Diego, CA, USA) and a library of 1,700 approved drugs (TargetMol, Boston, MA, USA), FRT-AN06 cells were treated with 25 mM compounds.
Bicyclic bromodomain inhibitors
John Frederick Quinn [US]; Bryan Cordell Duffy [US]; Shuang Liu [US]; Ruifang Wang [US]; May Xiaowu Jiang [US]; Gregory Scott Martin [US]; Gregory Steven Wagner [US]; Peter Ronald Young [US]
Publication date: 2022-09-20 | Patent publication No.: US-11446306-B2 | Assignees: Zenith Epigenetics Ltd. [CA] | IPC: A61K31/5377; A61K31/4184; A61K31/422; A61K31/423; A61K31/437; A61K31/4545; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/517; A61K31/52; A61K45/06; C07D413/04; C07D471/04; C07D473/34; A61P1/16; A61P11/00; A61P1/00; A61P1/02; A61P1/04; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/14; A61P5/50; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/02; A61P11/16; A61P13/10; A61P13/12; A61P15/16; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/04; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; A61P43/00 | Oldest priority date: 2013-06-21 | Publication date: 2022-09-20
Score: 1.8987279 | Text size: 524734 | Find: similar documents
ChemDiv, Inc. in Chemical Abstracts Record No. 1340694-11-8, Entered into the Registry File Nov. 4, 2011.
Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents
Jan Steyaert [BE]; Els Pardon [BE]; Toon Laeremans [BE]; Cedric Govaerts [BE]; Magdalena Grodecka [PL]; Maud Sigoillot [BE]; Marie Overtus [BE]; Marianne Sylvia Carlon [BE]; Marjolein Ensinck [BE]; Abel Garcia-Pino [BE]
Publication date: 2022-09-15 | Patent publication No.: US-20220289837-A1 | Assignees: VIB VZW [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE]; UNIVERSITÉ LIBRE DE BRUXELLES [BE]; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D [BE] | IPC: C07K16/28; A61K45/06; A61K39/395; G16B15/30; A61K31/47 | Oldest priority date: 2019-04-30 | Publication date: 2022-09-15
Score: 4.3235645 | Text size: 231016 | Find: similar documents
Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).
PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF
Mark J. Burk [US]; Brandon Chen [US]
Publication date: 2022-09-01 | Patent publication No.: US-20220274997-A1 | Assignees: Snap Bio, Inc. [US] | IPC: C07D487/14; C07D471/22; A61P35/00 | Oldest priority date: 2019-04-29 | Publication date: 2022-09-01
Score: 8.611835 | Text size: 245096 | Find: similar documents
Numerous contract research organizations (CROs) offer PIM kinase assay services, including DiscoverX, Inc, (San Diego, Calif.), Reaction Biology Corporation (Malvern, Pa.), ChemDiv (San Diego, Calif.), and Cams Biosciences (Tokyo, Japan). ... The inhibitory activity of each compound against PIM kinases was measured with the LANCE® Ultra Kinase Assays by ChemDiv, Inc. ... All assays were performed by Reaction Biology Corporation (Malvern, Pa.) or ChemDiv, Inc.
Muthiah Manoharan [US]; Kallanthottathil G. Rajeev [US]; Akin Akinc [US]; Jayaprakash K. Nair [US]; Muthusamy Jayaraman [US]; Martin Maier [US]
Publication date: 2022-08-23 | Patent publication No.: US-11420931-B2 | Assignees: ARBUTUS BIOPHARMA CORPORATION [CA] | IPC: C07C219/06; A61K9/127; A61K31/325; C07C209/78; C07C233/36; C07C271/10; C07C323/25; A61K47/34 | Oldest priority date: 2006-10-03 | Publication date: 2022-08-23
Score: 10.328181 | Text size: 280810 | Find: similar documents
can be obtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet, Camelford, England; ChemDiv, SanDiego, Calif.
COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES AND CONDITIONS
TARKHOV, Andrei Evgenevich [RU]; AVKHACHEV, Konstantin Aleksandrovich [RU]; BURMISTROVA, Olga Andreevna [RU]; KHOLIN, Maksim Nikolaevich [RU]; FEDICHEV, Petr Olegovich [RU]
Publication date: 2022-08-18 | Patent publication No.: WO-2022173333-A2 | Assignees: GERO PTE. LTD. [SG] | IPC: A61K45/00; A61K38/00; A61P9/00; A61P25/16; A61P25/28; A61P3/06; A61P19/00; A61P27/02; A61P35/00 | Oldest priority date: 2021-02-10 | Publication date: 2022-08-18
Score: 6.145057 | Text size: 697071 | Find: similar documents
examples of the providers: eMolecules, Inc, Bio-Techne Corporation (NASDAQ: TECH), Mcule, Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals, ZelinskyInstitute, Specs, ChemicalBlock and Maybridge.
NOVEL SMALL MOLECULE COMPOUND INHIBITING SIGNAL TRANSMISSION PATH OF TLR7 AND TLR9 AND USE THEREOF
Sangdun CHOI [KR]; Haseeb MUHAMMAD [KR]; Mahesh PATRA [KR]; Yang-Seon CHOI [KR]
Publication date: 2022-08-18 | Patent publication No.: US-20220259155-A1 | Assignees: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR] | IPC: C07D233/88; C07D405/04 | Oldest priority date: 2019-07-26 | Publication date: 2022-08-18
Score: 13.962267 | Text size: 71578 | Find: similar documents
compounds ZINC druglike 14,480,911 ZINC leadlike 5,449,805 Enamine 3,006,354 ChemBridge 1,591,767 ChemDiv 1,960,042 Life Chemicals 500,011 Maybridge 72,257 Total 27,061,147 The structures were cleaned up
METHODS, COMPOSITIONS AND COMPOUNDS FOR TREATING AGE-RELATED DISEASES AND CONDITIONS
FEDICHEV, Petr Olegovich [RU]; TARKHOV, Andrei Evgenevich [RU]; AVKHACHEV, Konstantin Aleksandrovich [RU]; BURMISTROVA, Olga Andreevna [RU]; KHOLIN, Maksim Nikolaevich [RU]
Publication date: 2022-08-18 | Patent publication No.: WO-2022173334-A2 | Assignees: GERO PTE. LTD. [SG] | IPC: A61K45/00; A61K38/00; A61P9/00; A61P25/16; A61P25/28; A61P3/06; A61P19/00; A61P27/02; A61P35/00 | Oldest priority date: 2021-02-10 | Publication date: 2022-08-18
Score: 2.3034768 | Text size: 2907387 | Find: similar documents
examples of the providers: eMolecules, Inc, Bio-Techne Corporation (NASDAQ: TECH), Mcule, Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals, ZelinskyInstitute, Specs, ChemicalBlock and Maybridge.
Compounds and methods for promoting stress resistance
Cynthia Kenyon [US]; Peichuan Zhang [US]; James Cregg [US]; Kean-Hooi Ang [US]; Michelle Arkin [US]
Publication date: 2022-08-16 | Patent publication No.: US-11413278-B2 | Assignees: The Regents of the University of California [US] | IPC: A61K31/443; A61P9/00; A61P3/10; A61P29/00; A61K31/12; A61K31/341; A61K31/404; A61K31/4184; A61K31/437; A61K31/4406; A61K31/4439; A61K31/45; A61K31/519; A61K31/55; A61K31/44; A61P35/00 | Oldest priority date: 2015-10-08 | Publication date: 2022-08-16
Score: 8.066998 | Text size: 606219 | Find: similar documents
a “diversity library” that contains 104,121 small molecules ( ̃24K from ChemBridge; ̃50K from ChemDiv; and ̃30K from SPECS) selected to maximize the coverage of chemical space.
BISCHOFF, Matthias [DE]; LAMPE, Philipp [DE]; SIEVERS, Sonja [DE]; POLYCHRONIDOU, Vasiliki [DE]; ANTONCHICK, Andrey [DE]; THOMA, Annika [DE]; LUDWIG, Nicole [DE]; KAHMANN, Regine [DE]; MÜNCH, Karin [DE]; REISSMANN, Stefanie [DE]
Publication date: 2022-08-11 | Patent publication No.: WO-2022167503-A1 | Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE]; TECHNISCHE UNIVERSITÄT DORTMUND [DE] | IPC: A01N43/40; A01N43/48; A01N43/54; C07D239/72; C07D471/04 | Oldest priority date: 2021-02-03 | Publication date: 2022-08-11
Score: 15.288118 | Text size: 171255 | Find: similar documents
(http://comas.mpi- dortmund.mpg.de/index.php/workflow) were obtained from the chemical providers ChemDiv and Enamine in form of dry film which was dissolved in DMSO to yield a 10 mM stock solution and ... library (http://comas.mpi-dortmund.mpg.de/index.php) consisting mostly of screening compounds from ChemDiv and Enamine and also includes compounds with known mode of action as well as proprietary compounds
COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME
THATCHER, Gregory R. [US]; SHEN, Zhengnan [US]; XIONG, Rui [US]; RATIA, Kiira [US]; RONG, Lijun [US]; COOPER, Laura [US]
Publication date: 2022-08-11 | Patent publication No.: WO-2022169891-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US]; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US] | IPC: A61K31/24; C07C229/42; A61P31/12 | Oldest priority date: 2021-02-08 | Publication date: 2022-08-11
Score: 15.95058 | Text size: 328027 | Find: similar documents
by regulatory bodies in other countries (FIG.1B) and a 10,000-compound SMART library subset from ChemDiv (FIG. 1C). ... The libraries included in the screen were purchased from TargetMol (Bioactive Library) and ChemDiv (a 10,000-compound SMART library subset). ... An unbiased ChemDiv library (10,000-compound SMART library subset excluding PAINS compounds) and a biased, annotated
COMPOUND FOR TREATING NEURODEGENERATIVE DISORDERS
Boxun Lu [CN]; Yiyan Fei [CN]; Yu Ding [CN]; Yongjun Dang [CN]
Publication date: 2022-08-11 | Patent publication No.: US-20220249433-A1 | Assignees: FUDAN UNIVERSITY [CN] | IPC: A61K31/353; A61K31/517; A61P25/00 | Oldest priority date: 2019-03-11 | Publication date: 2022-08-11
Score: 14.432653 | Text size: 239332 | Find: similar documents
from Selleck, catalog number S1452; Compound 2: PubChem CID 5398649, can be purchased from ChemDiv, catalog numberD715-2435; Compound 3: Semaxanib, can be purchased from Selleck, CAS No. ... 6: can be purchased from TargetMol, CAS No. 842-01-3; Compound 7: can be purchased from ChemDiv.
SAELENS, Xavier [BE]; DE VLIEGER, Dorien [BE]; ROSSEY, Iebe [BE]; DE CAE, Sieglinde [BE]; SEDEYN, Koen [BE]; VAN SCHIE, Loes [BE]; EECKHAUT, Hannah [BE]; FIJALKOWSKA, Daria [BE]; STORTELERS, Catelijne [BE]; SCHEPENS, Bert [BE]; CALLEWAERT, Nico [BE]; REMAUT, Han [BE]; NERINCKX, Wim [BE]; ROOSE, Kenny [BE]; REITER, Dirk [BE]
Publication date: 2022-08-11 | Patent publication No.: WO-2022167666-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE] | IPC: A61K39/215; A61P31/14; C07K16/10 | Oldest priority date: 2021-02-05 | Publication date: 2022-08-11
Score: 9.930534 | Text size: 368045 | Find: similar documents
from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ, of California).
BISCHOFF, Matthias [DE]; LAMPE, Philipp [DE]; SIEVERS, Sonja [DE]; POLYCHRONIDOU, Vasiliki [DE]; ANTONCHICK, Andrey [DE]; THOMA, Annika [DE]; LUDWIG, Nicole [DE]; KAHMANN, Regine [DE]; MÜNCH, Karin [DE]; REIßMANN, Stefanie [DE]
Publication date: 2022-08-10 | Patent publication No.: EP-4039094-A1 | Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE] | IPC: A01N43/40; A01N43/48; A01N43/54; C07D239/72; C07D471/04 | Oldest priority date: 2021-02-03 | Publication date: 2022-08-10
Score: 18.151299 | Text size: 179069 | Find: similar documents
The tetrahydro-cyclopentapyrimidine compounds (Formula III) were purchased from ChemDiv using the "search for catalog numbers" option https://chemistryondemand.com:8443/eShop/. ... (http://comas.mpi-dortmund.mpg.de/index.php/workflow) were obtained from the chemical providers ChemDiv and Enamine in form of dry film which was dissolved in DMSO to yield a 10 mM stock solution and ... library (http://comas.mpi-dortmund.mpg.de/index.php) consisting mostly of screening compounds from ChemDiv and Enamine and also includes compounds with known mode of action as well as proprietary compounds ... Table 6: COMPOUNDChemDiv IDsIC50 1-C D468-0807 0.67 μM 2-C D468-0522 6.2 μM 3-C D468-0555 6.4 μM 4-C D468-0823 2 μM 5-C
TETRAHYDRO IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 INTERNALIZATION INDUCERS
LIU, Phillip C. [US]; VOLGINA, Alla [US]; WYNN, Richard [US]; ZOLOTARJOVA, Nina [US]; WU, Liangxing [US]; XIAO, Kaijiong [US]; MEI, Song [US]; LU, Liang [US]; ZHU, Wenyu [US]; YE, Yingda [US]; WANG, Haisheng [US]; QIAN, Ding-Quan [US]; YAO, Wenqing [US]
Publication date: 2022-08-10 | Patent publication No.: EP-3558990-B1 | Assignees: Incyte Corporation [US] | IPC: C07D471/04; A61K31/437; A61P37/00; A61P35/00; A61P37/04; C07D213/81; C07D263/57; C07D413/14; C07D413/06; C07D519/00 | Oldest priority date: 2017-10-09 | Publication date: 2022-08-10
Score: 8.066998 | Text size: 801797 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
NOVEL IMIDAZOPYRIMIDINE COMPOUNDS AND USES THEREOF
Ofer Levy [US]; David J. Dowling [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]; Frederic Feru [US]
Publication date: 2022-08-04 | Patent publication No.: US-20220242867-A1 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; Children's Medical Center Corporation [US] | IPC: C07D487/04; A61K31/519; A61K45/06 | Oldest priority date: 2017-11-14 | Publication date: 2022-08-04
Score: 13.851352 | Text size: 270451 | Find: similar documents
bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex (see attached pdf of all libraries). ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).
25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC
Chandani Limbad [US]; Ryosuke Doi [US]; Munemichi Ohe [JP]; Naoki Inoue [JP]
Publication date: 2022-08-04 | Patent publication No.: US-20220241316-A1 | Assignees: Buck Institute for Research on Aging [US] | IPC: A61K31/713; A61K31/575; A61K31/593 | Oldest priority date: 2019-04-19 | Publication date: 2022-08-04
Score: 8.605278 | Text size: 351521 | Find: similar documents
and real screening services are commercially available from a number of suppliers (see, e.g., ChemDiv (San Diego, Calif.), and the like).
METHODS FOR THE IDENTIFICATION OF SARM1 NADASE ACTIVITY INHIBITORS AND USES THEREOF
Publication date: 2022-08-04 | Patent publication No.: US-20220241416-A1 | Assignees: Bar Ilan University [US] | IPC: A61K41/00; A61P25/00; G01N21/64 | Oldest priority date: 2021-01-28 | Publication date: 2022-08-04
Score: 10.328181 | Text size: 245283 | Find: similar documents
Enamine (Drug-Like Set (DLS)) 20160 compounds; MayBridge (HitFinderTM Collection) 14400 compounds; ChemDiv (DIVERSet) 100000 compounds; Kinom Set (Kinom Set) 187 compounds; SGC (Epigenetic chemical probes)
A NEW MOLECULAR SCAFFOLD FOR TARGETING HRPN13
WALTERS, Kylie J. [US]; LU, Xiuxiu [US]; TARASOVA, Nadya I. [US]; SWENSON, Rolf Eric [US]; SABBASANI, Venkatareddy [US]; MOCK, Beverly Ann [US]; GAIKWAD, Snehal [US]; CITRIN, Deborah [US]; CHANDRAVANSHI, Monika [US]
Publication date: 2022-08-04 | Patent publication No.: WO-2022165099-A2 | Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: C07C255/44 | Oldest priority date: 2021-01-29 | Publication date: 2022-08-04
Score: 10.328181 | Text size: 315798 | Find: similar documents
commercially available (Enamine diversity set, Emolecules, Mcules, Asinex, UORSY, Chembridge, ChemDiv, ChemSpace) or capable of synthesis (Enamine’s diversity REAL database containing 15 million
Publication date: 2022-08-03 | Patent publication No.: EP-3458047-B1 | Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM) [FR]; Université de Lille [FR]; Institut Pasteur De Lille [FR]; Centre National de la Recherche Scientifique CNRS [FR] | IPC: A61K31/352; A61K31/277; A61P25/20; A61P43/00 | Oldest priority date: 2016-05-20 | Publication date: 2022-08-03
Score: 13.775837 | Text size: 90652 | Find: similar documents
Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE), or alternatively can be
PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA
Publication date: 2022-08-03 | Patent publication No.: EP-2696873-B1 | Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services [US] | IPC: C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; A61K31/498; A61K31/554; A61K31/433; A61P33/06; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; C07K14/445 | Oldest priority date: 2011-04-12 | Publication date: 2022-08-03
Score: 15.288118 | Text size: 152665 | Find: similar documents
methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, CA or Peakdale Molecular Limited, High Peak, England. ... temperature using a commercial library of 50,000 compounds with > 90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at
Compositions and methods for the diagnosis and treatment of lymphatic system disorders
Hakon Hakonarson [US]; Dong Li [US]; Lifeng Tian [US]; Kenny Nguyen [US]; Patrick Sleiman [US]
Publication date: 2022-08-02 | Patent publication No.: US-11401553-B2 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/68; C12Q1/6883; A61P43/00; A61K31/4184; A61K31/436; A61K31/4427; A61K31/4709; A61K31/501; A61K31/519; A61K31/5377; A61K45/06 | Oldest priority date: 2016-08-31 | Publication date: 2022-08-02
Score: 12.011612 | Text size: 156918 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
METHOD FOR ALPHAVIRUS INHIBITION
Glen A. COBURN [US]; Guo-Hua CHU [US]; Jodie C. HAMRICK [US]; Charlotte L. BOWSHER [US]; Daniel C. PEVEAR [US]
Publication date: 2022-07-28 | Patent publication No.: US-20220233549-A1 | Assignees: Venatorx Pharmaceuticals, Inc [US] | IPC: A61K31/542; A61K31/4375; A61K31/4985; A61K31/5383; A61K31/55 | Oldest priority date: 2019-05-10 | Publication date: 2022-07-28
Score: 13.245268 | Text size: 95555 | Find: similar documents
the acid, 2-(2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-3-ypacetic acid (available from ChemDiv, Inc., reference: Japan Patent JP63008387 A, Jan 14, 1988) (180 mg, 0.8 mmol) in DCM (16 mL) was added
RETROSYNTHESIS SYSTEMS AND METHODS
KONSTANTINOV, Anton [RU]; PUTIN, Evgeny Olegovich [RU]; ZAGRIBELNYY, Bogdan [CN]; IVANENKOV, Yan A. [RU]; ZAVORONKOVS, Aleksandrs [CN]
Publication date: 2022-06-02 | Patent publication No.: WO-2022113044-A1 | Assignees: INSILICO MEDICINE IP LIMITED [CN] | IPC: G16C20/10 | Oldest priority date: 2020-11-30 | Publication date: 2022-06-02
Score: 12.913692 | Text size: 142589 | Find: similar documents
ready-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases, such as Clarivate Analytics Integrity (Cortellis Drug Discovery
METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES
Boxun Lu [CN]; Yiyan Fei [CN]; Yu Ding [CN]; Yongjun Dang [CN]
Publication date: 2022-06-02 | Patent publication No.: US-20220170930-A1 | Assignees: FUDAN UNIVERSITY [CN] | IPC: G01N33/566; G01N33/68; A61K31/404; A61K31/352; A61K31/517; A61P25/28 | Oldest priority date: 2019-03-11 | Publication date: 2022-06-02
Score: 15.755042 | Text size: 132416 | Find: similar documents
from Specs, catalog number AN-655/15003575; Compound 4: PubChem CID 5398649, available from ChemDiv, catalog number D715-2435; Compound 5: Semaxanib, available from Selleck, CAS No. ... 377090-84-1; Compound 7: available from TargetMol, CAS No. 842-01-3; Compound 8: available from ChemDiv.
