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ChemDiv in Publications and Patents

Identification of human phosphoglycerate mutase 1 (PGAM1) inhibitors using hybrid virtual screening approaches

Numan YousafRima D AlharthyMaryamIqra KamalMuhammad SaleemMuhammad Muddassar

PMC ID: PMC10084823 | DOI: 10.7717/peerj.14936 | ISSN: 2167-8359 | Journal: PeerJ, 11 Publication date: 2023 | Print publication date: 2023

Original document: Medline | Score: 10.21365 | Text size: 2227 | Find: similar documents

The best query model was then employed for performing shape, color, and electrostatics complementarity-based virtual screening of the ChemDiv database.

 

Identification of a novel small-molecule inhibitor targeting TIM-3 for cancer immunotherapy

Menghan WuAijun WuXiangrui ZhangYang LiBeibei LiShengzhe JinQingyu DongXiaoshuang NiuLihan ZhangXiaowen ZhouJiangfeng DuYahong WuWenjie ZhaiXiuman ZhouLu QiuYanfeng GaoWenshan Zhao

DOI: 10.1016/j.bcp.2023.115583 | ISSN: 1873-2968 | Journal: Biochemical pharmacology, 212 pp. 115583-115583 | Publisher: Elsevier Science | Publication date: 2023-05-04 | Print publication date: 2023-05-04

Original document: Medline | Score: 12.223339 | Text size: 1396 | Find: similar documents

Here, to identify small molecule inhibitors targeting TIM-3, the docking pocket in TIM-3 was analyzed by Molecular Operating Environment (MOE) and the Chemdiv compound database was screened.

 

Exploring allosteric hits of the NS2B-NS3 protease of DENV2 by structure-guided screening

Aditi GangopadhyayAchintya Saha

DOI: 10.1016/j.compbiolchem.2023.107876 | ISSN: 1476-928X | Journal: Computational biology and chemistry, 104 pp. 107876-107876 | Publisher: Elsevier | Publication date: 2023-04-29 | Print publication date: 2023-04-29

Original document: Medline | Score: 10.21365 | Text size: 2227 | Find: similar documents

This study aimed to identify serotype-specific hits against the allosteric site in the NS2B-NS3 protease of DENV serotype 2 (DENV2) from the Enamine, Selleck, and ChemDiv antiviral libraries.

 

Machine learning- and structure-based discovery of a novel chemotype as FXR agonists for potential treatment of nonalcoholic fatty liver disease

Tong QinXuefeng GaoLei LeiJing FengWenxuan ZhangYuhua HuZhufang ShenZhenming LiuYi HuanSong WuJie XiaLiangren Zhang

DOI: 10.1016/j.ejmech.2023.115307 | ISSN: 1768-3254 | Journal: European journal of medicinal chemistry, 252 pp. 115307-115307 | Publisher: Editions Scientifiques Elsevier | Publication date: 2023-03-27 | Print publication date: 2023-04-05

Original document: Medline | Score: 14.456684 | Text size: 2581 | Find: similar documents

To this end, we developed a multi-stage computational workflow to screen the Specs and ChemDiv chemical library for FXR agonists, which consisted of machine learning (ML)-based classifiers, shape-based and electrostatic-based models, a FRED-based molecular docking protocol, an ADMET prediction protocol and substructure search. ... As a result, we identified a novel chemotype that has never been reported before, with compound XJ02862 (ChemDiv ID: Y020-6413) as the representative.

 

Virtual Screening and In Vitro Experimental Verification of LuxS Inhibitors for Escherichia coli O157:H7

Yu-Bin BaiXiao-Rong YangBing LiXu-Zheng ZhouWei-Wei WangFu-Sheng ChengJi-Yu Zhang

PMC ID: PMC10100900 | DOI: 10.1128/spectrum.03502-22 | ISSN: 2165-0497 | Journal: Microbiology spectrum | Publisher: ASM Press | Publication date: 2023-02-21 | Print publication date: 2023-02-21

Original document: Medline | Score: 8.771491 | Text size: 2730 | Find: similar documents

High-affinity inhibitors were screened from the ChemDiv database (1,535,478 compounds) using LuxS as a ligand.

 

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Leah AmodRoxanne MohunlalNicole TeixeiraTimothy J EganKathryn J Wicht

PMC ID: PMC9929333 | DOI: 10.1038/s41598-023-29273-w | ISSN: 2045-2322 | Journal: Scientific reports, 13(1) pp. 2648-2648 | Publisher: Nature Publishing Group | Publication date: 2023-02-14 | Print publication date: 2023-02-14

Original document: Medline | Score: 13.557122 | Text size: 1349 | Find: similar documents

In this study, molecular docking and machine learning techniques, including Bayesian and support vector machine classifiers, were used in sequence to screen the in silico ChemDiv 300k Representative Compounds library for inhibitors of βH with retained activity against P. falciparum.

 

Identifying Dopamine D3 Receptor Ligands through Virtual Screening and Exploring the Binding Modes of Hit Compounds

Hongshan JinChengjun WuRui SuTiemin SunXingzhou LiChun Guo

PMC ID: PMC9862751 | DOI: 10.3390/molecules28020527 | ISSN: 1420-3049 | Journal: Molecules (Basel, Switzerland), 28(2) Publisher: MDPI | Publication date: 2023-01-05 | Print publication date: 2023-01-05

Original document: Medline | Score: 9.682976 | Text size: 2444 | Find: similar documents

All molecules in the ChemDiv library (>1,500,000) were narrowed down to a final set of 37 molecules for the binding assays.

 

Ligand-Based Drug Design of Novel Antimicrobials against Staphylococcus aureus by Targeting Bacterial Transcription

Jiqing YeXiao YangCong Ma

PMC ID: PMC9820117 | DOI: 10.3390/ijms24010339 | ISSN: 1422-0067 | Journal: International journal of molecular sciences, 24(1) Publisher: MDPI | Publication date: 2022-12-25 | Print publication date: 2022-12-25

Original document: Medline | Score: 10.8058605 | Text size: 2040 | Find: similar documents

The ligand-based models-including the pharmacophore model, 3D QSAR, AutoQSAR, and ADME/T calculation-were integrated and used in the following virtual screening of the ChemDiv PPI database.

 

Inhibiting the growth of ovarian cancer cells in vitro and in vivo by a small molecular inhibitor targeting La-RNA interactions

Yueyan LiXuan HuangJing Tang

DOI: 10.1016/j.ejphar.2022.175471 | ISSN: 1879-0712 | Journal: European journal of pharmacology, 940 pp. 175471-175471 | Publisher: Elsevier Science | Publication date: 2022-12-19 | Print publication date: 2023-02-05

Original document: Medline | Score: 9.682976 | Text size: 2238 | Find: similar documents

A docking virtual assay on the Chemdiv database was used to screen La binders, and their affinity were measured by surface plasmon resonance (SPR).

 

Molecular docking and dynamics guided approach to identify potential anti-inflammatory molecules as NRF2 activator to protect against drug-induced liver injury (DILI): a computational study

Ajay MiliSubham DasKrishnadas NandakumarRichard Lobo

DOI: 10.1080/07391102.2022.2141885 | ISSN: 1538-0254 | Journal: Journal of biomolecular structure & dynamics, pp. 1-18 | Publisher: Taylor & Francis | Publication date: 2022-11-03 | Print publication date: 2022-11-03

Original document: Medline | Score: 10.8058605 | Text size: 2007 | Find: similar documents

Acquiring and preparing the KEAP1-NRF2 Protein (PDB: 4L7D) with Schrodinger Suite was followed by developing a ligand library (Anti-inflammatory library downloaded from ChemDiv database).

 

Computational investigation of peptidomimetics as potential inhibitors of SARS-CoV-2 spike protein

Mayar Tarek IbrahimPeng Tao

PMC ID: PMC9971351 | DOI: 10.1080/07391102.2022.2116601 | ISSN: 1538-0254 | Journal: Journal of biomolecular structure & dynamics, pp. 1-14 | Publisher: Taylor & Francis | Publication date: 2022-08-29 | Print publication date: 2022-08-29

Original document: Medline | Score: 15.672428 | Text size: 1864 | Find: similar documents

Virtual screening of two different peptidomimetics databases, ChEMBL and ChemDiv databases, was carried out against both S1 and S2 subunits. ... Multi-layered filtration, based on physicochemical properties and docking scores, of nearly 114,000 compounds found in the ChEMBL database and nearly 14,000 compounds in the ChemDiv database was employed.

 

Prediction of novel and potent inhibitors of lanosterol 14-α demethylase

Mohd WaseemJitendra K ThakurNaidu Subbarao

DOI: 10.1080/07391102.2022.2096116 | ISSN: 1538-0254 | Journal: Journal of biomolecular structure & dynamics, pp. 1-13 | Publisher: Taylor & Francis | Publication date: 2022-07-09 | Print publication date: 2022-07-09

Original document: Medline | Score: 11.470976 | Text size: 1619 | Find: similar documents

In this study, we have screened a large number of small molecules from different chemical databases (ZINC, DrugBank, ChEMBL, and ChemDiv) to find out novel and potential inhibitors of LDM.

 

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity

Tanaporn UengwetwanitNopporn ChutiwitoonchaiKanin WichapongNitsara Karoonuthaisiri

PMC ID: PMC8813674 | DOI: 10.1016/j.csbj.2022.02.001 | ISSN: 2001-0370 | Journal: Computational and structural biotechnology journal, 20 pp. 882-890 | Publication date: 2022 | Print publication date: 2022

Original document: Medline | Score: 12.223339 | Text size: 1549 | Find: similar documents

Molecular docking was employed to screen inhibitors of SARS-CoV-2 from the ZINC ChemDiv database.

 

In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

Ziyi WangXuesong WangZhe GuoHaiyan LiaoYan ChaiZiwen WangZhong Wang

PMC ID: PMC9792167 | DOI: 10.3389/fcimb.2022.1050497 | ISSN: 2235-2988 | Journal: Frontiers in cellular and infection microbiology, 12 pp. 1050497-1050497 | Publisher: Frontiers Media SA | Publication date: 2022 | Print publication date: 2022

Original document: Medline | Score: 13.9169035 | Text size: 2549 | Find: similar documents

The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database (https://www.chemdiv.com/complete-list/) and use the system to screen for AKT1 activation agents, which may provide clues for the research and development of new drugs to treat SALI. ... Based on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency.

 

Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors

Gbolahan O OduseluRufus AfolabiIbitayo AdemuwagunAshley VaughanEzekiel Adebiyi

PMC ID: PMC9877529 | DOI: 10.3389/fmed.2022.1022429 | ISSN: 2296-858X | Journal: Frontiers in medicine, 9 pp. 1022429-1022429 | Publication date: 2022 | Print publication date: 2022

Original document: Medline | Score: 10.8058605 | Text size: 2191 | Find: similar documents

The best model of the tertiary structure of Pf 5-ALAS was obtained using MolProbity, while the following databases were explored for the pharmacophore-based virtual screening: CHEMBL, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC databases.

 

Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches

Sathya BabuSanthosh Kumar NagarajanSruthy SathishVir Singh NegiHonglae SohnThirumurthy Madhavan

PMC ID: PMC9068899 | DOI: 10.3389/fphar.2022.837369 | ISSN: 1663-9812 | Journal: Frontiers in pharmacology, 13 pp. 837369-837369 | Publication date: 2022 | Print publication date: 2022

Original document: Medline | Score: 9.204724 | Text size: 2774 | Find: similar documents

Based on the validation results, the best pharmacophore models ADHRRR, DDHRRR, DDRRR, DPRRR, DHRRR, ADRRR, DDHRR, and ADPRR were selected and taken for virtual screening against the Maybridge, Asinex, Chemdiv, Enamine, Lifechemicals, and Zinc database to identify the new molecules with novel scaffold that can bind to JAK1.

 

Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

Danfeng ShiQianqian PangQianyu QinXinsheng YaoXiaojun YaoYang Yu

PMC ID: PMC9638114 | DOI: 10.3389/fphar.2022.1026306 | ISSN: 1663-9812 | Journal: Frontiers in pharmacology, 13 pp. 1026306-1026306 | Publication date: 2022 | Print publication date: 2022

Original document: Medline | Score: 10.8058605 | Text size: 1952 | Find: similar documents

Four compounds (Chemdiv codes: 8012-0567, 8018-6529, 8018-7168, 8018-7603) were proved with above 40% inhibitory ratio targeting PARP-1 under 20 μM, and further performed binding mode prediction and dynamic effect evaluation by molecular dynamics simulation.

 

Virtual screening based on the structure of more than 105 compounds against four key proteins of SARS-CoV-2: MPro, SRBD, RdRp, and PLpro

Farzan NabatiAyshin KamyabiaminehRamin KosariFaezeh GhasemiSeyedehmasoumeh SeyedebrahimiSobhan MohammadiMohammad Moradi

PMC ID: PMC9652154 | DOI: 10.1016/j.imu.2022.101134 | ISSN: 2352-9148 | Journal: Informatics in medicine unlocked, 35 pp. 101134-101134 | Publication date: 2022 | Print publication date: 2022

Original document: Medline | Score: 10.8058605 | Text size: 1947 | Find: similar documents

We performed structure-based virtual screening (SBVS) of a library that was built from ChemDiv and PubChem databases against four SARS-CoV-2 target proteins: S-protein (spike), main protease (MPro), RNA-dependent RNA polymerase, and PLpro.

 

In silico identification and in vitro antiviral validation of potential inhibitors against Chikungunya virus

Jyoti VermaAbdul HasanSujatha SunilNaidu Subbarao

DOI: 10.1007/s10822-022-00463-4 | ISSN: 1573-4951 | Journal: Journal of computer-aided molecular design, 36(7) pp. 521-536 | Publisher: Springer | Publication date: 2022-07 | Print publication date: 2022-07

Original document: Medline | Score: 17.851965 | Text size: 2218 | Find: similar documents

Another potential inhibitor with ID ChemDiv 8015-3006 binds at both the target sites and shows anti-CHIKV activity at EC50 = 41 μM. ... The results show dose-dependent inhibitory effects of Taxifolin, Rutin and ChemDiv 8015-3006 against the CHIKV with minimal cytotoxicity. ... In conclusion, our study reports Taxifolin, Rutin and ChemDiv 8015-3006 as potential inhibitors of the CHIKV entry.

 

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays

Yaodong LiuSibtain AhmedYaowei FangMeng ChenJia AnGuang YangXiaoyue HouJing LuQinwen YeRongjun ZhuQitong LiuShu Liu

PMC ID: PMC9628821 | DOI: 10.4014/jmb.2201.01009 | ISSN: 1738-8872 | Journal: Journal of microbiology and biotechnology, 32(4) pp. 504-513 | Publisher: Korean Society for Microbiology and Biotechnology | Publication date: 2022-04-28 | Print publication date: 2022-04-28

Original document: Medline | Score: 12.637784 | Text size: 1540 | Find: similar documents

In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening.

MasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference

Olanrewaju Ayodeji DurojayeNkwachukwu Oziamara OkoroArome Solomon OdibaBennett Chima Nwanguma

PMC ID: PMC10141821 | DOI: 10.1038/s41598-023-33024-2 | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-04-28

Original document: PMC | Score: 9.797036 | Text size: 76768 | Find: similar documents

The chemical compound databases screened (based on pharmacophore-matching) include the CHEMBL30, ChemDiv, ChemSpace, Mcule, Mcule-ultimate, MolPort, NCI Open Chemical Repository, WuXi LabNetwork, and the ZINC databases. ... ChemDiv

 

Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors

Francesca CurreliKent ChauThanh-Thuy TranIsabella NicolauShahad AhmedPujita DasChristopher D. HillyerMary Premenko-LanierAsim K. DebnathYinzhong Shen

PMC ID: PMC10141620 | DOI: 10.3390/v15041001 | Journal: Viruses, 15(1) Publisher: MDPI | Publication date: 2023-04-19

Original document: PMC | Score: 7.26731 | Text size: 59967 | Find: similar documents

We screened a set of twenty-two small molecules, of which NBCoV35-37 were purchased from Chembridge Corporation (San Diego, CA, USA) and NBCoV62-82 were purchased from ChemDiv, Inc.

 

Exploring potential SARS-CoV-2 Mpro non-covalent inhibitors through docking, pharmacophore profile matching, molecular dynamic simulation, and MM-GBSA

Yunfan ShiLiting DongZhuang JuQiufu LiYanru CuiYiran LiuJiaoyu HeXianping Ding

PMC ID: PMC10100623 | DOI: 10.1007/s00894-023-05534-3 | ISSN: 1610-2940 | Journal: Journal of Molecular Modeling, 29(1) Publisher: Springer Berlin Heidelberg | Publication date: 2023-04-13 | Print publication date: 2023

Original document: PMC | Score: 13.953599 | Text size: 38164 | Find: similar documents

ChemDiv ID ... ChemDiv ID ... The database are from TargetMol and the compound files are from ChemDiv.

 

Identification of human phosphoglycerate mutase 1 (PGAM1) inhibitors using hybrid virtual screening approaches

Numan YousafRima D. AlharthyMaryamIqra KamalMuhammad SaleemMuhammad MuddassarPedro Silva

PMC ID: PMC10084823 | DOI: 10.7717/peerj.14936 | Journal: PeerJ, 11(1) | Publisher: PeerJ Inc. | Publication date: 2023-04-07

Original document: PMC | Score: 15.234975 | Text size: 50044 | Find: similar documents

The best query model was then employed for performing shape, color, and electrostatics complementarity-based virtual screening of the ChemDiv database. ... Chemdiv database was prepared by implementing drug like filter criteria to remove unwanted chemical structures, duplicates and salts. ... Toxicological and pharmacokinetics studies were conducted on virtually screened compounds mined from Chemdiv database by using online tool PreADMETv.2.0 (https://preadmet.bmdrc.kr/adme/) (Lee et al., 2004; Lee et al., 2003). ... After generating optimized query model, the Chemdiv database was screened by matching the query features with its compounds.

 

VSFlow: an open-source ligand-based virtual screening tool

Sascha JungHelge VatheuerPaul Czodrowski

PMC ID: PMC10064649 | DOI: 10.1186/s13321-023-00703-1 | Journal: Journal of Cheminformatics, 15(1) | Publisher: Springer International Publishing | Publication date: 2023-03-31

Original document: PMC | Score: 10.434273 | Text size: 24957 | Find: similar documents

The web tool SwissSimilarity allows for the 2D fingerprint and 3D shape screening of common public databases and compound libraries of most commercial vendors such as Enamine or ChemDiv [15, 16].

 

Computational Approaches Drive Developments in Immune-Oncology Therapies for PD-1/PD-L1 Immune Checkpoint Inhibitors

Patrícia S. SobralVanessa C. C. LuzJoão M. G. C. F. AlmeidaPaula A. VideiraFlorbela PereiraJean Christopher ChamcheuJean Fotie

PMC ID: PMC10054797 | DOI: 10.3390/ijms24065908 | Journal: International Journal of Molecular Sciences, 24(1) Publisher: MDPI | Publication date: 2023-03-21

Original document: PMC | Score: 5.9023848 | Text size: 87828 | Find: similar documents

Lyu et al. [85] aimed to identify novel inhibitors by using a structure-based virtual screening approach, retrieving about 500 molecules with a high binding affinity from the Chemdiv-Plus database.

 

Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface

Hassina MassudiJie-Si LuoJessica K. HolienSatyanarayana GaddeSukriti KrishanMika HerathJessica KoachBrendan W. StevensonMichael A. GormanPooja VenkatChelsea MayohXue-Qun LuoMichael W. ParkerBelamy B. CheungGlenn M. MarshallVladimir Spiegelman

PMC ID: PMC10046377 | DOI: 10.3390/cancers15061822 | Journal: Cancers, 15(1) | Publisher: MDPI | Publication date: 2023-03-17

Original document: PMC | Score: 7.26731 | Text size: 60232 | Find: similar documents

All compounds were purchased from Chemdiv (

 

Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

Beatrice BalboniFrancesco RinaldiViola PrevitaliAndrea CiamaroneStefania GirottoAndrea CavalliJohn J. Turchi

PMC ID: PMC10046612 | DOI: 10.3390/cancers15061817 | Journal: Cancers, 15(1) | Publisher: MDPI | Publication date: 2023-03-17

Original document: PMC | Score: 8.771591 | Text size: 94741 | Find: similar documents

Virtual screening (docking – PDB: 5JRB ssDNA groove: 47,737 cpds Targeted Diversity Library (TDL) – Chemdiv database, DOCK6.5 software) ... Virtual screening (docking – PDB: 5JRB self-association pocket: 66,608 cpds - Chemdiv database, DOCK6.5 software)

 

Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads

Siyun YangSupratik Kar

PMC ID: PMC9993391 | DOI: 10.1007/s11224-023-02148-6 | ISSN: 1040-0400 | Journal: Structural Chemistry, pp. 1-19 | Publisher: Springer US | Publication date: 2023-03-08

Original document: PMC | Score: 7.26731 | Text size: 59496 | Find: similar documents

In this study, 8722 chemical entities were collected from Asinex-Antiviral Library, 3700 compounds were collected from Enamine-Antiviral Library, and 67,470 molecules were taken from ChemDiv-Antiviral Library.

 

Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer

Weitao FuHao YangChenxian HuJianing LiaoZhou GongMinkui ZhangShuai YangShangxiang YeYixuan LeiRong ShengZhiguo ZhangXiaojun YaoChun TangDan LiTingjun Hou

PMC ID: PMC10141604 | DOI: 10.1021/acscentsci.2c01548 | ISSN: 2374-7943 | Journal: ACS Central Science, 9(1) pp. 675-684 | Publisher: American Chemical Society | Publication date: 2023-03-08

Original document: PMC | Score: 9.110828 | Text size: 35835 | Find: similar documents

Through compound library filtering using Lipinski’s rule-of-five, cascade molecular docking, and structural clustering, a total of 476 structurally diverse compounds were screened out from the ChemDiv database (∼1.6 million compounds) and submitted for AR transcriptional activity assay.

 

Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis

Zachariah P. SchuursJohn P. McDonaldLaura V. CroftDerek J. RichardRoger WoodgateNeha S. Gandhi

PMC ID: PMC10020695 | DOI: 10.3389/fcimb.2023.1051602 | Journal: Frontiers in Cellular and Infection Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2023-03-03

Original document: PMC | Score: 17.08099 | Text size: 69792 | Find: similar documents

A structure-based virtual screening was performed with the ChemDiv library peptidomimetics of β-turn motifs (ChemDiv, 2019). ... The top 53 compounds were subsequently ordered from ChemDiv to test in vitro. ... The ChemDiv libraries Covalent Generic and Smart Inhibitors (ChemDiv, 2020) was docked to the WT LexA using the CovDock (Toledo Warshaviak et al., 2014; Zhu et al., 2014) workflow in the Schrödinger Maestro suite 2019-4. ... The 80 top scoring compounds were ordered from ChemDiv (San Diego, CA). ... A total of 133 compounds from the two screens were ordered from ChemDiv (San Diego, CA), which consisted of 80 molecules from the covalent screen, and 53 molecules from the β-turn library. ... ChemDiv. ... ChemDiv.

 

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders

Ibitayo Abigail AdemuwagunGbolahan Oladipupo OduseluSolomon Oladapo RotimiEzekiel Adebiyi

PMC ID: PMC9989394 | DOI: 10.1177/11779322231158254 | Journal: Bioinformatics and Biology Insights, 17(1) | Publisher: SAGE Publications | Publication date: 2023-03-02

Original document: PMC | Score: 8.495119 | Text size: 43363 | Find: similar documents

The Pharmit web server was configured to include best hits from the following databases: PubChem, MCULE, ZINC database, MolPort, CHEMBL30, ChemDiv, ChemSpace, MCULE-ULTIMATE, NCI Open Chemical Repository, and LabNetwork.13 Specifically, the following features were used as thresholds to filter databases in accordance with Lipinski rule of 5, Veber, Ghose, Egan, and Muegge rules.14-17 These include molecular weight ⩽ 500 g, number of rotable bonds ⩽ 10, logP (octanol-water partition coefficient) value ⩽ 5, topological polar surface area (TPSA) ⩽ 140 Å, hydrogen bonds acceptor ⩽ 10, hydrogen bonds donor ⩽ 5, and number of aromatics ⩽ 2.17

 

Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro

Sheli R. RadoshitzkyPatrick IversenXianghan LuJing ZouSuzanne J. F. KapteinKelly S. StuthmanSean A. Van TongerenJesse SteffensRuoyu GongHoa TruongAnnapurna A. SapreHuiling YangXiaodong XieJia Jun ChiaZhijuan J. SongStacey M. LeventhalJosolyn ChanAlex ShornikovXin ZhangDavid CowferHelen YuTravis WarrenTomas CihlarDanielle P. PorterJohan NeytsPei-Yong ShiJay WellsJohn P. BilelloJoy Y. Feng

PMC ID: PMC9950143 | DOI: 10.1038/s41598-023-29517-9 | Journal: Scientific Reports, 13(1) Publisher: Nature Publishing Group UK | Publication date: 2023-02-23

Original document: PMC | Score: 6.8701305 | Text size: 70342 | Find: similar documents

E864-0360 was purchased from ChemDiv (San Diego, CA).

 

Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay

Anice Sabag-DaigleErin F. BoulangerPankajavalli ThirugnanasambanthamJamison D. LawAlex J. BogardEdward J. BehrmanVenkat GopalanBrian M. M. AhmerCarlos J. Blondel

PMC ID: PMC10100877 | DOI: 10.1128/spectrum.04606-22 | Journal: Microbiology Spectrum, 11(1) Publisher: American Society for Microbiology | Publication date: 2023-02-21

Original document: PMC | Score: 13.455724 | Text size: 46886 | Find: similar documents

ChemDiv ... ChemDiv ... ChemDiv

 

Virtual Screening and In Vitro Experimental Verification of LuxS Inhibitors for Escherichia coli O157:H7

Yu-Bin BaiXiao-Rong YangBing LiXu-Zheng ZhouWei-Wei WangFu-Sheng ChengJi-Yu ZhangLivnat Afriat-Jurnou

PMC ID: PMC10100900 | DOI: 10.1128/spectrum.03502-22 | Journal: Microbiology Spectrum, 11(1) Publisher: American Society for Microbiology | Publication date: 2023-02-21

Original document: PMC | Score: 15.859128 | Text size: 58848 | Find: similar documents

High-affinity inhibitors were screened from the ChemDiv database (1,535,478 compounds) using LuxS as a ligand. ... The present study screened quorum-sensing inhibitors (QSIs) from the ChemDiv database (1,535,478 compounds). ... A virtual screening was performed using the FRED software, where multiple conformations of each compound from the ChemDiv database (1,535,478 compounds, version 2019; ChemDiv, San Diego, CA) were docked to the LuxS pocket. ... Through the rigid docking strategy, 682 compounds with high affinity were screened from the ChemDiv database. ... The ChemDiv database, a commercially available small-molecule database from Shanghai TopScience Biotechnology Co. with more than 1 million compounds, was used as the screening library.

 

Phosphomevalonate Kinase Controls β‐Catenin Signaling via the Metabolite 5‐Diphosphomevalonate

Zhiqiang ChenXinyi ZhouXiaojun ZhouYi TangMingzhu LuJianhong ZhaoChenhui TianMingzhi WuYanliang LiuEdward V. ProchownikFubing WangYoujun Li

PMC ID: PMC10131864 | DOI: 10.1002/advs.202204909 | Journal: Advanced Science, 10(1) Publisher: John Wiley and Sons Inc. | Publication date: 2023-02-21

Original document: PMC | Score: 12.559463 | Text size: 63715 | Find: similar documents

Using a virtual screen, we identified the putative PMVK inhibitor top 5 (PMVKi5) (C24H23ClN2O6,N‐[(E)‐[3‐[(4‐chloro‐3,5‐dimethylphenoxy)methyl]‐4‐methoxyphenyl]methylideneamino]‐3,4,5‐trihydroxybenzamide) from a library of 1.7 million ChemDiv small molecule compounds (Figure 7A). ... The PMVK‐based crystal structure (PDB: 3CH4) was used for computer‐based virtual docking of 1.7 million small molecules from the ChemDiv database. ... Small molecules were downloaded from the ChemDiv database (https://www.chemdiv.com).

 

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

Chia-Ju HsiehSam GiannakouliasE. James PeterssonRobert H. MachIrina Velikyan

PMC ID: PMC9964981 | DOI: 10.3390/ph16020317 | Journal: Pharmaceuticals, 16(1) | Publisher: MDPI | Publication date: 2023-02-18

Original document: PMC | Score: 11.418604 | Text size: 78038 | Find: similar documents

[62,63], WuXi AppTec [64], ChemDiv Inc. ... ChemDiv Compound Libraries ... 1.5 M/ChemDiv

 

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Leah AmodRoxanne MohunlalNicole TeixeiraTimothy J. EganKathryn J. Wicht

PMC ID: PMC9929333 | DOI: 10.1038/s41598-023-29273-w | Journal: Scientific Reports, 13(1) Publisher: Nature Publishing Group UK | Publication date: 2023-02-14

Original document: PMC | Score: 17.088491 | Text size: 40062 | Find: similar documents

In this study, molecular docking and machine learning techniques, including Bayesian and support vector machine classifiers, were used in sequence to screen the in silico ChemDiv 300k Representative Compounds library for inhibitors of βH with retained activity against P. falciparum. ... The ChemDiv 300k Representative Compounds library was initially filtered for druglikeness using Lipinski’s Rule of Five and OSIRIS DataWarrior’s24 inhouse score. ... Virtual screening of the ChemDiv 300k Representative Compounds library and prioritisation of in-silico hits for purchasing and experimental testing against βH and whole-cell cultures of Pf. ... 40.ChemDiv Inc. http://www.chemdiv.com/. ... (ChemDiv Inc.).

 

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity

Melissa L. SykesEmily K. KennedyVicky M. AveryKatharine Carter

PMC ID: PMC9967867 | DOI: 10.3390/microorganisms11020476 | Journal: Microorganisms, 11(1) Publisher: MDPI | Publication date: 2023-02-14

Original document: PMC | Score: 6.1931806 | Text size: 80014 | Find: similar documents

Ethyl oxo{[2-(4-phenyl-1-piperazinyl)-2-(3-pyridinyl)ethyl]amino} acetate: 20 mM (E155-0206; Chemdiv, San Diego, CA, USA).

 

In Silico Discovery of Small Molecule Modulators Targeting the Achilles’ Heel of SARS-CoV-2 Spike Protein

Qing WangFanhao MengYuting XieWei WangYumin MengLinjie LiTao LiuJianxun QiXiaodan NiSanduo ZhengJianhui HuangNiu Huang

PMC ID: PMC9924089 | DOI: 10.1021/acscentsci.2c01190 | ISSN: 2374-7943 | Journal: ACS Central Science | Publisher: American Chemical Society | Publication date: 2023-02-08

Original document: PMC | Score: 6.8701305 | Text size: 64011 | Find: similar documents

Our in-house compound library for virtual screening was constructed from the ChemDiv database (

Sorafenib/2800Z Co-Loaded into Cholesterol and PEG Grafted Polylysine NPs for Liver Cancer Treatment

Chen ZhangWu ZhongYing CaoBohao LiuXiaojun TaoZhuan LiSilviya Zustiak

PMC ID: PMC9865580 | DOI: 10.3390/ph16010119 | Journal: Pharmaceuticals, 16(1) Publisher: MDPI | Publication date: 2023-01-13

Original document: PMC | Score: 7.957362 | Text size: 50224 | Find: similar documents

Sorafenib (BAY 43–9006) was purchased from Selleck Chemicals (Shanghai, China), and 2800Z was purchased from Chemdiv (San Diego, CA, USA).

 

Opportunities and challenges in application of artificial intelligence in pharmacology

Mandeep KumarT. P. Nhung NguyenJasleen KaurThakur Gurjeet SinghDivya SoniRandhir SinghPuneet Kumar

PMC ID: PMC9838466 | DOI: 10.1007/s43440-022-00445-1 | ISSN: 1734-1140 | Journal: Pharmacological Reports, pp. 1-16 | Publisher: Springer International Publishing | Publication date: 2023-01-09

Original document: PMC | Score: 6.5141163 | Text size: 77691 | Find: similar documents

It is built on six datasets collected from the ChEMBL database (EGFR inhibitors); the DNN model also obtained high performance in comparison with the RF method by cross-validation or screening a large compound library (PubChem, ChemDiv database) [87].

 

Identifying Dopamine D3 Receptor Ligands through Virtual Screening and Exploring the Binding Modes of Hit Compounds

Hongshan JinChengjun WuRui SuTiemin SunXingzhou LiChun GuoDmitri B. Kireev

PMC ID: PMC9862751 | DOI: 10.3390/molecules28020527 | Journal: Molecules, 28(1) Publisher: MDPI | Publication date: 2023-01-05

Original document: PMC | Score: 15.354868 | Text size: 59245 | Find: similar documents

All molecules in the ChemDiv library (>1,500,000) were narrowed down to a final set of 37 molecules for the binding assays. ... The molecules in the ChemDiv compound database (consisting of 1,535,478 compounds at the time this study was initiated) were analyzed by molecular docking using the AutoDock Vina package in short-searching mode. ... Bioinformatics software, such as AutoDock Vina [10], Schrödinger [25], and Pymol [26] and online resources, such as the National Center for Biotechnology Information [27] and ChemDiv Database ( ... ChemDiv in-stock diverse collection database (downloaded from ... Parametric ChemDiv compounds (recorded in PDBQT files) were docked to the ligand-binding site of D3R with AutoDock Vina using the short docking mode and other conFigureurations described in Section 2.1.3.

 

Targeting SOST using a small-molecule compound retards breast cancer bone metastasis

Lisha SunYixiao ZhangGuanglei ChenYaoting JiQingtian MaXinbo QiaoSijin WuLin ZhouJiawen BuXudong ZhuXiaoying ZhangXiaofan JiangChao LiuXinnan LiYang LiuYongliang YangCaigang Liu

PMC ID: PMC9798707 | DOI: 10.1186/s12943-022-01697-4 | Journal: Molecular Cancer, 21(1) Publisher: BioMed Central | Publication date: 2022-12-29

Original document: PMC | Score: 7.26731 | Text size: 57449 | Find: similar documents

S6 (C29H24N6O2S, molecular weight 520.62, Chemdiv, USA) was dissolved in PBS and adjusted to different concentrations for BLI.

 

Huanglongbing Pandemic: Current Challenges and Emerging Management Strategies

Dilip GhoshSunil KokaneBrajesh Kumar SavitaPranav KumarAshwani Kumar SharmaAli OzcanAmol KokaneSwadeshmukul SantraSubhas HajeriMadhurababu Kunta

PMC ID: PMC9824665 | DOI: 10.3390/plants12010160 | Journal: Plants, 12(1) | Publisher: MDPI | Publication date: 2022-12-29

Original document: PMC | Score: 3.1194367 | Text size: 225215 | Find: similar documents

The identified compound ChemDiv C549-0604 specifically inhibits the activity of CLas transcription regulator VisN [161,162,163,164,165], which suggests that the small lead molecules that target transcription regulators of CLas can potentially mitigate HLB.

 

Identification of probable inhibitors for the DNA polymerase of Monkeypox virus through the virtual screening approach

Swati KumariSayan ChakrabortyMohammed AhmadVarun KumarPrafullakumar B. TailorBichitra K. Biswal

PMC ID: PMC9794403 | DOI: 10.1016/j.ijbiomac.2022.12.252 | ISSN: 0141-8130 | Journal: International Journal of Biological Macromolecules | Publisher: Elsevier B.V. | Publication date: 2022-12-28

Original document: PMC | Score: 11.093979 | Text size: 53650 | Find: similar documents

To identify MPXV DPol specific inhibitors, we screened two compound libraries: drug-like molecules (available at ZINC database [41]) and the antiviral annotated library (ChemDiv, available at https://www.chemdiv.com/catalog/sets/Antiviral annotated-library/). ... In this study, about 7.5 million drug-like compounds from the ZINC database and 21,667 antiviral annotated compounds from ChemDiv Library were virtually screened for identifying the molecule with potential drug-like features.

 

Ligand-Based Drug Design of Novel Antimicrobials against Staphylococcus aureus by Targeting Bacterial Transcription

Jiqing YeXiao YangCong MaGiulio Vistoli

PMC ID: PMC9820117 | DOI: 10.3390/ijms24010339 | Journal: International Journal of Molecular Sciences, 24(1) | Publisher: MDPI | Publication date: 2022-12-25

Original document: PMC | Score: 11.093979 | Text size: 52980 | Find: similar documents

The ligand-based models—including the pharmacophore model, 3D QSAR, AutoQSAR, and ADME/T calculation—were integrated and used in the following virtual screening of the ChemDiv PPI database. ... The selected pharmacophore model was used for pharmacophore-based virtual screening of a focused compounds library from ChemDiv containing 222,447 molecules.

 

Anti-tuberculosis drug development via targeting the cell envelope of Mycobacterium tuberculosis

Xinyue XuBaoyu DongLijun PengChao GaoZhiqun HeChuan WangJumei Zeng

PMC ID: PMC9810820 | DOI: 10.3389/fmicb.2022.1056608 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-21

Original document: PMC | Score: 7.26731 | Text size: 59469 | Find: similar documents

Kumar et al. (2020) analyzed two peptide compound libraries (Asinex and ChemDiv) based on the structure of MurA, and they found that four compounds have acceptable pharmacokinetic properties.

 

Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli

Linhui LiPengfei SheShasha LiuYimin LiZehao LiYifan YangLinying ZhouYong Wu

PMC ID: PMC9800007 | DOI: 10.3389/fmicb.2022.1078318 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-15

Original document: PMC | Score: 7.713231 | Text size: 53444 | Find: similar documents

The MINI Scaffold library contains a total of 5,033 molecules with its own scaffold based on more than 16,000,000 drug-like small molecules from ChemDiv.

 

A Comprehensive Survey of Prospective Structure-Based Virtual Screening for Early Drug Discovery in the Past Fifteen Years

Hui ZhuYulin ZhangWei LiNiu HuangAlexandre G. de Brevern

PMC ID: PMC9781938 | DOI: 10.3390/ijms232415961 | Journal: International Journal of Molecular Sciences, 23(1) Publisher: MDPI | Publication date: 2022-12-15

Original document: PMC | Score: 7.26731 | Text size: 64384 | Find: similar documents

1/15/n.a. (SPECS and Chemdiv libraries)

 

In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

Ziyi WangXuesong WangZhe GuoHaiyan LiaoYan ChaiZiwen WangZhong Wang

PMC ID: PMC9792167 | DOI: 10.3389/fcimb.2022.1050497 | Journal: Frontiers in Cellular and Infection Microbiology, 12(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-12

Original document: PMC | Score: 17.515972 | Text size: 46829 | Find: similar documents

The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database ( ... Based on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency. ... The pharmacophore model of SC79 was used to match the ChemDiv pharmacophore database model. ... The original ChemDiv Database contained 2091084 compounds, and after preprocessing, it contained 2465124 compounds. ... ChemDiv pharmacophore database model was constructed by using each molecule of ChemDiv database to generate pharmacophore model.

 

Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth

Karthiga Santhana KumarCyrill BrunnerMatthias SchusterLevi Luca KoppAlexandre GriesShen YanSimon JurtKerstin MoehleDominique BrunsMichael GrotzerOliver ZerbeGisbert SchneiderMartin Baumgartner

PMC ID: PMC10060354 | DOI: 10.1007/s13402-022-00753-x | ISSN: 2211-3428 | Journal: Cellular Oncology (Dordrecht), 46(1) pp. 331-356 | Publisher: Springer Netherlands | Publication date: 2022-12-10 | Print publication date: 2023

Original document: PMC | Score: 8.19944 | Text size: 109900 | Find: similar documents

Collection of commercially available fast-delivery compounds of the suppliers Asinex Corp., ChemBridge Corp., ChemDiv, Enamine, Specs, UkrOrgSyntez Ltd. ... The generated pharmacophore was run against a database containing all fast-delivery compounds of the suppliers Asinex Corp., ChemBridge Corp., ChemDiv, Enamine, Specs, UkrOrgSyntez Ltd.

 

DrugCentral 2023 extends human clinical data and integrates veterinary drugs

Sorin AvramThomas B WilsonRamona CurpanLiliana HalipAna BorotaAlina BoraCristian G BologaJayme HolmesJeffrey KnockelJeremy J YangTudor I Oprea

PMC ID: PMC9825566 | DOI: 10.1093/nar/gkac1085 | ISSN: 0305-1048 | Journal: Nucleic Acids Research, 51(1) pp. D1276-D1287 | Publisher: Oxford University Press | Publication date: 2022-12-09

Original document: PMC | Score: 7.713231 | Text size: 56955 | Find: similar documents

He served on the Scientific Advisory Board of ChemDiv Inc. and InSilico Medicine.

 

A Subset Screen of the Compounds Australia Scaffold Library Identifies 7-Acylaminodibenzoxazepinones as Potent and Selective Hits for Anti-Giardia Drug Discovery

Christopher J. S. HartAndrew G. RichesSnigdha TiashErin ClapperSoumya RamuJohannes ZueggJohn H. RyanTina S. Skinner-AdamsPéter Mátyus

PMC ID: PMC9775191 | DOI: 10.3390/biomedicines10123182 | Journal: Biomedicines, 10(1) Publisher: MDPI | Publication date: 2022-12-08

Original document: PMC | Score: 12.167842 | Text size: 44268 | Find: similar documents

SN00797640 (M013-0086) and SN00776497 (ZZ22822646) were repurchased from ChemDiv (San Diego, CA, USA) and Enamine (Kyiv, Ukraine) respectively for additional activity assays. ... However, the set are a series of regioisomeric 7-acylamides (ChemDiv personal communication and [22]).

 

Mechano-biochemical marine stimulation of inversion, gastrulation, and endomesoderm specification in multicellular Eukaryota

Ngoc Minh NguyenTatiana MerleFlorence Broders-BondonAnne-Christine BrunetAude BattistellaEmelie Britt Linnea LandFlorian SarronAditya JhaJean-Luc GennissonEric RöttingerMaría Elena Fernández-SánchezEmmanuel Farge

PMC ID: PMC9754125 | DOI: 10.3389/fcell.2022.992371 | Journal: Frontiers in Cell and Developmental Biology, 10(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-01

Original document: PMC | Score: 9.088693 | Text size: 94365 | Find: similar documents

The S381-0393 small molecule (https://www.chemdiv.com/search-element.php?q=S381-0393) has been selected in silico by ChemDiv upon request from in silico-designed inhibitors of βcat signaling targeting all of the βcat reactive and protein interacting site (https://www.chemdiv.com/catalog/focused-and-targeted-libraries/inhibitors-of-beta-catenin-signaling/?sphrase-id=40485). ... The S381-0393 was selected by ChemDiv as a specific inhibitor of Y654-βcat phosphorylation by mimicking best the α-helix subdomain of E-cadherin that includes I657, A656, and D665 and interacts with Y654 βcat to dock Y654-bcat and thus prevent its phosphorylation.

 

Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

Yongmei FengStefan GrotegutPredrag JovanovicValentina GandinSteven H. OlsonRabi MuradAnne BeallSharon ColaycoPaul De-JesusSumit ChandaBrian P. EnglishRobert H. SingerMichael JacksonIvan TopisirovicZe’ev A. Ronai

PMC ID: PMC9751428 | DOI: 10.3389/fphar.2022.1029093 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-01

Original document: PMC | Score: 6.5141163 | Text size: 73068 | Find: similar documents

We used a large library of approximately 320,000 compounds selected from a pool of over three million compounds from five chemical vendors (ChemBridge, Asinex, Enamine, Life Chemicals, and ChemDiv).

 

Evaluation of action of steroid molecules on SARS-CoV-2 by inhibiting NSP-15, an endoribonuclease

Anantha Krishnan DhanabalanSriram Srinivasa RaghavanSelvakumar RajendranVelavan RamasamyShaik Abdul Azeez AbdulNandhagopal NarayanasamyGunasekaran Krishnasamy

PMC ID: PMC9715282 | DOI: 10.1007/s11030-022-10576-5 | ISSN: 1381-1991 | Journal: Molecular Diversity, pp. 1-14 | Publisher: Springer International Publishing | Publication date: 2022-12-01

Original document: PMC | Score: 16.647287 | Text size: 29129 | Find: similar documents

A total of 533 steroid like compounds were retrieved from ChemDiv database and eight steroid compounds with anti-viral activity as reported [2] were chosen for the structure based virtual screening against NSP-15 protein target. ... To identify a suitable steroid like ligand against NSP-15, ChemDiv DB chemical database was used and SBVS protocol was employed. ... The library of 533 steroids compounds from ChemDIV database was screened against NSP-15 through structure based docking using glide XP module. ... From these analysis, three compounds from ChemDIV (0449-0045, N001-0004, N006-0008) and two compounds (Dexamethasone and Cortisone) from tested compounds were identified as potential compounds based on glide scoring function and ligand–protein interaction profiles.

 

Discovery of novel DNA‐damaging agents through phenotypic screening for DNA double‐strand break

Doudou ZhangTakashi ShimokawaQianqian GuoShingo DanYoshio MikiShigeaki Sunada

PMC ID: PMC9986057 | DOI: 10.1111/cas.15659 | ISSN: 1347-9032 | Journal: Cancer Science, 114(1) pp. 1108-1117 | Publisher: John Wiley and Sons Inc. | Publication date: 2022-11-30

Original document: PMC | Score: 9.822761 | Text size: 30966 | Find: similar documents

DDA‐1 was obtained from Enamine; analogue numbers 1, 4, 6, 7, 8, and 9 were from Pharmeks, 2 and 5 were from ChemDiv, 3 and 11 from Vitas‐M, and 10 from Life Chemicals.

 

Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

Matic ProjMartina HrastGregor BajcRok FrlanAnže MedenMatej ButalaStanislav Gobec

PMC ID: PMC9718554 | DOI: 10.1080/14756366.2022.2149745 | ISSN: 1475-6366 | Journal: Journal of Enzyme Inhibition and Medicinal Chemistry, 38(1) pp. 387-397 | Publisher: Taylor & Francis | Publication date: 2022-11-29

Original document: PMC | Score: 14.207614 | Text size: 54004 | Find: similar documents

For fragment library preparation, we selected compounds from more than 4500 in-house chemicals and more than 1.57 million compounds available for cherry-picking from ChemDiv (the database was downloaded on 05 October 2020). ... Compound were purchased from several vendors (ChemBridge Corporation, ChemDiv, Enamine, Maybridge, Vitas-M Laboratory, and Wuxi LabNetwork) and used as received. ... (2-Ethoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)(pyridin-2-yl)methanone (6, ChemDiv, S422-0111) ... 7–(4-Chlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (12, ChemDiv, C201-1701)

 

Pharos 2023: an integrated resource for the understudied human proteome

Keith J KelleherTimothy K SheilsStephen L MathiasJeremy J YangVincent T MetzgerVishal B SiramshettyDac-Trung NguyenLars Juhl JensenDušica VidovićStephan C SchürerJayme HolmesKarlie R SharmaAjay PillaiCristian G BologaJeremy S EdwardsEwy A MathéTudor I Oprea

PMC ID: PMC9825581 | DOI: 10.1093/nar/gkac1033 | ISSN: 0305-1048 | Journal: Nucleic Acids Research, 51(1) pp. D1405-D1416 | Publisher: Oxford University Press | Publication date: 2022-11-29

Original document: PMC | Score: 7.713231 | Text size: 55875 | Find: similar documents

He served on the scientific advisory board of ChemDiv Inc. and InSilico Medicine.

Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

Danfeng ShiQianqian PangQianyu QinXinsheng YaoXiaojun YaoYang Yu

PMC ID: PMC9638114 | DOI: 10.3389/fphar.2022.1026306 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-10-24

Original document: PMC | Score: 15.052543 | Text size: 57102 | Find: similar documents

Four compounds (Chemdiv codes: 8012-0567, 8018-6529, 8018-7168, 8018-7603) were proved with above 40% inhibitory ratio targeting PARP-1 under 20 μM, and further performed binding mode prediction and dynamic effect evaluation by molecular dynamics simulation. ... Then, a protocol of virtual screening workflow is evaluated and designed for the discovery of novel scaffolds of PARP-1 inhibitors, and 20 compounds were purchased from the Chemdiv database for in vitro assays. ... The Chemdiv database (https://www.chemdiv.com/) that contains over 1.5 million compounds was applied for the screening of PARP-1 inhibitors.

 

Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence

Theresa NoonanKatrin DenzingerValerij TalagayevYu ChenKristina PulsClemens Alexander WolfSijie LiuTrung Ngoc NguyenGerhard WolberPavel PolishchukThomas Seidel

PMC ID: PMC9695541 | DOI: 10.3390/ph15111304 | Journal: Pharmaceuticals, 15(1) Publisher: MDPI | Publication date: 2022-10-22

Original document: PMC | Score: 7.697359 | Text size: 125521 | Find: similar documents

The optimized model was then used as the first VS step filtering the ChemDiv library with 1,492,362 compounds yielding 141,916 compounds. ... The DNN and CNN classification models were then used to screen the ChemDiv library (1178506 compounds).

 

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

Alessia CaputoSara SartiniElisabetta LevatiIlaria MinatoGian Marco ElisiAdriana Di StasiCatherine GuillouPeter G. GoekjianPierre GarciaDavid GueyrardStéphane BachArnaud ComteSimone OttonelloSilvia RivaraBarbara MontaniniFlorie DesriacYannick Fleury

PMC ID: PMC9598883 | DOI: 10.3390/antibiotics11101449 | Journal: Antibiotics, 11(1) Publisher: MDPI | Publication date: 2022-10-21

Original document: PMC | Score: 7.713231 | Text size: 53659 | Find: similar documents

Compound 4 was purchased from ChemDiv (San Diego, CA, USA).

 

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy LewisSaray SánchezGiulio BertiBelen Pan-CastilloAnke NijhuisShameer MehtaLiliane EleidHannah GordonRadha GadhokChristopher KimberleyAnnamaria MinicozziJoanne Chin-AleongRoger FeakinsRobert KyptaJames Oliver LindsayAndrew Silver

PMC ID: PMC9583737 | DOI: 10.1042/CS20210889 | ISSN: 0143-5221 | Journal: Clinical Science (London, England : 1979), 136(1) pp. 1405-1423 | Publisher: Portland Press Ltd. | Publication date: 2022-10-14 | Print publication date: 2022-10

Original document: PMC | Score: 6.8701305 | Text size: 72844 | Find: similar documents

For all cell treatments, cells were serum starved overnight prior to 48 h treatment with 10 μM ICG-001 dissolved in DMSO, or 100 nM porcupine inhibitor Wnt-C59 (Selleckchem S7037), or 10 μM FZD8 inhibitor 3235-0367 (C1, ChemDiv), alone or in combination with 10 ng/mL-recombinant human TGFβ1 (R&D Systems).

 

The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation

Radwa E. MahgoubFeda E. MohamedLara AlzyoudBassam R. AliJuliana FerreiraWael M. RabehShaikha S. AlNeyadiNoor AtatrehMohammad A. GhattasDmitri B. Kireev

PMC ID: PMC9572942 | DOI: 10.3390/molecules27196710 | Journal: Molecules, 27(1) Publisher: MDPI | Publication date: 2022-10-09

Original document: PMC | Score: 10.625123 | Text size: 61128 | Find: similar documents

A total of 178 compounds from all the screened libraries (i.e., TimTec: 59, ChEMBL: 48, and ChemDiv: 60) were further investigated using MD simulation and MM-GBSA scoring. ... Four libraries were initially downloaded for virtual screening: NCI [40], TimTec [41], ChEMBL [42], and ChemDiv [43].

 

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

Rachel ForfarMashal HussainPuneet KhuranaJennifer CookSteve LewisDillon PopatDavid JacksonEd McIverJeff JermanDebra TaylorAdrian JL ClarkLi F Chan

PMC ID: PMC9641778 | DOI: 10.1530/EC-22-0338 | Journal: Endocrine Connections, 11(1) | Publisher: Bioscientifica Ltd | Publication date: 2022-10-06

Original document: PMC | Score: 9.822761 | Text size: 30319 | Find: similar documents

The eight chemical libraries used in our screening were as follows: LOPAC1280 (Sigma-Aldrich), HitFinder (Maybridge, Cornwall, UK), bioactive compounds (InterBioScreen, Moscow, Russia), BBP-2080 library (BioBiopha, Kunming, China), MEGxm and MEGxp (Analy-Ticon Discovery, Potsdam, Germany), Prestwick chemical library (Prestwick, Illkirch, France), Tocriscreen Total (Tocris, Bristol, UK), and GPCR-targeted library (ChemDiv, San Diego, CA, USA).

 

Discovery of novel SARS-CoV-2 3CL protease covalent inhibitors using deep learning-based screen

Liying WangZhongtian YuShiwei WangZheng GuoQi SunLuhua Lai

PMC ID: PMC9528019 | DOI: 10.1016/j.ejmech.2022.114803 | ISSN: 0223-5234 | Journal: European Journal of Medicinal Chemistry | Publisher: Elsevier Masson SAS. | Publication date: 2022-10-03

Original document: PMC | Score: 7.713231 | Text size: 50048 | Find: similar documents

Cysteine Targeted Covalent Library from ChemDiv (https://www.chemdiv.com) contains 39, 301 compounds that have specific warheads, which were designed to react with cysteine.

 

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors

Yi ZangMingbo SuQingxing WangXi ChengWenru ZhangYao ZhaoTong ChenYingyan JiangQiang ShenJuan DuQiuxiang TanPeipei WangLixin GaoZhenming JinMengmeng ZhangCong LiYa ZhuBo FengBixi TangHan XieMing-Wei WangMingyue ZhengXiaoyan PanHaitao YangYechun XuBeili WuLeike ZhangZihe RaoXiuna YangHualiang JiangGengfu XiaoQiang ZhaoJia Li

PMC ID: PMC9871955 | DOI: 10.1093/procel/pwac016 | ISSN: 1674-800X | Journal: Protein & Cell, 14(1) pp. 17-27 | Publisher: Oxford University Press | Publication date: 2022-09-28

Original document: PMC | Score: 7.713231 | Text size: 54823 | Find: similar documents

The ~1,800,000 compounds of CNCL bought from ChemDiv (USA), ChemBridge (USA), Life Chemicals (Canada), Specs (Holland) and donated by NovoNordisk (Denmark) were primarily screened against Mpro and PLpro at the concentration of 10 and 8 μg/mL respectively.