RETROSYNTHESIS SYSTEMS AND METHODS
Anton Konstantinov [RU]; Evgeny Olegovich Putin [RU]; Bogdan Zagribelnyy [HK]; Yan A. Ivanenkov [RU]; Aleksandrs Zavoronkovs [HK]
Publication date: 2022-06-02 | Patent publication No.: US-20220172802-A1 | Assignees: Insilico Medicine IP Limited [HK] | IPC: G16C20/10; G16C20/70 | Oldest priority date: 2020-11-30 | Publication date: 2022-06-02
Score: 12.913692 | Text size: 139811 | Find: similar documents
ready-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases, such as Clarivate Analytics Integrity (Cortellis Drug Discovery
NOVEL SMALL MOLECULE COMPOUND INHIBITING SIGNAL TRANSMISSION PATH OF TLR7 AND TLR9 AND USE THEREOF
CHOI, Sangdun [KR]; MUHAMMAD, Haseeb [KR]; PATRA, Mahesh [KR]; CHOI, Yang-Seon [KR]
Publication date: 2022-06-01 | Patent publication No.: EP-4006013-A1 | Assignees: Ajou University Industry-Academic Cooperation Foundation [KR] | IPC: C07D233/88; C07D405/04; A61K31/4168; A61K31/4178; A61P37/00; A61P29/00 | Oldest priority date: 2019-07-26 | Publication date: 2022-06-01
Score: 13.962267 | Text size: 71929 | Find: similar documents
compounds ZINC druglike 14,480,911 ZINC leadlike 5,449,805 Enamine 3,006,354 ChemBridge 1,591,767 ChemDiv 1,960,042 Life Chemicals 500,011 Maybridge 72,257 Total 27,061,147 The structures were cleaned up
Nathan, Ilana [IL]; Khalfin, Boris [IL]
Publication date: 2022-06-01 | Patent publication No.: EP-4005569-A2 | Assignees: ELA Pharma Ltd [IL] | IPC: A61K31/426; A61K31/00; A61K31/415; A61K31/4178; A61K31/4196; A61K31/4439; A61K31/454; A61K31/496; A61K31/4045; A61K31/428; A61K31/536; C07K16/40; C12N15/113; A61P9/10; A61P25/28; A61P39/00; A61P43/00; A61P25/00 | Oldest priority date: 2015-06-04 | Publication date: 2022-06-01
Score: 15.628418 | Text size: 275429 | Find: similar documents
All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, CA. ... 3D structure similarities and topological analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.
Identification of stabilizers of multimeric proteins
Isabella A. Graef [US]; Mamoun M. Alhamadsheh [US]
Publication date: 2022-05-24 | Patent publication No.: US-11337935-B2 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; C07D231/12; A61K31/4196; A61K31/428; A61K31/433; C07D487/04; A61K31/519; A61K31/166; G01N21/64 | Oldest priority date: 2010-05-07 | Publication date: 2022-05-24
Score: 12.297968 | Text size: 142091 | Find: similar documents
120,000 compounds from the Stanford IITBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS, and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from
METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS
Charles E. MURRY [US]; Xiulan YANG [US]
Publication date: 2022-05-19 | Patent publication No.: US-20220152117-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: A61K35/34; A61K45/06; A61P3/04; A61P3/10; C12N5/0793; C12N5/077; C12N9/12 | Oldest priority date: 2019-03-18 | Publication date: 2022-05-19
Score: 10.988179 | Text size: 220455 | Find: similar documents
for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.
COMPOSITIONS AND METHODS FOR TARGETING THE INTERACTION OF HOST MYO5B+D AND CORONAVIRUS M PROTEINS
TANGY, Frédéric [FR]; VIDALAIN, Pierre-Olivier [FR]; GOLDENRING, James R. [US]; ROLAND, Joseph T. [US]; LAPIERRE, Lynne A. [US]; MANNING, Elizabeth [US]; DE HAAN, Cornelis Alexander Maria [NL]
Publication date: 2022-05-12 | Patent publication No.: WO-2022099260-A1 | Assignees: VANDERBILT UNIVERSITY [US]; UNIVERSITEIT UTRECHT HOLDING B.V. [NL] | IPC: A61K39/215; C07K14/165; C07K16/10 | Oldest priority date: 2020-11-05 | Publication date: 2022-05-12
Score: 13.417523 | Text size: 100883 | Find: similar documents
ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,
SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS
ELLIOT J. ANDROPHY [US]; SAMY MEROUEH [US]; ZHIJIAN LU [US]; Anne RIETZ [US]
Publication date: 2022-05-12 | Patent publication No.: US-20220142973-A1 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS, INC. [US] | IPC: A61K31/381; A61K9/00 | Oldest priority date: 2020-04-17 | Publication date: 2022-05-12
Score: 13.417523 | Text size: 108584 | Find: similar documents
#V012-2359), EIN-130(cat #V031-2694), and EIN-131(cat #V031-2717) were each purchased from ChemDiv.
Compositions and methods for the inhibition of pruritus
Mark A. Hoon [US]; Hans Juergen Solinski [DE]; James Inglese [US]; Patricia Dranchak [US]
Publication date: 2022-05-10 | Patent publication No.: US-11324725-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/422; A61P17/04; A61K31/5513; A61K31/55; A61K31/506; A61K31/4439; A61K31/497; A61K31/395; A61K31/4545 | Oldest priority date: 2017-11-03 | Publication date: 2022-05-10
Score: 18.49596 | Text size: 94307 | Find: similar documents
(Chemdiv Inc., catalog number S217-0244); (m) N-benzyl-1-(2-cyanobenzyl)-4-oxo-1,5-diazacycloundecane-8-carboxamide (Chemdiv Inc., catalog number S733-0866); or (n) N-benzyl-N-methyl-8-phenylimidazo[1,2-a]pyrazine-2-carboxamide (Chemdiv Inc., catalog number T425-0460). ... (Franklin, Mass.), JS-11 was from Chembridge (San Diego, Calif.), and JS-12-JS-14 were from Chemdiv (San Diego, Calif.
NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAM
YANAGISAWA, Katsuhiko [JP]; KAWAI, Akiyoshi [JP]
Publication date: 2022-05-04 | Patent publication No.: EP-3275440-B1 | Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: A61K31/4245; A61K31/41; A61K31/4178; A61K31/4196; A61K31/4709; A61K31/5377; A61P25/28 | Oldest priority date: 2015-03-25 | Publication date: 2022-05-04
Score: 12.011612 | Text size: 312903 | Find: similar documents
UORSY Ltd., Vitas-M Laboratory Ltd., Interbioscreen Ltd., Interchim Inc., Ryan Scientific Inc., ChemDiv Inc., through Namiki Shoji Co., Ltd. or Kishida Chemical Co., Ltd., when purchased in Japan.
POSITIVE ALLOSTERIC MODULATORS OF SWEET TASTE
Anandasankar RAY [US]; Joel KOWALEWSKI [US]
Publication date: 2022-04-28 | Patent publication No.: US-20220125086-A1 | Assignees: The Regents of the University of California [US] | IPC: A23L27/00; A23L27/30 | Oldest priority date: 2019-02-19 | Publication date: 2022-04-28
Score: 13.594319 | Text size: 224595 | Find: similar documents
other well-known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.
VERKMAN, Alan [US]; LEVIN, Marc, H. [US]; CIL, Onur [US]
Publication date: 2022-04-27 | Patent publication No.: EP-3394083-B9 | Assignees: The Regents of the University of California [US] | IPC: C07D285/135; C07D417/12; C07K5/078; C07K5/062; A61P27/04; A61P1/10 | Oldest priority date: 2015-12-24 | Publication date: 2022-04-27
Score: 16.176003 | Text size: 419260 | Find: similar documents
was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, California, USA) and Asinex (Winston-Salem, North Carolina, USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, California, USA) and Asinex (Winston-Salem, North Carolina, USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.
USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE
David J. Dowling [US]; Ofer Levy [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]
Publication date: 2022-04-21 | Patent publication No.: US-20220118085-A9 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2022-04-21
Score: 12.211837 | Text size: 385599 | Find: similar documents
bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).
METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS
Beibei Chen [US]; Toren Finkel [US]; Yuan Liu [US]
Publication date: 2022-04-14 | Patent publication No.: US-20220112218-A1 | Assignees: University of Pittsburgh - Of the Commonwealth System of Higher Education [US] | IPC: C07D519/00; A61P25/28 | Oldest priority date: 2019-01-03 | Publication date: 2022-04-14
Score: 15.064883 | Text size: 206195 | Find: similar documents
The following compounds (free base) provided in Table 2 were obtained from commercial sources (ChemDIV, Inc. and Mol port, Inc.): TABLE 2 No. ... The following compounds shown in Table 4 were purchased from ChemDIV, Inc. TABLE 4 No.
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS
Hakon Hakonarson [US]; Yoav Dori [US]; Dong Li [US]; Michael March [US]; Charlly Kao [US]; Christoph Seiler [US]
Publication date: 2022-04-14 | Patent publication No.: US-20220112558-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61K45/06; C12Q1/6869; C12Q1/6827; A61K31/4184 | Oldest priority date: 2018-09-07 | Publication date: 2022-04-14
Score: 11.227331 | Text size: 252490 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
COMPOUNDS WITH GLUCOCORTICOID SPARING EFFECTS AND USES THEREOF
CARSON, Dennis, A. [US]; HAYASHI, Tomoko [US]; CORR, Mary, Patricia [US]; COTTAM, Howard, B. [US]; HOSOYA, Tadashi [US]; SHUKLA, Nikunj [US]
Publication date: 2022-04-14 | Patent publication No.: WO-2022076473-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/495; A61K31/505; A61K31/519; C07D487/02; C07D487/04 | Oldest priority date: 2020-10-05 | Publication date: 2022-04-14
Score: 12.913692 | Text size: 115726 | Find: similar documents
commercially purchased. [0091] Hit compounds were purchased from Chem Bridge (San Diego, CA) and ChemDiv (San Diego, CA) and dissolved in dimethyl sulfoxide (DMSO, Sigma Aldrich, St Louis.
COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
HOON, Mark A. [US]; SOLINSKI, Hans Juergen [DE]; INGLESE, James [US]; DRANCHAK, Patricia [US]
Publication date: 2022-04-13 | Patent publication No.: EP-3703682-B1 | Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services [US] | IPC: A61K31/422; A61P43/00; A61P17/04; A61K31/5517; A61K31/5513; A61K31/55; A61K31/519; A61K31/506; A61K31/4985; A61K31/4545; A61K31/439; A61K31/437; A61K31/42; A61K31/015; A61K31/4184; C07D413/12; C07D471/04; C07D487/04 | Oldest priority date: 2018-05-14 | Publication date: 2022-04-13
Score: 13.775837 | Text size: 86296 | Find: similar documents
Discovery (Franklin, MA), JS-11 was from Chembridge (San Diego, CA), and JS-12 - JS-14 were from Chemdiv (San Diego, CA).
FLY AVATARS FOR CANCER AND USES THEREOF
CAGAN, Ross [US]; BANGI, Erdem [US]
Publication date: 2022-04-13 | Patent publication No.: EP-3397051-B1 | Assignees: Icahn School of Medicine at Mount Sinai [US] | IPC: A01K67/033; C07K14/82; G01N33/50; A61K31/405; A61K31/519; C12N9/16 | Oldest priority date: 2015-12-30 | Publication date: 2022-04-13
Score: 15.95058 | Text size: 240334 | Find: similar documents
Compound Library MedChem Express MAPK Compound Library MedChem Express Akt-Targeted Library ChemDiv PI3K-Targeted Library ChemDiv KRAS-Targeted Library ChemDiv EXPRESS-Pick Collection ChemBridge DIVERSetTM-EXP ChemBridge CORE Library ChemBridge DIVERSetTM-CL
COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL KILLER CELL ACTIVATION AND FUNCTION
Publication date: 2022-03-31 | Patent publication No.: US-20220096551-A1 | Assignees: BAR ILAN UNIVERSITY [IL] | IPC: A61K35/17; A61K31/7105; A61K9/14; A61P35/00 | Oldest priority date: 2019-01-28 | Publication date: 2022-03-31
Score: 8.902286 | Text size: 331890 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
Catherine Tachdjian [US]; Andrew P. Patron [US]; Sara L. Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; Vincent Darmohusodo [US]; Stephen Terrence Hobson [US]; Xiaodong Li [US]; Ming Qi [CN]; Daniel H. Rogers [US]; Marketa Rinnova [US]; Guy Servant [US]; Xiao-Qing Tang [US]; Mark Zoller [US]; David Wallace [US]; Amy Xing [US]; Klaus Gubernator [US]
Publication date: 2022-03-08 | Patent publication No.: US-11268952-B2 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00 | Oldest priority date: 2003-08-06 | Publication date: 2022-03-08
Score: 9.562369 | Text size: 374581 | Find: similar documents
offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif.
SMALL MOLECULE MODULATORS OF GSK-3 ACTIVITY
ELDAR-FINKELMAN, Hagit [IL]; SENDEROWITZ, Hanoch [IL]
Publication date: 2022-03-03 | Patent publication No.: WO-2022044024-A1 | Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD. [IL]; BAR-ILAN UNIVERSITY [IL] | IPC: C07D413/14; C07D413/10; C07D413/04; C07D491/113; C07F9/38; A61K31/496; A61K31/4439; A61K31/438; A61K31/675; A61P25/28; A61P25/24; A61P3/10; A61P9/00; A61P9/10; A61P33/00; A61P33/06; A61P35/00; A61P43/00 | Oldest priority date: 2020-08-31 | Publication date: 2022-03-03
Score: 12.011612 | Text size: 173651 | Find: similar documents
by virtual screening were purchased from MolPort Riga, Latvia, that supplied compounds from ChemDiv Inc., San Diego, CA USA, Specs, Zoetermeer, The Netherlands, and Enamine Ltd. NJ, USA.
ANTHRANILIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS
Otto PHANSTIEL, IV [US]; Holly MOOTS [US]; Patrick MALONEY [US]; Paul HERSHBERGER [US]; Satyamaheshwar PEDDIBHOTLA [US]
Publication date: 2022-03-03 | Patent publication No.: US-20220064133-A1 | Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US]; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US] | IPC: C07D295/155; C07D211/46; A61K45/06 | Oldest priority date: 2018-08-10 | Publication date: 2022-03-03
Score: 18.151299 | Text size: 199883 | Find: similar documents
round of SAR was primarily fueled by 38 compounds, which were purchased from commercial vendors (ChemDiv) while a robust synthetic route was under development. ... (0800678) 6 13.3 ± 0.04 EC8 = 6 EC25 = 6 (8-2) 9 (0754479) 8 16.8 ± 0.1 EC49 = 8 EC5 = 8 (8-3) ChemDiv (F687-0882) 9 >50 EC38 = 9 EC11 = 8 (8-4) ChemDiv (F687-0884) 9 46.3 ± 0.02 EC43 = 9 EC0 = 9 (8-5) 33 (0800676) 8 22. ... In terms of toxicity profiles, compounds ChemDiv F687-0882 and ChemDiv F687-0884 and compounds 50 and 64 gave IC50 values >38 μM and were deemed relatively non-toxic.
Cells expressing apolipoprotein E and uses thereof
Susan L. Lindquist [US]; Priyanka Narayan [US]
Publication date: 2022-03-01 | Patent publication No.: US-11261453-B2 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C12N15/81; C07K14/775; C07K14/47; G01N33/92; C12Q1/02; G01N33/50; G01N33/68; A61K38/00 | Oldest priority date: 2014-09-12 | Publication date: 2022-03-01
Score: 8.066998 | Text size: 401412 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
QUORUM SENSING INHIBITORS AND METHODS OF USE
VAN KESSEL BOCHMAN, Julia, Cathering [US]; BROWN, Laura, Caroline [US]
Publication date: 2022-02-17 | Patent publication No.: WO-2022036282-A1 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US] | IPC: A61K31/16; A61K31/18; A61P31/04; C07C307/00; C07C307/04 | Oldest priority date: 2020-08-13 | Publication date: 2022-02-17
Score: 15.755042 | Text size: 154017 | Find: similar documents
We screened ~60,000 molecules in the ChemBridge and Chemdiv libraries and identified nine compounds that inhibited LuxR activation and/or repression but did ... P1120 D05 and P0074 N08 were purchased from EnamineStore, and P0053 118 was purchased from ChemDiv.
COMPOUND FOR TREATING NEURODEGENERATIVE DISORDERS
LU, Boxun [CN]; FEI, Yiyan [CN]; DING, Yu [CN]; DANG, Yongjun [CN]
Publication date: 2022-02-16 | Patent publication No.: EP-3954368-A1 | Assignees: Fudan University [CN] | IPC: A61K31/353; A61K31/517; A61P25/00 | Oldest priority date: 2019-10-21 | Publication date: 2022-02-16
Score: 14.432653 | Text size: 232331 | Find: similar documents
from Selleck, catalog number S1452; Compound 2: PubChem CID 5398649, can be purchased from ChemDiv, catalog numberD715-2435; Compound 3: Semaxanib, can be purchased from Selleck, CAS No. ... 6: can be purchased from TargetMol, CAS No. 842-01-3; Compound 7: can be purchased from ChemDiv.
TREX1 INHIBITORS AND USES THEREOF
PERRINO, Fred W. [US]; HOLLIS, Thomas [US]; HARVEY, Scott E. [US]; HEMPHILL, Wayne O. [US]
Publication date: 2022-02-10 | Patent publication No.: WO-2022031640-A1 | Assignees: WAKE FOREST UNIVERSITY HEALTH SCIENCES [US] | IPC: A61K31/122; C07C309/44; A61P35/00 | Oldest priority date: 2020-08-04 | Publication date: 2022-02-10
Score: 18.57923 | Text size: 91650 | Find: similar documents
(HTS) We applied structure-based virtual screening (SBVS) to the commercial 150k-compound ChemDiv Diversity Library and the ~1.2M-compound ChemBridge CORE+EXPRESS libraries. ... The top-scoring 698 and 2004 compounds from the ChemDiv and ChemBridge libraries, respectively, were selected for further study and ordered as physical ... All ChemDiv and Chembridge candidates plus 51/222 (-23%) of the Nanosyn candidates were commercially available, ... The compounds are available from one or more of the following vendors: Ambinter, ChemDiv, ChemBridge, Nanosyn, Sigma-Aldrich.
COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES
Jason Barbour [US]; David Ott [US]
Publication date: 2022-02-03 | Patent publication No.: US-20220031701-A1 | Assignees: Synkrino Biotherapeutics, Inc. [US] | IPC: A61K31/515; A61P37/06; A61P19/02; G16B25/10; G16B40/00; A61K31/437; A61K31/496; A61K31/50; A61K45/06; C12Q1/6883 | Oldest priority date: 2018-08-21 | Publication date: 2022-02-03
Score: 16.251385 | Text size: 87934 | Find: similar documents
Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state. ... TABLE 1 CompoundChemDiv Compound IdentifierNormalized Average of MIG/CXCL9Normalized Average of IP-10/CXCL10Normalized
TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS
Steven Albert Everett [US]; Saraj Ulhaq [GB]
Publication date: 2022-02-03 | Patent publication No.: US-20220031852-A1 | Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54; A61K31/343; A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16; C07D311/18; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; C07D487/04; C07D491/22; A61K31/37; A61K31/381; A61K31/513; A61K31/52; A61K31/665 | Oldest priority date: 2009-05-01 | Publication date: 2022-02-03
Score: 16.116692 | Text size: 220210 | Find: similar documents
for CYP181 The target enzyme CYP1B1 was screened against two commercial libraries including the ChemDiv Diversity 50,000 test compound collection and the ChemDiv Kinase Targeted 10,000 test compound collection with a view to identifying activity differentiating ... cross validation on a training set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverse and Kinase libraries.
COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION
Raymond MOELLERING [US]; John COUKOS [US]; Gihoon LEE [US]; Jae Won CHANG [US]; Gokhan MUTLU [US]
Publication date: 2022-02-03 | Patent publication No.: US-20220031656-A1 | Assignees: The University of Chicago [US] | IPC: A61K31/381 | Oldest priority date: 2018-10-14 | Publication date: 2022-02-03
Score: 15.518069 | Text size: 139140 | Find: similar documents
CBR-470-0 and CBR-581-9 were from ChemDiv. CBR-470-1 (initially from ChemDiv as D470-2172) and related analogs were synthesized in house according to full methods described in
ANTIBACTERIAL COMPOUNDS AND USES THEREOF
Paula I. WATNICK [US]; Julie Szu YU [US]
Publication date: 2022-01-27 | Patent publication No.: US-20220023270-A1 | Assignees: The Children's Medical Center Corporation [US] | IPC: A61K31/433; A61K31/165; A61K31/4525; A61K31/341; A61K31/357; A61K31/519; A61P31/04 | Oldest priority date: 2018-12-06 | Publication date: 2022-01-27
Score: 14.637417 | Text size: 190761 | Find: similar documents
A chemical library comprised of compounds from the Targeted Diversity Library at ChemDiv and purchased and maintained by the Institute of Chemistry and Chemical Biology-Longwood ... Compound O06 was purchased from ChemDiv under the catalog number 8019-0105.
CFTR regulators and methods of use thereof
Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Sujin Lee [US]
Publication date: 2022-01-25 | Patent publication No.: US-11230535-B2 | Assignees: The Regents of the University of California [US] | IPC: C07D251/52; C07D251/46; A61P1/10; A61P27/04; A61K31/496; A61K31/53; A61K31/5377; A61K31/55; A61K45/06; C07D403/04; C07D413/12 | Oldest priority date: 2015-12-24 | Publication date: 2022-01-25
Score: 15.000084 | Text size: 592839 | Find: similar documents
was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.
POTTS, Ryan [US]; CHEN, Taosheng [US]; RANKOVIC, Zoran [US]; MIN, Jaeki [US]; LIN, Wenwei [US]; YANG, Seung Wook [US]; MAYASUNDARI, Anand [US]
Publication date: 2022-01-20 | Patent publication No.: WO-2022015974-A2 | Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. [US] | IPC: C07D407/12 | Oldest priority date: 2020-07-15 | Publication date: 2022-01-20
Score: 9.562369 | Text size: 338749 | Find: similar documents
commercial sources including Sigma, Microsource (Gaylordsville, CT), selleckchem (Houston, TX), ChemDiv (San Diego, CA), ChemBridge (San Diego, CA), Enamine (Monmouth Jet.
METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES
LU, Boxun [CN]; FEI, Yiyan [CN]; DING, Yu [CN]; DANG, Yongjun [CN]
Publication date: 2022-01-19 | Patent publication No.: EP-3940384-A1 | Assignees: Fudan University [CN] | IPC: G01N33/68; G01N33/58; G01N21/64; G01N21/552; G01N21/76; G01N25/48; A61K31/404; A61K31/517; A61K31/352; A61P25/16; A61P25/28 | Oldest priority date: 2019-10-21 | Publication date: 2022-01-19
Score: 15.755042 | Text size: 130423 | Find: similar documents
from Specs, catalog number AN-655/15003575; Compound 4: PubChem CID 5398649, available from ChemDiv, catalog number D715-2435; Compound 5: Semaxanib, available from Selleck, CAS No. ... 377090-84-1; Compound 7: available from TargetMol, CAS No. 842-01-3; Compound 8: available from ChemDiv.
LIVNEH, Ido [IL]; COHEN-KAPLAN, Victoria [IL]; CIECHANOVER, Aaron [IL]; GOLDHIRSH, Gilad [IL]; ZOHAR, Yaniv [IL]; LAVI, Noa [IL]; FABRE, Bertrand Francois [FR]
Publication date: 2022-01-13 | Patent publication No.: WO-2022009212-A1 | Assignees: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. [IL]; RAMBAM MED-TECH LTD. [IL] | IPC: A61K31/198; A61P35/00; G01N33/50 | Oldest priority date: 2020-07-09 | Publication date: 2022-01-13
Score: 7.592094 | Text size: 469435 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
S3QELS TO PROTECT AGAINST INTESTINAL PERMEABILITY
Mark A. Watson [GB]; Martin D. Brand [US]; Pankaj Kapahi [US]
Publication date: 2022-01-06 | Patent publication No.: US-20220000873-A1 | Assignees: Buck Institute for Research on Aging [US] | IPC: A61K31/519; A61K31/517; A61K31/343; A61K31/4365; A61K31/495; A61K31/445; A61P1/00; A61P3/04 | Oldest priority date: 2018-12-12 | Publication date: 2022-01-06
Score: 12.297968 | Text size: 137180 | Find: similar documents
Thus, for example, the following S3QELs are available from Chemdiv: S3QEL-1 (catalog ID K284-4710), S3QEL-1.1 (K284-4711), S3QEL-1.2 (K284-4767), S3QEL-1.
Ligands of the mu, kappa, and delta opioid receptors
Evan N. Feinberg [US]; Vijay S. Pande [US]; Susruta Majumdar [US]; Gavril Pasternak [US]
Publication date: 2022-01-04 | Patent publication No.: US-11213518-B2 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US]; Memorial Sloan-Kettering Cancer Center [US] | IPC: A61K31/4453; A61K31/415; A61K9/00 | Oldest priority date: 2017-11-14 | Publication date: 2022-01-04
Score: 19.328047 | Text size: 78827 | Find: similar documents
5421855 298.471 [[image:EMI-C00003]] 4 ChemBridge Corp 5359784 286.419 [[image:EMI-C00004]] 5 ChemDiv, Inc. K416-0034 331.45 [[image:EMI-C00005]] 6 ChemDiv, Inc. 6030-4029 277.408 [[image:EMI-C00006]] 7 ChemDiv, Inc. D171-0103 284.403 [[image:EMI-C00007]] 8 ChemDiv, Inc. K808-9296 317.388 [[image:EMI-C00008]] 9 ChemDiv, Inc. C296-0706 379.43 [[image:EMI-C00009]] 10 ChemDiv, Inc. C656-0381 347.353 [[image:EMI-C00010]] 11 InterBioScreen Ltd. STOCK1S-36272 255.
Isolated human lung progenitor cells and uses thereof
Jayaraj Rajagopal [US]; Hongmei Mou [US]
Publication date: 2022-01-04 | Patent publication No.: US-11214769-B2 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N5/074; C12N5/071; A61K35/42; A61L27/38; A61L27/56; A61L27/58; G01N33/68; A61K9/00 | Oldest priority date: 2012-01-13 | Publication date: 2022-01-04
Score: 9.930534 | Text size: 267627 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
Zhi-Ren Liu [US]; Haizhen Wang [US]
Publication date: 2022-01-04 | Patent publication No.: US-11214624-B2 | Assignees: Proda Biotech LLC [US] | IPC: C07K16/40; C12N9/14; C07K14/47; A61K38/46; G01N33/50; G01N33/573; A61K38/00 | Oldest priority date: 2012-03-14 | Publication date: 2022-01-04
Score: 13.245268 | Text size: 92806 | Find: similar documents
of chemical libraries including but not limited to ChemBridge Corporation (San Diego, Calif.), ChemDiv (San Diego, Calif.), Life Chemicals (Orange, Conn.), and Maybridge (Cornwall, UK).
Kang-Yell Choi [KR]; Seol Hwa Seo [KR]; Eunhwan Kim [KR]
Publication date: 2021-12-30 | Patent publication No.: US-20210403432-A1 | Assignees: CK Biotech Inc. [KR] | IPC: C07D215/38; C07D487/04; C07D471/04; C07D207/44; C07D513/04; C07D239/42; C07D498/04; C07D209/40; C07D217/16; C07C229/36; C07D309/38; C07D311/30; C07C237/48; C07C39/215; C07D295/088; C07D487/22; A61P3/04; A61P3/10; G01N33/68 | Oldest priority date: 2018-10-15 | Publication date: 2021-12-30
Score: 15.319015 | Text size: 228995 | Find: similar documents
that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280 Screen Format Concentration(s) tested Plate controls Reagent/compound ... of the CXXC5-DVL interface, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction
HAKONARSON, Hakon [US]; LI, Yun Rose [US]; KEATING, Brendan [US]
Publication date: 2021-11-24 | Patent publication No.: EP-3337465-B1 | Assignees: The Children's Hospital of Philadelphia [US] | IPC: A61K31/00; A61P1/00; C12Q1/68 | Oldest priority date: 2016-04-08 | Publication date: 2021-11-24
Score: 9.930534 | Text size: 296191 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
MICROFLUIDIC DEVICE AND USES THEREOF
Publication date: 2021-11-18 | Patent publication No.: US-20210354140-A1 | Assignees: Bar Ilan University [IL] | IPC: B01L3/00; G02B21/26; G02B21/00 | Oldest priority date: 2020-05-18 | Publication date: 2021-11-18
Score: 9.22053 | Text size: 315123 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
RETROSYNTHESIS-RELATED SYNTHETIC ACCESSIBILITY
ZAGRIBELNYY, Bogdan [CN]; PUTIN, Evgeny Olegovich [RU]; FEDORCHENKO, Sergei Andreevich [RU]; IVANENKOV, Yan A. [RU]; ZAVORONKOVS, Aleksandrs [CN]
Publication date: 2021-11-18 | Patent publication No.: WO-2021229454-A1 | Assignees: INSILICO MEDICINE IP LIMITED [CN] | IPC: G16C20/30; G16C20/10; G16C20/70 | Oldest priority date: 2020-05-14 | Publication date: 2021-11-18
Score: 14.350686 | Text size: 86172 | Find: similar documents
-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases such as Clarivate Analytics Integrity (Cortellis Drug Discovery
SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF
STEVENS, Susan [US]; STENZEL-POORE, Mary [US]; FOSS, Marie [US]; NILSEN, Aaron [US]; JIN, Haihong [US]
Publication date: 2021-11-11 | Patent publication No.: WO-2021226129-A1 | Assignees: NEURALEXO, INC. [US] | IPC: A61K31/495; A61K31/496; C07D295/04; C07D295/092 | Oldest priority date: 2020-05-04 | Publication date: 2021-11-11
Score: 9.22053 | Text size: 295182 | Find: similar documents
library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv.
CELL ENTRY-MODULATING AGENTS AND USES THEREFOR
JENNINGS, Michael Paul [AU]; DAY, Christopher James [AU]; KIEFEL, Milton [AU]; HASELHORST, Thomas [AU]
Publication date: 2021-11-11 | Patent publication No.: WO-2021222988-A1 | Assignees: GRIFFITH UNIVERSITY [AU] | IPC: A61K38/10; A61K31/4184; A61K31/4188; A61K31/4745; A61K31/496; A61K31/655; C07D491/22; C07K7/08; A61P31/14 | Oldest priority date: 2020-05-07 | Publication date: 2021-11-11
Score: 11.227331 | Text size: 213173 | Find: similar documents
- 1,050, eDrugs - 1,610, Ligandbox Kegg - 5,814, PRESTWICK OFF PATENTS - 2,062, OTAVA - 9,765, CHEMDIV - 33,145) as 2D SDF molecular format.
CFTR REGULATORS AND METHODS OF USE THEREOF
Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Mark J. Kurth [US]
Publication date: 2021-11-11 | Patent publication No.: US-20210347742-A1 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; C07D403/04; C07D405/04; C07D498/06; C07D409/04; C07D401/06; C07D405/06; C07D409/06 | Oldest priority date: 2015-12-24 | Publication date: 2021-11-11
Score: 15.528575 | Text size: 712123 | Find: similar documents
was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.
COMPOSITIONS AND METHODS FOR TARGETING A VIRAL INFECTION
Bing CHEN [US]; Gary FREY [US]; Tianshu XIAO [US]
Publication date: 2021-11-04 | Patent publication No.: US-20210338659-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4709 | Oldest priority date: 2018-07-27 | Publication date: 2021-11-04
Score: 13.489152 | Text size: 294973 | Find: similar documents
1 (Winston-Salem, N.C.), Bionet (Ryan Scientific, Mount Pleasant, S.C.), CEREP (Redmond, Wash.), ChemDiv (San Diego, Calif.), and ChemBridge (San Diego, Calif. ... 1 (Winston-Salem, N.C.), Bionet (Ryan Scientific, Mount Pleasant, S.C.), CEREP (Redmond, Wash.), ChemDiv (San Diego, Calif.), and ChemBridge (San Diego, Calif.
Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
David J. Tweardy [US]; Moses M. Kasembeli [US]; Marvin X. Xu [CN]; Thomas Kristian Eckols [US]
Publication date: 2021-11-02 | Patent publication No.: US-11161831-B2 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D215/36; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/31; C07C311/24; C07C311/29; C07C311/44; C07C311/49; C07C311/06; A61K31/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513; C07C311/21; C07C323/49; C07C381/06; A61K45/06 | Oldest priority date: 2013-07-18 | Publication date: 2021-11-02
Score: 14.233541 | Text size: 279831 | Find: similar documents
Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.
Compounds that enhance Atoh1 expression
Albert Edge [US]; Sang-Jun Jeon [KR]; Kathleen Seyb [US]; Marcie Glicksman [US]; Lixin Qiao [US]; Gregory D. Cuny [US]
Publication date: 2021-11-02 | Patent publication No.: US-11160808-B2 | Assignees: Massachusetts Eye & Ear Infirmary [US]; Brigham & Women's Hospital, Inc. [US] | IPC: A61K31/5377; A61K31/343; A61K31/381; A61K31/415; A61K31/423; A61K31/4245; A61K31/426; A61K31/428; A61K31/341; A61K31/4184; A61K9/00; A61K31/353; A61K31/4436; A61K31/496; A61K31/498; A61K31/517; A61K31/519; A61K35/28; A61K35/545; A61K31/352; A61K31/404; A61K31/4155; A61K31/4192; A61K31/4365; A61K31/437; A61K31/44; A61K31/4439 | Oldest priority date: 2008-02-07 | Publication date: 2021-11-02
Score: 20.760141 | Text size: 210379 | Find: similar documents
N-(4-bromo-3- methylphenyl) quinazolin-4-amine CHEMDIV (3651-6031) CP- 0067053 [[image:EMI-C00070]] 60. N-(4-methoxyphenyl) quinazolin-4-amine CHEMDIV (4491-0691) CP- 0072720 [[image:EMI-C00071]] 61. N-(3-methoxyphenyl)- 9H-purin-6-amine CHEMDIV (8009-2985) CP- 0079810 [[image:EMI-C00072]] 62. N,N-diethyl-1-m-tolyl- 1H-pyrazolo[3,4- d]pyrimidin-4-amine CHEMDIV (K402- 0503) or IFLAB/ LIFE- CHEMICALS (F0518- 0004) CP- 0061777 [[image:EMI-C00073]] 63. (5-(4- bromophenyl)furan-2- yl)(morpholino)methanone CHEMDIV (1975-0198) CP- 0066008 [[image:EMI-C00074]] 64. (Z)-4-bromo-N′-(furan-2- carbonyloxy)benzimida- mide CHEMDIV (4260-1000) CP- 0072253 [[image:EMI-C00075]] 65. N-(4-iodophenyl)furan-2- carboxamide CHEMDIV (8002-5214) CP- 0099289 [[image:EMI-C00076]] 66.
Kang-Yell Choi [KR]; Sehee Choi [KR]; Seol Hwa Seo [KR]; Eunhwa Kim [KR]
Publication date: 2021-10-21 | Patent publication No.: US-20210323918-A1 | Assignees: CK Biotech Inc. [KR] | IPC: C07D209/34; A61P19/08; C07D513/14; C07D221/18; C07C237/48; C07D487/22; G01N33/68; A61K9/00 | Oldest priority date: 2018-10-15 | Publication date: 2021-10-21
Score: 17.002005 | Text size: 122516 | Find: similar documents
that inhibited the CXXCS-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280 Screen Format Concentration(s) tested Plate controls Reagent/compound ... delay growth plate senescence, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction
SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS
ANDROPY, Elliot J. [US]; MEROUEH, Samy [US]; LU, Zhijian [US]
Publication date: 2021-10-21 | Patent publication No.: WO-2021212010-A2 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS INC. [US] | Oldest priority date: 2020-04-17 | Publication date: 2021-10-21
Score: 13.245268 | Text size: 115556 | Find: similar documents
V012-2359), EIN-130(cat# V031-2694), and EIN-131(cat# V031-2717) were each purchased from ChemDiv.