 

Lin28 Regulates Cancer Cell Stemness for Tumour Progression

Zhuohui LinMariia RadaevaArtem CherkasovXuesen DongKavita Shah

PMC ID: PMC9564245 | DOI: 10.3390/cancers14194640 | Journal: Cancers, 14(1) Publisher: MDPI | Publication date: 2022-09-24

Original document: PMC | Score: 5.6376715 | Text size: 87902 | Find: similar documents

127,007 compounds from LOPAC, Prestwick, Maybridge, ChemDiv, and UMich libraries

 

Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells

Gregory Gauthier-ColesAngelika BröerMalcolm Donald McLeodAmee J. GeorgeRoss D. HannanStefan Bröer

PMC ID: PMC9532951 | DOI: 10.3389/fphar.2022.963066 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-21

Original document: PMC | Score: 18.556135 | Text size: 77822 | Find: similar documents

ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv

 

Highly multiplexed selection of RNA aptamers against a small molecule library

Brent TownshendMatias KaplanChristina D. SmolkeFloyd Romesberg

PMC ID: PMC9477273 | DOI: 10.1371/journal.pone.0273381 | Journal: PLoS ONE, 17(1) Publisher: Public Library of Science | Publication date: 2022-09-15

Original document: PMC | Score: 12.764881 | Text size: 80266 | Find: similar documents

The target compound library comprises 5,120 small molecule compounds randomly selected from a ChemDiv representative diversity library obtained via the Stanford High-Throughput Bioscience Center [22]. ... However, the second-sourced sample of CDIQ165-N09 showed a clear peak with an m/z corresponding to an M+H adduct of the expected chemical whereas the ChemDiv sample showed no corresponding peak. ... Thus, the difference in observed responses is likely due to the expected chemical not being present in the ChemDiv sample at the expected concentration, possibly caused by degradation or handling of the library prior to our work.

 

Review of in silico studies dedicated to the nuclear receptor family: Therapeutic prospects and toxicological concerns

Asma SellamiManon RéauMatthieu MontesNathalie Lagarde

PMC ID: PMC9513233 | DOI: 10.3389/fendo.2022.986016 | Journal: Frontiers in Endocrinology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-13

Original document: PMC | Score: 4.780143 | Text size: 122095 | Find: similar documents

ChemDiv database (7476 compounds) for prospective screening

 

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Enrique CrismanPablo DuarteEsteban DaudenAntonio CuadradoMaría Isabel Rodríguez‐FrancoManuela G. LópezRafael León

PMC ID: PMC10087726 | DOI: 10.1002/med.21925 | ISSN: 0198-6325 | Journal: Medicinal Research Reviews, 43(1) pp. 237-287 | Publisher: John Wiley and Sons Inc. | Publication date: 2022-09-10 | Print publication date: 2023-01

Original document: PMC | Score: 3.892117 | Text size: 165955 | Find: similar documents

Kim et al. 136 identified compound 53 (Table 2) after performing a virtual screening of Asinex and Chemdiv chemical libraries using a ligand‐based pharmacophore, structure‐based pharmacophore, and docking combination strategy.

 

Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening

Chujiao HuZhirui ZengDan MaZhixin YinShanshan ZhaoTengxiang ChenLei TangShi Zuo

PMC ID: PMC9491111 | DOI: 10.3389/fphar.2022.982375 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-07

Original document: PMC | Score: 13.219877 | Text size: 50053 | Find: similar documents

ChemDiv (2019 version) database with more than 1.5 million molecules was used for the virtual screening. ... ChemDiv, a sub-database of the ZINC15 database, was used as the virtual screening library. ... In summary, the study identified a potent IDH1-R132C inhibitor based on molecular docking-based virtual screening using the ChemDiv database and cellular assays.

 

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Bingwu WangJian GaoZhongjun ZhaoXuefei ZhongHao CuiHui HouYanping ZhangJunnian ZhengJiehui DiYong Liu

PMC ID: PMC9450376 | DOI: 10.1186/s10020-022-00537-x | ISSN: 1076-1551 | Journal: Molecular Medicine, 28(1) Publisher: BioMed Central | Publication date: 2022-09-07

Original document: PMC | Score: 7.713231 | Text size: 49706 | Find: similar documents

The small molecule database used as the screening library was the ChemDiv database (commercially available) from TopScience Co. (Shanghai, China), which comprises more than 1 million compounds.

 

Small molecule SJ572946 activates BAK to initiate apoptosis

Giridhar SekarGeetika SinghXingping QinCristina D. GuibaoBrittany SchwamZintis IndeChristy R. GraceWeixing ZhangP. Jake SlavishWenwei LinTaosheng ChenRichard E. LeeZoran RankovicKristopher SarosiekTudor Moldoveanu

PMC ID: PMC9485059 | DOI: 10.1016/j.isci.2022.105064 | Journal: iScience, 25(1) | Publisher: Elsevier | Publication date: 2022-09-06

Original document: PMC | Score: 5.6376715 | Text size: 89818 | Find: similar documents

ChemDiv

 

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Tiffany S. DwyerJoseph B. O’BrienChristopher P. PtakJustin E. LaVigneDaniel P. FlahertyVal J. WattsDavid L. Roman

PMC ID: PMC9486168 | DOI: 10.3389/fphar.2022.977742 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-06

Original document: PMC | Score: 16.915955 | Text size: 84849 | Find: similar documents

ChemDiv CNS targeted library FP screen ... For the ChemDiv CNS targeted library (ChemDiv, San Diego, CA) of compounds, the protocol is the same as that outlined for the FDA-approved library, with minor differences as the MMSP and ChemBridge DIVERSet libraries. ... The test plate’s final ChemDiv CNS targeted compounds’ concentration was 14.64 μM (0.147% DMSO). ... The ChemDiv CNS targeted library (CDI, ChemDiv, San Diego, CA) is comprised of compounds selected for CNS protein targets (98 protein sub-families/unit targets) based on literature searches (ranging from 2014-present) as well as novel X-ray and Cryo-EM structures deposited in the PDB.

 

Virtual Screening in the Identification of Sirtuins’ Activity Modulators

Elena AbbottoNaomi ScaranoFrancesco PiacenteEnrico MilloElena CicheroSantina BruzzoneDmitri B. Kireev

PMC ID: PMC9457788 | DOI: 10.3390/molecules27175641 | Journal: Molecules, 27(1) Publisher: MDPI | Publication date: 2022-09-01

Original document: PMC | Score: 12.4384985 | Text size: 182466 | Find: similar documents

They were merged together to form a single dynamic pharmacophore model, which was then used to screen the CHEMDIV database [258]. ... Maybridge (60,000), Chembridge (50,000), NCI (200,000), and ChemDiv (700 000) ... CHEMDIV database (700 000) ... Specs, ChemDiv, Selleck, and MedChemExpress and in-house database ... Chemdiv database (939319) ... More recently, in 2020, compound Hit20 was also discovered as SIRT-6 activator, thanks to molecular docking adopted to screen commercial chemical databases including Specs, ChemDiv, Selleck, and MedChemExpress, as well as an in-house database (see Section 2.6.1) [173]. ... Subsequent VS screening was carried out by Autodock Vina [301] by taking into account the Chemdiv database [258] containing 939,319 structurally diverse compounds.

 

Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma

Valeria NapolitanoCharlotte A. SoftleyArtur BlatVishal C. KalelKenji SchorppTill SiebenmorgenKamyar HadianRalf ErdmannMichael SattlerGrzegorz M. PopowiczGrzegorz Dubin

PMC ID: PMC9424529 | DOI: 10.1038/s41598-022-18841-1 | Journal: Scientific Reports, 12(1) Publisher: Nature Publishing Group UK | Publication date: 2022-08-29

Original document: PMC | Score: 9.45341 | Text size: 34007 | Find: similar documents

An in-house 30,000 molecules diversity set (ChemBridge, ChemDiv, Enamine, PPI) and FDA-approved drug library were used in high throughput screening.

 

New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity

Ana MitrovićEmanuela SenjorMarko JukićLara BolčinaMateja PrunkMatic ProjMilica Perišić NanutStanislav GobecJanko Kos

PMC ID: PMC9459403 | DOI: 10.1016/j.csbj.2022.08.046 | Journal: Computational and Structural Biotechnology Journal, 20(1) pp. 4667-4687 | Publisher: Research Network of Computational and Structural Biotechnology | Publication date: 2022-08-28

Original document: PMC | Score: 5.6376715 | Text size: 90683 | Find: similar documents

Compounds were obtained from various sources (Life Chemicals, ENAMINE, Vitas-M, ChemDiv, UkrOrgSynthesis, Otava ltd in InterBioScreen) and used as received.

Hydrogen bonding penalty used for virtual screening to discover potent inhibitors for Papain‐Like cysteine proteases of SARS‐CoV‐2

Guangjian ZhaoXiaochun LiuSuyun WangZhongyue BaiSiyu ZhangYifan WangHaibo YuXiming Xu

PMC ID: PMC9349924 | DOI: 10.1111/cbdd.14115 | ISSN: 1747-0277 | Journal: Chemical Biology & Drug Design | Publisher: John Wiley and Sons Inc. | Publication date: 2022-07-26

Original document: PMC | Score: 8.217452 | Text size: 46817 | Find: similar documents

The ligand library is taken from “TargetMol, USA” (ChemDiv and “Bioactive Compound Library”).

 

Molecular docking and dynamics based approach for the identification of kinase inhibitors targeting PI3Kα against non-small cell lung cancer: a computational study†

Debojyoti HalderSubham DasAiswarya R.Jeyaprakash R. S.

PMC ID: PMC9346375 | DOI: 10.1039/d2ra03451d | Journal: RSC Advances, 12(1) pp. 21452-21467 | Publisher: The Royal Society of Chemistry | Publication date: 2022-07-21

Original document: PMC | Score: 13.219877 | Text size: 49098 | Find: similar documents

In this research work, a specific biological target PI3Kα, which has a pan and a selective inhibitor, was selected and a kinase inhibitor database of 36 324 molecules from ChemDiv was chosen for the structure-based virtual screening to obtain the top ten hits, for further MMGBSA free binding energy analysis, ADMET predictions, IFD (induced fit docking) analysis and MD (molecular dynamics) simulations for the optimization of the kinase inhibitors for pan and selective inhibition of PI3Kα in the treatment of NSCLC squamous carcinoma. ... PI3K is a kind of kinase enzyme which readily mutates in squamous cell carcinoma in NSCLC, and therefore, the kinase inhibitor library from ChemDiv was chosen for the virtual screening.

 

Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses

Paul Andrei NegruDenisa Claudia MiculasTapan BehlAlexa Florina BungauRuxandra-Cristina MarinSimona Gabriela Bungau

PMC ID: PMC9289048 | DOI: 10.1016/j.biopha.2022.113432 | ISSN: 0753-3322 | Journal: Biomedicine & Pharmacotherapy | Publisher: The Author(s). Published by Elsevier Masson SAS. | Publication date: 2022-07-18

Original document: PMC | Score: 6.1931806 | Text size: 81496 | Find: similar documents

ChemDiv

 

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

Daniela G. DenglerQing SunKaleeckal G. HarikumarLaurence J. MillerEduard A. Sergienko

PMC ID: PMC9580343 | DOI: 10.1016/j.slasd.2022.07.001 | ISSN: 2472-5552 | Journal: SLAS discovery : advancing life sciences R & D, 27(1) pp. 384-394 | Publication date: 2022-07-16 | Print publication date: 2022-10

Original document: PMC | Score: 7.26731 | Text size: 59423 | Find: similar documents

(Camelford, Cornwall, UK), ChemBridge Corporation (San Diego, CA, USA), ChemDiv, Inc.

 

A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer

Vaishnavi MuralikrishnanFang FangTyler C. GivenRam PodichetiMikhail ChtcherbinineTara X. MetcalfeShruthi SriramkumarHeather M. O’HaganThomas D. HurleyKenneth P. NephewChristina M. AnnunziataAdam R. Karpf

PMC ID: PMC9318275 | DOI: 10.3390/cancers14143437 | Journal: Cancers, 14(1) | Publisher: MDPI | Publication date: 2022-07-15

Original document: PMC | Score: 11.093979 | Text size: 59259 | Find: similar documents

Compounds purchased from ChemDiv Corporation (San Diego, CA, USA) and ChemBridge Corporation (San Diego, CA, USA) were >95% pure based on vendor specifications (NMR spectra for the compounds can be found in the ). ... To avoid the potential off-target effects due to the structure of CM38, 974 was chosen amongst the ALDH1A1 inhibitors with high structural similarity to CM38 from commercial sources (ChemDiv Corporation and ChemBridge Corporation, San Diego, CA, USA).

 

Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors

Aliakbar Khalili YazdiPaknoosh PakarianSumera PerveenTaraneh HajianVijayaratnam SanthakumarAlbina BolotokovaFengling LiMasoud Vedadi

PMC ID: PMC9305828 | DOI: 10.1021/acsinfecdis.2c00165 | Journal: ACS Infectious Diseases | Publisher: American Chemical Society | Publication date: 2022-07-13

Original document: PMC | Score: 11.093979 | Text size: 51452 | Find: similar documents

SARS-CoV-2 nsp13 was screened against a library of potential kinase inhibitors containing 5000 small molecules (ChemDiv Kinase Library) at 50 μM using the optimized ssDNA+ ATPase assay. ... Protein expression and purification details, ChemDiv catalogue numbers for selected eight reproducible hits, detection of nsp13 ATPase activities using the bioluminescence assays, SARS-CoV-2 nsp13 purification, assay optimization, tests of the top eight hits in a counter screen, and dose-response analysis of six hits from the original in-house samples (PDF)

 

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

Katherine ChewBranden LeeSimon D. van HarenEtsuro NanishiTimothy O’MearaJennifer B. SplaineMaria DeLeonDheeraj SoniHyuk-Soo SeoSirano Dhe-PaganonAl OzonoffJennifer A. SmithOfer LevyDavid J. Dowling

PMC ID: PMC9298130 | DOI: 10.1101/2022.06.17.496630 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2022-07-11

Original document: PMC | Score: 6.8701305 | Text size: 70072 | Find: similar documents

704 molecules were chosen for known activity toward PBMCs; these molecules filled up two library plates and originated from the ChemDiv6 library (ChemDiv Inc, San Diego, CA).

 

CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction

Woo Dae JangMi Young LeeJihye MunGyutae LimKwang-Seok OhSeungho Baek

PMC ID: PMC9313426 | DOI: 10.3390/biomedicines10071671 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-07-11

Original document: PMC | Score: 8.217452 | Text size: 46289 | Find: similar documents

CDI (CAT#, NO75-0015) was obtained from ChemDiv (San Diego, CA, USA).

 

Fragment‐based drug discovery—the importance of high‐quality molecule libraries

Marta BonAlan BilslandJustin BowerKirsten McAulay

PMC ID: PMC9627785 | DOI: 10.1002/1878-0261.13277 | ISSN: 1574-7891 | Journal: Molecular Oncology, 16(1) pp. 3761-3777 | Publisher: John Wiley and Sons Inc. | Publication date: 2022-07-10 | Print publication date: 2022-11

Original document: PMC | Score: 9.797036 | Text size: 78283 | Find: similar documents

(A) General fragment sets were obtained from Maybridge (30 061 compounds), Life Chemicals (50 597 compounds), Enamine (172 689 compounds) and ChemDiv (11 269 compounds). ... High Fidelity Library (1920 compounds); Life Chemicals, General Fragment Library (50 607 compounds); ChemDiv, Fragments Library (11 269 compounds); Bionet, 2nd Generation Premium Library (1166 compounds).

 

Characterization of Dense Granule Metalloproteinase INS-16 in Cryptosporidium parvum

Hao CuiRui XuYu LiYaqiong GuoZiding ZhangLihua XiaoYaoyu FengNa LiCristina Sánchez-Camacho

PMC ID: PMC9315855 | DOI: 10.3390/ijms23147617 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-07-10

Original document: PMC | Score: 12.167842 | Text size: 41216 | Find: similar documents

Although we failed to obtain the full INS-16 protein with enzymatic activity, based on the structure of human IDE together with known inhibitors, we were able to simulate the active structure of INS-16, leading to the identification of 48 potential inhibitors from the ChemDiv database through molecular docking. ... A total of 48 compounds were selected from the ChemDiv database through the molecular docking of INS-16 as described previously [30] (Table 1).

 

Modulating mitofusins to control mitochondrial function and signaling

Emmanouil ZacharioudakisBogos AgianianVasantha Kumar MVNikolaos BirisThomas P. GarnerInna Rabinovich-NikitinAmanda T. OuchidaVictoria MarguletsLars Ulrik NordstrømJoel S. RileyIgor DolgalevYun ChenAndre J. H. WittigRyan PeksonChris MathewPeter WeiAristotelis TsirigosStephen W. G. TaitLorrie A. KirshenbaumRichard N. KitsisEvripidis Gavathiotis

PMC ID: PMC9262907 | DOI: 10.1038/s41467-022-31324-1 | Journal: Nature Communications, 13(1) Publisher: Nature Publishing Group UK | Publication date: 2022-07-07

Original document: PMC | Score: 8.19944 | Text size: 107705 | Find: similar documents

Screened MASMs were purchased from Enamine, ChemBridge and ChemDiv. ... The rest of the screened MFIs were purchased from Enamine, ChemBridge, ChemDiv, Vitas M, and UORSY.

 

Glioblastoma: Current Status, Emerging Targets, and Recent Advances

Amandeep ThakurChetna FaujdarRam SharmaSachin SharmaBasant MalikKunal NepaliJing Ping Liou

PMC ID: PMC9297300 | DOI: 10.1021/acs.jmedchem.1c01946 | ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 65(1) pp. 8596-8685 | Publisher: American Chemical Society | Publication date: 2022-07-05 | Print publication date: 2022-07-14

Original document: PMC | Score: 2.2328758 | Text size: 332970 | Find: similar documents

To establish the SAR, a total of 89 compounds from the Chemdiv library and NCI development program were tested using the PDI reductase assay.

 

Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors

Gbolahan O. OduseluRufus AfolabiIbitayo AdemuwagunAshley VaughanEzekiel Adebiyi

PMC ID: PMC9877529 | DOI: 10.3389/fmed.2022.1022429 | Journal: Frontiers in Medicine, 9(1) | Publisher: Frontiers Media S.A. | Publication date: 2022

Original document: PMC | Score: 15.052543 | Text size: 54985 | Find: similar documents

The best model of the tertiary structure of Pf 5-ALAS was obtained using MolProbity, while the following databases were explored for the pharmacophore-based virtual screening: CHEMBL, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC databases. ... The pharmacophore-based screening of the different databases (CHEMBL30, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC) gave rise to 2,755 hits (Table 4). ... The total number of hits obtained from the databases are in the order: ChemSpace > ZINC > MCULE > MolPort > CHEMBL30 > ChemDiv > LabNetwork > NCI Open Chemical Repository > MCULE-ULTIMATE.

 

A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

Karel MiettinenNattawat LeelahakornAldo AlmeidaYong ZhaoLukas R. HansenIben E. NikolajsenJens B. AndersenMichael GivskovDan StaerkSøren BakSotirios C. Kampranis

PMC ID: PMC9237071 | DOI: 10.1038/s41467-022-31357-6 | Journal: Nature Communications, 13(1) Publisher: Nature Publishing Group UK | Publication date: 2022-06-27

Original document: PMC | Score: 5.9023848 | Text size: 90076 | Find: similar documents

ANT4 (#3888-1206) and ANT5 (#3909-7498) were bought from ChemDiv, US.

 

Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies

Said MoshawihAi Fern LimChrismawan ArdiantoKhang Wen GohNurolaini KifliHui Poh GohQais JarrarLong Chiau MingSupriyo BhattacharyaXiaolin Cheng

PMC ID: PMC9312989 | DOI: 10.3390/biom12070878 | Journal: Biomolecules, 12(1) | Publisher: MDPI | Publication date: 2022-06-23

Original document: PMC | Score: 4.780143 | Text size: 125484 | Find: similar documents

Commercially available protein-protein interaction small molecules from ChemDiv

 

Discovery and Characterization of Multiple Classes of Human CatSper Blockers

Erick J. CarlsonRawle FrancisYutong LiuPing LiMaximilian LyonCelia M. SantiDerek J. HookJon E. HawkinsonGunda I. Georg

PMC ID: PMC9378630 | DOI: 10.1002/cmdc.202000499 | ISSN: 1860-7179 | Journal: Chemmedchem, 17(1) Publisher: John Wiley and Sons Inc. | Publication date: 2022-06-14 | Print publication date: 2022-08-03

Original document: PMC | Score: 10.19429 | Text size: 65842 | Find: similar documents

Over 72,000 compounds from the following libraries were tested in the primary screen at 10 μM: the National Cancer Institute set, the ChemDiv Peptidomimetic and Kinase libraries, the TOCRIS Tocriscreen Complete and Kinase Inhibitor Library, the ChemBridge MicroFormat Library, the LOPAC library, the NIH Clinical Library, the Prestwick Chemical Library, and the MicroSource Spectrum Collection. ... [43] Hits 1 a and 2 a were identified from the LOPAC library, hits 3 a, 4 a, and 5 a came from the ChemBridge library, 6 a from the MicroSource library and compound 7 a from the ChemDiv kinase library.

 

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility

Yukari EndoLinda GroomAlper CelikNatalia KraevaChang Seok LeeSung Yun JungLois GardnerMarie-Anne ShawSusan L. HamiltonPhilip M. HopkinsRobert T. DirksenSheila RiaziJames J. Dowling

PMC ID: PMC9192596 | DOI: 10.1038/s41467-022-31088-8 | Journal: Nature Communications, 13(1) Publisher: Nature Publishing Group UK | Publication date: 2022-06-13

Original document: PMC | Score: 6.5141163 | Text size: 73965 | Find: similar documents

To assess the motor function, 3-dpf fish were individually transferred to a 96-well plate and incubated with 10 μM optovin 6b8 (ChemDiv) at 28.5 °C for 5 min as previously described59.

 

Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization

Beatrice MercorelliJenny DesantisMarta CelegatoAlessandro BazzaccoLydia SiragusaPaolo BenedettiMichela EleuteriFederico CrociGabriele CrucianiLaura GoracciArianna Loregian

PMC ID: PMC9172283 | DOI: 10.1016/j.antiviral.2022.105350 | ISSN: 0166-3542 | Journal: Antiviral Research, 204(1) pp. 105350-105350 | Publisher: Elsevier B.V. | Publication date: 2022-06-07 | Print publication date: 2022-08

Original document: PMC | Score: 12.154662 | Text size: 61716 | Find: similar documents

In approaches (1-1) and (1–2) (Fig. 1B), a database of small molecules composed of structures from Specs and ChemDiv vendors (overall 793,212 compounds) was generated by applying the following filters: molecular weight range = 150–500; logP >5; protonation state = most abundant protomer at pH = 7.4; up to 50 conformers with RMSD >0.1. ... Compounds 1–5 were purchased from ChemDiv, compounds 6–8 from Specs, compounds 9–20 from Vitas-M, compound 21 from Fluorochem, and compounds 22–24 from Sigma Aldrich (more details in Dataset S1). ... First, we performed LBVS campaigns on N3 and 13b using a dataset of commercially available compounds (almost 800,000 small molecules from Specs and ChemDiv) employing the FLAP software (Baroni et al., 2007) (Fig. 1B, approaches 1-1 and 1–2).

 

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease

Xiaodong DouQi SunGuofeng XuYameng LiuCaifang ZhangBingding WangYangbin LuZheng GuoLingyu SuTongyu HuoXinyi ZhaoChen WangZhongtian YuSong SongLiangren ZhangZhenming LiuLuhua LaiNing Jiao

PMC ID: PMC9162962 | DOI: 10.1016/j.ejmech.2022.114508 | ISSN: 0223-5234 | Journal: European Journal of Medicinal Chemistry | Publisher: Published by Elsevier Masson SAS. | Publication date: 2022-06-03

Original document: PMC | Score: 9.42958 | Text size: 73278 | Find: similar documents

A total of 70 compounds were captured and purchased from the ChemDiv and SPECS commercial databases. ... Compounds used for SARS-CoV-2 Mpro inhibitors screening were purchased from ChemDiv (https://www.chemdiv.com/) and SPECS (https://www.specs.net/) commercial databases.

 

ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL-8/Notch signaling cascade

Valerio CicconeErika TerzuoliEmma RistoriArianna FilippelliMarina ZicheLucia MorbidelliSandra Donnini

PMC ID: PMC9186295 | DOI: 10.3892/ijmm.2022.5155 | ISSN: 1107-3756 | Journal: International Journal of Molecular Medicine, 50(1) Publisher: D.A. Spandidos | Publication date: 2022-06-02

Original document: PMC | Score: 6.1931806 | Text size: 79064 | Find: similar documents

The ALDH1A1 inhibitor CM037 was from ChemDiv Inc.

Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

Fanfan ShuYu LiWenlun ChuXuehua ChenZiding ZhangYaqiong GuoYaoyu FengLihua XiaoNa Li

PMC ID: PMC9090282 | DOI: 10.3389/fmicb.2022.883674 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-25

Original document: PMC | Score: 11.880346 | Text size: 45180 | Find: similar documents

Using molecular docking of the simulated CpCDPK2A structure, small molecules were selected from the ChemDiv database. ... A total of 50 compounds were selected from the ChemDiv core database according to the scores from molecular docking of CpCDPK2A (Table 1).

 

Novel Inhibitors of 2′-O-Methyltransferase of the SARS-CoV-2 Coronavirus

Alexey SulimovDanil KutovIvan IlinYibei XiaoSheng JiangVladimir SulimovAthina Geronikaki

PMC ID: PMC9100384 | DOI: 10.3390/molecules27092721 | Journal: Molecules, 27(1) Publisher: MDPI | Publication date: 2022-04-23

Original document: PMC | Score: 16.607422 | Text size: 42506 | Find: similar documents

Here, we performed high-throughput docking into the SAM-binding site of nsp16 for almost 40 thousand structures, prepared for compounds from three libraries: Enamine Coronavirus Library, Enamine Nucleoside Mimetics Library, and Chemdiv Nucleoside Analogue Library. ... The results of calculations for the best ligands and their structures are presented in Table 6 and Figure 8 (ligands selected from the Enamine Coronavirus Library) and Figure 9 (ligands selected from the Chemdiv Nucleoside Analogue Library), respectively. ... Similarly to sinefungin and SAM, three of the four top compounds from the Chemdiv Nucleoside Analogue Library belong to purines.

 

Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches

Sathya BabuSanthosh Kumar NagarajanSruthy SathishVir Singh NegiHonglae SohnThirumurthy Madhavan

PMC ID: PMC9068899 | DOI: 10.3389/fphar.2022.837369 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-21

Original document: PMC | Score: 13.442831 | Text size: 85497 | Find: similar documents

Based on the validation results, the best pharmacophore models ADHRRR, DDHRRR, DDRRR, DPRRR, DHRRR, ADRRR, DDHRR, and ADPRR were selected and taken for virtual screening against the Maybridge, Asinex, Chemdiv, Enamine, Lifechemicals, and Zinc database to identify the new molecules with novel scaffold that can bind to JAK1. ... The selected pharmacophore models were screened against Maybridge, Lifechemicals, Enamine, Chemdiv, Asinex, and Zinc (chemical and natural) databases for the identification of new hits. ... The fitness score was set to >1.5 for the Maybridge, Asinex, Chemdiv, Lifechemicals, and Enamine databases, whereas for the Zinc database, the fitness score was set to >2 because of high number of molecules retrieved from the Zinc database.

 

Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry

Chongyun ChengMiaomiao LiuXiaoqin GaoDong WuMengchen PuJun MaRonald J. QuinnZhicheng XiaoZhijie Liu

PMC ID: PMC9088906 | DOI: 10.1021/acsomega.2c00340 | Journal: ACS Omega, 7(1) pp. 13925-13931 | Publisher: American Chemical Society | Publication date: 2022-04-14

Original document: PMC | Score: 9.110828 | Text size: 35916 | Find: similar documents

The compounds were purchased from ChemDiv and Enamine.

 

Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy

Zheyuan ShenWeihao ZhuangKang LiYu GuoBingxue QuSikang ChenJian GaoJing LiuLei XuXiaowu DongJinxin CheQimeng LiDmitri B. Kireev

PMC ID: PMC9024667 | DOI: 10.3390/molecules27082543 | Journal: Molecules, 27(1) Publisher: MDPI | Publication date: 2022-04-14

Original document: PMC | Score: 9.822761 | Text size: 33395 | Find: similar documents

To ensure the molecular diversity of our covalent compound library, compounds from ChemDiv compound libraries and TargetMol with well-developed skeleton diversities were initially included.

 

A Small Molecule Promoting Neural Differentiation Suppresses Cancer Stem Cells in Colorectal Cancer

Jung Kyu ChoiIhn-Sil KwakSae-Bom YoonHeeyeong ChoByoung-San MoonMassimo MoroLuca Falzone

PMC ID: PMC9025482 | DOI: 10.3390/biomedicines10040859 | Journal: Biomedicines, 10(1) Publisher: MDPI | Publication date: 2022-04-06

Original document: PMC | Score: 8.792208 | Text size: 41016 | Find: similar documents

Specifically, we used a 2000-compound ChemDiv drug screening library platform to identify compounds that would decrease TOP-flash reporter activity in the HEK293 TCF/LEF cell line.

 

Targeting papain-like protease for broad-spectrum coronavirus inhibition

Shuofeng YuanXiaopan GaoKaiming TangJian-Piao CaiMenglong HuPeng LuoLei WenZi-Wei YeCuiting LuoJessica Oi-Ling TsangChris Chun-Yiu ChanYaoqiang HuangJianli CaoRonghui LiangZhenzhi QinBo QinFeifei YinHin ChuDong-Yan JinRen SunJasper Fuk-Woo ChanSheng CuiKwok-Yung Yuen

PMC ID: PMC8983325 | DOI: 10.1007/s13238-022-00909-3 | ISSN: 1674-800X | Journal: Protein & Cell, pp. 1-14 | Publisher: Higher Education Press | Publication date: 2022-04-06

Original document: PMC | Score: 7.713231 | Text size: 55754 | Find: similar documents

The SmartTM chemical library was purchased from Chemdiv (San Diego, USA), which contains 50,080 small-molecule compounds with enhanced diversity and drug-like properties.

 

Advances in Pathogenesis, Progression, Potential Targets and Targeted Therapeutic Strategies in SARS-CoV-2-Induced COVID-19

Hong ZhouWei-Jian NiWei HuangZhen WangMing CaiYan-Cai Sun

PMC ID: PMC9016159 | DOI: 10.3389/fimmu.2022.834942 | Journal: Frontiers in Immunology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-05

Original document: PMC | Score: 3.892117 | Text size: 156041 | Find: similar documents

Virtual screening: High-throughput screening is carried out to identify possible lead compounds from existing compound databases, such as ZINC, DrugBank, or ChemDiv, on the basis of structural biology and homology modeling analysis of protein structure.

 

A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis

Jinyeong HeoDahae KohMinjeong WooDoyoon KwonVirgínia Carla de Almeida FalcãoConnor WoodHonggun LeeKideok KimInhee ChoiJichan JangPriscille BrodinDavid ShumVincent Delorme

PMC ID: PMC8980009 | DOI: 10.1038/s41598-022-08209-w | Journal: Scientific Reports, 12(1) Publisher: Nature Publishing Group UK | Publication date: 2022-04-04

Original document: PMC | Score: 7.26731 | Text size: 57782 | Find: similar documents

A total of 104,783 small molecules were assembled, including 51,406 compounds from Enamine and 53,377 compounds from various suppliers: ChemDiv (12,270), ChemBridge (11,709), Life Chemicals (7917), Vitas-M (5000), Princeton BioMolecular Research (4751), InterBioScreen (3436), Otava Chemicals (3366), Thermo Fisher Scientific (Maybridge collection, 2951) and Specs (1977).

 

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives

Irene BrusaElvira SondoFederico FalchiNicoletta PedemonteMarinella RobertiAndrea Cavalli

PMC ID: PMC9014417 | DOI: 10.1021/acs.jmedchem.1c01897 | ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 65(1) pp. 5212-5243 | Publisher: American Chemical Society | Publication date: 2022-04-04 | Print publication date: 2022-04-14

Original document: PMC | Score: 3.4632015 | Text size: 180864 | Find: similar documents

In a different proof-of-principle study, Buchner and co-workers showed that a drug-like small molecule could specifically interfere with the catalytic function of the cochaperone Aha1, without affecting complex formation with Hsp90 (Figure 9, panel 3).113 For that, they screened a library of ∼15,000 chemical compounds from ChemDiv by a FRET-based assay that monitored the interaction between Hsp90 and Aha1 and identified nearly 40 compounds as possible modulators.

 

STAT3 pathway in cancers: Past, present, and future

Han‐Qi WangQi‐Wen ManFang‐Yi HuoXin GaoHao LinSu‐Ran LiJing WangFu‐Chuan SuLulu Cai,Yi ShiBing Liu,Lin‐Lin Bu

PMC ID: PMC8942302 | DOI: 10.1002/mco2.124 | Journal: MedComm, 3(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2022-03-23

Original document: PMC | Score: 4.4422913 | Text size: 144025 | Find: similar documents

Moreover, to prevent off‐target side effects, inS3‐54 analogs were searched in the virtual Chemdiv database, and analog A18 was demonstrated to specifically bind to the DBD of STAT3 and inhibit its activity.

 

A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening

Matic ProjSteven De JongheTom Van LoyMarko JukičAnže MedenLuka CiberČrtomir PodlipnikUroš GrošeljJanez KoncDominique ScholsStanislav Gobec

PMC ID: PMC8972196 | DOI: 10.3389/fphar.2022.855653 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-18

Original document: PMC | Score: 7.713231 | Text size: 54897 | Find: similar documents

The third library used for pharmacophore-based screening contained 1.1 million compounds based on curated diversity sets from Asinex, ChemBridge, ChemDiv, Enamine, KeyOrganics, and Pharmeks.

 

A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis

Yuanyuan YanMiao HeLin ZhaoHuizhe WuYanyun ZhaoLi HanBinbin WeiDongman YeXuemei LvYan WangWeifan YaoHaishan ZhaoBo ChenZining JinJian WenYan ZhuTao YuFeng JinMinjie Wei

PMC ID: PMC9433403 | DOI: 10.1038/s41418-022-00963-8 | ISSN: 1350-9047 | Journal: Cell Death and Differentiation, 29(1) pp. 1769-1789 | Publisher: Nature Publishing Group UK | Publication date: 2022-03-17 | Print publication date: 2022-09

Original document: PMC | Score: 8.475872 | Text size: 93408 | Find: similar documents

Recombinant human SOD2 (Abcam, ab93946), Paclitaxel (Sigma, T7402), Doxorubicin, (Sigma, D1515), Mitoxantrone (Sigma, M2305000), Cisplatin (Sigma, P4394), Docetaxel (Sigma, 01885), Mito TEMPO (Sigma, SML0737), PDI inhibitor 16F16 (Sigma, SML0021), YQ-0629 (Topscience, chemdiv diversity discovery library), (3-Aminopropyl) triethoxysilane (sigma, A3648), Glutaraldehyde solution (sigma, G7651). ... The chemical library was from chemdiv diversity discovery library (Topscience Co., Ltd).

 

CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection

Kate R. FortneySara N. SmithJulia J. van RensburgJulie A. BrothwellJessi J. GardnerBarry P. KatzNagib AhsanAdam S. DuerfeldtHarry L. T. MobleyStanley M. SpinolaBonnie Chase Prokesch

PMC ID: PMC9045377 | DOI: 10.1128/spectrum.02430-21 | Journal: Microbiology Spectrum, 10(1) Publisher: American Society for Microbiology | Publication date: 2022-03-17

Original document: PMC | Score: 7.26731 | Text size: 59485 | Find: similar documents

Compounds 1 and 6 were purchased from ChemDiv and Aurum Pharmatech, respectively (31, 32).

 

Changes in Triple-Negative Breast Cancer Molecular Subtypes in Patients Without Pathologic Complete Response After Neoadjuvant Systemic Chemotherapy

Hiroko MasudaKenichi HaranoSakiko MiuraYing WangYuko HirotaOi HaradaMohit Kumar JollyYuki MatsunagaBora LimAnita L. WoodNapa ParinyanitikulHee Jin LeeGyungyub GongJason T. GeorgeHerbert LevineJangsoon LeeXiaoping WangAnthony LucciArvind RaoBrock L. SchweitzerO. Rayne LawrenceRobert S. SeitzStephan W. MorrisDavid R. HoutSeigo NakamuraSavitri KrishnamurthyNaoto T. Ueno

PMC ID: PMC8939918 | DOI: 10.1200/PO.20.00368 | Journal: JCO Precision Oncology, 6(1) Publisher: Wolters Kluwer Health | Publication date: 2022-03-16

Original document: PMC | Score: 12.167842 | Text size: 41233 | Find: similar documents

Jangsoon Lee Research Funding: AnHeart Therapeutics, CytoDyn, ChemDiv ... Jangsoon Lee Research Funding: AnHeart Therapeutics, CytoDyn, ChemDiv

 

Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening

Huizhen GeLizeng PengZhou SunHuanxiang LiuYulin ShenXiaojun Yao

PMC ID: PMC8967249 | DOI: 10.3389/fphar.2022.850855 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-14

Original document: PMC | Score: 13.700139 | Text size: 41700 | Find: similar documents

About 1.5 million molecules from the ChemDiv database (version 2019) were used for virtual screening. ... About 1.5 million molecules in the ChemDiv (version 2019) database were used as the screening source. ... In this study, the Glide docking-based virtual screening and kinase inhibition assay were conducted to discover HPK1 inhibitors from the ChemDiv database.

 

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

Yixiao ZhangLisha SunHaonan LiLiping AiQingtian MaXinbo QiaoJie YangHao ZhangXunyan OuYining WangGuanglei ChenJinqi XueXudong ZhuYu ZhaoYongliang YangCaigang LiuRenata PasqualiniMone Zaidi

PMC ID: PMC8937232 | DOI: 10.7554/eLife.68481 | Journal: eLife, 11(1) Publisher: eLife Sciences Publications, Ltd | Publication date: 2022-03-14

Original document: PMC | Score: 9.797036 | Text size: 73390 | Find: similar documents

Chemdiv Compond, San Diego, CA ... The results showed that C67399 (C38H48O5, 584.79 Da, 4903–2135, Chemdiv Compond, San Diego, CA) could obviously inhibit the cell viability of MDA-MB-231 cells (Figure 5—figure supplement 1C).

 

An Overview of the Mechanisms Against “Candidatus Liberibacter asiaticus”: Virulence Targets, Citrus Defenses, and Microbiome

Chuanyu YangVeronica Ancona

PMC ID: PMC8982080 | DOI: 10.3389/fmicb.2022.850588 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-10

Original document: PMC | Score: 9.42958 | Text size: 85779 | Find: similar documents

Bortezomib, Chemdiv C549-0604, and Chemdiv D244-0326 etc.

 

Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors

Ekaterina IlgovaSimon GalkinMaria KhrenovaMarina SerebryakovaMarina GottikhAndrey AnisenkoNuno Taveira

PMC ID: PMC8951179 | DOI: 10.3390/ijms23062908 | Journal: International Journal of Molecular Sciences, 23(1) Publisher: MDPI | Publication date: 2022-03-08

Original document: PMC | Score: 12.154662 | Text size: 65386 | Find: similar documents

To select such compounds, the representative Diversity Library containing 50,000 compounds with high diversity scoring (ChemDiv, Moscow, Russia) was used for docking into the Ku heterodimer pocket (PDB ID: 1JEQ). ... A total of 50,000 molecules from ChemDiv Diversity Library were selected for structure-based virtual screening against HIV-1 integrase putative binding site of Ku heterodimer. ... All compounds in ChemDiv diversity dataset were filtered for PAINS [58].

 

Geneticin shows selective antiviral activity against SARS-CoV-2 by targeting programmed −1 ribosomal frameshifting

Carmine VarricchioGregory MathezLaurent KaiserCaroline TapparelAndrea BrancaleValeria Cagno

PMC ID: PMC8923105 | DOI: 10.1101/2022.03.08.483429 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2022-03-08

Original document: PMC | Score: 11.3442745 | Text size: 50145 | Find: similar documents

A library of commercially available RNA-targeting compounds was downloaded from Enamine and ChemDiv website. ... To test the druggability of the binding site, we screened an RNA targeted library (Enamine, ChemDIV), which contains 44520 commercially available RNA-binding compounds, against site

Structure-Based Discovery of N-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication

Yang YangYu YanJiaxin YinJie HuXuefei CaiJieli HuJie XiaKai WangNi TangLuyi HuangKoichi Watashi

PMC ID: PMC8876525 | DOI: 10.3390/v14020348 | Journal: Viruses, 14(1) Publisher: MDPI | Publication date: 2022-02-08

Original document: PMC | Score: 11.093979 | Text size: 54984 | Find: similar documents

Compounds for screening were obtained from Chemdiv Inc. ... Small molecules from ChemDiv and Vitas-M libraries were prepared using Open Babel [42] and were docked into the SBA binding site using AutoDock Vina [43].

 

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays

Yaodong LiuSibtain AhmedYaowei FangMeng ChenJia AnGuang YangXiaoyue HouJing LuQinwen YeRongjun ZhuQitong LiuShu Liu

PMC ID: PMC9628821 | DOI: 10.4014/jmb.2201.01009 | ISSN: 1017-7825 | Journal: Journal of Microbiology and Biotechnology, 32(1) pp. 504-513 | Publisher: The Korean Society for Microbiology and Biotechnology | Publication date: 2022-02-05 | Print publication date: 2022-04-28

Original document: PMC | Score: 17.81079 | Text size: 35511 | Find: similar documents

In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. ... In this study, the 3D structure of AnCDA (pdb code: 2Y8U) was applied as the most reliable docking structure and used to screen the ChemDiv library through the SBVS method. ... The top-ranked 30 compounds derived from the ChemDiv database by structure-based pharmacophore virtual screening were purchased from ChemDiv, Inc. ... Representative molecular properties and key parameters identified in docking-based VS of the 23 purchased compounds from ChemDiv database. ... The compound number labeled in the ChemDiv database. ... According to the purity statements, the purity of all compounds purchased from the ChemDiv database is higher than 95%.

 

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity

Tanaporn UengwetwanitNopporn ChutiwitoonchaiKanin WichapongNitsara Karoonuthaisiri

PMC ID: PMC8813674 | DOI: 10.1016/j.csbj.2022.02.001 | Journal: Computational and Structural Biotechnology Journal | Publisher: The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. | Publication date: 2022-02-04

Original document: PMC | Score: 13.953599 | Text size: 39315 | Find: similar documents

Molecular docking was employed to screen inhibitors of SARS-CoV-2 from the ZINC ChemDiv database. ... To discover candidate inhibitors that can bind SARS-CoV-2 RdRp, molecular docking was carried out to screen for potential hit compounds from the Zinc (purchasable ChemDiv library) which contain diverse scaffolds [26]. ... Compounds from the purchasable Zinc ChemDiv library were docked into the binding pocket of the SARS-CoV-2 RdRp structure to predict the binding affinity.

 

Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays

Jin-ping PangXue-ping HuYun-xia WangJia-ning LiaoXin ChaiXu-wen WangChao ShenJia-jia WangLu-lu ZhangXin-yue WangFeng ZhuQin-jie WengLei XuTing-jun HouDan Li

PMC ID: PMC8809242 | DOI: 10.1038/s41401-021-00855-6 | ISSN: 1671-4083 | Journal: Acta Pharmacologica Sinica, pp. 1-10 | Publisher: Springer Singapore | Publication date: 2022-02-02

Original document: PMC | Score: 14.207614 | Text size: 52284 | Find: similar documents

By screening the ChemDiv chemical library, 54 potential compounds were identified and submitted to bioassays. ... Before molecule docking, the small molecules in the ChemDiv chemical library were prepared using the LigPrep module in Schrödinger, and filtered by the Lipinski’s rule-of-five [32] and Oprea’s [33] rules. ... We evaluated the toxicity of the compounds purchased from Chemdiv.

 

Comparative Characterization of CpCDPK1 and CpCDPK9, Two Potential Drug Targets against Cryptosporidiosis

Jiayuan SuYiting ShenNa LiYu LiZiding ZhangLihua XiaoYaqiong GuoYaoyu FengEric ViscogliosiGabriela CertadMagali Chabé

PMC ID: PMC8875172 | DOI: 10.3390/microorganisms10020333 | Journal: Microorganisms, 10(1) Publisher: MDPI | Publication date: 2022-02-01

Original document: PMC | Score: 8.217452 | Text size: 47108 | Find: similar documents

These small molecules were selected based on the factors of molecular weight, ligand efficiency, coulomb energy, and H-bond energy in molecular docking of CpCDPK1 and CpCDPK9 in the ChemDiv database.

 

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems

Cristina V. IancuGiovanni BocciMohd IshtikharMoumita KhamraiMislav OrebTudor I. OpreaJun-yong Choe

PMC ID: PMC8791944 | DOI: 10.1038/s41598-022-05383-9 | Journal: Scientific Reports, 12(1) Publisher: Nature Publishing Group UK | Publication date: 2022-01-26

Original document: PMC | Score: 7.26731 | Text size: 62641 | Find: similar documents

He is on the Scientific Advisory Board of ChemDiv Inc. and Insilico Medicine.

 

Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

Andrey A. PoloznikovSergey V. NikulinDmitry M. HushpulianAnna Yu. KhristichenkoAndrey I. OsipyantsAndrey F. AsachenkoOlga V. ShurupovaSvyatoslav S. SavinSue H. LeeIrina N. GaisinaGregory R. J. ThatcherAnthony NarcisoEric P. ChangSergey V. KazakovNancy KrucherVladimir I. TishkovBobby ThomasIrina G. GazaryanStanley Omaye

PMC ID: PMC8868400 | DOI: 10.3390/antiox11020220 | Journal: Antioxidants, 11(1) Publisher: MDPI | Publication date: 2022-01-24

Original document: PMC | Score: 13.455724 | Text size: 47541 | Find: similar documents

Branched-tail oxyquinolines were purchased from ChemDiv (Moscow, Russia) or synthesized using the established protocol [9]; the minimum purity guaranteed by the supplier was 90%, and all purchased compounds were provided with NMR spectra. ... All compounds are commercially available from ChemDiv (Skolkovo, Russia). ... Other compounds are commercially available from ChemDiv (Skolkovo, Russia).

 

In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease

Muya XiongTianqing NieQiang ShaoMinjun LiHaixia SuYechun Xu

PMC ID: PMC8783839 | DOI: 10.1016/j.ejmech.2022.114130 | ISSN: 0223-5234 | Journal: European Journal of Medicinal Chemistry | Publisher: Published by Elsevier Masson SAS. | Publication date: 2022-01-23

Original document: PMC | Score: 13.953599 | Text size: 38116 | Find: similar documents

In this work, we collected covalent warheads observed among the known peptidomimetic inhibitors of the SARS-CoV-2 3CLpro and used them as reference to pick up the potential covalent binders from the list resulting from the virtual screening on ChemDiv database. ... Our protocol for in silico screening consisted of two stages: a large-scale non-covalent virtual screening of compounds from ChemDiv database, which was followed by a covalent docking of the compounds containing the warheads shown in Fig. 1 . ... ChemDiv ID

 

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors

Arup R. ChakrabortyAlex VassilevSushil K. JaiswalConstandina E. O'ConnellJohn F. AhrensBarbara S. MallonMartin F. PeraMelvin L. DePamphilis

PMC ID: PMC8828683 | DOI: 10.1016/j.stemcr.2021.12.013 | Journal: Stem Cell Reports, 17(1) pp. 397-412 | Publisher: Elsevier | Publication date: 2022-01-20

Original document: PMC | Score: 7.26731 | Text size: 60240 | Find: similar documents

WX8 (Specs, ChemDiv), Apilimod (Selleck Chemicals), and Adriamycin (MilliporeSigma) were purchased.

 

Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern

Luca MurerRomain VolleVardan AndriasyanAnthony PetkidisAlfonso Gomez-GonzalezLiliane YangNicole MeiliMaarit SuomalainenMichael BauerDaniela SequeiraDominik OlszewskiFanny GeorgiFabien KuttlerGerardo TurcattiUrs F. Greber

PMC ID: PMC8760634 | DOI: 10.1016/j.crviro.2022.100019 | Journal: Current Research in Virological Science | Publisher: Published by Elsevier B.V. | Publication date: 2022-01-15

Original document: PMC | Score: 5.173614 | Text size: 106219 | Find: similar documents

The remaining compounds were purchased from abcr GmbH, AK Scientific, Inc., Abcam plc., Acros Organics, AdipoGen Life Sciences, Inc., Advanced ChemBlocks Inc., Alinda Chemical Trade Company Ltd., Angene, Apollo Scientific Ltd., Axon Medchem, BIOTREND Chemikalien GmbH, BLD Pharmatech Ltd., Biosynth Carbosynth, Cayman Chemical Company, ChemBridge Corporation, ChemDiv Inc., Chemodex Ltd., Cohesion Biosciences Ltd., Combi-Blocks, Inc., Enamine Ltd.

 

The SwissSimilarity 2021 Web Tool: Novel Chemical Libraries and Additional Methods for an Enhanced Ligand-Based Virtual Screening Experience

Maiia E. BraginaAntoine DainaMarta A. S. PerezOlivier MichielinVincent ZoeteBruno Pagano

PMC ID: PMC8776004 | DOI: 10.3390/ijms23020811 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-01-12

Original document: PMC | Score: 12.786698 | Text size: 36135 | Find: similar documents

Enamine, ChemBridge, Maybridge, Asinex, AsisChem, Otava, SPECS, TimTec, Vitas, Life Chemicals, ChemDiv, Innovapharm. ... In particular, on top of ZINC (drug-like, lead-like, and fragments), it is possible to screen compounds in the following commercially available chemical libraries: Enamine, ChemBridge, Maybridge, Asinex, AsisChem, Otava, SPECS, TimTec, Vitas, Life Chemicals, ChemDiv, and Innovapharm.

 

A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes‐Associated Breast Cancer

Qiongyu HaoZhimin HuangQun LiDingxie LiuPiwen WangKun WangJieqing LiWei CaoWenhong DengKe WuRui SuZhongmin LiuJay VadgamaYong Wu

PMC ID: PMC8867195 | DOI: 10.1002/advs.202102303 | Journal: Advanced Science, 9(1) Publisher: John Wiley and Sons Inc. | Publication date: 2022-01-12

Original document: PMC | Score: 11.3442745 | Text size: 50770 | Find: similar documents

A total of 237 (113 from enamine; 84 from chemdiv, 40 from Chembridge) potential hits were identified using the docking‐based virtual screening. ... We then virtually screened seven commercial compound libraries (ChemBridge, ChemDiv, Enamine, InterBioScreen, Life Chemicals, Maybridge and SPECS), including more than 5 million compounds, targeting the binding pocket.

COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDERS

 

John M. SEDIVY [US]Gerwald JOGL [US]Alexandra D'ORDINE [US]

Publication date: 2023-05-04 | Patent publication No.: US-20230139684-A1 | Assignees: Brown University [US] | IPC: A61K31/4741; A61K31/198; A61K31/366; A61K31/145; A61K31/17; A61K31/4192; A61K31/445; A61K31/166; A61K31/167; A61K31/64; A61K31/4035; A61K31/505; A61K31/423; A61K31/381; A61K31/53; A61K31/635 | Oldest priority date: 2019-11-22 | Publication date: 2023-05-04

Score: 12.352504 | Text size: 114680 | Find: similar documents

Compounds were obtained from the following sources: AD1 (National Cancer Institute), AD2 (Alinda), AD3 (ChemBridge), AD4 (AK Scientific), AD5 (ChemDiv), AD6 (ChemBridge), AD7 (Enamine), AD8 (Sigma), AD9 (ChemDiv), AD10 (ChemBridge), AD11 (ChemDiv), AD12 (Sigma), AD13 (Specs), AD14 (Specs), AD15 (TargetMol), AD16 (Vitas), AD17 (Vitas), AD18 (UkrOrgSynthesis), AD19 (TimTec), AD20 (Vitas).

 

INHIBITORS OF VIRAL HELICASES BINDING TO A NOVEL ALLOSTERIC BINDING SITE

 

MENZER, William M. [DE]KNOBLOCH, Gunnar [DE]SCHOMBURG, Adrian [DE]LIELEG, Corinna [DE]SENNHENN, Peter [DE]

Publication date: 2023-05-04 | Patent publication No.: WO-2023073222-A1 | Assignees: EISBACH BIO GMBH [DE] | IPC: A61K31/4155; A61K31/433; A61K31/517; A61P31/12; C07D231/00 | Oldest priority date: 2021-10-29 | Publication date: 2023-05-04

Score: 4.3235645 | Text size: 213643 | Find: similar documents

All compounds that have been rationally designed as described in Example 1 were ordered from the manufacturers Enamine (Riga, Latvia), ChemDiv (San Diego CA, USA), or Intonation Research Laboratories (Hyderabad, India) under CDA as shown in the table in Fig. 20.

 

Pyrazoles

 

Rudolf Schindler [DE]Hans-Joachim Lankau [DE]Norbert Höfgen [DE]Christian Grunwald [DE]Ute Egerland [DE]Barbara Langen [DE]Rita Dost [DE]Thorsten Hage [DE]Simon Ward [GB]

Publication date: 2023-05-02 | Patent publication No.: US-RE049517-E1 | Assignees: JANSSEN PHARMACEUTICALS, INC. [US] | IPC: C07D231/12; A61K31/4155; A61K31/03; C07D403/06 | Oldest priority date: 2014-08-15 | Publication date: 2023-05-02

Score: 12.433797 | Text size: 179865 | Find: similar documents

4-(chloroethyl)-3,5-dimethyl-1H-pyrazole, available from ChemDiv, order ID: BB01-4360 ... 3-(chloromethyl)-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB20-2557 ... 4-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB57-1549 ... 5-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB57-3435 ... The reaction mixture was stirred at room temperature for 20 minutes, then 4-(2-chloro-ethyl)-3,5-dimethyl-1H-pyrazole (159 mg, 1.0 mmol) (ChemDiv, BB01-4360) was added.

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USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

 

David J. Dowling [US]Ofer Levy [US]Francesco Borriello [US]David A. Scott [US]Spencer E. Brightman [US]

Publication date: 2023-04-27 | Patent publication No.: US-20230132397-A9 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2023-04-27

Score: 4.9277406 | Text size: 385657 | Find: similar documents

The chemical libraries screened included known bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... The chemical libraries screened included known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).