Compositions and methods for treating diseases associated with uncontrolled inflammatory responses
Jason Barbour [US]; David Ott [US]
Publication date: 2021-10-19 | Patent publication No.: US-11147815-B2 | Assignees: Synkrino Biotherapeutics, Inc. | IPC: A61K31/495; A61K31/496; A61K31/513; A61K31/435; A61P19/02; A61P35/00; A61K31/515; A61K31/437; A61K31/50; A61K45/06; C12Q1/6883; G16B40/00; G16B25/10; A61P37/06 | Oldest priority date: 2018-08-21 | Publication date: 2021-10-19
Score: 16.251385 | Text size: 92960 | Find: similar documents
Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state. ... TABLE 1 CompoundChemDiv Compound IdentifierNormalized Average of MIG/CXCL9Normalized Average of IP-10/CXCL10Normalized
METHODS AND COMPOSITIONS TO TREAT CANCER
Jeffrey A. Whitsett [US]; Yutaka Maeda [US]; Takuya Fukazawa [JP]
Publication date: 2021-10-14 | Patent publication No.: US-20210315903-A1 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2021-10-14
Score: 14.656486 | Text size: 44997 | Find: similar documents
(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.
Ilana Nathan [IL]; Boris Khalfin [IL]
Publication date: 2021-10-07 | Patent publication No.: US-20210309620-A1 | Assignees: Ela Pharma Ltd [IL] | IPC: C07D265/22; A61K31/4178; A61K31/426; A61K31/454; C07D277/42; C12N15/113; A61K31/00; A61K31/496; A61K31/415; C07D405/06; C07D277/56; A61K31/4439; C07D233/44; C07D417/12; A61K31/4196; A61K31/4045; A61P25/00; A61K31/167; A61K31/428; A61K31/536; A61K45/06; C07C233/24; C07D233/48; C07D275/06; C12N5/077 | Oldest priority date: 2015-04-07 | Publication date: 2021-10-07
Score: 15.95058 | Text size: 243527 | Find: similar documents
All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, Calif. ... 3D Structure Similarities and Topological Analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.
NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND
Okuyama, Masahiro [JP]; Fukunaga, Kenji [JP]; Usui, Kenji [JP]; Hayashi, Norimitsu [JP]; Iijima, Daisuke [JP]; Horiuchi, Hideki [JP]; Itagaki, Noriaki [JP]
Publication date: 2021-10-06 | Patent publication No.: EP-3683222-B1 | Assignees: Mitsubishi Tanabe Pharma Corporation [JP] | IPC: C07D513/04; C07D471/04; C07D487/04; C07D513/14; A61K31/437; A61K31/5025; A61K31/519; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00 | Oldest priority date: 2014-04-23 | Publication date: 2021-10-06
Score: 6.4525156 | Text size: 1112016 | Find: similar documents
sold by plural companies (e.g., AKos Consulting & Solutions GmbH, Ambinter, Aurora Fine Chemicals, ChemDiv, Inc.). However, a KAT-II inhibitory action and other pharmacological activities of these compounds have
Sara Buhrlage [US]; Ellen Weisberg [US]; James D. Griffin [US]
Publication date: 2021-10-05 | Patent publication No.: US-11136409-B2 | Assignees: Dana-Farber Cancer Institute, Inc. [US] | IPC: A61P31/00; C07K16/30; A61P35/02; C12Q1/6886; G01N33/50; G01N33/574; A01K67/027; C12Q1/02; C12Q1/6806; C12Q1/6841; C12Q1/6851; C12Q1/686; A61K45/06 | Oldest priority date: 2016-09-20 | Publication date: 2021-10-05
Score: 8.066998 | Text size: 446194 | Find: similar documents
HBX19818 analogs were purchased from ChemDiv and dissolved in DMSO to obtain a 10 mM stock solution.
Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
Catherine Tachdjian [US]; Donald Karanewsky [US]; Xiao Qing Tang [US]; Hanghui Liu [US]
Publication date: 2021-09-28 | Patent publication No.: US-11129397-B2 | Assignees: FIREMENICH INCORPORATED [US] | IPC: A23L2/56; A23L27/00; A23L27/20; A61K47/26; A61K47/22 | Oldest priority date: 2010-08-12 | Publication date: 2021-09-28
Score: 9.562369 | Text size: 467664 | Find: similar documents
other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.
Small-molecule UT-A-selective urea transport inhibitors
Alan S. Verkman [US]; Cristina Esteva-Font [US]
Publication date: 2021-09-21 | Patent publication No.: US-11123340-B2 | Assignees: The Regents of the University of California [US] | IPC: A61K31/4709; A61K31/425; A61K31/426; A61K31/427; A61K31/47 | Oldest priority date: 2014-05-09 | Publication date: 2021-09-21
Score: 15.755042 | Text size: 143988 | Find: similar documents
screening was done using a collection of 50,000 chemically diverse, drug-like compounds from ChemDiv (San Diego, Calif.). For analysis of structure-activity relationships, >300 commercially available analogs (ChemDiv and Asinex, Winston-Salem, N.C.) were tested.
SHI, Taoda [US]; CHAPMAN, Eli [US]; AMBROSE, Andrew J. [US]
Publication date: 2021-09-16 | Patent publication No.: WO-2021183942-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US] | IPC: A61K31/16; A61K31/165; A61K31/166; C07C233/00; C07C233/04; C07C233/06 | Oldest priority date: 2020-03-13 | Publication date: 2021-09-16
Score: 13.077378 | Text size: 122356 | Find: similar documents
1, N-(3-methyl-l-oxo-l-(thiazol-2-ylamino)butan-2-yl)thiophene-2- carboxamide, was purchased from ChemDIV Inc. (San Diego, CA).
INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF
Gary E. Schiltz [US]; Daniela E. Matei [US]; Purav Vagadia [US]
Publication date: 2021-09-09 | Patent publication No.: US-20210276960-A1 | Assignees: Northwestern University [US]; United States Goverment as represented by the Department of Veterans Affairs [US] | IPC: C07D239/48; A61P35/00; C07D239/42; C07D401/12; C07D403/12; C07D409/12 | Oldest priority date: 2020-03-04 | Publication date: 2021-09-09
Score: 18.463318 | Text size: 190284 | Find: similar documents
To this end, we completed a high throughput screening (HTS) campaign of compounds in the ChemDiv library by using a newly developed AlphaLISA assay that robustly measured the TG2/FN complex ... We had previously reported TG53 as a lead inhibitor selected from high throughput screening of the ChemDiv library using an Alpha-Lisa assay (13). ... the TG2-FN complex formation and were discovered through AlphaLISA based HTS applied to the ChemDiv library11. ... Discovery of TG2/FN inhibitors—HTS using the ChemDiv library: Next, the ChemDiv library containing 10,000 diverse compounds arrayed at 10 μM each was screened using the assay
SCHEPENS, Bert [BE]; SAELENS, Xavier [BE]; CALLEWAERT, Nico [BE]; DE VLIEGER, Dorien [BE]; VAN SCHIE, Loes [BE]; NERINCKX, Wim [BE]; ROOSE, Kenny [BE]; VAN BREEDAM, Wander [BE]; EECKHAUT, Hannah [BE]; FIJALKOWSKA, Daria [BE]; LONIGRO, Chiara [BE]; DE CAE, Sieglinde [BE]; DOMBRECHT, Bruno [BE]; STORTELERS, Catelijne [BE]; NEYTS, Johan [BE]; DELANG, Leen [BE]; KAPTEIN, Suzanne [NL]; DUARTE DA ROCHA PEREIRA, Joana [BE]; GRAHAM, Barney [US]; MCLELLAN, Jason [US]; WRAPP, Daniel [US]; REMAUT, Han [BE]
Publication date: 2021-08-12 | Patent publication No.: WO-2021156490-A2 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE]; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]; TRUSTEES OF DARTMOUTH COLLEGE [US]; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D [BE]; EXEVIR BIO BV [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE] | IPC: A61K39/215 | Oldest priority date: 2020-02-06 | Publication date: 2021-08-12
Score: 9.562369 | Text size: 377714 | Find: similar documents
from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Flungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).
CFTR regulators and methods of use thereof
Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Mark J. Kurth [US]
Publication date: 2021-08-10 | Patent publication No.: US-11084795-B2 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; C07D401/06; C07D405/06; C07D409/06; C07D403/04; C07D405/04; C07D498/06; C07D409/04 | Oldest priority date: 2015-12-24 | Publication date: 2021-08-10
Score: 15.528575 | Text size: 764864 | Find: similar documents
was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.
USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE
David J. Dowling [US]; Ofer Levy [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]
Publication date: 2021-08-05 | Patent publication No.: US-20210236632-A1 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2021-08-05
Score: 12.211837 | Text size: 385572 | Find: similar documents
bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).
Michael Yoonsuk CHOI [US]; Byeong-Moo KIM [US]
Publication date: 2021-08-05 | Patent publication No.: US-20210238604-A1 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N15/113; A61P1/16; A61K35/407 | Oldest priority date: 2016-05-20 | Publication date: 2021-08-05
Score: 11.227331 | Text size: 200752 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
PAK1 inhibitors and uses thereof
Ulrich Steidl [US]; Ashley M. Eckel [US]; Robert F. Stanley [US]; Boris Rogovoy [US]; Ilya Okun [US]
Publication date: 2021-07-20 | Patent publication No.: US-11065251-B2 | Assignees: ALBERT EINSTEIN COLLEGE OF MEDICINE [US] | IPC: A61K31/519; A61P35/00; A61K31/437; A61K31/496; C07D471/04 | Oldest priority date: 2016-05-06 | Publication date: 2021-07-20
Score: 14.153812 | Text size: 70668 | Find: similar documents
Compounds were screened for PAK1 inhibition using a 50,024 compound library by ChemDiv (San Diego, Calif.
TACHDJIAN, Catherine [US]; KARANEWSKY, Donald [US]; WERNER, Sara [US]; DARMOHUSODO, Vincent [US]; YAMAMOTO, Jeff [US]
Publication date: 2021-07-14 | Patent publication No.: EP-3593648-B1 | Assignees: Firmenich Incorporated [US] | IPC: A23L27/00; A23L2/60; A23L2/56; C07D417/12; C07D417/14; A23L29/30 | Oldest priority date: 2013-03-13 | Publication date: 2021-07-14
Score: 11.477125 | Text size: 221700 | Find: similar documents
other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, PA, ChemDiv of San Diego, CA, Chembridge of San Diego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the
Gerard M. Housey [US]; Monica E. Balash [US]
Publication date: 2021-07-08 | Patent publication No.: US-20210207135-A1 | Assignees: Housey Pharmaceutical Research Laboratories, L.L.C. [US] | IPC: C12N15/113; G01N33/50; G01N33/563; A61K45/06 | Oldest priority date: 2018-05-17 | Publication date: 2021-07-08
Score: 12.297968 | Text size: 156156 | Find: similar documents
and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-XInfinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,
SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES
Luke L. Lairson [US]; Michael J. Bollong [US]; Peter G. Schultz [US]; Sendurai A. Mani [US]
Publication date: 2021-07-01 | Patent publication No.: US-20210196713-A1 | Assignees: The Scripps Research Institute [US]; Board of Regents, The University of Texas System [US] | IPC: A61K31/502; A61K31/437; A61K31/4704; A61K31/4741; A61K31/497; A61K31/4985; A61K31/551; A61P35/00 | Oldest priority date: 2017-10-30 | Publication date: 2021-07-01
Score: 16.51147 | Text size: 107793 | Find: similar documents
Selected hit compounds were reordered from ChemDiv and tested for selective toxicity in 10-point response assays as above. ... a library of ̃50,000 diverse heterocyclic compounds and biologically active small molecules (ChemDiv, San Diego, Calif., USA) for cytotoxic activity against both cell lines.
CELLS EXPRESSING APOLIPOPROTEIN E AND USES THEREOF
LINDQUIST, Susan L. [US]; NARAYAN, Priyanka [US]
Publication date: 2021-06-30 | Patent publication No.: EP-3842514-A1 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C12N1/19; C12N15/81; C12Q1/02; C07K14/47 | Oldest priority date: 2014-09-12 | Publication date: 2021-06-30
Score: 7.592094 | Text size: 433990 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
Cellular discovery platform for neurodegenerative diseases
Susan L. Lindquist [US]; Vikram Khurana [US]; Chee-Yeun Chung [US]
Publication date: 2021-06-29 | Patent publication No.: US-11047848-B2 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: G01N33/50; G01N33/68; C12Q1/6883 | Oldest priority date: 2013-03-15 | Publication date: 2021-06-29
Score: 7.1699963 | Text size: 565577 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
SELECTIVE CALCIUM CHANNEL ANTAGONISTS
Dalton J. Surmeier, Jr. [US]; Richard B. Silverman [US]; Soo Sung Kang [US]; Garry Cooper [US]
Publication date: 2021-06-24 | Patent publication No.: US-20210186970-A1 | Assignees: Northwestern University [US] | IPC: A61K31/515; C07D239/62 | Oldest priority date: 2011-01-19 | Publication date: 2021-06-24
Score: 13.245268 | Text size: 99718 | Find: similar documents
to screen 60,480 commercial compounds (ADSI set 6,800; ChemBridge diverse/lead like set 20,000; ChemDiv diverse set 30,000; NIH clinical trial set 480, NCl/DTP set 3,200).
COMPOSITIONS FOR TREATMENT OF FIBROSIS
TWEARDY, David, J. [US]; KASEMBELI, Moses, M. [US]; XU, Marvin, X. [CN]; AGARWAL, Sandeep, K. [US]; PEDROZA, Mesias [US]
Publication date: 2021-06-23 | Patent publication No.: EP-3021839-B1 | Assignees: Baylor College Of Medicine [US] | IPC: A61K31/18; A61K31/05; A61K31/4196; A61K45/06; A61P17/02; A61P35/00; A61K31/343; A61K31/39; A61P19/04 | Oldest priority date: 2013-07-18 | Publication date: 2021-06-23
Score: 15.999366 | Text size: 142511 | Find: similar documents
Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.
ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY
CHATTOPADHYAY, Shrikanta [US]; YUSUF, Rushdia [US]; VAN GASTEL, Nick [BE]; SHARDA, Azeem, S. [US]; SAEZ, Borja [ES]; VISWANATHAN, Vasanthi, S. [US]; SCADDEN, David, T. [US]
Publication date: 2021-06-17 | Patent publication No.: WO-2021119215-A1 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]; THE BROAD INSTITUTE, INC. [US]; THE GENERAL HOSPITAL CORPORATION [US] | IPC: A61P35/00; C12N9/04; A61K45/06 | Oldest priority date: 2019-12-09 | Publication date: 2021-06-17
Score: 10.988179 | Text size: 199135 | Find: similar documents
The initial screen will be performed on the ChemDiv 6 library, a select set of 44,000 public domain compounds.
SELBERG, Simona [EE]; ŽUSINAITE, Eva [EE]; MERITS, Andres [EE]; SELI, Neinar [EE]; KARELSON, Mati [EE]
Publication date: 2021-06-17 | Patent publication No.: WO-2021116476-A1 | Assignees: CHEMESTMED LTD. [EE] | IPC: A61K31/435; A61K31/495; A61P31/18 | Oldest priority date: 2019-12-12 | Publication date: 2021-06-17
Score: 14.9756 | Text size: 35975 | Find: similar documents
Methyl piperazine-2-carboxylate (IX) (ChemDiv, Inc., Catalog Number: FF20-0374, Purity > 90%). Ethyl 2-oxopiperidine-3-carboxylate (X) (Enamine, Ltd.
COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY
RAMSDEN, Dr. Nigel [GB]; FOX, Dr. David John [GB]; HUNTINGTON, Prof. James Andrew [GB]; TOMLINSON, Dr. James Michael [GB]
Publication date: 2021-06-17 | Patent publication No.: WO-2021116703-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D207/48; C07D211/96; C07D401/12; A61K31/40; A61K31/445; A61K31/4709 | Oldest priority date: 2019-12-13 | Publication date: 2021-06-17
Score: 15.196177 | Text size: 41754 | Find: similar documents
This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.
ALPHA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
Iwao Ojima [US]; Dale Deutsch [US]; Martin Kaczocha [US]; Kongzhen Hu [US]; Simon Tong [US]; Matthew Elmes [US]; Su Yan [US]
Publication date: 2021-06-17 | Patent publication No.: US-20210179535-A1 | Assignees: The Research Foundation for The State University of New York [US] | IPC: C07C69/753; C07C69/757; C07C205/55; C07D249/06; C07D309/06; C07C233/25; C07C61/04; C07D215/06 | Oldest priority date: 2016-03-11 | Publication date: 2021-06-17
Score: 13.077378 | Text size: 120610 | Find: similar documents
Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49.
SMALL MOLECULE INHIBITORS OF VOLTAGE-GATED SODIUM CHANNEL 1.7 AND METHODS OF USING SAME
BORTSOV, Andrey [US]; CHANDRA, Sharat [US]; JI, Ru-Rong [US]
Publication date: 2021-06-17 | Patent publication No.: WO-2021119157-A1 | Assignees: DUKE UNIVERSITY [US] | IPC: C07D209/08; C07D401/12; C07D401/14 | Oldest priority date: 2019-12-11 | Publication date: 2021-06-17
Score: 19.189526 | Text size: 136261 | Find: similar documents
For virtual screening, a database of 1.5 million compounds was downloaded from the Chemdiv website (chemdiv.com, ChemDiv Inc., San Diego, CA). ... A similarity threshold value of 0.5 against the compounds from the Chemdiv database was used to screen for potential Navi.7 inhibitors. ... Similarity search of the ChemDiv database (ChemDiv Inc, San Diego, CA) containing 1.5 million pre- synthetized compounds yielded a set of 2000 compounds ... and sufficient quantity (1 mg or more) available in stock were selected and purchased from ChemDiv for in vitro and in vivo activity assessment. [0139] Patch-clamp recordings of Navl.
SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION
Pearlie Burnette [US]; Harshani Lawrence [US]; Nicholas J. Lawrence [US]
Publication date: 2021-06-17 | Patent publication No.: US-20210177825-A1 | Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: A61K31/4545; A61K31/454; A61K31/517; A61K31/513; A61K31/404; A61K31/45; A61K31/4725; A61K31/4525; A61K31/4015; A61K31/5377; A61K31/50; A61K31/4523 | Oldest priority date: 2016-03-16 | Publication date: 2021-06-17
Score: 8.605278 | Text size: 476034 | Find: similar documents
32,000 compounds LifeChemicals 6000 compounds NCl fucused collections 4,000 compounds ChemDiv 30,000 compounds Chembridge 60,000 compounds Kinase libraries.
Methods and compositions for treating mesothelioma and small lung cancer that express midkine
Jeffrey A. Whitsett [US]; Yutaka Maeda [US]; Takuya Fukazawa [JP]
Publication date: 2021-06-08 | Patent publication No.: US-11026950-B2 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2021-06-08
Score: 14.656486 | Text size: 56241 | Find: similar documents
(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.
α- and γ-truxillic acid derivatives and pharmaceutical compositions thereof
Iwao Ojima [US]; Dale Deutsch [US]; Martin Kaczocha [US]; William T. Berger [US]; Robert Rizzo [US]; Trent E. Balius [US]
Publication date: 2021-06-08 | Patent publication No.: US-11026910-B2 | Assignees: The Research Foundation for The State University of New York [US] | IPC: A61K31/216; C07C67/08; C07C211/58; C07C233/11; C07C233/58; C07C235/38; C07C235/40; C07C69/753; C07C69/76; C07C67/48; C07C69/757; G01N33/566; A61K31/194; G01N33/68 | Oldest priority date: 2012-07-20 | Publication date: 2021-06-08
Score: 19.70499 | Text size: 144954 | Find: similar documents
Energetically DOCK selected ligands from the ChemDiv library that did not have unfavorable interaction, both VDW and ES, intrinsically selecting ... The following compounds are available from ChemDiv (San Diego, Calif., USA): StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334 [[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from Cayman Chemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv, Inc. (Moscow, Russia). ... Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49. ... Virtual Screening A high-throughput virtual screening of over one million molecules from the ChemDiv subset of the ZINC database (http://zinc.docking.
RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHODS OF USING SAME
PYLE, Anna, Marie [US]; RAWLING, David [US]; JAGDMANN, G., Erik [US]; POTAPOVA, Olga [US]
Publication date: 2021-05-14 | Patent publication No.: WO-2021091958-A1 | Assignees: YALE UNIVERSITY [US] | IPC: A61K31/403; A61K31/712; A61P35/00 | Oldest priority date: 2019-11-04 | Publication date: 2021-05-14
Score: 13.077378 | Text size: 123000 | Find: similar documents
11 libraries, including the ChemBridge, Enzo Kinase Inhibitor, Enzo Phosphatase Inhibitor, ChemDiv and Nuclear Receptor Libraries, was screened.
Vijay K. Kuchroo [US]; Chao Wang [US]; Aviv Regev [US]
Publication date: 2021-05-13 | Patent publication No.: US-20210139601-A1 | Assignees: The Broad Institute, Inc. [US]; The Brigham and Women's Hospital, Inc. [US]; Massachusetts Institute of Technology [US] | IPC: C07K16/28; C07K14/705; A61K38/17; A61K39/395; A61K45/06; A61P35/00 | Oldest priority date: 2017-05-25 | Publication date: 2021-05-13
Score: 6.7923617 | Text size: 634947 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA
Anna Pyle [US]; Olga Fedorova [US]; Erik Gunnar Jagdmann [US]; Michael Van Zandt [US]; Lin Yuan [US]; Albert DeBerardinis [US]
Publication date: 2021-05-13 | Patent publication No.: US-20210139512-A1 | Assignees: YALE UNIVERSITY [US] | IPC: C07F5/02; C07D307/83; C07D307/80; C07C233/73; C07D405/04; C07D277/26; C07D405/12; C07C243/38; C07D307/52; C07D239/26; C07C49/84; C07C233/65; C07D217/04; C07D207/08; C07D211/16; C07D413/04; C07D233/64; C07D277/24; C07D295/192; C07D277/66; C07D295/215; A61P31/10 | Oldest priority date: 2018-01-26 | Publication date: 2021-05-13
Score: 10.328181 | Text size: 285136 | Find: similar documents
(76 compounds), protease inhibitors (53 compounds) and additional compounds from ChemBridge MW and ChemDiv to bring the total number of compounds to 10000. The D135 ribozyme (Su et al.
INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS
Sanjay A. Desai [US]; Ajay D. Pillai [IN]
Publication date: 2021-04-29 | Patent publication No.: US-20210121476-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: A61K31/553; A61K31/165; A61K31/4155; A61K31/423; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741; A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D403/08; C07D498/04; C07D263/57; C07D281/16; C07D413/14; C07D417/06; C07D491/048; C07D513/04; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2021-04-29
Score: 14.451191 | Text size: 51257 | Find: similar documents
methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England.
FERROCHELATASE INHIBITORS AND METHODS OF USE
Timothy W. CORSON [US]; Kamakshi SISHTLA [US]; Seung-Yong SEO [KR]; Bit LEE [KR]
Publication date: 2021-04-29 | Patent publication No.: US-20210121465-A1 | Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US]; Gachon University of Industry-Academic Cooperation [KR] | IPC: A61K31/519; A61K41/00; A61K38/17; A61K39/395; A61K31/4025; A61K31/4706; A61K31/49; A61K31/37; A61K31/4709; A61K31/122; A61K31/155; A61K31/409; A61K31/343; C12N15/113; A61K45/06; C07D487/04; C07D249/14; A61P27/02; A61K31/4196; C07K16/22 | Oldest priority date: 2018-04-30 | Publication date: 2021-04-29
Score: 15.999366 | Text size: 141607 | Find: similar documents
at the Indiana University School of Medicine Chemical Genomics Core Facility (CGCF) using the ChemDiv 10K and a portion (10,000 compounds) of the ChemBridge 50K libraries of chemical compounds. ... IC50 Determination Compounds, reordered from ChemDiv or synthesized as described above, were made to 10 mM in DMSO and tested in the FECH enzymatic
REACTIVE AFFINITY PROBE-INTERACTION DISCOVERY PLATFORM
LABENSKI, Matthew, T. [US]; RETTENMAIER, Terry, J. [US]; JONES, Lyn, H. [US]; MUNCIPINTO, Giovanni [US]
Publication date: 2021-04-22 | Patent publication No.: WO-2021076680-A1 | Assignees: JNANA THERAPEUTICS, INC. [US] | IPC: G01N33/68; G01N33/561; C08G65/32; G01N33/58; C07K7/06 | Oldest priority date: 2019-10-15 | Publication date: 2021-04-22
Score: 14.656486 | Text size: 52535 | Find: similar documents
for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.
RESPIRATORY AND SWEAT GLAND IONOCYTES
Jayaraj Rajagopal [US]; Aviv Regev [US]; Moshe Biton [US]; Adam Haber [US]; Daniel Montoro [US]; Orit Rozenblatt-Rosen [US]
Publication date: 2021-04-22 | Patent publication No.: US-20210115407-A1 | Assignees: The Broad Institute, Inc. [US]; The General Hospital Corporation [US]; Massachusetts Institute of Technology [US] | IPC: C12N5/071; A61K35/42; A61P11/00; G01N33/50 | Oldest priority date: 2017-04-12 | Publication date: 2021-04-22
Score: 7.592094 | Text size: 511847 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM among others.
INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION
Mark D. Andrake [US]; Anna Marie Skalka [US]; George W. Merkel [US]
Publication date: 2021-04-22 | Patent publication No.: US-20210113570-A1 | Assignees: Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center [US] | IPC: A61K31/53; A61K31/4245; A61K31/454 | Oldest priority date: 2017-01-26 | Publication date: 2021-04-22
Score: 17.199627 | Text size: 51249 | Find: similar documents
formation (see FIG. 1B), and used it to screen the 50,000 compound chemical diversity library of ChemDiv, ltd. at 10 uM concentration. ... day were performed to screen the entire Chemical Diversity set of 50,000 compounds obtained from ChemDiv, Ltd.
NATURAL SWEETENER COMPOSITIONS
Anandasankar RAY [US]; Sean Michael BOYLE [US]
Publication date: 2021-04-22 | Patent publication No.: US-20210112839-A1 | Assignees: Sensorygen, Inc. [US] | IPC: A23L27/30; A23L33/125; A23L33/17; A23L2/60 | Oldest priority date: 2016-11-16 | Publication date: 2021-04-22
Score: 12.913692 | Text size: 221423 | Find: similar documents
other well-known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.
METHODS FOR DETECTING PROTEIN-PROTEIN INTERACTIONS
CABANTOUS, Stéphanie [FR]; KORAÏCHI, Faten [FR]; FAVRE, Gilles [FR]
Publication date: 2021-04-21 | Patent publication No.: EP-3314260-B1 | Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale) [FR]; Université Paul Sabatier Toulouse III [FR] | IPC: G01N33/542; G01N33/68 | Oldest priority date: 2015-09-30 | Publication date: 2021-04-21
Score: 13.077378 | Text size: 128423 | Find: similar documents
It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.
SMALL MOLECULE INHIBITORS OF Id PROTEINS
BENEZRA, Robert [US]; OUERFELLI, Ouathek [US]
Publication date: 2021-04-08 | Patent publication No.: WO-2021067393-A1 | Assignees: MEMORIAL SLOAN KETTERING CANCER CENTER [US] | IPC: A61K31/131; A61K31/135; A61K31/137; C07C211/01; C07C211/03; C07C211/08 | Oldest priority date: 2019-10-01 | Publication date: 2021-04-08
Score: 10.759004 | Text size: 240527 | Find: similar documents
Compiled lists of commercially available compounds (libraries available from ChemBridge, ChemDiv, Maybridge, and Salor) were screened using a beta release of Autodock 4.0 (The Scripps Research
Substituted thiazoles for preventing and/or treating cell or tissue necrosis
Ilana Nathan [IL]; Boris Khalfin [IL]
Publication date: 2021-04-06 | Patent publication No.: US-10968185-B2 | Assignees: ELA PHARMA LTD. [IL] | IPC: A61K31/427; C07D277/20; C07D265/22; A61K31/4178; A61K31/426; A61K31/454; C07D277/42; C12N15/113; A61K31/00; A61K31/496; A61K31/415; C07D405/06; C07D277/56; A61K31/4439; C07D233/44; C07D417/12; A61K31/4196; A61K31/4045; A61P25/00; A61K31/167; A61K31/428; A61K31/536; A61K45/06; C07C233/24; C07D233/48; C07D275/06; C12N5/077 | Oldest priority date: 2015-04-07 | Publication date: 2021-04-06
Score: 15.95058 | Text size: 246336 | Find: similar documents
All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, Calif. ... 3D Structure Similarities and Topological Analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.
Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
Iwao Ojima [US]; Dale Deutsch [US]; Martin Kaczocha [US]; Kongzhen Hu [US]; Simon Tong [US]; Matthew Elmes [US]; Su Yan [US]
Publication date: 2021-04-06 | Patent publication No.: US-10968163-B2 | Assignees: The Research Foundation for the State University of New York [US] | IPC: C07C69/753; C07C61/04; C07C69/757; C07C205/55; C07D249/06; C07D309/06; C07C233/25; C07D215/06 | Oldest priority date: 2016-03-11 | Publication date: 2021-04-06
Score: 13.077378 | Text size: 127287 | Find: similar documents
Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49.
Ali Shilatifard [US]; Kaivvei Liang [US]; Edwin R. Smith [US]; Gary E. Schiitz [US]; Rama K. Mishra [US]; Kristen Stoltz [US]
Publication date: 2021-04-01 | Patent publication No.: US-20210094907-A1 | Assignees: NORTHWESTERN UNIVERSITY [US] | IPC: C07C235/74; C07C235/78; C07D241/20; C07D213/40; C07D257/06; C07D271/07; C07D277/46; C07D213/75; C07D239/42; C07D261/18; C07D231/14; C07D239/36; A61P35/00 | Oldest priority date: 2018-03-21 | Publication date: 2021-04-01
Score: 15.288118 | Text size: 192069 | Find: similar documents
Based on the structure of KL-1 (FIG. 1C), we performed a KL-1 similarity search with ChemDiv compounds and tested the top 32 most similar compounds. ... The candidate chemicals from the in silico screening were purchased from the vendors ChemDiv, ChemBridge and Enamine. MDA231-LM2 Tumor Model.
PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA
Publication date: 2021-03-25 | Patent publication No.: US-20210085679-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: A61K31/501; A61K31/496; A61K45/06; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K31/423; A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date: 2011-04-12 | Publication date: 2021-03-25
Score: 15.755042 | Text size: 131078 | Find: similar documents
methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England. ... room temperature using a commercial library of 50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at
USE OF THIAZOLE AMIDE COMPOUNDS FOR MODULATING HUMAN IMMUNE RESPONSE
DOWLING, David J. [US]; LEVY, Ofer [US]; BORRIELLO, Francesco [US]
Publication date: 2021-03-25 | Patent publication No.: WO-2021055386-A1 | Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A23L1/30; A23L2/52; A61K36/14 | Oldest priority date: 2019-09-17 | Publication date: 2021-03-25
Score: 12.507937 | Text size: 351345 | Find: similar documents
bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).
Philippe Guedat [FR]; Anne Bertolotti [GB]
Publication date: 2021-03-23 | Patent publication No.: US-10954198-B2 | Assignees: United Kingdom Research and Innovation [GB]; Inflectis Bioscience [FR] | IPC: C07D253/075; A61K31/155; A61K31/44; A61K31/53; C07C281/18; C07D213/61; A61K45/06; A61K31/165; A61K31/216; C07C281/16 | Oldest priority date: 2013-01-10 | Publication date: 2021-03-23
Score: 16.251385 | Text size: 109228 | Find: similar documents
EXAMPLES Methods & Materials Example 1 was purchased from Chemdiv ref: 1683-6588 Example 2 was purchased from Chembridge ref: 5173161 Example 4 was purchased from Enamine ref: Z49562642 Example 6 was purchased from Chemdiv ref: 1683-6502 Preparation of the Compounds According to the Present Invention The reactants and
Compounds useful as modulators of TRPM8
Chad Priest [US]; Alain Noncovich [US]; Andrew Patron [US]; Jane Ung [US]
Publication date: 2021-03-23 | Patent publication No.: US-10953007-B2 | Assignees: Firmenich Incorporated [US] | IPC: A61K31/381; A61K31/4155; A61K31/497; A23L27/00; C07C233/11; C07C235/20; C07C235/24; C07C235/34; C07D213/40; C07D213/75; C07D231/40; C07D277/28; C07D307/52; C07D333/20; C07D333/24; C07D333/32; C07D405/12; C07D407/12; C07D409/14; C07D413/12; C07D417/12; C07D471/04; A61K8/42; A61K8/49; A61K8/69; A61Q19/00; C07D409/12; A01N43/10; A01N43/40; A01N43/56; A01N43/60; A01N43/76; A01N43/80; A01N43/90; A23L33/10; A01N37/18; A01N43/78; A61K31/165; A61K31/415; A61K31/422; A61K31/426; A61K31/437; A61K31/4409; A61K31/4436; A61Q1/02; A61Q5/02; A61Q5/12; A61Q9/02; A61Q11/00; A61Q15/00; A61Q17/02; A61Q17/04; A61Q19/10 | Oldest priority date: 2010-11-05 | Publication date: 2021-03-23
Score: 19.40844 | Text size: 247612 | Find: similar documents
93 This compound was purchased from Chemdiv. ... 96 This compound was purchased from Chemdiv. ... 109 This compound was purchased from Chemdiv. ... 116 This compound was purchased from Chemdiv. ... 123 This compound was purchased from Chemdiv. ... 128 This compound was purchased from Chemdiv. ... 132 This compound was purchased from Chemdiv. ... 163 This compound was purchased from Chemdiv. ... 166 This compound was purchased from Chemdiv. ... 169 This compound was purchased from Chemdiv.
HAKONARSON, Hakon [US]; QU, Huiqi [US]
Publication date: 2021-03-18 | Patent publication No.: WO-2021050608-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: A01H1/00; A01H5/00; C07K14/415; C07K16/16; C12N1/21; C12N5/10; C12N15/63 | Oldest priority date: 2019-09-09 | Publication date: 2021-03-18
Score: 13.775837 | Text size: 86074 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
HAKONARSON, Hakon [US]; SLEIMAN, Patrick [US]
Publication date: 2021-03-18 | Patent publication No.: WO-2021050445-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: A61P11/06; C12Q1/6827; C12Q1/6883 | Oldest priority date: 2019-09-09 | Publication date: 2021-03-18
Score: 13.594319 | Text size: 86771 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
YUE, Jianbo [CN]; LU, Yingying [CN]
Publication date: 2021-01-13 | Patent publication No.: EP-3107543-B1 | Assignees: Versitech Limited [CN] | IPC: A61K31/5377; A61P35/00; A61P33/06; A61K31/337; A61K31/436; A61K31/513 | Oldest priority date: 2014-02-19 | Publication date: 2021-01-13
Score: 14.656486 | Text size: 53377 | Find: similar documents
Figure 14 shows a virtual screening strategy for vacuolin-1 analogue identification using ChemDiv.
Inhibitors of HIV-1 integrase multimerization
Mark D. Andrake [US]; Anna Marie Skalka [US]; George W. Merkel [US]
Publication date: 2021-01-12 | Patent publication No.: US-10888564-B2 | Assignees: Institute for Cancer Research [US] | IPC: A61K31/4245; A61K31/454; A61K31/53 | Oldest priority date: 2017-01-26 | Publication date: 2021-01-12
Score: 17.199627 | Text size: 54983 | Find: similar documents
formation (see FIG. 1B), and used it to screen the 50,000 compound chemical diversity library of ChemDiv, ltd. at 10 uM concentration. ... day were performed to screen the entire Chemical Diversity set of 50,000 compounds obtained from ChemDiv, Ltd.
PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
Vladimir L. Katanaev [CH]; Alexey Koval [CH]
Publication date: 2021-01-07 | Patent publication No.: US-20210002265-A1 | Assignees: Université de Lausanne [CH] | IPC: C07D405/14; A61P35/00; C07D405/10; C07D401/04 | Oldest priority date: 2018-03-02 | Publication date: 2021-01-07
Score: 19.328047 | Text size: 81564 | Find: similar documents
Compound Identification A commercial (ChemDiv Inc., San Diego, Calif., US) small molecule library (high-diversity GPCR-targeted compound library containing 1000 compounds selected by ChemDiv focusing on maximizing chemical diversity from the 40′000 GPCR-targeted compound library [see http://www.chemdiv.com, particularly http://www.chemdiv. ... overall chemical (Tanimoto) and substructural (via generalized structure search) similarity in the ChemDiv collection (ca. 1.5 mio compounds). The overall set of similars (ca. ... (106, F2-99) V006-4971 24.1 85.2 26 (108) V012-3790 16.5 72.7 27 (109) V008-3606 14.3 86.5 *ChemDiv library catalogue number Example 2: Structure of Identified Wnt Pathway Inhibitors TABLE 2:
Inhibitors of the plasmodial surface anion channel as antimalarials
Sanjay A. Desai [US]; Ajay D. Pillai [IN]
Publication date: 2021-01-05 | Patent publication No.: US-10881669-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/00; A61K31/553; A61K31/165; A61K31/4155; A61K31/423; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741; A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D403/08; C07D498/04; C07D263/57; C07D281/16; C07D413/14; C07D417/06; C07D491/048; C07D513/04; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2021-01-05
Score: 14.553114 | Text size: 52320 | Find: similar documents
methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England.
Method to detect activity of a polymerase
Tim Bergbrede [DE]; Nils-Göran Larsson [DE]; Claes Gustafsson [SE]; Maria Falkenberg-Gustafsson [SE]
Publication date: 2021-01-05 | Patent publication No.: US-10883137-B2 | Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE]; LEAD DISCOVERY CENTER GMBH [DE] | IPC: C12Q1/6818; C12Q1/68; C12Q1/6825; G01N33/542; G01N33/58; C12Q1/48 | Oldest priority date: 2015-05-29 | Publication date: 2021-01-05
Score: 13.077378 | Text size: 111794 | Find: similar documents
in the assay was 4-methyl-5-[2-(pyrimidin-2-ylamino)thiazol-4yl]thiazol-2-amine (available at ChemDiv) and is applied using contact-free acoustic droplet-dispensing (Labcyte Echo®) from 10 mM compound
AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR
HAQUE, Aftabul [US]; LINDQUIST, Susan L. [US]
Publication date: 2020-12-30 | Patent publication No.: EP-3155003-B9 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C07K14/47; C12N15/81; C12N15/85; G01N33/50 | Oldest priority date: 2014-06-13 | Publication date: 2020-12-30
Score: 12.913692 | Text size: 134804 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
CONE, Roger [US]; SWEENEY, Patrick [US]
Publication date: 2020-12-24 | Patent publication No.: WO-2020257662-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US] | IPC: A61P3/04; C07K7/06; A61K38/00 | Oldest priority date: 2019-06-19 | Publication date: 2020-12-24
Score: 11.738287 | Text size: 165775 | Find: similar documents
A screen was performed with a series of 4160 samples from the ChemDiv 100,000 compound diversity set maintained at CCG (Fig. 2D-F).
IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE
Phillip C. Liu [US]; Alla Volgina [US]; Richard Wynn [US]; Nina Zolotarjova [US]; Liangxing Wu [US]; Kaijiong Xiao [US]; Song Mei [US]; Liang Lu [US]; Wenyu Zhu [US]; Yingda Ye [US]; Haisheng Wang [US]; Ding-Quan Qian [US]; Wenqing Yao [US]
Publication date: 2020-12-24 | Patent publication No.: US-20200397893-A1 | Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61P37/00; A61P37/04; A61P35/00; A61K45/06; C07D213/81; C07D263/57; C07D413/06; C07D413/14; C07D471/04; C07D519/00; G01N33/50 | Oldest priority date: 2016-12-22 | Publication date: 2020-12-24
Score: 8.327448 | Text size: 635928 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
PHOSPHATIDYLSERINE DECARBOXYLASE INHIBITORS
BEN MAMOUN, Choukri [US]; HOYER, Denton [US]; PLUMMER, Mark [US]; THEKKINIATH, Jose [US]; VOELKER, Dennis R. [US]; CHOI, Jae-Yeon [US]
Publication date: 2020-12-24 | Patent publication No.: WO-2020257753-A1 | Assignees: YALE UNIVERSITY [US]; NATIONAL JEWISH HEALTH [US] | IPC: G01N21/64; A61K49/00; C12Q1/527; G01N21/63; G01N33/50 | Oldest priority date: 2019-06-20 | Publication date: 2020-12-24
Score: 12.59831 | Text size: 130889 | Find: similar documents
in Humans” Collection (Yale Center for Molecular Discovery), and bioactive collections from ChemDiv, ChemBridge, and Analyticon.
Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
Publication date: 2020-12-22 | Patent publication No.: US-10869865-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Serv [US] | IPC: A61K31/506; A61K31/496; A61K31/501; A61K45/06; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K31/423; A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date: 2011-04-12 | Publication date: 2020-12-22
Score: 15.999366 | Text size: 142367 | Find: similar documents
methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England. ... room temperature using a commercial library of 50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at
Publication date: 2020-12-17 | Patent publication No.: US-20200390740-A1 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]; UNIVERSITE DE LILLE [FR]; INSTITUT PASTEUR DE LILLE [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - [FR] | IPC: A61K31/353; A61K31/277; A61P1/00 | Oldest priority date: 2016-05-20 | Publication date: 2020-12-17
Score: 13.775837 | Text size: 87730 | Find: similar documents
Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (San Diego, Calif.), ChemDiv (San Diego, Calif.), SPECS (Delft, The Netherlands), Timtec (Newark, Del.
METHODS TO IDENTIFY MODULATORS OF ACTIN-BINDING PROTEINS
Adam William Avery [US]; Thomas S. Hays [US]; David D. Thomas [US]; Michael E. Fealey [US]; Robyn T. Rebbeck [US]
Publication date: 2020-12-17 | Patent publication No.: US-20200393445-A1 | Assignees: Regents of the University of Minnesota [US] | IPC: G01N33/50; G01N21/64 | Oldest priority date: 2019-06-11 | Publication date: 2020-12-17
Score: 13.245268 | Text size: 112512 | Find: similar documents
and include AM:RI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,
Molecules, compositions and methods for modulation of SIRT6
Haim Yosef Cohen [IL]; Yariv Kanfi [IL]
Publication date: 2020-12-08 | Patent publication No.: US-10857170-B1 | Assignees: SirTLab Corporation [IL] | IPC: A61K31/7048; A61K31/428 | Oldest priority date: 2015-12-31 | Publication date: 2020-12-08
Score: 19.510805 | Text size: 61276 | Find: similar documents
High Throughput Screening In the primary screening, compounds from a library (ChemDiv Inc.) were tested at a single concentration of 20 micromolar for their potential to modulate SIRT6 ... an internal identifier; column 2 gives the CAS number for the molecule while column 3 shows its ChemDiv ID; column 4 gives the molecular structure; and column 5 shows percent activity of the molecule in ... TABLE 1 # CAS number ChemDiv ID Structure% activity 20 uM% activity Max. conc. ... stereoisomer of molecule 768382-41-8 D715-0284 [[image:EMI-C00003]] 70 195 TABLE 2 # CAS numberChemDiv ID Structure% activity 20 uM% activity 100 uM 1 332173-46-3 2803-0068 [[image:EMI-C00004]] 88 428 2
Methods for treatment of retinal disease by photoreceptor gene expression modulation
Thomas A. Reh [US]; Paul Nakamura [US]; Sheng Ding [US]
Publication date: 2020-12-01 | Patent publication No.: US-10849904-B2 | Assignees: University of Washington [US]; The J. David Gladstone Institutes, a Teatamentary Trust Established Under the Will of J. David. Gladstone [US] | IPC: A61K31/519; C07D495/04; A61K31/426; A61K9/00; A61P27/02 | Oldest priority date: 2015-03-27 | Publication date: 2020-12-01
Score: 18.309502 | Text size: 64672 | Find: similar documents
(I) is CA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commercially available from ChemDiv (San Diego, Calif. ... (II) is CA9513: [[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially available from ChemDiv (San Diego, Calif. ... Nr2e3 interacting molecules specifically identified herein were obtained commercially from ChemDiv (San Diego, Calif.
AUTOPHAGY MODULATORS FOR USE IN TREATING CANCER
Melvin L. DePamphilis [US]; Gaurav Sharma [IN]; Juan Jose Marugan [US]; Marc Ferrer [US]; Ajit Roy [US]
Publication date: 2020-11-26 | Patent publication No.: US-20200369649-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: C07D403/12; C07D251/54; C07D239/50; A61P35/00 | Oldest priority date: 2017-12-01 | Publication date: 2020-11-26
Score: 12.913692 | Text size: 129680 | Find: similar documents
Materials and Methods Reagents Compounds 1, 4, 5, 3, and 2 (Specs, ChemDiv, Life Chemicals) and Rapamycin (S1039, Selleck Chemicals) were dissolved in dimethyl sulfoxide
PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR TREATMENT OF RETINAL DISEASE
Thomas A. Reh [US]; Paul Nakamura [US]; Andy Shimchuk [US]; Shibing Tang [CN]; Sheng Ding [US]
Publication date: 2020-11-26 | Patent publication No.: US-20200368234-A1 | Assignees: University of Washington [US]; The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J David Gladst [US] | IPC: A61K31/517; A61K9/00 | Oldest priority date: 2017-08-10 | Publication date: 2020-11-26
Score: 14.867696 | Text size: 40027 | Find: similar documents
It was initially obtained from ChemDiv and then synthesized and purified in large quantities in the lab after initial screening.
Methods to diagnose and treat attention-deficit, hyperactivity disorder (ADHD)
Joseph Glessner [US]; Josephine Elia [US]; Hakon Hakonarson [US]
Publication date: 2020-11-24 | Patent publication No.: US-10844434-B2 | Assignees: The Children's Hospital of Philadelphia [US] | IPC: C12Q1/6883; C12Q1/6876; A61K31/454 | Oldest priority date: 2010-08-24 | Publication date: 2020-11-24
Score: 10.759004 | Text size: 259413 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS
Steven Albert Everett [US]; Saraj Ulhaq [GB]
Publication date: 2020-11-19 | Patent publication No.: US-20200360521-A1 | Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54; A61K31/343; A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16; C07D311/18; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; C07D487/04; C07D491/22; A61K31/37; A61K31/381; A61K31/513; A61K31/52; A61K31/665 | Oldest priority date: 2009-05-01 | Publication date: 2020-11-19
Score: 16.116692 | Text size: 221424 | Find: similar documents
for CYP181 The target enzyme CYP1B1 was screened against two commercial libraries including the ChemDiv Diversity 50,000 test compound collection and the ChemDiv Kinase Targeted 10,000 test compound collection with a view to identifying activity differentiating ... cross validation on a training set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverse and Kinase libraries.
COMPOUNDS FOR TREATING DENGUE VIRUS INFECTION AND OTHER VIRAL INFECTIONS
Priscilla L. Yang [US]; Wenlong Lian [US]; Nathanael S. Gray [US]; Nicholas Paul Kwiatkowski [US]; Jinhua Wang [US]; Jaebong Jang [KR]
Publication date: 2020-11-19 | Patent publication No.: US-20200360381-A1 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; President and Fellows of Harvard College [US] | IPC: A61K31/5025; A61K31/4045; A61K31/416; A61K31/47; A61K31/277; A61K31/167; A61K31/53; A61P31/16 | Oldest priority date: 2017-05-15 | Publication date: 2020-11-19
Score: 10.759004 | Text size: 297179 | Find: similar documents
about 20,000 compounds at the concentration of 10 μM (Selleck Known Bioactive library) or 5 μg/ml (ChemDiv library) in duplicate were applied in the AlphaScreen based competition assay using automation
Piotr SLIZ [US]; Yunsun NAM [US]
Publication date: 2020-11-19 | Patent publication No.: US-20200362350-A1 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/113; A61K31/7105; A61K45/06; A61K31/7115; A61K31/712; A61K31/713; C07K14/47; A61K47/60; A61K47/64; C07H21/02 | Oldest priority date: 2011-11-09 | Publication date: 2020-11-19
Score: 10.328181 | Text size: 292964 | Find: similar documents
2, Prestwick 2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge 3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5. These libraries can be screened using the
Mark Fields [US]; Lucian Del Priore [US]; Huey Cai [US]; Denton Hoyer [US]
Publication date: 2020-10-29 | Patent publication No.: US-20200338081-A1 | Assignees: YALE UNIVERSITY [US] | IPC: A61K31/519; A61K47/40 | Oldest priority date: 2018-01-08 | Publication date: 2020-10-29
Score: 16.124392 | Text size: 102942 | Find: similar documents
As used herein, “compound 414” or “YU162779-01” refers to ChemDiv library compound number C325-0414, or a salt, solvate or hydrate thereof, having the formula: [[image:EMI-C00011]] As used herein, “compound 434” or “YU162787-01” refers to ChemDiv library compound number C325-0434, or a salt, solvate or hydrate thereof, having the
Hakonarson, Hakon [US]; Yun, Rose Li [US]; Keating, Brendan [US]
Publication date: 2020-10-28 | Patent publication No.: EP-3730188-A1 | Assignees: The Children's Hospital of Philadelphia [US] | IPC: A61P1/04; C12Q1/68 | Oldest priority date: 2016-04-08 | Publication date: 2020-10-28
Score: 9.22053 | Text size: 312243 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
ISOLATED HUMAN LUNG PROGENITOR CELLS AND USES THEREOF
RAJAGOPAL, Jayaraj [US]; MOU, Hongmei [US]
Publication date: 2020-10-28 | Patent publication No.: EP-2802647-B1 | Assignees: The General Hospital Corporation [US] | IPC: C12N5/071; C12N5/077; A61K35/42; A61P11/00; A61L27/38; A61L27/56; A61L27/58; A61K9/00; G01N33/68 | Oldest priority date: 2012-04-03 | Publication date: 2020-10-28
Score: 10.328181 | Text size: 254262 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
SINGH, Kailash [CN]; CHOW, Billy Kwok Chong [CN]
Publication date: 2020-10-22 | Patent publication No.: WO-2020211772-A1 | Assignees: VERSITECH LIMITED [CN] | IPC: A61K31/5377; A61P9/12 | Oldest priority date: 2019-04-16 | Publication date: 2020-10-22
Score: 13.245268 | Text size: 113705 | Find: similar documents
available small molecule libraries used include, but not limited to, PubChem, CHEMBL, MolProt, ChemDiv, ChemSpace, NCI open and ZINC.
METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA
David J. Tweardy [US]; Moses M. Kasembeli [US]; Marvin X. Xu [CN]; Thomas Kristian Eckols [US]
Publication date: 2020-10-22 | Patent publication No.: US-20200331880-A1 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D215/36; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/21; C07C311/24; C07C311/29; C07C311/44; C07C323/49; C07C381/06; A61K45/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513 | Oldest priority date: 2013-07-18 | Publication date: 2020-10-22
Score: 14.233541 | Text size: 272534 | Find: similar documents
Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.
25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC
OHE, Munemichi [JP]; INOUE, Naoki [JP]; LIMBAD, Chandani [US]; DOI, Ryosuke [US]
Publication date: 2020-10-22 | Patent publication No.: WO-2020214993-A1 | Assignees: BUCK INSTITUTE FOR RESEARCH ON AGING [US]; ASTELLAS PHARMA INC. [JP] | IPC: A61K31/352; A61K31/506 | Oldest priority date: 2019-04-19 | Publication date: 2020-10-22
Score: 8.902286 | Text size: 356441 | Find: similar documents
and real screening services are commercially available from a number of suppliers (see, e.g., ChemDiv (San Diego, CA), and the like).
Immunomodulator compounds and methods of use
Liang Lu [US]; Wenyu Zhu [US]; Ding-Quan Qian [US]; Kaijiong Xiao [US]
Publication date: 2020-10-20 | Patent publication No.: US-10806785-B2 | Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61P37/00; A61P37/04; A61P35/00; A61K45/06; C07D213/81; C07D263/57; C07D413/06; C07D413/14; C07D471/04; C07D519/00; G01N33/50; A61K39/00 | Oldest priority date: 2016-12-22 | Publication date: 2020-10-20
Score: 8.605278 | Text size: 618747 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bio net (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
PAK1 INHIBITORS AND USES THEREOF
Ulrich Steidl [US]; Ashley M. Eckel [US]; Robert F. Stanley [US]; Boris Rogovoy [US]; Ilya Okun [US]
Publication date: 2020-10-15 | Patent publication No.: US-20200323855-A1 | Assignees: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. [US] | IPC: A61K31/519; A61K31/437; A61K31/496; A61P35/00 | Oldest priority date: 2016-05-06 | Publication date: 2020-10-15
Score: 14.350686 | Text size: 67504 | Find: similar documents
Compounds were screened for PAK1 inhibition using a 50,024 compound library by ChemDiv (San Diego, Calif.
NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES
Publication date: 2020-10-14 | Patent publication No.: EP-3721877-A1 | Assignees: InFlectis BioScience [FR] | IPC: A61K31/155; A61K31/44; A61K31/53; A61P31/00; A61P29/00 | Oldest priority date: 2014-07-02 | Publication date: 2020-10-14
Score: 15.288118 | Text size: 154239 | Find: similar documents
& METHODS Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1 - Preparation of the compounds according to the present invention The reactants
PLASMINOGEN ACTIVATOR-1 INHIBITORS AND METHODS OF USE THEREOF
LAWRENCE, Daniel, A. [US]; EMAL, Cory [US]; REINKE, Ashley [US]; LI, Shih-Hon [US]; WARNOCK, Mark [US]; ABERNATHY, Gregory [US]
Publication date: 2020-10-14 | Patent publication No.: EP-2914575-B1 | Assignees: The Regents of The University of Michigan [US]; Eastern Michigan University [US] | IPC: C07C233/08; C07C233/05; A61K31/16; A61K31/165; C07C259/06; C07C271/16; C07C275/64; C07C69/84; C07C311/17; C07C311/29; C07D417/04; C07C323/60; C07D261/18; C07C235/34; C07D271/113; C07D277/34; C07C243/26; C07D207/48; C07C251/76; C07D209/08 | Oldest priority date: 2012-10-31 | Publication date: 2020-10-14
Score: 12.297968 | Text size: 143816 | Find: similar documents
Chemical Methodologies Libraries Development (Boston University), Maybridge, Chembridge, ChemDiv, National Cancer Institute-Development Therapeutics Program Library, the Cayman Cannabinoid and
High-throughput, high-precision methods for detecting protein structural changes in living cells
David D. Thomas [US]; Simon Joseph Gruber [US]; Razvan L. Cornea [US]; Gregory David Gillispie [US]; Kurt C. Peterson [US]; Seth Louis Robia [US]
Publication date: 2020-10-06 | Patent publication No.: US-10794898-B2 | Assignees: Regents of the University of Minnesota [US]; Loyola University Chicago [US] | IPC: G01N33/50; G01N21/64; G01N33/58 | Oldest priority date: 2014-01-17 | Publication date: 2020-10-06
Score: 12.913692 | Text size: 131545 | Find: similar documents
and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,
MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
John Schneekloth, JR. [US]; John Simmons [US]; Kenneth Felsenstein [US]; Beverly Mock [US]; Lindsey Saunders [US]; David Calabrese [US]; Elena Leon [US]
Publication date: 2020-10-01 | Patent publication No.: US-20200308128-A1 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Servic [US] | IPC: C07D307/84; A61K31/343; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496; A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 | Publication date: 2020-10-01
Score: 17.89937 | Text size: 186723 | Find: similar documents
20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... No.Peggy (% c-Myc expression compared to untreated) IC50 1 [[image:EMI-C00030]] Commercial: ChemDiv No. D089-0563 50% (at 10 μM) 7.6 μM 2 [[image:EMI-C00031]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:EMI-C00032]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:EMI-C00033]] Commercial: ChemDiv No. ... ChemBridge No. 6238398 69% (at 10 μM) 89% viability (at 10 μM) 12 [[image:EMI-C00041]] Commercial: ChemDiv No. D089-0350 43% (at 10 μM) 3.4 μM 13 [[image:EMI-C00042]] Commercial: Otava Chemical No.
TARGETING THE TLK1/NEK1 AXIS IN PROSTATE CANCER
Arrigo DeBENEDETTI [US]; Siddhant BHOIR [IN]; Vibha SINGH [US]; Javeena HUSSAIN [IN]; Rupesh CHIKHALE [GB]; Richard BRYCE [GB]; Sivapriya KIRUBAKARAN [IN]
Publication date: 2020-10-01 | Patent publication No.: US-20200306258-A1 | Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College [US] | IPC: A61K31/5415; A61K31/167; A61P35/00 | Oldest priority date: 2019-03-29 | Publication date: 2020-10-01
Score: 12.913692 | Text size: 104561 | Find: similar documents
The inventors have screened the Prestwick Library, partially the ChemDiv, and two proprietary libraries (10,000 compounds) for inhibitors of TLK with a high throughput
METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS
MURRY, Charles E. [US]; YANG, Xiulan [US]
Publication date: 2020-09-24 | Patent publication No.: WO-2020190939-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: A61K35/34; A61P9/00; A61P3/10; A61P3/04; A61P3/00 | Oldest priority date: 2019-03-18 | Publication date: 2020-09-24
Score: 10.759004 | Text size: 227455 | Find: similar documents
for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.