 

Small molecule antiviral drug treatment for human papillomavirus infections

 

Elliot J. Androphy [US]Samy Meroueh [US]Zhijian Lu [US]

Publication date: 2023-04-18 | Patent publication No.: US-11628158-B2 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS, INC. [US] | IPC: A61K31/381; A61P31/20; A61K9/00; C07D215/06; C07D487/04; C07D495/04; A61K38/10 | Oldest priority date: 2020-04-17 | Publication date: 2023-04-18

Score: 6.3513765 | Text size: 110204 | Find: similar documents

EIN-116(cat #V008-7329), EIN-117(cat #V008-7342), EIN-118(cat #V009-0689), EIN-119(cat #V009-0721), EIN-120(cat #V009-8145), EIN-121(cat #V013-5084), EIN-123(cat #V009-3346), EIN-124(cat #V001-3096), EIN-125(cat #V001-3172), EIN-126(cat #V002-4119), EIN-127(cat #V002-4126), EIN-128(cat #V002-4718), EIN-129(cat #V012-2359), EIN-130(cat #V031-2694), and EIN-131(cat #V031-2717) were each purchased from ChemDiv.

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Methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1/OBR complex signaling pathway

 

Zakia Belaid-Choucair [FR]Olivier Hermine [FR]Carmen Garrido-Fleury [FR]Claude Cochet [FR]Odile Filhol-Cochet [FR]Renaud Seigneuric [FR]

Publication date: 2023-04-18 | Patent publication No.: US-11629192-B2 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) [FR]; UNIVERSITÉ PARIS CITÉ [FR]; FONDATION IMAGINE [FR]; ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]; UNIVERSITE GRENOBLE ALPES [FR]; COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES [FR]; UNIVERSITE DE BOURGOGNE [FR] | IPC: A61K31/00; A61K39/00; C07K16/28; A61K38/17; A61K31/4745; A61K31/7105; A61K31/713; A61K39/395; A61K45/06; C12N15/113; G01N33/566 | Oldest priority date: 2014-02-18 | Publication date: 2023-04-18

Score: 5.952544 | Text size: 141168 | Find: similar documents

Starting materials useful for preparing compounds of the invention and intermediates thereof are commercially available from sources, such as Aldrich Chemical Co. (Milwaukee, Wis.), Sigma Chemical Co. (St. Louis, Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (San Diego, Calif.), ChemDiv (San Diego, Calif.), SPECS (Delft, The Netherlands), Timtec (Newark, Del.), or alternatively can be prepared by well-known synthetic methods (see, e.g., Harrison et al., “Compendium of Synthetic Organic Methods”, Vols.

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TLR8 AGONIST FOR MODULATING IMMUNE RESPONSE

 

DOWLING, David, J. [US]LEVY, Ofer [US]VAN HAREN, Simon, D. [US]CHEW, Katherine [US]SONI, Dheeraj [US]DE LEON, Maria [US]

Publication date: 2023-04-06 | Patent publication No.: WO-2023056337-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4184; A01N43/52; A61P31/04; A61P35/00; C07D235/04; C07D235/20 | Oldest priority date: 2021-09-30 | Publication date: 2023-04-06

Score: 4.530187 | Text size: 212389 | Find: similar documents

These molecules originated from various bioactive and commercial libraries such as ChemDiv, ChemB ridge, and Asinex.

 

TLR4 AGONIST FOR MODULATING IMMUNE RESPONSE

 

LEVY, Ofer [US]DOWLING, David, J. [US]VAN HAREN, Simon, D. [US]CHEW, Katherine [US]SAITO, Yoshine [US]

Publication date: 2023-04-06 | Patent publication No.: WO-2023056334-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61P31/04; A61P31/12 | Oldest priority date: 2021-09-30 | Publication date: 2023-04-06

Score: 4.530187 | Text size: 206951 | Find: similar documents

These molecules originated from various bioactive and commercial libraries such as ChemDiv, ChemBridge, and Asinex.

 

Identification of Stabilizers of Multimeric Proteins

 

Isabella A. Graef [US]Mamoun M. Alhamadsheh [US]

Publication date: 2023-04-06 | Patent publication No.: US-20230105307-A1 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; A61K31/4196; A61K31/428; A61K31/433; C07D231/12; C07D487/04; A61K31/519; A61K31/166 | Oldest priority date: 2010-05-07 | Publication date: 2023-04-06

Score: 5.952544 | Text size: 136723 | Find: similar documents

Approximately 120,000 compounds from the Stanford HTBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS. and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from Sigma).

 

PHARMACEUTICAL COMPOSITIONS FOR USE IN PREVENTION AND/OR TREATMENT AND/OR CURE OF HEPATITIS B VIRUS

The designation of the inventor has not yet been filed

Publication date: 2023-04-05 | Patent publication No.: EP-4159213-A1 | Assignees: Katholieke Universiteit Leuven [BE] | IPC: A61K31/4422; A61P31/20 | Oldest priority date: 2021-10-01 | Publication date: 2023-04-05

Score: 12.252368 | Text size: 69943 | Find: similar documents

An additional compound library consisting of 556 analogues was purchased from ChemDiv Inc. ... The inhibitory potential of all compounds of the Spectrum Collection (n = 2000) and the ChemDiv library (n = 556) were determined at equimolar concentrations with 3 μM tauro-nor-THCA-24-DBD.

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MYCOBACTERIUM ABSCESSUS GROWTH INHIBITOR AND MODEL

 

GRÜBER, Gerhard [SG]SHIN, Joon [SG]AMARAVADHI, Venkata Krishna Harikishore [SG]WONG, Chui Fann [SG]RAGUNATHAN, Priya [SG]

Publication date: 2023-03-30 | Patent publication No.: WO-2023048641-A2 | Assignees: NANYANG TECHNOLOGICAL UNIVERSITY [SG] | Oldest priority date: 2021-09-21 | Publication date: 2023-03-30

Score: 10.849978 | Text size: 88143 | Find: similar documents

ChemDiv vendor library was employed using the default settings in Phase ligand preparation (Schrodinger release (2020-4) phase. New York, NY: Schrodinger, LLC; 2019; and Dixon, S. L. et al., J. Comput. ... Database screening with this pharmacophore model yielded about 30,000 molecules from the 1.3 million ChemDiv commercial library (San Diego, CA, USA) for further virtual screening studies.

 

NON-FIBRILLAR HEMOGLOBIN S OLIGOMERS AND METHODS TO IDENTIFY MODULATORS OF HEMOGLOBIN S POLYMERIZATION

 

David Kevin Wood [US]Jonathan N. Sachs [US]Nagamani Vunnam [US]Chih Hung Lo [SG]

Publication date: 2023-03-30 | Patent publication No.: US-20230095509-A1 | Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US] | IPC: G01N33/72; G01N21/64 | Oldest priority date: 2021-09-27 | Publication date: 2023-03-30

Score: 7.9492164 | Text size: 80817 | Find: similar documents

Small molecule libraries are available, and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library, LOPAC 1280TH, MicroSource Spectrum Collection, Pharmakon, The Prestwick Chemical Library®, SPECS, NIH Clinical Collection, Chiral Centers Diversity Library.

 

PURMORPHAMINE AS A SMALL COMPOUND POSITIVE ALLOSTERIC MODULATOR OF SECRETIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION

 

Kailash SINGH [CN]Billy Kwok Chong CHOW [CN]

Publication date: 2023-03-30 | Patent publication No.: US-20230099367-A1 | Assignees: VERSITECH LIMITED [CN] | IPC: A61K31/5377; A61P9/12 | Oldest priority date: 2019-04-16 | Publication date: 2023-03-30

Score: 10.262654 | Text size: 113338 | Find: similar documents

Publicly available small molecule libraries used include, but not limited to, PubChem, CHEMBL, MolProt, ChemDiv, ChemSpace, NCI open and ZINC. ... Hits from both the pharmacophore searches were combined together and a total of 1,03,555 small compounds were selected as hits (CHEMBL-11010hits; ChemDiv-330 hits; ChemSpace-8173, Molprot-5,163 hits; NCI open-422; PubChem-71,630; ZINC-6,827) via Pharmit tools.

 

COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES

LU, Boxun [CN]FU, Yuhua [CN]DING, Yu [CN]

Publication date: 2023-03-29 | Patent publication No.: EP-4155294-A1 | Assignees: Fudan University [CN] | IPC: C07D209/34; C07D403/06; C07D311/16; C07D239/88; C07D403/12; C07D487/04; C07D401/12; C07D513/04; C07D409/14; C07D239/70; C07J9/00; A61P3/00; A61P3/04; A61P3/10; A61P1/16; A61P35/00; A61P9/10; A61P25/28; A61K31/352; A61K31/404 | Oldest priority date: 2020-04-23 | Publication date: 2023-03-29

Score: 6.047818 | Text size: 409246 | Find: similar documents

Compound A4: commercially purchased from ChemDiv, CAS No. 779-27-1; ... Compound A5: also numbered AN2, PubChem CID 5398649, commercially purchased from ChemDiv, catalog number D715-2435; ... Compound A7: commercially purchased from ChemDiv;

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SMALL MOLECULE INHIBITORS OF VOLTAGE-GATED SODIUM CHANNEL 1.7 AND METHODS OF USING SAME

 

Andrey BORTSOV [US]Sharat CHANDRA [US]Ru-Rong JI [US]

Publication date: 2023-03-23 | Patent publication No.: US-20230090372-A1 | Assignees: Duke University [US] | IPC: A61K31/4045; A61P17/04; A61K9/00 | Oldest priority date: 2019-12-11 | Publication date: 2023-03-23

Score: 14.708862 | Text size: 132748 | Find: similar documents

For virtual screening, a database of 1.5 million compounds was downloaded from the Chemdiv website (chemdiv.com, ChemDiv Inc., San Diego, Calif.). ... A similarity threshold value of 0.5 against the compounds from the Chemdiv database was used to screen for potential Nav1.7 inhibitors. ... Similarity search of the ChemDiv database (ChemDiv Inc, San Diego, Calif.) containing 1.5 million pre-synthetized compounds yielded a set of 2000 compounds structurally similar to the query molecules—known inhibitors of Nav1.7. ... Of those, 9 compounds with unique scaffolds and sufficient quantity (1 mg or more) available in stock were selected and purchased from ChemDiv for in vitro and in vivo activity assessment.

 

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY

 

Nigel RAMSDEN [GB]David John FOX [GB]James Andrew HUNTINGTON [GB]James Michael TOMLINSON [GB]

Publication date: 2023-03-23 | Patent publication No.: US-20230089087-A1 | Assignees: Z Factor Limited [GB] | IPC: A61K31/451; A61K31/4709; A61K31/4015; A61P1/16; A61P11/00 | Oldest priority date: 2019-12-13 | Publication date: 2023-03-23

Score: 10.621242 | Text size: 39504 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

 

Leucine-Rich Repeat Kinase 2 Allosteric Modulators

 

Wim Versées [BE]Ranjan Kumar Singh [BE]Arjan Kortholt [NL]Christian-Johannes Gloeckner [DE]

Publication date: 2023-03-23 | Patent publication No.: US-20230087785-A1 | Assignees: VIB VZW [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE]; RIJKSUNIVERSITEIT GRONINGEN [NL]; DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E.V. [DE] | IPC: C07K16/40; G01N33/68 | Oldest priority date: 2020-02-25 | Publication date: 2023-03-23

Score: 4.3235645 | Text size: 232358 | Find: similar documents

Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).

 

INHIBITORS OF HSP70 PROTEINS

 

Eli Chapman [US]Andrew J. Ambrose [US]Taoda Shi [US]

Publication date: 2023-03-23 | Patent publication No.: US-20230091297-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US] | IPC: A61K31/426; A61K31/427; A61K31/428; A61P35/00 | Oldest priority date: 2020-03-13 | Publication date: 2023-03-23

Score: 6.3513765 | Text size: 120208 | Find: similar documents

Compound 1, N-(3-methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)thiophene-2-carboxamide, was purchased from ChemDIV Inc.

 

INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF

 

Jinah JEONG [KR]Hyunjung KWAK [KR]Gunhee KIM [KR]Jeongeun KIM [KR]Sanghwan LEE [KR]Seolhee LEE [KR]Jinhee LEE [KR]Jihye CHOI [KR]Hongchul YOON [KR]Joontae PARK [KR]Kyungmi AN [KR]Jungwoo LEE [KR]Eunjung LEE [KR]

Publication date: 2023-03-16 | Patent publication No.: US-20230080054-A1 | Assignees: ILDONG PHARMACEUTICAL CO., LTD. [KR] | IPC: C07D405/12; C07D307/52; C07D405/14; C07D237/20; C07D401/12; C07D403/12; C07D409/12; C07C237/30; C07D241/20; C07D239/42; C07D413/14; C07D409/14; C07D471/08; C07D213/74; C07D417/12; C07D271/07; C07D213/38; C07D239/26; C07D241/12; C07D211/98 | Oldest priority date: 2021-01-22 | Publication date: 2023-03-16

Score: 19.20178 | Text size: 404586 | Find: similar documents

Chemdiv, Inc ... ChemDiv, Inc. ... ChemDiv, Inc. ... ChemDiv, Inc. ... 

 

COMPOSITIONS AND APPLICATIONS THEREOF

 

Todor A. Popov [BG]Peter David Josling [GB]

Publication date: 2023-03-09 | Patent publication No.: US-20230075885-A1 | Assignees: Nasaleze Patents Limited [GB] | IPC: A61K9/16; A61K47/46; A61K31/675; A61K31/352; A61K41/00; A61K38/21; A61K31/215; A61K31/7056; A61K31/513; A61K36/16; A61K31/07; A61K31/375; A61K31/355; A61K36/258; A61K36/82; A61K31/522; A61K31/122; A61K36/23 | Oldest priority date: 2020-02-12 | Publication date: 2023-03-09

Score: 12.913415 | Text size: 93700 | Find: similar documents

A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl) benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370). ... A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370). ... A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370).

DIRECT REPROGRAMMING OF SOMATIC CELLS INTO MYOGENIC CELLS

 

Konrad HOCHEDLINGER [US]Ori BAR-NUR [US]

Publication date: 2023-02-09 | Patent publication No.: US-20230042917-A1 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N5/077; C12N15/85; C12Q1/6883; A61K35/34 | Oldest priority date: 2016-04-06 | Publication date: 2023-02-09

Score: 5.2883806 | Text size: 164100 | Find: similar documents

Compound libraries can be obtained commercially, for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

 

Compositions and methods of treatment using nicotinamide mononucleotide

 

Shin-ichiro Imai [US]Alessia Grozio [US]

Publication date: 2023-01-31 | Patent publication No.: US-11564936-B2 | Assignees: Washington University [US] | IPC: A61K31/706; A61P3/04; A61K45/06; A61K48/00; C12N15/86; G01N33/50; G01N33/68 | Oldest priority date: 2017-08-10 | Publication date: 2023-01-31

Score: 5.2883806 | Text size: 156540 | Find: similar documents

For experiments with Sirt1 and Sirt6 inhibitors, the ilea from 24-month-old female B6 mice were pre-incubated for 2 h at 37° C. in 500 μl of secretion media contending 0.2% DMSO (vehicle), 20 M EX527 (Cayman chemical, MI) or 20 M STK665401 (ChemDiv, cat #8018-9378; Sociali, G. et al., Eur. J. Med.

External link

 

METHODS FOR IDENTIFYING ADAR1 INHIBITORS, AND COMPOSITIONS AND METHODS OF USE IN TREATING CANCER

 

NISHIKURA, Kazuko [US]

Publication date: 2023-01-26 | Patent publication No.: WO-2023004342-A2 | Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US] | IPC: C12Q1/6883; G16B20/00 | Oldest priority date: 2021-07-20 | Publication date: 2023-01-26

Score: 4.530187 | Text size: 202787 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.), Fluka Chemika-Biochemica-Analytika (Buchs Switzerland) and the like.

 

METHODS FOR IDENTIFYING ADAR1 INHIBITORS, AND COMPOSITIONS AND METHODS OF USE IN TREATING CANCER

 

NISHIKURA, Kazuko [US]

Publication date: 2023-01-26 | Patent publication No.: WO-2023004342-A9 | Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US] | IPC: C12Q1/68; C12N9/22 | Oldest priority date: 2021-07-20 | Publication date: 2023-01-26

Score: 4.530187 | Text size: 202941 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.), Fluka Chemika-Biochemica-Analytika (Buchs Switzerland) and the like.

 

CRYSTAL STRUCTURES OF ALK AND LTK RECEPTOR TYROSINE KINASES AND THEIR LIGANDS

 

SAVVIDES, Savvas [BE]DE MUNCK, Steven [BE]

Publication date: 2023-01-12 | Patent publication No.: WO-2023280766-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE] | IPC: C12N9/12; C07K16/40; C07K14/52; C07K14/715; C30B29/58; G16B15/30 | Oldest priority date: 2021-07-07 | Publication date: 2023-01-12

Score: 6.3513765 | Text size: 123298 | Find: similar documents

Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands).

 

ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY

 

Rushdia Yusuf [US]Shrikanta Chattopadhyay [US]David T. Scadden [US]Nick Van Gastel [BE]Azeem S. Sharda [US]Borja Saez [ES]Vasanthi S. Viswanathan [US]

Publication date: 2023-01-05 | Patent publication No.: US-20230000896-A1 | Assignees: Rushdia Yusuf [US]; Shrikanta Chattopadhyay [US]; President and Fellows of Harvard College [US]; The Broad Institute, Inc. [US]; The General Hospital Corporation [US] | IPC: A61K31/713; A61P35/00; A61K31/381; A61K31/437; A61K31/496 | Oldest priority date: 2019-12-09 | Publication date: 2023-01-05

Score: 4.530187 | Text size: 205906 | Find: similar documents

The initial screen will be performed on the ChemDiv 6 library, a select set of 44,000 public domain compounds.

 

TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA) SMALL MOLECULE INHIBITOR

 

Sang Dun CHOI [KR]Mahesh Chandra PATRA [KR]Nasir JAVAID [KR]Maria BATOOL [KR]Dae-Hyun HAHM [KR]

Publication date: 2023-01-05 | Patent publication No.: US-20230000861-A1 | Assignees: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]; UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY [KR] | IPC: A61K31/502; A61P29/00; A61P37/00; C07D417/14; C07D417/12 | Oldest priority date: 2019-11-05 | Publication date: 2023-01-05

Score: 11.169593 | Text size: 89229 | Find: similar documents

SPD304 (MolPort ID: MolPort-042-665-817; ChemDiv catalog #4031-0592), C87 (Tocris Cookson, Bristol, UK), rhTNF-α (Miltenyi Biotec, Auburn, Calif., USA), rhTNF-α (Miltenyi Biotec), act-D (Thermo Fisher Scientific, Inc.), and BS3 (Thermo Fisher Scientific, Inc.) were purchased from the respective companies, noted in parentheses above. ... ChemDiv

 

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY

 

RAMSDEN, Nigel [GB]FOX, David John [GB]

Publication date: 2022-12-22 | Patent publication No.: WO-2022263817-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: C07D211/96; A61P1/16; A61P11/00; A61P35/00; A61K31/445 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22

Score: 13.446067 | Text size: 15363 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

 

COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

 

RAMSDEN, Nigel [GB]FOX, David John [GB]HUNTINGTON, James Andrew [GB]

Publication date: 2022-12-22 | Patent publication No.: WO-2022263816-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61K31/445; A61P11/00 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22

Score: 10.057776 | Text size: 43695 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

 

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

 

RAMSDEN, Nigel [GB]FOX, David John [GB]

Publication date: 2022-12-22 | Patent publication No.: WO-2022263820-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D241/04; C07D265/30; A61K31/495; A61K31/5375 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22

Score: 12.766966 | Text size: 19482 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

 

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY

 

RAMSDEN, Nigel [GB]FOX, David John [GB]

Publication date: 2022-12-22 | Patent publication No.: WO-2022263819-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D211/96; A61K31/445 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22

Score: 13.446067 | Text size: 14861 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

 

E3 LIGASE INHIBITORS AND METHODS OF USE THEREOF

 

RAPE, Michael [US]SCHALETZKY, Julia Sabine [US]WEHRI, Edward Eric [US]MANFORD, Andrew Garrett [US]

Publication date: 2022-12-22 | Patent publication No.: WO-2022266321-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/42; A61K31/4164; A61P35/00; A61K31/423; A61K31/4709 | Oldest priority date: 2021-06-17 | Publication date: 2022-12-22

Score: 7.061031 | Text size: 104533 | Find: similar documents

Diversity and Antibacterial chemical libraries containing 100,000 and 15,000 small molecule compounds, respectively, were purchased from (Chemdiv, San Diego, CA) with same storage conditions.

 

RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHODS OF USING SAME

 

Anna Marie Pyle [US]David Rawling [US]Erik G. Jagdmann [US]Olga Potapova [US]

Publication date: 2022-12-15 | Patent publication No.: US-20220395487-A1 | Assignees: YALE UNIVERSITY [US] | IPC: A61K31/403; A61K31/4184; A61P37/00 | Oldest priority date: 2019-11-04 | Publication date: 2022-12-15

Score: 6.3513765 | Text size: 123176 | Find: similar documents

Using this assay, a library of over 11,000 compounds spanning 11 libraries, including the ChemBridge, Enzo Kinase Inhibitor, Enzo Phosphatase Inhibitor, ChemDiv and Nuclear Receptor Libraries, was screened.

 

SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF

 

Susan Stevens [US]Mary Stenzel-Poore [US]Marie Foss [US]Aaron Nilsen [US]Haihong Jin [US]

Publication date: 2022-12-15 | Patent publication No.: US-20220395500-A1 | Assignees: Neuralexo, Inc. [US] | IPC: A61K31/496; A61P9/10; A61K31/167; A61K31/519; A61K31/5377; A61K31/341; A61K31/381; A61K31/423; A61K31/428; A61K31/427; A61K31/4365; A61K31/437; A61K31/4439; A61K31/4245; A61K31/4178; A61K31/55 | Oldest priority date: 2020-05-04 | Publication date: 2022-12-15

Score: 3.3945959 | Text size: 288502 | Find: similar documents

This library was purchased from SIGA Technologies in 2014 and is made up of compounds from the ChemBridge DIVERSetTM-CL library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv.

 

COMPOUNDS THAT BIND NON-CANONICAL G-QUADRUPLEX STRUCTURES AND METHODS OF MAKING AND USING THE SAME

 

SCHNEEKLOTH, John S. [US]YANG, Mo [US]LIANG, Xiao [US]FULLENKAMP, Christopher [US]

Publication date: 2022-12-15 | Patent publication No.: WO-2022261296-A1 | Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: C07D413/04; C07D413/14; A61P35/00; A61K31/501 | Oldest priority date: 2021-06-09 | Publication date: 2022-12-15

Score: 8.120042 | Text size: 273393 | Find: similar documents

Other sequences of DNA/RNA samples used for binding specificity study are summarized in FIGS.1-2: Hit compounds for binding validation were purchased from ChemDiv and Chembridge. ... In these examples, compounds for SAR study were either purchased from ChemDiv (MY-1, MY-2, MY-3, MY-4, MY-9, MY-10, MY-11, MY-12) or synthesized in the lab (MY-5, MY-6, MY-7, MY-8, MY-13, MY-14). ... Briefly, ~15,000 compounds (10 mM in DMSO) from ChemDiv and Chembridge libraries as well as control dyes (Alexa Fluor 647 and 488, 10 μM in DMSO) were prepared in 384 well plates (Arrayjet JetstarTM).

 

INTEGRATED DRUG DISCOVERY PLATFORM FOR PROTEIN MISFOLDING DISORDERS ASSOCIATED WITH METABOLITE ACCUMULATION

 

Ehud GAZIT [IL]Dana LAOR [IL]Dorin SADE YAZDI [IL]

Publication date: 2022-12-08 | Patent publication No.: US-20220390471-A1 | Assignees: Ramot at Tel-Aviv University Ltd. [IL] | IPC: G01N33/68 | Oldest priority date: 2021-06-03 | Publication date: 2022-12-08

Score: 3.3945959 | Text size: 318328 | Find: similar documents

Compound libraries are commercially available from a number of companies including but not limited to Maybridge Chemical Co. (Trevillet, Cornwall, UK), Comgenex (Princeton, N.J.), Microsource (New Milford, Conn.), Aldrich (Milwaukee, Wis.), AKos Consulting and Solutions GmbH (Basel, Switzerland), Ambinter (Paris, France), Asinex (Moscow, Russia), Aurora (Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.), Chemical Block Lt, (Moscow, Russia).

 

PHARMACEUTICAL COMPOSITION FOR TREATING THYROID CANCER COMPRISING TYROSINE KINASE ACTIVITY INHIBITOR AS ACTIVE INGREDIENT

 

Byeong Cheol AHN [KR]Ji Min OH [KR]

Publication date: 2022-12-01 | Patent publication No.: US-20220378796-A1 | Assignees: Kyungpook National University Industry-Academic Cooperation Foundation [KR] | IPC: A61K31/519; A61P35/04 | Oldest priority date: 2017-10-20 | Publication date: 2022-12-01

Score: 10.621242 | Text size: 41046 | Find: similar documents

Among the TKI candidates, TKI-0266 was selected, purchased from Chemdiv (USA), dissolved in DMSO, and then stored at −80° C.

 

COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING NEURODEGENERATIVE DISEASES AND/OR A CLINICAL CONDITION THEREOF

 

Kang-Yell CHOI [KR]Minguen YOON [KR]Soung-Hoon LEE [KR]

Publication date: 2022-12-01 | Patent publication No.: US-20220378741-A1 | Assignees: CK Regeon Inc. [KR] | IPC: A61K31/404; A61P25/28; A61P25/16 | Oldest priority date: 2019-11-04 | Publication date: 2022-12-01

Score: 10.548147 | Text size: 102776 | Find: similar documents

To initially identify small molecules that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280

 

WEED CONTROL METHOD

 

WHITTINGHAM, William Guy [GB]SCUTT, James Nicholas [GB]HENNESSY, Alan Joseph [GB]FRYE, Elizabeth Catherine [GB]DALE, Suzanna [GB]ASPINALL, Ian Henry [GB]

Publication date: 2022-11-24 | Patent publication No.: WO-2022243155-A1 | Assignees: SYNGENTA CROP PROTECTION AG [CH] | IPC: A01N37/10; C07C69/614 | Oldest priority date: 2021-05-19 | Publication date: 2022-11-24

Score: 7.061031 | Text size: 97018 | Find: similar documents

1-186, 1-6, 1-2 and 1-473 are obtainable as of the priority date of the present application from commercial sources, such as Enamine, Accela and ChemDiv.