Megan Foley [US]; Bradley Tait [US]; Matthew Cullen [US]
Publication date: 2020-09-24 | Patent publication No.: US-20200299270-A1 | Assignees: Proteostasis Therapeutics, Inc. [US] | IPC: C07D403/06; C07D207/333; C07D207/337; C07D231/12; C07D249/06; C07D263/32; C07D275/02; C07D295/185; C07D333/20; C07D401/06; C07D405/06; C07D471/04; C07D333/22 | Oldest priority date: 2011-05-12 | Publication date: 2020-09-24
Score: 11.738287 | Text size: 208821 | Find: similar documents
Compound A47 (also shown below) was purchased from ChemDiv, San Diego, Calif.
SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)
LIST, Alan F. [US]; WEI, Sheng [US]
Publication date: 2020-09-23 | Patent publication No.: EP-3711484-A1 | Assignees: H. Lee Moffitt Cancer Center And Research Institute, Inc. [US] | IPC: A01N25/00; A61K39/00; C12P21/04 | Oldest priority date: 2014-04-10 | Publication date: 2020-09-23
Score: 11.477125 | Text size: 168410 | Find: similar documents
ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,
Methods for detecting protein-protein interactions
Stéphanie Cabantous [FR]; Faten Koraïchi [FR]; Gilles Favre [FR]
Publication date: 2020-09-22 | Patent publication No.: US-10782304-B2 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]; UNIVERSITÉ PAUL SABATIER TOULOUSE III [FR] | IPC: G01N33/68; G01N33/542; C07K16/18; C40B30/04; G01N33/50; G01N33/533 | Oldest priority date: 2015-06-24 | Publication date: 2020-09-22
Score: 13.417523 | Text size: 112605 | Find: similar documents
It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.
CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF
SAVVIDES, Savvas [BE]; VERSTRAETE, Kenneth [BE]
Publication date: 2020-09-17 | Patent publication No.: WO-2020182615-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE] | IPC: C12N9/88; C30B29/58 | Oldest priority date: 2019-03-08 | Publication date: 2020-09-17
Score: 13.594319 | Text size: 106637 | Find: similar documents
from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands).
NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES
Publication date: 2020-09-17 | Patent publication No.: US-20200289436-A1 | Assignees: InFlectis BioScience [FR] | IPC: A61K31/155; A61K31/44; A61K31/53 | Oldest priority date: 2014-07-02 | Publication date: 2020-09-17
Score: 15.288118 | Text size: 155351 | Find: similar documents
& Methods Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1—Preparation of the Compounds According to the Present Invention The reactants
Materials and method for inhibiting replication protein A and uses thereof
Publication date: 2020-09-15 | Patent publication No.: US-10774063-B2 | Assignees: Indiana University Research and Technology Corporation [US] | IPC: C07D401/04; A61P35/00; C07D403/04; C07D231/06; A61K45/06; A61K47/26; A61K47/38; C07D401/14; C07D413/14; A61K9/00 | Oldest priority date: 2014-11-13 | Publication date: 2020-09-15
Score: 13.775837 | Text size: 80367 | Find: similar documents
Chemical compounds, either purchased from ChemDiv or synthesized in the laboratory, were suspended in DMSO and titrated as detailed in each figure.
ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
Dan THEODORESCU [US]; Michael Fitzpatrick WEMPE [US]; David ROSS [US]; Chao YAN [US]; Phillip REIGAN [US]
Publication date: 2020-08-13 | Patent publication No.: US-20200255442-A1 | Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61P35/04; A61K45/06 | Oldest priority date: 2014-07-10 | Publication date: 2020-08-13
Score: 12.297968 | Text size: 143369 | Find: similar documents
The ChemDiv library [v2006.
GUEDAT, Philippe [FR]; BERTOLOTTI, Anne [GB]
Publication date: 2020-08-12 | Patent publication No.: EP-3115357-B1 | Assignees: United Kingdom Research and Innovation [GB]; InFlectis BioScience [FR] | IPC: C07C281/18; C07D253/075; C07D213/61; A61K31/155; A61K31/165; A61K31/216; A61K31/44; A61K31/53; A61K45/06; A61P3/10; A61P25/00; A61P25/16; A61P25/28; A61P35/00 | Oldest priority date: 2013-01-10 | Publication date: 2020-08-12
Score: 16.251385 | Text size: 108206 | Find: similar documents
EXAMPLES Methods & Materials Example 1 was purchased from Chemdiv ref: 1683-6588 Example 2 was purchased from Chembridge ref: 5173161 Example 4 was purchased from Enamine ref: Z49562642 Example 6 was purchased from Chemdiv ref: 1683-6502 Preparation of the compounds : used in the present invention The reactants and
Inhibitors of RAD52 recombination protein and methods using same
Publication date: 2020-08-11 | Patent publication No.: US-10738061-B2 | Assignees: Drexel University [US] | IPC: A61P35/00; A61K31/4188; A61K31/5377; A61K31/4741; A61K45/06; A61K31/55; A61K31/47; A61K31/4525; A61K31/496; A61K31/517; C07D491/056; C07D491/048; C07D471/04; C07D307/82; C07D495/04; C07D405/12; C07D239/95; C07D215/38 | Oldest priority date: 2015-06-04 | Publication date: 2020-08-11
Score: 12.59831 | Text size: 134936 | Find: similar documents
The compounds for confirmation analysis were purchased from Asinex Ltd., ChemBridge Co., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific Services Inc., InterBioScreen Ltd., Life Chemicals Inc.
Byeong Cheol AHN [KR]; Ji Min OH [KR]
Publication date: 2020-08-06 | Patent publication No.: US-20200246341-A1 | Assignees: Kyungpook National University Industry-Academic Cooperation Foundation [KR] | IPC: A61K31/519; A61P35/04 | Oldest priority date: 2017-10-20 | Publication date: 2020-08-06
Score: 14.9756 | Text size: 40797 | Find: similar documents
Among the TKI candidates, TKI-0266 was selected, purchased from Chemdiv (USA), dissolved in DMSO, and then stored at −80° C. 5. Protein Isolation and Western
COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL KILLER CELL ACTIVATION AND FUNCTION
Publication date: 2020-08-06 | Patent publication No.: WO-2020157750-A1 | Assignees: BAR ILAN UNIVERSITY [IL] | IPC: A61K31/7105; A61K35/17; A61K9/14; A61P35/00 | Oldest priority date: 2019-01-28 | Publication date: 2020-08-06
Score: 8.902286 | Text size: 338346 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Ft, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
PYRAZOLOPYRIMIDINE MODULATORS OF RAS GTPASE
GARLAND, William A. [US]; UNGASHE, Solomon B. [US]; YANOFSKY, Stephen D. [US]; LIAW, Philip [US]; LENNEK, Annie L. [US]
Publication date: 2020-08-06 | Patent publication No.: WO-2020159942-A1 | Assignees: TOSK, INC. [US] | IPC: C07D487/04; A61K31/519; A61P35/00 | Oldest priority date: 2019-01-29 | Publication date: 2020-08-06
Score: 12.59831 | Text size: 144424 | Find: similar documents
A library of over 16,000 distinct chemicals was purchased from ChemDiv, San Diego, CA.
AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR
HAQUE, Aftabul [US]; LINDQUIST, Susan L. [US]
Publication date: 2020-08-05 | Patent publication No.: EP-3155003-B1 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C07K14/47; C12N15/81; C12N15/85; G01N33/50 | Oldest priority date: 2014-06-13 | Publication date: 2020-08-05
Score: 12.913692 | Text size: 134796 | Find: similar documents
(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive
Use of aldehyde dehydrogenase as biomarker for beta-cell dysfunction and loss
Domenico Accili [US]; Ja Young Kim-Muller [US]
Publication date: 2020-08-04 | Patent publication No.: US-10732173-B2 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: G01N33/50; C12N5/071 | Oldest priority date: 2015-09-15 | Publication date: 2020-08-04
Score: 12.011612 | Text size: 258055 | Find: similar documents
Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed
Pyrazolopyrimidine Modulators of RAS GTPase
William A. Garland [US]; Solomon B. Ungashe [US]; Stephen D. Yanofsky [US]; Philip Liaw [US]; Annie L. Lennek [US]
Publication date: 2020-07-30 | Patent publication No.: US-20200239479-A1 | Assignees: Tosk, Inc. [US] | IPC: C07D487/04; A61P35/00 | Oldest priority date: 2019-01-29 | Publication date: 2020-07-30
Score: 12.59831 | Text size: 130836 | Find: similar documents
3 Identification of Structure 1 A library of over 16,000 distinct chemicals was purchased from ChemDiv, San Diego, Calif.
THEODORESCU, Dan [US]; WEMPE, Michael [US]; ROSS, David [US]; YAN, Chao [US]; REIGAN, Philip [US]
Publication date: 2020-07-29 | Patent publication No.: EP-3686202-A1 | Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61P35/00; A61P35/04 | Oldest priority date: 2014-07-10 | Publication date: 2020-07-29
Score: 12.297968 | Text size: 150328 | Find: similar documents
The ChemDiv library [v2006.
HUMAN PLURIPOTENT STEM CELL DERIVED ENDOCARDIAL ENDOTHELIUM
Charles E. Murry [US]; Lil Pabon [US]; Nathan Palpant [US]
Publication date: 2020-07-23 | Patent publication No.: US-20200231933-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: C12N5/077; A61K35/545 | Oldest priority date: 2016-02-19 | Publication date: 2020-07-23
Score: 10.759004 | Text size: 207588 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND
Okuyama, Masahiro [JP]; Fukunaga, Kenji [JP]; Usui, Kenji [JP]; Hayashi, Norimitsu [JP]; Iijima, Daisuke [JP]; Horiuchi, Hideki [JP]; Itagaki, Noriaki [JP]
Publication date: 2020-07-22 | Patent publication No.: EP-3683222-A1 | Assignees: Mitsubishi Tanabe Pharma Corporation [JP] | IPC: C07D513/04; C07D471/04; C07D487/04; C07D513/14; A61K31/437; A61K31/5025; A61K31/519; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00 | Oldest priority date: 2014-04-23 | Publication date: 2020-07-22
Score: 6.4525156 | Text size: 1029257 | Find: similar documents
sold by plural companies (e.g., AKos Consulting & Solutions GmbH, Ambinter, Aurora Fine Chemicals, ChemDiv, Inc.). However, a KAT-II inhibitory action and other pharmacological activities of these compounds have
Catherine TACHDJIAN [US]; Andrew P. PATRON [US]; Sara L. ADAMSKI-WERNER [US]; Farid BAKIR [US]; Qing CHEN [US]; Vincent DARMOHUSODO [US]; Stephen Terrence HOBSON [US]; Xiaodong LI [US]; Ming QI [CN]; Daniel H. ROGERS [US]; Marketa RINNOVA [US]; Guy SERVANT [US]; Xiao-Qing TANG [US]; Mark ZOLLER [US]; David WALLACE [US]; Amy XING [US]; Klaus GUBERNATOR [US]
Publication date: 2020-07-16 | Patent publication No.: US-20200225217-A1 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; A23L27/00; C07F9/655; C07D405/12; A61K47/24; A61K47/22; A61K8/55; A61K8/49; A23L2/56; G01N33/50; C07D307/82; C07D307/79; C07D307/68; C07D307/52; C07D213/40; C07D285/135; C07D209/42; C07D277/64; C07D209/08; C07D275/03; C07D271/12; C07D261/18; C07D417/12; C07D409/12; C07D401/04; C07D333/38; C07D333/24; C07D231/14; C07D217/06; C07D215/48; C07D213/85; C07D213/81; C07D263/56; A23L27/20; G01N33/74; G01N33/566; C07D317/68; C07D307/84; C07C275/34; C07C275/30; C07C235/54; C07C233/65 | Oldest priority date: 2003-08-06 | Publication date: 2020-07-16
Score: 9.562369 | Text size: 325239 | Find: similar documents
offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego CA, Chembridge of San Diego Calif.
XPA INHIBITOR COMPOUNDS AND THEIR USE
John J. TURCHI [US]; Navath GAVANDE [US]; Pamela S. VANDERVERE-CAROZZA [US]
Publication date: 2020-07-16 | Patent publication No.: US-20200222367-A1 | Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: A61K31/4155 | Oldest priority date: 2017-09-19 | Publication date: 2020-07-16
Score: 15.518069 | Text size: 174633 | Find: similar documents
Compound X80 (1) (FIG. 2A) and its commercially available analogs 2-24 were purchased from ChemDiv (San Diego, USA) and AKos GmbH (Steinen, Germany) library with highest purity (≥95%) and prepared ... binding pockets and identify inhibitors with improved potency, we first searched the virtual Chemdiv (San Diego, USA) and AKos GmbH (Steinen, Germany) library for X80 analogs with a criterion of
Therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies
Publication date: 2020-07-14 | Patent publication No.: US-10709677-B2 | Assignees: INFLECTIS BIOSCIENCE [FR] | IPC: A61K31/155; A61K31/44; A61K31/53 | Oldest priority date: 2014-07-02 | Publication date: 2020-07-14
Score: 15.288118 | Text size: 153760 | Find: similar documents
& Methods Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1—Preparation of the Compounds According to the Present Invention The reactants
METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS
CHEN, Beibei [US]; FINKEL, Toren [US]; LIU, Yuan [US]
Publication date: 2020-07-09 | Patent publication No.: WO-2020142748-A1 | Assignees: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US] | IPC: A61K31/519; C07D239/72; A61P25/00 | Oldest priority date: 2019-01-03 | Publication date: 2020-07-09
Score: 14.432653 | Text size: 245570 | Find: similar documents
The following compounds (free base) provided in Table 2 were obtained from commercial sources (ChemDIV, Inc. and Molport, Inc. ... The following compounds shown in Table 4 were purchased from ChemDIV, Inc.
COMPOSITIONS AND METHODS OF TREATMENT USING NICOTINAMIDE MONONUCLEOTIDE
Shin-ichiro Imai [US]; Alessia Grozio [US]
Publication date: 2020-07-09 | Patent publication No.: US-20200215087-A1 | Assignees: Washington University [US] | IPC: A61K31/706; A61K45/06; A61K48/00; A61P3/04; C12N15/86; G01N33/50; G01N33/68 | Oldest priority date: 2017-08-10 | Publication date: 2020-07-09
Score: 11.738287 | Text size: 160101 | Find: similar documents
media contending 0.2% DMSO (vehicle), 20 M EX527 (Cayman chemical, MI) or 20 M STK665401 (ChemDiv, cat #8018-9378; Sociali, G. et al., Eur. J. Med. Chem., 2015, 102, 530-539).
Materials for cathepsin B enhancement and methods of use
Publication date: 2020-07-07 | Patent publication No.: US-10702571-B2 | Assignees: The University of North Carolina at Pembroke [US] | IPC: A61K31/70; A61K31/27; A61K38/05; A61K31/352; C07K5/065; A61K45/06; A61P25/28; A61K9/00 | Oldest priority date: 2015-12-03 | Publication date: 2020-07-07
Score: 12.913692 | Text size: 106619 | Find: similar documents
Z-Phe-Pro-OH is commercially available from ChemDiv Inc. (San Diego, Calif., USA).
Piotr Sliz [US]; Yunsun Nam [US]
Publication date: 2020-07-07 | Patent publication No.: US-10704049-B2 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/113; A61K45/06; A61K47/60; C07K14/47; A61K47/64; C07H21/02; A61K48/00; A61K31/7105; A61K31/7115; A61K31/712; A61K31/713 | Oldest priority date: 2011-11-09 | Publication date: 2020-07-07
Score: 10.328181 | Text size: 297420 | Find: similar documents
2, Prestwick 2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge 3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5. These libraries can be screened using the
TAF1 inhibitors for the therapy of cancer
Sara Sdelci [AT]; Stefan Kubicek [AT]
Publication date: 2020-07-07 | Patent publication No.: US-10702518-B2 | Assignees: CeMM—Forschungszentrum für Molekulare Medizin GmbH [AT] | IPC: A61K31/4725; A61K31/5517; A61P35/00; C07D413/12; C07D217/26; C07D407/12; C07D401/12; A61K45/06; A61K31/44; A61K31/513; G01N33/50; G01N33/68; G01N33/574; A61K31/4433; A61K31/472; A61K31/22; A61K31/517 | Oldest priority date: 2016-02-15 | Publication date: 2020-07-07
Score: 10.759004 | Text size: 232763 | Find: similar documents
Compounds A2, A3, A4 and A5 were purchased from ChemDiv (San Diego, USA). Synthesis of all other analogs was carried out by Enamine Ltd.
Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
David J. Tweardy [US]; Moses M. Kasembeli [US]; Marvin X. Xu [CN]; Thomas Kristian Eckols [US]
Publication date: 2020-06-09 | Patent publication No.: US-10676455-B2 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/44; A61K31/194; C07C311/21; C07D215/36; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/24; C07C311/29; C07C311/44; C07C323/49; C07C381/06; A61K45/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513 | Oldest priority date: 2013-07-18 | Publication date: 2020-06-09
Score: 14.233541 | Text size: 273813 | Find: similar documents
Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.
Anti-cancer compounds targeting Ral GTPases and methods of using the same
Dan Theodorescu [US]; Michael Fitzpatrick Wempe [US]; David Ross [US]; Chao Yan [US]; Phillip Reigan [US]
Publication date: 2020-06-09 | Patent publication No.: US-10676480-B2 | Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61K45/06; A61P35/04 | Oldest priority date: 2014-07-10 | Publication date: 2020-06-09
Score: 12.59831 | Text size: 162784 | Find: similar documents
The ChemDiv library [v2006.
Methods and compositions for treating mesothelioma and small lung cancer that express midkine
Takuya Fukazawa [JP]; Jeffrey A. Whitsett [US]; Yutaka Maeda [US]
Publication date: 2020-06-02 | Patent publication No.: US-10668078-B2 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2020-06-02
Score: 14.656486 | Text size: 55756 | Find: similar documents
(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.
NETRIN- 1 AND DEPENDENCE RECEPTOR PROTEINS AND METHOD OF USE
Publication date: 2020-05-28 | Patent publication No.: US-20200165308-A1 | Assignees: UNIVERSITY OF MANITOBA [CA] | IPC: C07K14/475; C07K16/18; A61K39/395; C07K14/705; C07K14/47 | Oldest priority date: 2014-02-10 | Publication date: 2020-05-28
Score: 12.913692 | Text size: 130967 | Find: similar documents
and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,
Mayland Chang [US]; Shahriar Mobashery [US]; Edward Spink [GB]; Derong Ding [US]; Sebastian Testero [AR]; Erika Leemans [BE]; Marc Boudreau [US]
Publication date: 2020-05-26 | Patent publication No.: US-10662164-B2 | Assignees: University of Notre Dame du Lac [US] | IPC: A61K31/4245; C07D271/107; C07D413/04; C07D471/04; C07D271/06; C07F9/653 | Oldest priority date: 2014-09-25 | Publication date: 2020-05-26
Score: 15.288118 | Text size: 174083 | Find: similar documents
A library of 1.2 million drug-like compounds from the ChemDiv subset of the ZINC database (Irwin et al., J. Chem. Inf. Model. ... From these, 29 compounds were selected and purchased from ChemDiv for in vitro activity experiments. Syntheses.
Aviv Regev [US]; Vijay K. Kuchroo [US]; Chao Wang [US]
Publication date: 2020-05-21 | Patent publication No.: US-20200157237-A1 | Assignees: The Broad Institute, Inc. [US]; Massachusetts Institute of Technology [US]; The Brigham and Women's Hospital, Inc. [US] | IPC: C07K16/28; C07K16/30; C12N15/113; G01N33/50; G01N33/574; G16B50/30; G16H50/70 | Oldest priority date: 2017-05-25 | Publication date: 2020-05-21
Score: 6.7923617 | Text size: 644529 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES
Publication date: 2020-05-20 | Patent publication No.: EP-3164123-B1 | Assignees: InFlectis BioScience [FR] | IPC: A61K31/155; A61K31/44; A61K31/53; A61P9/10; A61P9/12; A61P3/04; A61P19/10 | Oldest priority date: 2014-07-02 | Publication date: 2020-05-20
Score: 15.288118 | Text size: 168703 | Find: similar documents
& METHODS Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1 - Preparation of the compounds according to the present invention The reactants
COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES
Publication date: 2020-05-20 | Patent publication No.: EP-3135672-B9 | Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36; C07D498/04; A61K31/4162; A61P35/00 | Oldest priority date: 2008-10-10 | Publication date: 2020-05-20
Score: 11.738287 | Text size: 207681 | Find: similar documents
Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE) or can be synthesized.
Small molecule inhibitors of USP1 deubiquitinating enzyme activity
Alan D. D'Andrea [US]; Gregory D. Cuny [US]; Ross L. Stein [US]; Marcie Glicksman [US]; April Case [US]; Jun Xian [US]; David Wilson [US]; Min Huang [CN]
Publication date: 2020-05-19 | Patent publication No.: US-10653676-B2 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; The Brigham and Women's Hospital, Inc. [US] | IPC: A61K31/423; C07D405/06; C07D263/60; A61K31/136; A61K31/472; A61K31/4725; A61K45/06; C07C225/30; C07D217/24 | Oldest priority date: 2010-04-30 | Publication date: 2020-05-19
Score: 11.738287 | Text size: 199526 | Find: similar documents
consists of known bioactive libraries, natural product libraries, and commercial libraries such as ChemDiv, ChemBridge, etc.
Richard Lifton [US]; Ute Scholl [DE]
Publication date: 2020-05-14 | Patent publication No.: US-20200147113-A1 | Assignees: The Rockefeller University [US] | IPC: A61K31/7048; G01N33/74 | Oldest priority date: 2017-05-18 | Publication date: 2020-05-14
Score: 20.795069 | Text size: 190171 | Find: similar documents
70.1 75.5 72.8 YU039827 Microsource 2300165 Amiodarone hydrochloride 77.8 65.9 71.8 YU200116 ChemDiv G281-2440 54.5 87.7 71.1 YU164429 ChemDiv D089-0725 65.8 75.6 70.7 YU182169 ChemDiv D393-0253 63.3 77.5 70.4 YU163288 ChemDiv C620-0363 70.5 68.6 69.5 YU164416 ChemDiv D089-0533 53.7 82.7 68.2 YU214875 ChemDiv L491-0661 84.0 52.1 68.1 YU165270 ChemDiv D297-0001 94.9 40.9 67.9 YU164350 ChemDiv D089-0310 81.9 50.4 66.1 YU039449 NCC SAM001246981 Indatraline 70.6 61.3 65.9 YU171244 ChemDiv 5340-0013 58.6 73.1 65.8 YU155938 ChemDiv 2434-0134 83.4 47.9 65.7 YU195274 ChemDiv F580-1522 74.6 49.9 62.3 YU156667 ChemDiv 3534-0434 68.1 56.0 62.0 YU164338 ChemDiv D089-0264 54.7 69.0 61.9 YU164351 ChemDiv D089-0311 77.7 44.0 60.8 YU164423 ChemDiv D089-0559 66.6 54.9 60.8 YU200600 ChemDiv G345-0648 84.
CFTR REGULATORS AND METHODS OF USE THEREOF
Alan S. VERKMAN [US]; Marc H. LEVIN [US]; Onur Cil [US]
Publication date: 2020-05-07 | Patent publication No.: US-20200140402-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C07D285/135; A61P27/04; A61P1/10; C07D417/12 | Oldest priority date: 2015-12-24 | Publication date: 2020-05-07
Score: 15.926296 | Text size: 420283 | Find: similar documents
was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.
1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER
BASTIAN, Jolie Anne [US]; CHEN, Jiehao [US]; COHEN, Jeffrey Daniel [US]; HENRY, James Robert [US]; MCMILLEN, William Thomas [US]; REAMAN, Bradley Earl [US]; RUBIO, Almudena [US]; SALL, Daniel Jon [US]; ZHAO, Gaiying [US]
Publication date: 2020-04-29 | Patent publication No.: EP-3468965-B1 | Assignees: Eli Lilly and Company [US] | IPC: C07D405/06; A61K31/4045; A61P35/00 | Oldest priority date: 2016-06-10 | Publication date: 2020-04-29
Score: 12.59831 | Text size: 133158 | Find: similar documents
of unlabeled 1-(2,4-difluorophenyl)-3-{[1-(phenylcarbonyl)-2,3-dihydro-1H-indol-5-yl]methyl}urea (ChemDiv, Cat# G714-0242) )100 μM to 50 nM
CHOI, Kang-Yell [KR]; CHOI, Sehee [KR]; SEO, Seol Hwa [KR]; KIM, Eunhwan [KR]
Publication date: 2020-04-23 | Patent publication No.: WO-2020079570-A1 | Assignees: CK BIOTECHNOLOGY CO. [KR] | IPC: A61K31/404; A61K9/107; A61K47/40; A61P3/00; A61P3/04; A61P3/10; A23L33/10 | Oldest priority date: 2018-10-15 | Publication date: 2020-04-23
Score: 15.755042 | Text size: 118797 | Find: similar documents
that inhibited the CXXC5–DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described ... delay growth plate senescence, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5–DVL interaction
COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION
MOELLERING, Raymond [US]; COUKOS, John [US]; LEE, Gihoon [US]; CHANG, Jae Won [US]; MUTLU, Gokhan [US]
Publication date: 2020-04-23 | Patent publication No.: WO-2020081446-A1 | Assignees: THE UNIVERSITY OF CHICAGO [US] | IPC: A61P35/04; C07D333/48 | Oldest priority date: 2018-10-14 | Publication date: 2020-04-23
Score: 15.518069 | Text size: 138489 | Find: similar documents
CBR-470-0 and CBR-581-9 were from ChemDiv. CBR-470- 1 (initially from ChemDiv as D470-2172) and related analogs were synthesized in house according to full methods described in
CHOI, Kang-Yell [KR]; SEO, Seol Hwa [KR]; KIM, Eunhwan [KR]
Publication date: 2020-04-23 | Patent publication No.: WO-2020079569-A1 | Assignees: CK BIOTECHNOLOGY CO. [KR] | IPC: A61K31/404; A61K9/107; A61K47/40; A61P3/00; A61P3/04; A61P3/10; A23L33/10 | Oldest priority date: 2018-10-15 | Publication date: 2020-04-23
Score: 15.628418 | Text size: 228572 | Find: similar documents
that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... Library size single compounds at 10 mM in DMSO Library composition Small molecules Source ChemDiv and Sigma LOP AC 1280 Screen Format 96-well black polystyrene plates Coneentration(s) tested ... of the CXXC5-DVL interface, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction
RNF41 as a biomarker predicting response to lenalidomide in non-del(5q) MDS
Publication date: 2020-04-07 | Patent publication No.: US-10612097-B2 | Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc. [US] | IPC: C12Q1/68; G01N33/574; C12Q1/6883; G01N33/573; A61K45/06; A61K31/454 | Oldest priority date: 2012-12-05 | Publication date: 2020-04-07
Score: 14.656486 | Text size: 45103 | Find: similar documents
Corporation (16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, Calif.
Human pluripotent stem cell derived endocardial endothelium
Charles E. Murry [US]; Lil Pabon [US]; Nathan Palpant [US]
Publication date: 2020-04-07 | Patent publication No.: US-10612002-B2 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: C12N5/00; C12N5/02; C12N5/077; A61K35/545 | Oldest priority date: 2016-02-19 | Publication date: 2020-04-07
Score: 10.759004 | Text size: 222748 | Find: similar documents
for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.
CFTR regulators and methods of use thereof
Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Sujin Lee [US]
Publication date: 2020-03-31 | Patent publication No.: US-10604492-B2 | Assignees: THE REGENTS OF THE UNIVERSTIY OF CALIFORNIA [US] | IPC: C07D251/52; C07D251/46; C07D403/04; A61K45/06; A61K31/53; A61K31/5377; A61K31/496; A61P27/04; A61P1/10; A61K31/55; C07D413/12 | Oldest priority date: 2015-12-24 | Publication date: 2020-03-31
Score: 15.221389 | Text size: 548871 | Find: similar documents
was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.
MYC G-quadruplex stabilizing small molecules and their use
John Schneekloth, Jr. [US]; John Simmons [US]; Kenneth Felsenstein [US]; Beverly Mock [US]; Lindsey Saunders [US]; David Calabrese [US]; Elena Leon [US]
Publication date: 2020-03-31 | Patent publication No.: US-10604499-B2 | Assignees: The United States of America as represented by the Secretary, Department of Health and Human Service [US] | IPC: C07D307/84; A61K31/343; A61P35/00; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496; A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 | Publication date: 2020-03-31
Score: 17.89937 | Text size: 191734 | Find: similar documents
20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... Catalog No.Peggy (% c-Myc expression compared to untreated IC50 1 [[image:EMI-C00029]] Commercial: ChemDiv No. D089-563 50% (at 10 μM) 7.6 μM 2 [[image:EMI-C00030]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:EMI-C00031]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:EMI-C00032]] Commercial: ChemDiv No. ... No. 6238398 69% (at 10 μM) 89% viability (at 10 μM) 12 [[image:EMI-C00040]] Commercial: ChemDiv No. D089-0350 43% (at 10 μM) 3.4 μM 13 [[image:EMI-C00041]] Commercial: Otava Chemical No.
Hans-Willem SNOECK [US]; Ya-Wen CHEN [US]
Publication date: 2020-03-26 | Patent publication No.: US-20200093959-A1 | Assignees: Hans-Willem SNOECK [US]; Ya-Wen CHEN [US] | IPC: A61L27/36; A61L27/38; G01N33/50; A61L27/52 | Oldest priority date: 2017-03-24 | Publication date: 2020-03-26
Score: 12.913692 | Text size: 154155 | Find: similar documents
(A division of Key Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego, Calif.; ChemDiv Inc, San Diego, Calif.; ChemRx Advanced Technologies, South San Francisco, Calif.; ComGenex Inc.
BRAIN OSTEOCALCIN RECEPTOR AND COGNITIVE DISORDERS
Gerard KARSENTY [US]; Arnaud OBRI [US]; Lori KHRIMIAN [US]
Publication date: 2020-03-05 | Patent publication No.: US-20200069775-A1 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: A61K38/23; A61P25/28; G01N33/68 | Oldest priority date: 2017-02-15 | Publication date: 2020-03-05
Score: 10.759004 | Text size: 254322 | Find: similar documents
Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed
COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES
BARBOUR, Jason [US]; OTT, David [US]
Publication date: 2020-02-27 | Patent publication No.: WO-2020041533-A1 | Assignees: SF17 THERAPEUTICS, INC. [US] | IPC: A61K31/135; A61K31/137; A61K31/165; A61P29/00 | Oldest priority date: 2018-08-21 | Publication date: 2020-02-27
Score: 13.245268 | Text size: 93189 | Find: similar documents
Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state.
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS
Hakon Hakonarson [US]; Dong Li [US]; Lifeng Tian [US]; Kenny Nguyen [US]; Patrick Sleiman [US]
Publication date: 2020-02-20 | Patent publication No.: US-20200056238-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61K31/4184; A61K31/4427; A61K31/4709; A61K31/501; A61K31/436; A61K31/519; A61K31/5377; A61P43/00 | Oldest priority date: 2016-08-31 | Publication date: 2020-02-20
Score: 12.011612 | Text size: 151277 | Find: similar documents
Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.
SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)
Alan F. List [US]; Sheng Wei [US]
Publication date: 2020-02-20 | Patent publication No.: US-20200055916-A1 | Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: C07K14/705; G01N33/68; A61K47/69; C07K19/00; A61K38/17 | Oldest priority date: 2013-07-05 | Publication date: 2020-02-20
Score: 11.477125 | Text size: 161706 | Find: similar documents
Corporation (16981 Via Taxon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, Calif.
COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES
Publication date: 2020-02-19 | Patent publication No.: EP-3135672-B1 | Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36; C07D498/04; A61K31/4162; A61P35/00 | Oldest priority date: 2008-10-10 | Publication date: 2020-02-19
Score: 11.738287 | Text size: 207682 | Find: similar documents
Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE) or can be synthesized.
LEGISA, Matic [SI]; LESNIK, Samo [SI]; KONC, Janez [SI]; SOLMAJER, Tomaz [SI]; VODOPIVEC, Tina [SI]; CAMERNIK, Katja [SI]; K POTOKAR, Urska [SI]; KAVCIC, Luka [SI]
Publication date: 2020-02-13 | Patent publication No.: WO-2020030613-A1 | Assignees: KEMIJSKI INSTITUT [SI] | IPC: A61K31/427; A61P35/00 | Oldest priority date: 2018-08-07 | Publication date: 2020-02-13
Score: 14.153812 | Text size: 66099 | Find: similar documents
and 18 potential PFK-P inhibitors were purchased from Enamine (1 -8), Chembridge (9-16) and ChemDiv (17 and 18) for in-depth testing (1 st generation of Inhibitors).
NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS
PHANSTIEL IV, Otto [US]; MOOTS, Holly [US]; MALONEY, Patrick [US]; HERSHBERGER, Paul [US]; PEDDIBHOTLA, Satyamaheshwar [US]
Publication date: 2020-02-13 | Patent publication No.: WO-2020033944-A2 | Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US]; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US] | IPC: A61K31/496 | Oldest priority date: 2018-08-10 | Publication date: 2020-02-13
Score: 17.002005 | Text size: 190919 | Find: similar documents
round of SAR was primarily fueled by 38 compounds, which were purchased from commercial vendors (ChemDiv) while a robust synthetic route was under development. ... In terms of toxicity profiles, compounds ChemDiv F687-0882 and ChemDiv F687-0884 and compounds 50 and 64 gave IC50 values >38 mM and were deemed relatively non-toxic.
Catherine Tachdjian [US]; Andrew P. Patron [US]; Sara L. Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; Vincent Darmohusodo [US]; Stephen Terrence Hobson [US]; Xiaodong Li [US]; Ming Qi [CN]; Daniel H. Rogers [US]; Marketa Rinnova [US]; Guy Servant [US]; Xiao-Qing Tang [US]; Mark Zoller [US]; David Wallace [US]; Amy Xing [US]; Klaus Gubernator [US]
Publication date: 2020-02-11 | Patent publication No.: US-10557845-B2 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82 | Oldest priority date: 2003-08-06 | Publication date: 2020-02-11
Score: 9.562369 | Text size: 375177 | Find: similar documents
offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif.
COMPOSITIONS AND METHODS FOR TARGETING A VIRAL INFECTION
CHEN, Bing [US]; FREY, Gary [US]; XIAO, Tianshu [US]
Publication date: 2020-01-30 | Patent publication No.: WO-2020023849-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4709 | Oldest priority date: 2018-07-27 | Publication date: 2020-01-30
Score: 13.489152 | Text size: 307779 | Find: similar documents
Asinex 1 (Winston-Salem, NC), Bionet (Ryan Scientific, Mount Pleasant, SC), CEREP (Redmond, WA), ChemDiv (San Diego, CA), and ChemBridge (San Diego, CA), ENAMINE (Ukraine), Life Chemicals (Burlington, ON, ... Asinex 1 (Winston-Salem, NC), Bionet (Ryan Scientific, Mount Pleasant, SC), CEREP (Redmond, WA), ChemDiv (San Diego, CA), and ChemBridge (San Diego, CA), ENAMINE (Ukraine), Life Chemicals (Burlington, ON,
USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE
DOWLING, David, J. [US]; LEVY, Ofer [US]; BORRIELLO, Francesco [US]; SCOTT, David, A. [US]; BRIGHTMAN, Spencer, E. [US]
Publication date: 2020-01-30 | Patent publication No.: WO-2020023872-A1 | Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE, INC. [US] | IPC: A01N43/04; A61K31/70 | Oldest priority date: 2018-07-27 | Publication date: 2020-01-30
Score: 12.211837 | Text size: 387085 | Find: similar documents
bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).
Methods for producing enteroendocrine cells that make and secrete insulin
Chutima Talchai [US]; Domenico Accili [US]
Publication date: 2020-01-28 | Patent publication No.: US-10544415-B2 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: C12N15/113; G01N33/50; A61K31/7088; A61K39/395; C12N5/071 | Oldest priority date: 2010-05-12 | Publication date: 2020-01-28
Score: 11.477125 | Text size: 206394 | Find: similar documents
Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed
MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
SCHNEEKLOTH, John, Jr. [US]; SIMMONS, John [US]; FELSENSTEIN, Kenneth [US]; MOCK, Beverly [US]; SAUNDERS, Lindsey [US]; GAREISS, Peter [US]; CALABRESE, David [US]; LEON, Elena [US]
Publication date: 2020-01-22 | Patent publication No.: EP-3597186-A1 | Assignees: The U.S.A. as represented by the Secretary, Department of Health and Human Services [US]; Yale University, Inc. [US] | IPC: A61K31/343; A61P35/00; C07D307/84 | Oldest priority date: 2015-01-05 | Publication date: 2020-01-22
Score: 18.024454 | Text size: 182184 | Find: similar documents
20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... No.Peggy (% c-Myc expression compared to untreated)IC50 1 [[image:ib0038]] Commercial: ChemDiv No. D089-0563 50% (at 10 μM) 7.6 μM 2 [[image:ib0039]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:ib0040]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:ib0041]] Commercial: ChemDiv No. D089-0559 73% (at 10 μM) 75% viability (at 10 μM) 5 [[image:ib0042]] Commercial: ChemBridge No.
Methods of treating muscular dystrophy
Dean Burkin [US]; Ryan Wuebbles [US]
Publication date: 2020-01-21 | Patent publication No.: US-10537553-B2 | Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; A61K45/06 | Oldest priority date: 2013-03-15 | Publication date: 2020-01-21
Score: 10.328181 | Text size: 367834 | Find: similar documents
et al., 2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds from the ChemDiv library. 3) LOPAC library (Sigma-RPI) consists of 1280 pharmaceutically active compounds.
Oxadiazole derivative and pharmaceutical containing same
Katsuhiko Yanagisawa [JP]; Akiyoshi Kawai [JP]
Publication date: 2020-01-21 | Patent publication No.: US-10538516-B2 | Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: C07D413/04; C07D413/14; C07D413/12; C07D413/06; C07D285/08; C07D285/12; C07D271/06; C07D271/10; A61K31/4196; A61K31/4709; A61K31/5377; A61K31/41; A61K31/4245; A61K31/4178 | Oldest priority date:&nbs