 

SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1

MCKENNA, Charles E. [US]PETOSA, Carlo [FR]GOVIN, Jerome [FR]KASHEMIROV, Boris A. [US]FERRI, Elena [US]MIETTON, Flore [FR]

Publication date: 2022-11-23 | Patent publication No.: EP-3490552-B1 | Assignees: University of Southern California [US]; CNRS [FR]; Université Grenoble Alpes [FR]; Inserm [FR]; Commissariat à l'Energie Atomique et aux Energies Alternatives [FR] | IPC: A61K31/554; A61K31/437; A61K31/454; C07D281/14; C07D417/12; C07D417/14; C07D471/04; C07D513/04; A61P31/10 | Oldest priority date: 2016-07-26 | Publication date: 2022-11-23

Score: 13.495927 | Text size: 145215 | Find: similar documents

DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; chemcats: ChemDiv Inc: XP002799331, Database accession no. 1358915-86-2 ... DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 March 2002 (2002-03-02), chemcats: ChemDiv Inco: "7-(5-(3-furanyl)-1,2,4-oxadiazol-3-yl)10- (1-methylethyl)-dibenzo(b,f)(1,4)thiazepin e-11(10H)-one", XP002799332, Database accession no. 1359492-68-4 ... DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 March 2002 (2002-03-02), chemcats: chemdiv inc: "N-(10-cyclopropyl-10,11,dihydro-11-oxodib enzo[b,f][1,4]thiazepin-7-yl)-2-pyridineca rboxamide", XP002799334, Database accession no. 1359492-28-6

External link

Anti-cancer compounds targeting Ral GTPases and methods of using the same

 

Dan Theodorescu [US]Michael Fitzpatrick Wempe [US]David Ross [US]Chao Yan [US]Phillip Reigan [US]

Publication date: 2022-10-18 | Patent publication No.: US-11472812-B2 | Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US] | IPC: C07D491/052; A61K31/4162; A61P35/04; A61K45/06 | Oldest priority date: 2014-07-10 | Publication date: 2022-10-18

Score: 5.0089407 | Text size: 164417 | Find: similar documents

The ChemDiv library [v2006.5, 500,000 compounds excluding those possessing reactive groups, known ADME/toxicity, physicochemical properties lie outside drug-likeness' parameters (Lipinski's rule of 5 and Veber's Rule of 2) at pH 7] was downloaded from ZINC database and docked into the identified site on RalA-GDP using rigid docking protocols.

External link

 

Autophagy modulators for use in treating cancer

 

Melvin L. DePamphilis [US]Gaurav Sharma [IN]Juan Jose Marugan [US]Marc Ferrer [US]Ajit Roy [US]

Publication date: 2022-10-18 | Patent publication No.: US-11471460-B2 | Assignees: The United States of Americans represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/53; A61P35/00; A61K31/506; C07D239/50; C07D251/54; C07D403/12 | Oldest priority date: 2017-12-01 | Publication date: 2022-10-18

Score: 5.952544 | Text size: 133677 | Find: similar documents

Compounds 1, 4, 5, 3, and 2 (Specs, ChemDiv, Life Chemicals) and Rapamycin (S1039, Selleck Chemicals) were dissolved in dimethyl sulfoxide (DMSO) at 20 mM concentrations and stored at −20° C. Compound 1 family compounds (FIG. 1) were assayed for purity by high pressure liquid chromatography and their identity confirmed by Mass spectroscopy.

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NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

 

Catherine TACHDJIAN [US]Andrew P. PATRON [US]Sara L. ADAMSKI-WERNER [US]Farid BAKIR [US]Qing CHEN [US]Vincent DARMOHUSODO [US]Stephen Terrence HOBSON [US]Xiaodong LI [US]Ming QI [CN]Daniel H. ROGERS [US]Marketa RINNOVA [US]Guy SERVANT [US]Xiao-Qing TANG [US]Mark ZOLLER [US]David WALLACE [US]Amy XING [US]Klaus GUBERNATOR [US]

Publication date: 2022-10-13 | Patent publication No.: US-20220326230-A1 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00 | Oldest priority date: 2003-08-06 | Publication date: 2022-10-13

Score: 2.9692738 | Text size: 326033 | Find: similar documents

USA and their subsidiaries Fluka and Riedel-de Haën, at their various other worldwide offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif., Asinex of Moscow Russia, SPECS/BIOSPECS of the Netherlands, Maybridge of Cornwall England, Acros, TimTec of Russia, Comgenex of South San Francisco Calif. and ASDI Biosciences of Newark Del.

 

CO-POTENTIATORS FOR THERAPY OF CYSTIC FIBROSIS CAUSED BY MINIMAL FUNCTION CFTR MUTANTS

 

Alan S. VERKMAN [US]Puay-Wah PHUAN [US]Peter M. HAGGIE [US]

Publication date: 2022-10-13 | Patent publication No.: US-20220323425-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/438; A61K31/47; A61K45/06; A61K31/4245 | Oldest priority date: 2019-08-28 | Publication date: 2022-10-13

Score: 7.629327 | Text size: 87877 | Find: similar documents

For screening, 120,000 diverse drug-like synthetic compounds (i.e., Structures (A), (B), (C), and (D); ChemDiv Inc., San Diego, Calif.) were tested.

 

CFTR REGULATORS AND METHODS OF USE THEREOF

VERKMAN, Alan [US]LEVIN, Marc, H [US]CIL, Onur [US]KURTH, Mark, J [US]

Publication date: 2022-10-12 | Patent publication No.: EP-4071140-A1 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; A61K31/502; A61P11/00; A61P27/02 | Oldest priority date: 2016-08-18 | Publication date: 2022-10-12

Score: 6.2266536 | Text size: 717013 | Find: similar documents

High-throughput screening was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. ... For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... High-throughput screening was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. ... For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... Commercial analogs were purchased from ChemDiv (San Diego, CA).

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NOVEL SULFONAMIDE SERIES OF QR2 INHIBITORS TO TACKLE OXIDATIVE STRESS AND COGNITIVE DECLINE

 

ROSENBLUM, Kobi [IL]GOULD, Natheniel [IL]EDRI, Efrat [IL]

Publication date: 2022-10-06 | Patent publication No.: WO-2022208499-A1 | Assignees: CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. [IL] | IPC: A61K31/40; C07D403/12; A61P25/00 | Oldest priority date: 2021-03-30 | Publication date: 2022-10-06

Score: 4.3235645 | Text size: 209193 | Find: similar documents

The chemical libraries used were Selleck Chemicals Bioactives, the Drug-like set from Enamine, HitFinder collection from Maybridge, Spectrum Collection from Microsource, Lopac from Sigma- Aldrich and the diversity sets from ChemDiv and ChemBridge.

 

TARGETING MELANOCORTIN 3 RECEPTOR FOR TREATMENT/PREVENTION OF EATING, METABOLISM, AND/OR EMOTIONAL DISORDERS

 

Roger Cone [US]Patrick Sweeney [US]

Publication date: 2022-10-06 | Patent publication No.: US-20220313789-A1 | Assignees: The Regents of the University of Michigan [US] | IPC: A61K38/34; A61K38/26; A61K31/485; A61K45/06; A61P25/24; A61P3/04 | Oldest priority date: 2019-06-19 | Publication date: 2022-10-06

Score: 5.2883806 | Text size: 165300 | Find: similar documents

A screen was performed with a series of 4160 samples from the ChemDiv 100,000 compound diversity set maintained at CCG (FIG. 2D-F).

 

COMPOSITIONS COMPRISING RARE GENETIC SEQUENCE VARIANTS ASSOCIATED WITH PULMONARY FUNCTION AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF ASTHMA IN AFRICAN AMERICAN PATIENTS

 

Hakon Hakonarson [US]Patrick Sleiman [US]

Publication date: 2022-10-06 | Patent publication No.: US-20220316008-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61P11/06; A61K31/5585; A61K31/135 | Oldest priority date: 2019-09-09 | Publication date: 2022-10-06

Score: 7.9492164 | Text size: 85748 | Find: similar documents

In addition, compound libraries are commercially available from a number of companies including but not limited to Maybridge Chemical Co. (Trevillet, Cornwall, UK), Comgenex (Princeton, N.J.), Microsource (New Milford, Conn.), Aldrich (Milwaukee, Wis.), AKos Consulting and Solutions GmbH (Basel, Switzerland), Ambinter (Paris, France), Asinex (Moscow, Russia), Aurora (Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive Chemistry, Ltd (Obninsk, Russia), Enamine (Kiev, Ukraine), Evotec (Hamburg, Germany), Indofine (Hillsborough, N.J.), Interbioscreen (Moscow, Russia), Interchim (Montlucon, France), Life Chemicals, Inc.

 

Autotaxin inhibitory compounds

 

Martin Lee Stockley [GB]Ellen Catherine Macdonald [GB]Pritom Shah [GB]Allan Jordan [GB]James Hitchin [GB]Niall Hamilton [GB]

Publication date: 2022-09-27 | Patent publication No.: US-11453666-B2 | Assignees: Cancer Research Technology Limited [GB] | IPC: A61P1/00; A61P1/16; A61P29/00; A61P31/20; A61P31/14; A61P31/12; A61P3/10; A61P7/12; A61P17/00; A61P17/04; A61P17/02; A61P35/00; A61P35/02; A61P7/04; A61P7/02; A61P13/02; A61P13/12; A61P9/12; A61P9/00; A61P43/00; A61P19/04; A61K31/5025; A61K31/444; A61K31/4545; A61K31/5377; A61K31/404; A61K31/551; A61K31/55; A61K31/496; A61K31/4184; A61K45/06; C07D235/02; C07D471/04; A61K31/437 | Oldest priority date: 2015-02-06 | Publication date: 2022-09-27

Score: 6.047818 | Text size: 397678 | Find: similar documents

XP-002756982; ChemDiv Screening Collection, “C614-0971”, Database CHEMCATS, Database accession No. 2058888426, May 13, 2015. ... XP-002756983; ChemDiv Screening Collection, “C614-0943”, Database CHEMCATS, Database accession No. 1904759099, May 13, 2015. ... XP-002756988; ChemDiv Screening Collection, “C614-0930”, Database CHEMCATS, Database accession No. 0674250759, May 13, 2015.

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Small molecules for disrupting the super elongation complex and inhibiting transcription elongation for cancer therapy

 

Ali Shilatifard [US]Kaiwei Liang [US]Edwin R. Smith [US]Gary E. Schiltz [US]Rama K. Mishra [US]Kristen Stoltz [US]

Publication date: 2022-09-27 | Patent publication No.: US-11453640-B2 | Assignees: Northwestern University [US] | IPC: C07C235/74; A61P35/00; C07C235/78; C07D213/40; C07D213/75; C07D231/14; C07D239/36; C07D239/42; C07D241/20; C07D257/06; C07D261/18; C07D271/07; C07D277/46 | Oldest priority date: 2018-03-21 | Publication date: 2022-09-27

Score: 7.161399 | Text size: 203009 | Find: similar documents

Based on the structure of KL-1 (FIG. 1C), we performed a KL-1 similarity search with ChemDiv compounds and tested the top 32 most similar compounds. ... The candidate chemicals from the in silico screening were purchased from the vendors ChemDiv, ChemBridge and Enamine.

External link

 

INHIBITORS OF ANO6 AND THEIR USES THEREOF

 

OH, Changmok [KR]KWON, Sungwook [KR]LIM, Dami [KR]LEE, Eunjung [KR]LEE, Seolhee [KR]YOON, Hongchul [KR]AN, Kyung Mi [KR]PARK, Joontae [KR]CHO, Sung Min [KR]CHOI, Won Gu [KR]LEE, Min Goo [KR]LEE, Jae Myun [KR]NAMKUNG, Wan [KR]LEE, JUNGWOO [KR]

Publication date: 2022-09-22 | Patent publication No.: WO-2022195522-A1 | Assignees: ILDONG PHARMACEUTICAL CO., LTD. [KR]; UIF (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY [KR] | IPC: A61K31/50; A61K31/505; A61K31/44; A61K31/506; A61K31/501; A61P31/14; C07D237/20; C07D239/42; C07D213/74; C07D405/04 | Oldest priority date: 2021-03-17 | Publication date: 2022-09-22

Score: 6.047818 | Text size: 388308 | Find: similar documents

Compound A24 (ChemDiv; Cat# F575-0482, 3-{[l-benzyl-2-(thiophen-2-yl)-lH-indol- 3-yl]methyl}-l-[(oxolan-2-yl)methyl]urea), Compound A24 (ChemDiv; Cat# F474-2423, ethyl 8-methyl-4-((4-(methylthio)benzyl)amino)-2-oxo-l,2-dihydroquinoline-3-carboxylate), abamectin (Cayman Chemical, Ann Arbor, MI, USA), ivermectin (Sigma-Aldrich, St. Louis, MO, USA), camostat mesylate (Sigma-Aldrich, #SML0057), BAPTA-AM (Sigma-Aldrich, #A1076), amphotericin B solution (Sigma-Aldrich, #A2942), and trypsin (Sigma-Aldrich, #T6567) were purchased commercially. ... For the high-throughput screening of a library of 54,000 drug like small-molecule compounds (Chemdiv, San Diego, CA, USA) and a library of 1,700 approved drugs (TargetMol, Boston, MA, USA), FRT-AN06 cells were treated with 25 mM compounds.

 

Bicyclic bromodomain inhibitors

 

John Frederick Quinn [US]Bryan Cordell Duffy [US]Shuang Liu [US]Ruifang Wang [US]May Xiaowu Jiang [US]Gregory Scott Martin [US]Gregory Steven Wagner [US]Peter Ronald Young [US]

Publication date: 2022-09-20 | Patent publication No.: US-11446306-B2 | Assignees: Zenith Epigenetics Ltd. [CA] | IPC: A61K31/5377; A61K31/4184; A61K31/422; A61K31/423; A61K31/437; A61K31/4545; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/517; A61K31/52; A61K45/06; C07D413/04; C07D471/04; C07D473/34; A61P1/16; A61P11/00; A61P1/00; A61P1/02; A61P1/04; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/14; A61P5/50; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/02; A61P11/16; A61P13/10; A61P13/12; A61P15/16; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/04; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; A61P43/00 | Oldest priority date: 2013-06-21 | Publication date: 2022-09-20

Score: 1.8987279 | Text size: 524734 | Find: similar documents

ChemDiv, Inc. in Chemical Abstracts Record No. 1340694-11-8, Entered into the Registry File Nov. 4, 2011.

External link

 

Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents

 

Jan Steyaert [BE]Els Pardon [BE]Toon Laeremans [BE]Cedric Govaerts [BE]Magdalena Grodecka [PL]Maud Sigoillot [BE]Marie Overtus [BE]Marianne Sylvia Carlon [BE]Marjolein Ensinck [BE]Abel Garcia-Pino [BE]

Publication date: 2022-09-15 | Patent publication No.: US-20220289837-A1 | Assignees: VIB VZW [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE]; UNIVERSITÉ LIBRE DE BRUXELLES [BE]; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D [BE] | IPC: C07K16/28; A61K45/06; A61K39/395; G16B15/30; A61K31/47 | Oldest priority date: 2019-04-30 | Publication date: 2022-09-15

Score: 4.3235645 | Text size: 231016 | Find: similar documents

Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).

 

PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF

 

Mark J. Burk [US]Brandon Chen [US]

Publication date: 2022-09-01 | Patent publication No.: US-20220274997-A1 | Assignees: Snap Bio, Inc. [US] | IPC: C07D487/14; C07D471/22; A61P35/00 | Oldest priority date: 2019-04-29 | Publication date: 2022-09-01

Score: 8.611835 | Text size: 245096 | Find: similar documents

Numerous contract research organizations (CROs) offer PIM kinase assay services, including DiscoverX, Inc, (San Diego, Calif.), Reaction Biology Corporation (Malvern, Pa.), ChemDiv (San Diego, Calif.), and Cams Biosciences (Tokyo, Japan). ... The inhibitory activity of each compound against PIM kinases was measured with the LANCE® Ultra Kinase Assays by ChemDiv, Inc. ... All assays were performed by Reaction Biology Corporation (Malvern, Pa.) or ChemDiv, Inc.

Lipid containing formulations

Muthiah Manoharan [US]Kallanthottathil G. Rajeev [US]Akin Akinc [US]Jayaprakash K. Nair [US]Muthusamy Jayaraman [US]Martin Maier [US]

Publication date: 2022-08-23 | Patent publication No.: US-11420931-B2 | Assignees: ARBUTUS BIOPHARMA CORPORATION [CA] | IPC: C07C219/06; A61K9/127; A61K31/325; C07C209/78; C07C233/36; C07C271/10; C07C323/25; A61K47/34 | Oldest priority date: 2006-10-03 | Publication date: 2022-08-23

Score: 10.328181 | Text size: 280810 | Find: similar documents

can be obtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet, Camelford, England; ChemDiv, SanDiego, Calif.

External link


COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES AND CONDITIONS

TARKHOV, Andrei Evgenevich [RU]AVKHACHEV, Konstantin Aleksandrovich [RU]BURMISTROVA, Olga Andreevna [RU]KHOLIN, Maksim Nikolaevich [RU]FEDICHEV, Petr Olegovich [RU]

Publication date: 2022-08-18 | Patent publication No.: WO-2022173333-A2 | Assignees: GERO PTE. LTD. [SG] | IPC: A61K45/00; A61K38/00; A61P9/00; A61P25/16; A61P25/28; A61P3/06; A61P19/00; A61P27/02; A61P35/00 | Oldest priority date: 2021-02-10 | Publication date: 2022-08-18

Score: 6.145057 | Text size: 697071 | Find: similar documents

examples of the providers: eMolecules, Inc, Bio-Techne Corporation (NASDAQ: TECH), Mcule, Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals, ZelinskyInstitute, Specs, ChemicalBlock and Maybridge.


NOVEL SMALL MOLECULE COMPOUND INHIBITING SIGNAL TRANSMISSION PATH OF TLR7 AND TLR9 AND USE THEREOF

Sangdun CHOI [KR]Haseeb MUHAMMAD [KR]Mahesh PATRA [KR]Yang-Seon CHOI [KR]

Publication date: 2022-08-18 | Patent publication No.: US-20220259155-A1 | Assignees: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR] | IPC: C07D233/88; C07D405/04 | Oldest priority date: 2019-07-26 | Publication date: 2022-08-18

Score: 13.962267 | Text size: 71578 | Find: similar documents

compounds ZINC druglike 14,480,911 ZINC leadlike 5,449,805 Enamine 3,006,354 ChemBridge 1,591,767 ChemDiv 1,960,042 Life Chemicals 500,011 Maybridge 72,257 Total 27,061,147 The structures were cleaned up


METHODS, COMPOSITIONS AND COMPOUNDS FOR TREATING AGE-RELATED DISEASES AND CONDITIONS

FEDICHEV, Petr Olegovich [RU]TARKHOV, Andrei Evgenevich [RU]AVKHACHEV, Konstantin Aleksandrovich [RU]BURMISTROVA, Olga Andreevna [RU]KHOLIN, Maksim Nikolaevich [RU]

Publication date: 2022-08-18 | Patent publication No.: WO-2022173334-A2 | Assignees: GERO PTE. LTD. [SG] | IPC: A61K45/00; A61K38/00; A61P9/00; A61P25/16; A61P25/28; A61P3/06; A61P19/00; A61P27/02; A61P35/00 | Oldest priority date: 2021-02-10 | Publication date: 2022-08-18

Score: 2.3034768 | Text size: 2907387 | Find: similar documents

examples of the providers: eMolecules, Inc, Bio-Techne Corporation (NASDAQ: TECH), Mcule, Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals, ZelinskyInstitute, Specs, ChemicalBlock and Maybridge.


Compounds and methods for promoting stress resistance

Cynthia Kenyon [US]Peichuan Zhang [US]James Cregg [US]Kean-Hooi Ang [US]Michelle Arkin [US]

Publication date: 2022-08-16 | Patent publication No.: US-11413278-B2 | Assignees: The Regents of the University of California [US] | IPC: A61K31/443; A61P9/00; A61P3/10; A61P29/00; A61K31/12; A61K31/341; A61K31/404; A61K31/4184; A61K31/437; A61K31/4406; A61K31/4439; A61K31/45; A61K31/519; A61K31/55; A61K31/44; A61P35/00 | Oldest priority date: 2015-10-08 | Publication date: 2022-08-16

Score: 8.066998 | Text size: 606219 | Find: similar documents

a “diversity library” that contains 104,121 small molecules ( ̃24K from ChemBridge; ̃50K from ChemDiv; and ̃30K from SPECS) selected to maximize the coverage of chemical space.

External link


NOVEL ANTIFUNGAL COMPOUNDS

BISCHOFF, Matthias [DE]LAMPE, Philipp [DE]SIEVERS, Sonja [DE]POLYCHRONIDOU, Vasiliki [DE]ANTONCHICK, Andrey [DE]THOMA, Annika [DE]LUDWIG, Nicole [DE]KAHMANN, Regine [DE]MÜNCH, Karin [DE]REISSMANN, Stefanie [DE]

Publication date: 2022-08-11 | Patent publication No.: WO-2022167503-A1 | Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE]; TECHNISCHE UNIVERSITÄT DORTMUND [DE] | IPC: A01N43/40; A01N43/48; A01N43/54; C07D239/72; C07D471/04 | Oldest priority date: 2021-02-03 | Publication date: 2022-08-11

Score: 15.288118 | Text size: 171255 | Find: similar documents

(http://comas.mpi- dortmund.mpg.de/index.php/workflow) were obtained from the chemical providers ChemDiv and Enamine in form of dry film which was dissolved in DMSO to yield a 10 mM stock solution and ... library (http://comas.mpi-dortmund.mpg.de/index.php) consisting mostly of screening compounds from ChemDiv and Enamine and also includes compounds with known mode of action as well as proprietary compounds


COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME

THATCHER, Gregory R. [US]SHEN, Zhengnan [US]XIONG, Rui [US]RATIA, Kiira [US]RONG, Lijun [US]COOPER, Laura [US]

Publication date: 2022-08-11 | Patent publication No.: WO-2022169891-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US]; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US] | IPC: A61K31/24; C07C229/42; A61P31/12 | Oldest priority date: 2021-02-08 | Publication date: 2022-08-11

Score: 15.95058 | Text size: 328027 | Find: similar documents

by regulatory bodies in other countries (FIG.1B) and a 10,000-compound SMART library subset from ChemDiv (FIG. 1C). ... The libraries included in the screen were purchased from TargetMol (Bioactive Library) and ChemDiv (a 10,000-compound SMART library subset). ... An unbiased ChemDiv library (10,000-compound SMART library subset excluding PAINS compounds) and a biased, annotated


COMPOUND FOR TREATING NEURODEGENERATIVE DISORDERS

Boxun Lu [CN]Yiyan Fei [CN]Yu Ding [CN]Yongjun Dang [CN]

Publication date: 2022-08-11 | Patent publication No.: US-20220249433-A1 | Assignees: FUDAN UNIVERSITY [CN] | IPC: A61K31/353; A61K31/517; A61P25/00 | Oldest priority date: 2019-03-11 | Publication date: 2022-08-11

Score: 14.432653 | Text size: 239332 | Find: similar documents

from Selleck, catalog number S1452; Compound 2: PubChem CID 5398649, can be purchased from ChemDiv, catalog numberD715-2435; Compound 3: Semaxanib, can be purchased from Selleck, CAS No. ... 6: can be purchased from TargetMol, CAS No. 842-01-3; Compound 7: can be purchased from ChemDiv.


SARBECOVIRUS BINDERS

SAELENS, Xavier [BE]DE VLIEGER, Dorien [BE]ROSSEY, Iebe [BE]DE CAE, Sieglinde [BE]SEDEYN, Koen [BE]VAN SCHIE, Loes [BE]EECKHAUT, Hannah [BE]FIJALKOWSKA, Daria [BE]STORTELERS, Catelijne [BE]SCHEPENS, Bert [BE]CALLEWAERT, Nico [BE]REMAUT, Han [BE]NERINCKX, Wim [BE]ROOSE, Kenny [BE]REITER, Dirk [BE]

Publication date: 2022-08-11 | Patent publication No.: WO-2022167666-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE] | IPC: A61K39/215; A61P31/14; C07K16/10 | Oldest priority date: 2021-02-05 | Publication date: 2022-08-11

Score: 9.930534 | Text size: 368045 | Find: similar documents

from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ, of California).


NOVEL ANTIFUNGAL COMPOUNDS

BISCHOFF, Matthias [DE]LAMPE, Philipp [DE]SIEVERS, Sonja [DE]POLYCHRONIDOU, Vasiliki [DE]ANTONCHICK, Andrey [DE]THOMA, Annika [DE]LUDWIG, Nicole [DE]KAHMANN, Regine [DE]MÜNCH, Karin [DE]REIßMANN, Stefanie [DE]

Publication date: 2022-08-10 | Patent publication No.: EP-4039094-A1 | Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE] | IPC: A01N43/40; A01N43/48; A01N43/54; C07D239/72; C07D471/04 | Oldest priority date: 2021-02-03 | Publication date: 2022-08-10

Score: 18.151299 | Text size: 179069 | Find: similar documents

The tetrahydro-cyclopentapyrimidine compounds (Formula III) were purchased from ChemDiv using the "search for catalog numbers" option https://chemistryondemand.com:8443/eShop/. ... (http://comas.mpi-dortmund.mpg.de/index.php/workflow) were obtained from the chemical providers ChemDiv and Enamine in form of dry film which was dissolved in DMSO to yield a 10 mM stock solution and ... library (http://comas.mpi-dortmund.mpg.de/index.php) consisting mostly of screening compounds from ChemDiv and Enamine and also includes compounds with known mode of action as well as proprietary compounds ... Table 6: COMPOUNDChemDiv IDsIC50 1-C D468-0807 0.67 μM 2-C D468-0522 6.2 μM 3-C D468-0555 6.4 μM 4-C D468-0823 2 μM 5-C

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TETRAHYDRO IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 INTERNALIZATION INDUCERS

LIU, Phillip C. [US]VOLGINA, Alla [US]WYNN, Richard [US]ZOLOTARJOVA, Nina [US]WU, Liangxing [US]XIAO, Kaijiong [US]MEI, Song [US]LU, Liang [US]ZHU, Wenyu [US]YE, Yingda [US]WANG, Haisheng [US]QIAN, Ding-Quan [US]YAO, Wenqing [US]

Publication date: 2022-08-10 | Patent publication No.: EP-3558990-B1 | Assignees: Incyte Corporation [US] | IPC: C07D471/04; A61K31/437; A61P37/00; A61P35/00; A61P37/04; C07D213/81; C07D263/57; C07D413/14; C07D413/06; C07D519/00 | Oldest priority date: 2017-10-09 | Publication date: 2022-08-10

Score: 8.066998 | Text size: 801797 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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NOVEL IMIDAZOPYRIMIDINE COMPOUNDS AND USES THEREOF

Ofer Levy [US]David J. Dowling [US]Francesco Borriello [US]David A. Scott [US]Spencer E. Brightman [US]Frederic Feru [US]

Publication date: 2022-08-04 | Patent publication No.: US-20220242867-A1 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; Children's Medical Center Corporation [US] | IPC: C07D487/04; A61K31/519; A61K45/06 | Oldest priority date: 2017-11-14 | Publication date: 2022-08-04

Score: 13.851352 | Text size: 270451 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex (see attached pdf of all libraries). ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).


25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC

Chandani Limbad [US]Ryosuke Doi [US]Munemichi Ohe [JP]Naoki Inoue [JP]

Publication date: 2022-08-04 | Patent publication No.: US-20220241316-A1 | Assignees: Buck Institute for Research on Aging [US] | IPC: A61K31/713; A61K31/575; A61K31/593 | Oldest priority date: 2019-04-19 | Publication date: 2022-08-04

Score: 8.605278 | Text size: 351521 | Find: similar documents

and real screening services are commercially available from a number of suppliers (see, e.g., ChemDiv (San Diego, Calif.), and the like).


METHODS FOR THE IDENTIFICATION OF SARM1 NADASE ACTIVITY INHIBITORS AND USES THEREOF

Yarden OPATOWSKY [IL]

Publication date: 2022-08-04 | Patent publication No.: US-20220241416-A1 | Assignees: Bar Ilan University [US] | IPC: A61K41/00; A61P25/00; G01N21/64 | Oldest priority date: 2021-01-28 | Publication date: 2022-08-04

Score: 10.328181 | Text size: 245283 | Find: similar documents

Enamine (Drug-Like Set (DLS)) 20160 compounds; MayBridge (HitFinderTM Collection) 14400 compounds; ChemDiv (DIVERSet) 100000 compounds; Kinom Set (Kinom Set) 187 compounds; SGC (Epigenetic chemical probes)


A NEW MOLECULAR SCAFFOLD FOR TARGETING HRPN13

WALTERS, Kylie J. [US]LU, Xiuxiu [US]TARASOVA, Nadya I. [US]SWENSON, Rolf Eric [US]SABBASANI, Venkatareddy [US]MOCK, Beverly Ann [US]GAIKWAD, Snehal [US]CITRIN, Deborah [US]CHANDRAVANSHI, Monika [US]

Publication date: 2022-08-04 | Patent publication No.: WO-2022165099-A2 | Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: C07C255/44 | Oldest priority date: 2021-01-29 | Publication date: 2022-08-04

Score: 10.328181 | Text size: 315798 | Find: similar documents

commercially available (Enamine diversity set, Emolecules, Mcules, Asinex, UORSY, Chembridge, ChemDiv, ChemSpace) or capable of synthesis (Enamine’s diversity REAL database containing 15 million


METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING MICROBIOME DYSREGULATIONS ASSOCIATED WITH CIRCADIAN CLOCK DISRUPTION

CHAMAILLARD, Mathias [FR]

Publication date: 2022-08-03 | Patent publication No.: EP-3458047-B1 | Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM) [FR]; Université de Lille [FR]; Institut Pasteur De Lille [FR]; Centre National de la Recherche Scientifique CNRS [FR] | IPC: A61K31/352; A61K31/277; A61P25/20; A61P43/00 | Oldest priority date: 2016-05-20 | Publication date: 2022-08-03

Score: 13.775837 | Text size: 90652 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE), or alternatively can be

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PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA

DESAI, Sanjay A. [US]

Publication date: 2022-08-03 | Patent publication No.: EP-2696873-B1 | Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services [US] | IPC: C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; A61K31/498; A61K31/554; A61K31/433; A61P33/06; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; C07K14/445 | Oldest priority date: 2011-04-12 | Publication date: 2022-08-03

Score: 15.288118 | Text size: 152665 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, CA or Peakdale Molecular Limited, High Peak, England. ... temperature using a commercial library of 50,000 compounds with > 90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at

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Compositions and methods for the diagnosis and treatment of lymphatic system disorders

Hakon Hakonarson [US]Dong Li [US]Lifeng Tian [US]Kenny Nguyen [US]Patrick Sleiman [US]

Publication date: 2022-08-02 | Patent publication No.: US-11401553-B2 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/68; C12Q1/6883; A61P43/00; A61K31/4184; A61K31/436; A61K31/4427; A61K31/4709; A61K31/501; A61K31/519; A61K31/5377; A61K45/06 | Oldest priority date: 2016-08-31 | Publication date: 2022-08-02

Score: 12.011612 | Text size: 156918 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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METHOD FOR ALPHAVIRUS INHIBITION

Glen A. COBURN [US]Guo-Hua CHU [US]Jodie C. HAMRICK [US]Charlotte L. BOWSHER [US]Daniel C. PEVEAR [US]

Publication date: 2022-07-28 | Patent publication No.: US-20220233549-A1 | Assignees: Venatorx Pharmaceuticals, Inc [US] | IPC: A61K31/542; A61K31/4375; A61K31/4985; A61K31/5383; A61K31/55 | Oldest priority date: 2019-05-10 | Publication date: 2022-07-28

Score: 13.245268 | Text size: 95555 | Find: similar documents

the acid, 2-(2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-3-ypacetic acid (available from ChemDiv, Inc., reference: Japan Patent JP63008387 A, Jan 14, 1988) (180 mg, 0.8 mmol) in DCM (16 mL) was added


RETROSYNTHESIS SYSTEMS AND METHODS

KONSTANTINOV, Anton [RU]PUTIN, Evgeny Olegovich [RU]ZAGRIBELNYY, Bogdan [CN]IVANENKOV, Yan A. [RU]ZAVORONKOVS, Aleksandrs [CN]

Publication date: 2022-06-02 | Patent publication No.: WO-2022113044-A1 | Assignees: INSILICO MEDICINE IP LIMITED [CN] | IPC: G16C20/10 | Oldest priority date: 2020-11-30 | Publication date: 2022-06-02

Score: 12.913692 | Text size: 142589 | Find: similar documents

ready-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases, such as Clarivate Analytics Integrity (Cortellis Drug Discovery


METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES

Boxun Lu [CN]Yiyan Fei [CN]Yu Ding [CN]Yongjun Dang [CN]

Publication date: 2022-06-02 | Patent publication No.: US-20220170930-A1 | Assignees: FUDAN UNIVERSITY [CN] | IPC: G01N33/566; G01N33/68; A61K31/404; A61K31/352; A61K31/517; A61P25/28 | Oldest priority date: 2019-03-11 | Publication date: 2022-06-02

Score: 15.755042 | Text size: 132416 | Find: similar documents

from Specs, catalog number AN-655/15003575; Compound 4: PubChem CID 5398649, available from ChemDiv, catalog number D715-2435; Compound 5: Semaxanib, available from Selleck, CAS No. ... 377090-84-1; Compound 7: available from TargetMol, CAS No. 842-01-3; Compound 8: available from ChemDiv.


RETROSYNTHESIS SYSTEMS AND METHODS

Anton Konstantinov [RU]Evgeny Olegovich Putin [RU]Bogdan Zagribelnyy [HK]Yan A. Ivanenkov [RU]Aleksandrs Zavoronkovs [HK]

Publication date: 2022-06-02 | Patent publication No.: US-20220172802-A1 | Assignees: Insilico Medicine IP Limited [HK] | IPC: G16C20/10; G16C20/70 | Oldest priority date: 2020-11-30 | Publication date: 2022-06-02

Score: 12.913692 | Text size: 139811 | Find: similar documents

ready-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases, such as Clarivate Analytics Integrity (Cortellis Drug Discovery


NOVEL SMALL MOLECULE COMPOUND INHIBITING SIGNAL TRANSMISSION PATH OF TLR7 AND TLR9 AND USE THEREOF

CHOI, Sangdun [KR]MUHAMMAD, Haseeb [KR]PATRA, Mahesh [KR]CHOI, Yang-Seon [KR]

Publication date: 2022-06-01 | Patent publication No.: EP-4006013-A1 | Assignees: Ajou University Industry-Academic Cooperation Foundation [KR] | IPC: C07D233/88; C07D405/04; A61K31/4168; A61K31/4178; A61P37/00; A61P29/00 | Oldest priority date: 2019-07-26 | Publication date: 2022-06-01

Score: 13.962267 | Text size: 71929 | Find: similar documents

compounds ZINC druglike 14,480,911 ZINC leadlike 5,449,805 Enamine 3,006,354 ChemBridge 1,591,767 ChemDiv 1,960,042 Life Chemicals 500,011 Maybridge 72,257 Total 27,061,147 The structures were cleaned up

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COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR STRUCTURALLY RELATED ENZYMES THERETO

Nathan, Ilana [IL]Khalfin, Boris [IL]

Publication date: 2022-06-01 | Patent publication No.: EP-4005569-A2 | Assignees: ELA Pharma Ltd [IL] | IPC: A61K31/426; A61K31/00; A61K31/415; A61K31/4178; A61K31/4196; A61K31/4439; A61K31/454; A61K31/496; A61K31/4045; A61K31/428; A61K31/536; C07K16/40; C12N15/113; A61P9/10; A61P25/28; A61P39/00; A61P43/00; A61P25/00 | Oldest priority date: 2015-06-04 | Publication date: 2022-06-01

Score: 15.628418 | Text size: 275429 | Find: similar documents

All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, CA. ... 3D structure similarities and topological analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.

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Identification of stabilizers of multimeric proteins

Isabella A. Graef [US]Mamoun M. Alhamadsheh [US]

Publication date: 2022-05-24 | Patent publication No.: US-11337935-B2 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; C07D231/12; A61K31/4196; A61K31/428; A61K31/433; C07D487/04; A61K31/519; A61K31/166; G01N21/64 | Oldest priority date: 2010-05-07 | Publication date: 2022-05-24

Score: 12.297968 | Text size: 142091 | Find: similar documents

120,000 compounds from the Stanford IITBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS, and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from

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METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS

Charles E. MURRY [US]Xiulan YANG [US]

Publication date: 2022-05-19 | Patent publication No.: US-20220152117-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: A61K35/34; A61K45/06; A61P3/04; A61P3/10; C12N5/0793; C12N5/077; C12N9/12 | Oldest priority date: 2019-03-18 | Publication date: 2022-05-19

Score: 10.988179 | Text size: 220455 | Find: similar documents

for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.


COMPOSITIONS AND METHODS FOR TARGETING THE INTERACTION OF HOST MYO5B+D AND CORONAVIRUS M PROTEINS

TANGY, Frédéric [FR]VIDALAIN, Pierre-Olivier [FR]GOLDENRING, James R. [US]ROLAND, Joseph T. [US]LAPIERRE, Lynne A. [US]MANNING, Elizabeth [US]DE HAAN, Cornelis Alexander Maria [NL]

Publication date: 2022-05-12 | Patent publication No.: WO-2022099260-A1 | Assignees: VANDERBILT UNIVERSITY [US]; UNIVERSITEIT UTRECHT HOLDING B.V. [NL] | IPC: A61K39/215; C07K14/165; C07K16/10 | Oldest priority date: 2020-11-05 | Publication date: 2022-05-12

Score: 13.417523 | Text size: 100883 | Find: similar documents

ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,


SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS

ELLIOT J. ANDROPHY [US]SAMY MEROUEH [US]ZHIJIAN LU [US]Anne RIETZ [US]

Publication date: 2022-05-12 | Patent publication No.: US-20220142973-A1 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS, INC. [US] | IPC: A61K31/381; A61K9/00 | Oldest priority date: 2020-04-17 | Publication date: 2022-05-12

Score: 13.417523 | Text size: 108584 | Find: similar documents

#V012-2359), EIN-130(cat #V031-2694), and EIN-131(cat #V031-2717) were each purchased from ChemDiv.


Compositions and methods for the inhibition of pruritus

Mark A. Hoon [US]Hans Juergen Solinski [DE]James Inglese [US]Patricia Dranchak [US]

Publication date: 2022-05-10 | Patent publication No.: US-11324725-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/422; A61P17/04; A61K31/5513; A61K31/55; A61K31/506; A61K31/4439; A61K31/497; A61K31/395; A61K31/4545 | Oldest priority date: 2017-11-03 | Publication date: 2022-05-10

Score: 18.49596 | Text size: 94307 | Find: similar documents

(Chemdiv Inc., catalog number S217-0244); (m) N-benzyl-1-(2-cyanobenzyl)-4-oxo-1,5-diazacycloundecane-8-carboxamide (Chemdiv Inc., catalog number S733-0866); or (n) N-benzyl-N-methyl-8-phenylimidazo[1,2-a]pyrazine-2-carboxamide (Chemdiv Inc., catalog number T425-0460). ... (Franklin, Mass.), JS-11 was from Chembridge (San Diego, Calif.), and JS-12-JS-14 were from Chemdiv (San Diego, Calif.

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NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAM

YANAGISAWA, Katsuhiko [JP]KAWAI, Akiyoshi [JP]

Publication date: 2022-05-04 | Patent publication No.: EP-3275440-B1 | Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: A61K31/4245; A61K31/41; A61K31/4178; A61K31/4196; A61K31/4709; A61K31/5377; A61P25/28 | Oldest priority date: 2015-03-25 | Publication date: 2022-05-04

Score: 12.011612 | Text size: 312903 | Find: similar documents

UORSY Ltd., Vitas-M Laboratory Ltd., Interbioscreen Ltd., Interchim Inc., Ryan Scientific Inc., ChemDiv Inc., through Namiki Shoji Co., Ltd. or Kishida Chemical Co., Ltd., when purchased in Japan.

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POSITIVE ALLOSTERIC MODULATORS OF SWEET TASTE

Anandasankar RAY [US]Joel KOWALEWSKI [US]

Publication date: 2022-04-28 | Patent publication No.: US-20220125086-A1 | Assignees: The Regents of the University of California [US] | IPC: A23L27/00; A23L27/30 | Oldest priority date: 2019-02-19 | Publication date: 2022-04-28

Score: 13.594319 | Text size: 224595 | Find: similar documents

other well-known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.


N-[5-[(3,4-DIMETHOXYPHENYL)METHYL]-1,3,4-THIADIAZOL-2-YL]-2-METHOXY-BENZENEACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CFTR ACTIVATORS FOR TREATING CONSTIPATION OR CHOLESTASIS

VERKMAN, Alan [US]LEVIN, Marc, H. [US]CIL, Onur [US]

Publication date: 2022-04-27 | Patent publication No.: EP-3394083-B9 | Assignees: The Regents of the University of California [US] | IPC: C07D285/135; C07D417/12; C07K5/078; C07K5/062; A61P27/04; A61P1/10 | Oldest priority date: 2015-12-24 | Publication date: 2022-04-27

Score: 16.176003 | Text size: 419260 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, California, USA) and Asinex (Winston-Salem, North Carolina, USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, California, USA) and Asinex (Winston-Salem, North Carolina, USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.

External link


USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

David J. Dowling [US]Ofer Levy [US]Francesco Borriello [US]David A. Scott [US]Spencer E. Brightman [US]

Publication date: 2022-04-21 | Patent publication No.: US-20220118085-A9 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2022-04-21

Score: 12.211837 | Text size: 385599 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).


METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS

Beibei Chen [US]Toren Finkel [US]Yuan Liu [US]

Publication date: 2022-04-14 | Patent publication No.: US-20220112218-A1 | Assignees: University of Pittsburgh - Of the Commonwealth System of Higher Education [US] | IPC: C07D519/00; A61P25/28 | Oldest priority date: 2019-01-03 | Publication date: 2022-04-14

Score: 15.064883 | Text size: 206195 | Find: similar documents

The following compounds (free base) provided in Table 2 were obtained from commercial sources (ChemDIV, Inc. and Mol port, Inc.): TABLE 2 No. ... The following compounds shown in Table 4 were purchased from ChemDIV, Inc. TABLE 4 No.


COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS

Hakon Hakonarson [US]Yoav Dori [US]Dong Li [US]Michael March [US]Charlly Kao [US]Christoph Seiler [US]

Publication date: 2022-04-14 | Patent publication No.: US-20220112558-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61K45/06; C12Q1/6869; C12Q1/6827; A61K31/4184 | Oldest priority date: 2018-09-07 | Publication date: 2022-04-14

Score: 11.227331 | Text size: 252490 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


COMPOUNDS WITH GLUCOCORTICOID SPARING EFFECTS AND USES THEREOF

CARSON, Dennis, A. [US]HAYASHI, Tomoko [US]CORR, Mary, Patricia [US]COTTAM, Howard, B. [US]HOSOYA, Tadashi [US]SHUKLA, Nikunj [US]

Publication date: 2022-04-14 | Patent publication No.: WO-2022076473-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/495; A61K31/505; A61K31/519; C07D487/02; C07D487/04 | Oldest priority date: 2020-10-05 | Publication date: 2022-04-14

Score: 12.913692 | Text size: 115726 | Find: similar documents

commercially purchased. [0091] Hit compounds were purchased from Chem Bridge (San Diego, CA) and ChemDiv (San Diego, CA) and dissolved in dimethyl sulfoxide (DMSO, Sigma Aldrich, St Louis.


COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS

HOON, Mark A. [US]SOLINSKI, Hans Juergen [DE]INGLESE, James [US]DRANCHAK, Patricia [US]

Publication date: 2022-04-13 | Patent publication No.: EP-3703682-B1 | Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services [US] | IPC: A61K31/422; A61P43/00; A61P17/04; A61K31/5517; A61K31/5513; A61K31/55; A61K31/519; A61K31/506; A61K31/4985; A61K31/4545; A61K31/439; A61K31/437; A61K31/42; A61K31/015; A61K31/4184; C07D413/12; C07D471/04; C07D487/04 | Oldest priority date: 2018-05-14 | Publication date: 2022-04-13

Score: 13.775837 | Text size: 86296 | Find: similar documents

Discovery (Franklin, MA), JS-11 was from Chembridge (San Diego, CA), and JS-12 - JS-14 were from Chemdiv (San Diego, CA).

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FLY AVATARS FOR CANCER AND USES THEREOF

CAGAN, Ross [US]BANGI, Erdem [US]

Publication date: 2022-04-13 | Patent publication No.: EP-3397051-B1 | Assignees: Icahn School of Medicine at Mount Sinai [US] | IPC: A01K67/033; C07K14/82; G01N33/50; A61K31/405; A61K31/519; C12N9/16 | Oldest priority date: 2015-12-30 | Publication date: 2022-04-13

Score: 15.95058 | Text size: 240334 | Find: similar documents

Compound Library MedChem Express MAPK Compound Library MedChem Express Akt-Targeted Library ChemDiv PI3K-Targeted Library ChemDiv KRAS-Targeted Library ChemDiv EXPRESS-Pick Collection ChemBridge DIVERSetTM-EXP ChemBridge CORE Library ChemBridge DIVERSetTM-CL

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COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL KILLER CELL ACTIVATION AND FUNCTION

Mira BARDA-SAAD [IL]

Publication date: 2022-03-31 | Patent publication No.: US-20220096551-A1 | Assignees: BAR ILAN UNIVERSITY [IL] | IPC: A61K35/17; A61K31/7105; A61K9/14; A61P35/00 | Oldest priority date: 2019-01-28 | Publication date: 2022-03-31

Score: 8.902286 | Text size: 331890 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof

Catherine Tachdjian [US]Andrew P. Patron [US]Sara L. Adamski-Werner [US]Farid Bakir [US]Qing Chen [US]Vincent Darmohusodo [US]Stephen Terrence Hobson [US]Xiaodong Li [US]Ming Qi [CN]Daniel H. Rogers [US]Marketa Rinnova [US]Guy Servant [US]Xiao-Qing Tang [US]Mark Zoller [US]David Wallace [US]Amy Xing [US]Klaus Gubernator [US]

Publication date: 2022-03-08 | Patent publication No.: US-11268952-B2 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00 | Oldest priority date: 2003-08-06 | Publication date: 2022-03-08

Score: 9.562369 | Text size: 374581 | Find: similar documents

offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif.

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SMALL MOLECULE MODULATORS OF GSK-3 ACTIVITY

ELDAR-FINKELMAN, Hagit [IL]SENDEROWITZ, Hanoch [IL]

Publication date: 2022-03-03 | Patent publication No.: WO-2022044024-A1 | Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD. [IL]; BAR-ILAN UNIVERSITY [IL] | IPC: C07D413/14; C07D413/10; C07D413/04; C07D491/113; C07F9/38; A61K31/496; A61K31/4439; A61K31/438; A61K31/675; A61P25/28; A61P25/24; A61P3/10; A61P9/00; A61P9/10; A61P33/00; A61P33/06; A61P35/00; A61P43/00 | Oldest priority date: 2020-08-31 | Publication date: 2022-03-03

Score: 12.011612 | Text size: 173651 | Find: similar documents

by virtual screening were purchased from MolPort Riga, Latvia, that supplied compounds from ChemDiv Inc., San Diego, CA USA, Specs, Zoetermeer, The Netherlands, and Enamine Ltd. NJ, USA.


ANTHRANILIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS

Otto PHANSTIEL, IV [US]Holly MOOTS [US]Patrick MALONEY [US]Paul HERSHBERGER [US]Satyamaheshwar PEDDIBHOTLA [US]

Publication date: 2022-03-03 | Patent publication No.: US-20220064133-A1 | Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US]; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US] | IPC: C07D295/155; C07D211/46; A61K45/06 | Oldest priority date: 2018-08-10 | Publication date: 2022-03-03

Score: 18.151299 | Text size: 199883 | Find: similar documents

round of SAR was primarily fueled by 38 compounds, which were purchased from commercial vendors (ChemDiv) while a robust synthetic route was under development. ... (0800678) 6 13.3 ± 0.04 EC8 = 6 EC25 = 6 (8-2) 9 (0754479) 8 16.8 ± 0.1 EC49 = 8 EC5 = 8 (8-3) ChemDiv (F687-0882) 9 >50 EC38 = 9 EC11 = 8 (8-4) ChemDiv (F687-0884) 9 46.3 ± 0.02 EC43 = 9 EC0 = 9 (8-5) 33 (0800676) 8 22. ... In terms of toxicity profiles, compounds ChemDiv F687-0882 and ChemDiv F687-0884 and compounds 50 and 64 gave IC50 values >38 μM and were deemed relatively non-toxic.


Cells expressing apolipoprotein E and uses thereof

Susan L. Lindquist [US]Priyanka Narayan [US]

Publication date: 2022-03-01 | Patent publication No.: US-11261453-B2 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C12N15/81; C07K14/775; C07K14/47; G01N33/92; C12Q1/02; G01N33/50; G01N33/68; A61K38/00 | Oldest priority date: 2014-09-12 | Publication date: 2022-03-01

Score: 8.066998 | Text size: 401412 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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QUORUM SENSING INHIBITORS AND METHODS OF USE

VAN KESSEL BOCHMAN, Julia, Cathering [US]BROWN, Laura, Caroline [US]

Publication date: 2022-02-17 | Patent publication No.: WO-2022036282-A1 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US] | IPC: A61K31/16; A61K31/18; A61P31/04; C07C307/00; C07C307/04 | Oldest priority date: 2020-08-13 | Publication date: 2022-02-17

Score: 15.755042 | Text size: 154017 | Find: similar documents

We screened ~60,000 molecules in the ChemBridge and Chemdiv libraries and identified nine compounds that inhibited LuxR activation and/or repression but did ... P1120 D05 and P0074 N08 were purchased from EnamineStore, and P0053 118 was purchased from ChemDiv.


COMPOUND FOR TREATING NEURODEGENERATIVE DISORDERS


LU, Boxun [CN]FEI, Yiyan [CN]DING, Yu [CN]DANG, Yongjun [CN]

Publication date: 2022-02-16 | Patent publication No.: EP-3954368-A1 | Assignees: Fudan University [CN] | IPC: A61K31/353; A61K31/517; A61P25/00 | Oldest priority date: 2019-10-21 | Publication date: 2022-02-16

Score: 14.432653 | Text size: 232331 | Find: similar documents

from Selleck, catalog number S1452; Compound 2: PubChem CID 5398649, can be purchased from ChemDiv, catalog numberD715-2435; Compound 3: Semaxanib, can be purchased from Selleck, CAS No. ... 6: can be purchased from TargetMol, CAS No. 842-01-3; Compound 7: can be purchased from ChemDiv.

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TREX1 INHIBITORS AND USES THEREOF

PERRINO, Fred W. [US]HOLLIS, Thomas [US]HARVEY, Scott E. [US]HEMPHILL, Wayne O. [US]

Publication date: 2022-02-10 | Patent publication No.: WO-2022031640-A1 | Assignees: WAKE FOREST UNIVERSITY HEALTH SCIENCES [US] | IPC: A61K31/122; C07C309/44; A61P35/00 | Oldest priority date: 2020-08-04 | Publication date: 2022-02-10

Score: 18.57923 | Text size: 91650 | Find: similar documents

(HTS) We applied structure-based virtual screening (SBVS) to the commercial 150k-compound ChemDiv Diversity Library and the ~1.2M-compound ChemBridge CORE+EXPRESS libraries. ... The top-scoring 698 and 2004 compounds from the ChemDiv and ChemBridge libraries, respectively, were selected for further study and ordered as physical ... All ChemDiv and Chembridge candidates plus 51/222 (-23%) of the Nanosyn candidates were commercially available, ... The compounds are available from one or more of the following vendors: Ambinter, ChemDiv, ChemBridge, Nanosyn, Sigma-Aldrich.


COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES

Jason Barbour [US]David Ott [US]

Publication date: 2022-02-03 | Patent publication No.: US-20220031701-A1 | Assignees: Synkrino Biotherapeutics, Inc. [US] | IPC: A61K31/515; A61P37/06; A61P19/02; G16B25/10; G16B40/00; A61K31/437; A61K31/496; A61K31/50; A61K45/06; C12Q1/6883 | Oldest priority date: 2018-08-21 | Publication date: 2022-02-03

Score: 16.251385 | Text size: 87934 | Find: similar documents

Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state. ... TABLE 1 CompoundChemDiv Compound IdentifierNormalized Average of MIG/CXCL9Normalized Average of IP-10/CXCL10Normalized


TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven Albert Everett [US]Saraj Ulhaq [GB]

Publication date: 2022-02-03 | Patent publication No.: US-20220031852-A1 | Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54; A61K31/343; A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16; C07D311/18; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; C07D487/04; C07D491/22; A61K31/37; A61K31/381; A61K31/513; A61K31/52; A61K31/665 | Oldest priority date: 2009-05-01 | Publication date: 2022-02-03

Score: 16.116692 | Text size: 220210 | Find: similar documents

for CYP181 The target enzyme CYP1B1 was screened against two commercial libraries including the ChemDiv Diversity 50,000 test compound collection and the ChemDiv Kinase Targeted 10,000 test compound collection with a view to identifying activity differentiating ... cross validation on a training set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverse and Kinase libraries.


COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION

Raymond MOELLERING [US]John COUKOS [US]Gihoon LEE [US]Jae Won CHANG [US]Gokhan MUTLU [US]

Publication date: 2022-02-03 | Patent publication No.: US-20220031656-A1 | Assignees: The University of Chicago [US] | IPC: A61K31/381 | Oldest priority date: 2018-10-14 | Publication date: 2022-02-03

Score: 15.518069 | Text size: 139140 | Find: similar documents

CBR-470-0 and CBR-581-9 were from ChemDiv. CBR-470-1 (initially from ChemDiv as D470-2172) and related analogs were synthesized in house according to full methods described in


ANTIBACTERIAL COMPOUNDS AND USES THEREOF

Paula I. WATNICK [US]Julie Szu YU [US]

Publication date: 2022-01-27 | Patent publication No.: US-20220023270-A1 | Assignees: The Children's Medical Center Corporation [US] | IPC: A61K31/433; A61K31/165; A61K31/4525; A61K31/341; A61K31/357; A61K31/519; A61P31/04 | Oldest priority date: 2018-12-06 | Publication date: 2022-01-27

Score: 14.637417 | Text size: 190761 | Find: similar documents

A chemical library comprised of compounds from the Targeted Diversity Library at ChemDiv and purchased and maintained by the Institute of Chemistry and Chemical Biology-Longwood ... Compound O06 was purchased from ChemDiv under the catalog number 8019-0105.


CFTR regulators and methods of use thereof

Alan S. Verkman [US]Marc H. Levin [US]Onur Cil [US]Sujin Lee [US]

Publication date: 2022-01-25 | Patent publication No.: US-11230535-B2 | Assignees: The Regents of the University of California [US] | IPC: C07D251/52; C07D251/46; A61P1/10; A61P27/04; A61K31/496; A61K31/53; A61K31/5377; A61K31/55; A61K45/06; C07D403/04; C07D413/12 | Oldest priority date: 2015-12-24 | Publication date: 2022-01-25

Score: 15.000084 | Text size: 592839 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.

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SUBSTITUTED 4-(3-AMINOPROP-1-YL)AMINOQUINOLINE ANALOGS AS MODULATORS OF MELANOMA-ASSOCIATED ANTIGEN 11 UBIQUITIN LIGASE

POTTS, Ryan [US]CHEN, Taosheng [US]RANKOVIC, Zoran [US]MIN, Jaeki [US]LIN, Wenwei [US]YANG, Seung Wook [US]MAYASUNDARI, Anand [US]

Publication date: 2022-01-20 | Patent publication No.: WO-2022015974-A2 | Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. [US] | IPC: C07D407/12 | Oldest priority date: 2020-07-15 | Publication date: 2022-01-20

Score: 9.562369 | Text size: 338749 | Find: similar documents

commercial sources including Sigma, Microsource (Gaylordsville, CT), selleckchem (Houston, TX), ChemDiv (San Diego, CA), ChemBridge (San Diego, CA), Enamine (Monmouth Jet.


METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES

LU, Boxun [CN]FEI, Yiyan [CN]DING, Yu [CN]DANG, Yongjun [CN]

Publication date: 2022-01-19 | Patent publication No.: EP-3940384-A1 | Assignees: Fudan University [CN] | IPC: G01N33/68; G01N33/58; G01N21/64; G01N21/552; G01N21/76; G01N25/48; A61K31/404; A61K31/517; A61K31/352; A61P25/16; A61P25/28 | Oldest priority date: 2019-10-21 | Publication date: 2022-01-19

Score: 15.755042 | Text size: 130423 | Find: similar documents

from Specs, catalog number AN-655/15003575; Compound 4: PubChem CID 5398649, available from ChemDiv, catalog number D715-2435; Compound 5: Semaxanib, available from Selleck, CAS No. ... 377090-84-1; Compound 7: available from TargetMol, CAS No. 842-01-3; Compound 8: available from ChemDiv.

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TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS mTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE

LIVNEH, Ido [IL]COHEN-KAPLAN, Victoria [IL]CIECHANOVER, Aaron [IL]GOLDHIRSH, Gilad [IL]ZOHAR, Yaniv [IL]LAVI, Noa [IL]FABRE, Bertrand Francois [FR]

Publication date: 2022-01-13 | Patent publication No.: WO-2022009212-A1 | Assignees: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. [IL]; RAMBAM MED-TECH LTD. [IL] | IPC: A61K31/198; A61P35/00; G01N33/50 | Oldest priority date: 2020-07-09 | Publication date: 2022-01-13

Score: 7.592094 | Text size: 469435 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive


S3QELS TO PROTECT AGAINST INTESTINAL PERMEABILITY

Mark A. Watson [GB]Martin D. Brand [US]Pankaj Kapahi [US]

Publication date: 2022-01-06 | Patent publication No.: US-20220000873-A1 | Assignees: Buck Institute for Research on Aging [US] | IPC: A61K31/519; A61K31/517; A61K31/343; A61K31/4365; A61K31/495; A61K31/445; A61P1/00; A61P3/04 | Oldest priority date: 2018-12-12 | Publication date: 2022-01-06

Score: 12.297968 | Text size: 137180 | Find: similar documents

Thus, for example, the following S3QELs are available from Chemdiv: S3QEL-1 (catalog ID K284-4710), S3QEL-1.1 (K284-4711), S3QEL-1.2 (K284-4767), S3QEL-1.


Ligands of the mu, kappa, and delta opioid receptors

Evan N. Feinberg [US]Vijay S. Pande [US]Susruta Majumdar [US]Gavril Pasternak [US]

Publication date: 2022-01-04 | Patent publication No.: US-11213518-B2 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US]; Memorial Sloan-Kettering Cancer Center [US] | IPC: A61K31/4453; A61K31/415; A61K9/00 | Oldest priority date: 2017-11-14 | Publication date: 2022-01-04

Score: 19.328047 | Text size: 78827 | Find: similar documents

5421855 298.471 [[image:EMI-C00003]] 4 ChemBridge Corp 5359784 286.419 [[image:EMI-C00004]] 5 ChemDiv, Inc. K416-0034 331.45 [[image:EMI-C00005]] 6 ChemDiv, Inc. 6030-4029 277.408 [[image:EMI-C00006]] 7 ChemDiv, Inc. D171-0103 284.403 [[image:EMI-C00007]] 8 ChemDiv, Inc. K808-9296 317.388 [[image:EMI-C00008]] 9 ChemDiv, Inc. C296-0706 379.43 [[image:EMI-C00009]] 10 ChemDiv, Inc. C656-0381 347.353 [[image:EMI-C00010]] 11 InterBioScreen Ltd. STOCK1S-36272 255.

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Isolated human lung progenitor cells and uses thereof

Jayaraj Rajagopal [US]Hongmei Mou [US]

Publication date: 2022-01-04 | Patent publication No.: US-11214769-B2 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N5/074; C12N5/071; A61K35/42; A61L27/38; A61L27/56; A61L27/58; G01N33/68; A61K9/00 | Oldest priority date: 2012-01-13 | Publication date: 2022-01-04

Score: 9.930534 | Text size: 267627 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

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Method to prevent cancer metastasis and inhibit inflammation by inhibition of p68 interaction with calmodulin

Zhi-Ren Liu [US]Haizhen Wang [US]

Publication date: 2022-01-04 | Patent publication No.: US-11214624-B2 | Assignees: Proda Biotech LLC [US] | IPC: C07K16/40; C12N9/14; C07K14/47; A61K38/46; G01N33/50; G01N33/573; A61K38/00 | Oldest priority date: 2012-03-14 | Publication date: 2022-01-04

Score: 13.245268 | Text size: 92806 | Find: similar documents

of chemical libraries including but not limited to ChemBridge Corporation (San Diego, Calif.), ChemDiv (San Diego, Calif.), Life Chemicals (Orange, Conn.), and Maybridge (Cornwall, UK).

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COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING METABOLIC DISEASES AND/OR A CLINICAL CONDITION THEREOF

Kang-Yell Choi [KR]Seol Hwa Seo [KR]Eunhwan Kim [KR]

Publication date: 2021-12-30 | Patent publication No.: US-20210403432-A1 | Assignees: CK Biotech Inc. [KR] | IPC: C07D215/38; C07D487/04; C07D471/04; C07D207/44; C07D513/04; C07D239/42; C07D498/04; C07D209/40; C07D217/16; C07C229/36; C07D309/38; C07D311/30; C07C237/48; C07C39/215; C07D295/088; C07D487/22; A61P3/04; A61P3/10; G01N33/68 | Oldest priority date: 2018-10-15 | Publication date: 2021-12-30

Score: 15.319015 | Text size: 228995 | Find: similar documents

that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280 Screen Format Concentration(s) tested Plate controls Reagent/compound ... of the CXXC5-DVL interface, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction


COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES


HAKONARSON, Hakon [US]LI, Yun Rose [US]KEATING, Brendan [US]

Publication date: 2021-11-24 | Patent publication No.: EP-3337465-B1 | Assignees: The Children's Hospital of Philadelphia [US] | IPC: A61K31/00; A61P1/00; C12Q1/68 | Oldest priority date: 2016-04-08 | Publication date: 2021-11-24

Score: 9.930534 | Text size: 296191 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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MICROFLUIDIC DEVICE AND USES THEREOF

Doron GERBER [IL]

Publication date: 2021-11-18 | Patent publication No.: US-20210354140-A1 | Assignees: Bar Ilan University [IL] | IPC: B01L3/00; G02B21/26; G02B21/00 | Oldest priority date: 2020-05-18 | Publication date: 2021-11-18

Score: 9.22053 | Text size: 315123 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


RETROSYNTHESIS-RELATED SYNTHETIC ACCESSIBILITY

ZAGRIBELNYY, Bogdan [CN]PUTIN, Evgeny Olegovich [RU]FEDORCHENKO, Sergei Andreevich [RU]IVANENKOV, Yan A. [RU]ZAVORONKOVS, Aleksandrs [CN]

Publication date: 2021-11-18 | Patent publication No.: WO-2021229454-A1 | Assignees: INSILICO MEDICINE IP LIMITED [CN] | IPC: G16C20/30; G16C20/10; G16C20/70 | Oldest priority date: 2020-05-14 | Publication date: 2021-11-18

Score: 14.350686 | Text size: 86172 | Find: similar documents

-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases such as Clarivate Analytics Integrity (Cortellis Drug Discovery


SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF

STEVENS, Susan [US]STENZEL-POORE, Mary [US]FOSS, Marie [US]NILSEN, Aaron [US]JIN, Haihong [US]

Publication date: 2021-11-11 | Patent publication No.: WO-2021226129-A1 | Assignees: NEURALEXO, INC. [US] | IPC: A61K31/495; A61K31/496; C07D295/04; C07D295/092 | Oldest priority date: 2020-05-04 | Publication date: 2021-11-11

Score: 9.22053 | Text size: 295182 | Find: similar documents

library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv.


CELL ENTRY-MODULATING AGENTS AND USES THEREFOR

JENNINGS, Michael Paul [AU]DAY, Christopher James [AU]KIEFEL, Milton [AU]HASELHORST, Thomas [AU]

Publication date: 2021-11-11 | Patent publication No.: WO-2021222988-A1 | Assignees: GRIFFITH UNIVERSITY [AU] | IPC: A61K38/10; A61K31/4184; A61K31/4188; A61K31/4745; A61K31/496; A61K31/655; C07D491/22; C07K7/08; A61P31/14 | Oldest priority date: 2020-05-07 | Publication date: 2021-11-11

Score: 11.227331 | Text size: 213173 | Find: similar documents

- 1,050, eDrugs - 1,610, Ligandbox Kegg - 5,814, PRESTWICK OFF PATENTS - 2,062, OTAVA - 9,765, CHEMDIV - 33,145) as 2D SDF molecular format.


CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. Verkman [US]Marc H. Levin [US]Onur Cil [US]Mark J. Kurth [US]

Publication date: 2021-11-11 | Patent publication No.: US-20210347742-A1 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; C07D403/04; C07D405/04; C07D498/06; C07D409/04; C07D401/06; C07D405/06; C07D409/06 | Oldest priority date: 2015-12-24 | Publication date: 2021-11-11

Score: 15.528575 | Text size: 712123 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.


COMPOSITIONS AND METHODS FOR TARGETING A VIRAL INFECTION

Bing CHEN [US]Gary FREY [US]Tianshu XIAO [US]

Publication date: 2021-11-04 | Patent publication No.: US-20210338659-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4709 | Oldest priority date: 2018-07-27 | Publication date: 2021-11-04

Score: 13.489152 | Text size: 294973 | Find: similar documents

1 (Winston-Salem, N.C.), Bionet (Ryan Scientific, Mount Pleasant, S.C.), CEREP (Redmond, Wash.), ChemDiv (San Diego, Calif.), and ChemBridge (San Diego, Calif. ... 1 (Winston-Salem, N.C.), Bionet (Ryan Scientific, Mount Pleasant, S.C.), CEREP (Redmond, Wash.), ChemDiv (San Diego, Calif.), and ChemBridge (San Diego, Calif.


Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia

David J. Tweardy [US]Moses M. Kasembeli [US]Marvin X. Xu [CN]Thomas Kristian Eckols [US]

Publication date: 2021-11-02 | Patent publication No.: US-11161831-B2 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D215/36; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/31; C07C311/24; C07C311/29; C07C311/44; C07C311/49; C07C311/06; A61K31/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513; C07C311/21; C07C323/49; C07C381/06; A61K45/06 | Oldest priority date: 2013-07-18 | Publication date: 2021-11-02

Score: 14.233541 | Text size: 279831 | Find: similar documents

Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.

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Compounds that enhance Atoh1 expression

Albert Edge [US]Sang-Jun Jeon [KR]Kathleen Seyb [US]Marcie Glicksman [US]Lixin Qiao [US]Gregory D. Cuny [US]

Publication date: 2021-11-02 | Patent publication No.: US-11160808-B2 | Assignees: Massachusetts Eye & Ear Infirmary [US]; Brigham & Women's Hospital, Inc. [US] | IPC: A61K31/5377; A61K31/343; A61K31/381; A61K31/415; A61K31/423; A61K31/4245; A61K31/426; A61K31/428; A61K31/341; A61K31/4184; A61K9/00; A61K31/353; A61K31/4436; A61K31/496; A61K31/498; A61K31/517; A61K31/519; A61K35/28; A61K35/545; A61K31/352; A61K31/404; A61K31/4155; A61K31/4192; A61K31/4365; A61K31/437; A61K31/44; A61K31/4439 | Oldest priority date: 2008-02-07 | Publication date: 2021-11-02

Score: 20.760141 | Text size: 210379 | Find: similar documents

N-(4-bromo-3- methylphenyl) quinazolin-4-amine CHEMDIV (3651-6031) CP- 0067053 [[image:EMI-C00070]] 60. N-(4-methoxyphenyl) quinazolin-4-amine CHEMDIV (4491-0691) CP- 0072720 [[image:EMI-C00071]] 61. N-(3-methoxyphenyl)- 9H-purin-6-amine CHEMDIV (8009-2985) CP- 0079810 [[image:EMI-C00072]] 62. N,N-diethyl-1-m-tolyl- 1H-pyrazolo[3,4- d]pyrimidin-4-amine CHEMDIV (K402- 0503) or IFLAB/ LIFE- CHEMICALS (F0518- 0004) CP- 0061777 [[image:EMI-C00073]] 63. (5-(4- bromophenyl)furan-2- yl)(morpholino)methanone CHEMDIV (1975-0198) CP- 0066008 [[image:EMI-C00074]] 64. (Z)-4-bromo-N′-(furan-2- carbonyloxy)benzimida- mide CHEMDIV (4260-1000) CP- 0072253 [[image:EMI-C00075]] 65. N-(4-iodophenyl)furan-2- carboxamide CHEMDIV (8002-5214) CP- 0099289 [[image:EMI-C00076]] 66.

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COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING A GROWTH RELATED DISEASE AND/OR A CLINICAL CONDITION THEREOF

Kang-Yell Choi [KR]Sehee Choi [KR]Seol Hwa Seo [KR]Eunhwa Kim [KR]

Publication date: 2021-10-21 | Patent publication No.: US-20210323918-A1 | Assignees: CK Biotech Inc. [KR] | IPC: C07D209/34; A61P19/08; C07D513/14; C07D221/18; C07C237/48; C07D487/22; G01N33/68; A61K9/00 | Oldest priority date: 2018-10-15 | Publication date: 2021-10-21

Score: 17.002005 | Text size: 122516 | Find: similar documents

that inhibited the CXXCS-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280 Screen Format Concentration(s) tested Plate controls Reagent/compound ... delay growth plate senescence, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction


SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS

ANDROPY, Elliot J. [US]MEROUEH, Samy [US]LU, Zhijian [US]

Publication date: 2021-10-21 | Patent publication No.: WO-2021212010-A2 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS INC. [US] | Oldest priority date: 2020-04-17 | Publication date: 2021-10-21

Score: 13.245268 | Text size: 115556 | Find: similar documents

V012-2359), EIN-130(cat# V031-2694), and EIN-131(cat# V031-2717) were each purchased from ChemDiv.


Compositions and methods for treating diseases associated with uncontrolled inflammatory responses

Jason Barbour [US]David Ott [US]

Publication date: 2021-10-19 | Patent publication No.: US-11147815-B2 | Assignees: Synkrino Biotherapeutics, Inc. | IPC: A61K31/495; A61K31/496; A61K31/513; A61K31/435; A61P19/02; A61P35/00; A61K31/515; A61K31/437; A61K31/50; A61K45/06; C12Q1/6883; G16B40/00; G16B25/10; A61P37/06 | Oldest priority date: 2018-08-21 | Publication date: 2021-10-19

Score: 16.251385 | Text size: 92960 | Find: similar documents

Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state. ... TABLE 1 CompoundChemDiv Compound IdentifierNormalized Average of MIG/CXCL9Normalized Average of IP-10/CXCL10Normalized

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METHODS AND COMPOSITIONS TO TREAT CANCER

Jeffrey A. Whitsett [US]Yutaka Maeda [US]Takuya Fukazawa [JP]

Publication date: 2021-10-14 | Patent publication No.: US-20210315903-A1 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2021-10-14

Score: 14.656486 | Text size: 44997 | Find: similar documents

(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.


COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR STRUCTURALLY RELATED ENZYMES THERETO

Ilana Nathan [IL]Boris Khalfin [IL]

Publication date: 2021-10-07 | Patent publication No.: US-20210309620-A1 | Assignees: Ela Pharma Ltd [IL] | IPC: C07D265/22; A61K31/4178; A61K31/426; A61K31/454; C07D277/42; C12N15/113; A61K31/00; A61K31/496; A61K31/415; C07D405/06; C07D277/56; A61K31/4439; C07D233/44; C07D417/12; A61K31/4196; A61K31/4045; A61P25/00; A61K31/167; A61K31/428; A61K31/536; A61K45/06; C07C233/24; C07D233/48; C07D275/06; C12N5/077 | Oldest priority date: 2015-04-07 | Publication date: 2021-10-07

Score: 15.95058 | Text size: 243527 | Find: similar documents

All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, Calif. ... 3D Structure Similarities and Topological Analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.


NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND


Okuyama, Masahiro [JP]Fukunaga, Kenji [JP]Usui, Kenji [JP]Hayashi, Norimitsu [JP]Iijima, Daisuke [JP]Horiuchi, Hideki [JP]Itagaki, Noriaki [JP]

Publication date: 2021-10-06 | Patent publication No.: EP-3683222-B1 | Assignees: Mitsubishi Tanabe Pharma Corporation [JP] | IPC: C07D513/04; C07D471/04; C07D487/04; C07D513/14; A61K31/437; A61K31/5025; A61K31/519; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00 | Oldest priority date: 2014-04-23 | Publication date: 2021-10-06

Score: 6.4525156 | Text size: 1112016 | Find: similar documents

sold by plural companies (e.g., AKos Consulting & Solutions GmbH, Ambinter, Aurora Fine Chemicals, ChemDiv, Inc.). However, a KAT-II inhibitory action and other pharmacological activities of these compounds have

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Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators

Sara Buhrlage [US]Ellen Weisberg [US]James D. Griffin [US]

Publication date: 2021-10-05 | Patent publication No.: US-11136409-B2 | Assignees: Dana-Farber Cancer Institute, Inc. [US] | IPC: A61P31/00; C07K16/30; A61P35/02; C12Q1/6886; G01N33/50; G01N33/574; A01K67/027; C12Q1/02; C12Q1/6806; C12Q1/6841; C12Q1/6851; C12Q1/686; A61K45/06 | Oldest priority date: 2016-09-20 | Publication date: 2021-10-05

Score: 8.066998 | Text size: 446194 | Find: similar documents

HBX19818 analogs were purchased from ChemDiv and dissolved in DMSO to obtain a 10 mM stock solution.

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Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer

Catherine Tachdjian [US]Donald Karanewsky [US]Xiao Qing Tang [US]Hanghui Liu [US]

Publication date: 2021-09-28 | Patent publication No.: US-11129397-B2 | Assignees: FIREMENICH INCORPORATED [US] | IPC: A23L2/56; A23L27/00; A23L27/20; A61K47/26; A61K47/22 | Oldest priority date: 2010-08-12 | Publication date: 2021-09-28

Score: 9.562369 | Text size: 467664 | Find: similar documents

other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.

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Small-molecule UT-A-selective urea transport inhibitors

Alan S. Verkman [US]Cristina Esteva-Font [US]

Publication date: 2021-09-21 | Patent publication No.: US-11123340-B2 | Assignees: The Regents of the University of California [US] | IPC: A61K31/4709; A61K31/425; A61K31/426; A61K31/427; A61K31/47 | Oldest priority date: 2014-05-09 | Publication date: 2021-09-21

Score: 15.755042 | Text size: 143988 | Find: similar documents

screening was done using a collection of 50,000 chemically diverse, drug-like compounds from ChemDiv (San Diego, Calif.). For analysis of structure-activity relationships, >300 commercially available analogs (ChemDiv and Asinex, Winston-Salem, N.C.) were tested.

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INHIBITORS OF HSP70 PROTEINS

SHI, Taoda [US]CHAPMAN, Eli [US]AMBROSE, Andrew J. [US]

Publication date: 2021-09-16 | Patent publication No.: WO-2021183942-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US] | IPC: A61K31/16; A61K31/165; A61K31/166; C07C233/00; C07C233/04; C07C233/06 | Oldest priority date: 2020-03-13 | Publication date: 2021-09-16

Score: 13.077378 | Text size: 122356 | Find: similar documents

1, N-(3-methyl-l-oxo-l-(thiazol-2-ylamino)butan-2-yl)thiophene-2- carboxamide, was purchased from ChemDIV Inc. (San Diego, CA).


INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF

Gary E. Schiltz [US]Daniela E. Matei [US]Purav Vagadia [US]

Publication date: 2021-09-09 | Patent publication No.: US-20210276960-A1 | Assignees: Northwestern University [US]; United States Goverment as represented by the Department of Veterans Affairs [US] | IPC: C07D239/48; A61P35/00; C07D239/42; C07D401/12; C07D403/12; C07D409/12 | Oldest priority date: 2020-03-04 | Publication date: 2021-09-09

Score: 18.463318 | Text size: 190284 | Find: similar documents

To this end, we completed a high throughput screening (HTS) campaign of compounds in the ChemDiv library by using a newly developed AlphaLISA assay that robustly measured the TG2/FN complex ... We had previously reported TG53 as a lead inhibitor selected from high throughput screening of the ChemDiv library using an Alpha-Lisa assay (13). ... the TG2-FN complex formation and were discovered through AlphaLISA based HTS applied to the ChemDiv library11. ... Discovery of TG2/FN inhibitors—HTS using the ChemDiv library: Next, the ChemDiv library containing 10,000 diverse compounds arrayed at 10 μM each was screened using the assay


CORONA VIRUS BINDERS

SCHEPENS, Bert [BE]SAELENS, Xavier [BE]CALLEWAERT, Nico [BE]DE VLIEGER, Dorien [BE]VAN SCHIE, Loes [BE]NERINCKX, Wim [BE]ROOSE, Kenny [BE]VAN BREEDAM, Wander [BE]EECKHAUT, Hannah [BE]FIJALKOWSKA, Daria [BE]LONIGRO, Chiara [BE]DE CAE, Sieglinde [BE]DOMBRECHT, Bruno [BE]STORTELERS, Catelijne [BE]NEYTS, Johan [BE]DELANG, Leen [BE]KAPTEIN, Suzanne [NL]DUARTE DA ROCHA PEREIRA, Joana [BE]GRAHAM, Barney [US]MCLELLAN, Jason [US]WRAPP, Daniel [US]REMAUT, Han [BE]

Publication date: 2021-08-12 | Patent publication No.: WO-2021156490-A2 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE]; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]; TRUSTEES OF DARTMOUTH COLLEGE [US]; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D [BE]; EXEVIR BIO BV [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE] | IPC: A61K39/215 | Oldest priority date: 2020-02-06 | Publication date: 2021-08-12

Score: 9.562369 | Text size: 377714 | Find: similar documents

from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Flungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).


CFTR regulators and methods of use thereof


Alan S. Verkman [US]Marc H. Levin [US]Onur Cil [US]Mark J. Kurth [US]

Publication date: 2021-08-10 | Patent publication No.: US-11084795-B2 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; C07D401/06; C07D405/06; C07D409/06; C07D403/04; C07D405/04; C07D498/06; C07D409/04 | Oldest priority date: 2015-12-24 | Publication date: 2021-08-10

Score: 15.528575 | Text size: 764864 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.

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USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

David J. Dowling [US]Ofer Levy [US]Francesco Borriello [US]David A. Scott [US]Spencer E. Brightman [US]

Publication date: 2021-08-05 | Patent publication No.: US-20210236632-A1 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2021-08-05

Score: 12.211837 | Text size: 385572 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).


USING MICRORNAS TO CONTROL ACTIVATION STATUS OF HEPATIC STELLATE CELLS AND TO PREVENT FIBROSIS IN PROGRESSIVE LIVER DISEASES

Michael Yoonsuk CHOI [US]Byeong-Moo KIM [US]

Publication date: 2021-08-05 | Patent publication No.: US-20210238604-A1 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N15/113; A61P1/16; A61K35/407 | Oldest priority date: 2016-05-20 | Publication date: 2021-08-05

Score: 11.227331 | Text size: 200752 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.


PAK1 inhibitors and uses thereof


Ulrich Steidl [US]Ashley M. Eckel [US]Robert F. Stanley [US]Boris Rogovoy [US]Ilya Okun [US]

Publication date: 2021-07-20 | Patent publication No.: US-11065251-B2 | Assignees: ALBERT EINSTEIN COLLEGE OF MEDICINE [US] | IPC: A61K31/519; A61P35/00; A61K31/437; A61K31/496; C07D471/04 | Oldest priority date: 2016-05-06 | Publication date: 2021-07-20

Score: 14.153812 | Text size: 70668 | Find: similar documents

Compounds were screened for PAK1 inhibition using a 50,024 compound library by ChemDiv (San Diego, Calif.

External link


SWEET FLAVOR MODIFIER


TACHDJIAN, Catherine [US]KARANEWSKY, Donald [US]WERNER, Sara [US]DARMOHUSODO, Vincent [US]YAMAMOTO, Jeff [US]

Publication date: 2021-07-14 | Patent publication No.: EP-3593648-B1 | Assignees: Firmenich Incorporated [US] | IPC: A23L27/00; A23L2/60; A23L2/56; C07D417/12; C07D417/14; A23L29/30 | Oldest priority date: 2013-03-13 | Publication date: 2021-07-14

Score: 11.477125 | Text size: 221700 | Find: similar documents

other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, PA, ChemDiv of San Diego, CA, Chembridge of San Diego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

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INHIBITION OF FOLLISTATIN

Gerard M. Housey [US]Monica E. Balash [US]

Publication date: 2021-07-08 | Patent publication No.: US-20210207135-A1 | Assignees: Housey Pharmaceutical Research Laboratories, L.L.C. [US] | IPC: C12N15/113; G01N33/50; G01N33/563; A61K45/06 | Oldest priority date: 2018-05-17 | Publication date: 2021-07-08

Score: 12.297968 | Text size: 156156 | Find: similar documents

and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-XInfinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,


SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES

Luke L. Lairson [US]Michael J. Bollong [US]Peter G. Schultz [US]Sendurai A. Mani [US]

Publication date: 2021-07-01 | Patent publication No.: US-20210196713-A1 | Assignees: The Scripps Research Institute [US]; Board of Regents, The University of Texas System [US] | IPC: A61K31/502; A61K31/437; A61K31/4704; A61K31/4741; A61K31/497; A61K31/4985; A61K31/551; A61P35/00 | Oldest priority date: 2017-10-30 | Publication date: 2021-07-01

Score: 16.51147 | Text size: 107793 | Find: similar documents

Selected hit compounds were reordered from ChemDiv and tested for selective toxicity in 10-point response assays as above. ... a library of ̃50,000 diverse heterocyclic compounds and biologically active small molecules (ChemDiv, San Diego, Calif., USA) for cytotoxic activity against both cell lines.


CELLS EXPRESSING APOLIPOPROTEIN E AND USES THEREOF

LINDQUIST, Susan L. [US]NARAYAN, Priyanka [US]

Publication date: 2021-06-30 | Patent publication No.: EP-3842514-A1 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C12N1/19; C12N15/81; C12Q1/02; C07K14/47 | Oldest priority date: 2014-09-12 | Publication date: 2021-06-30

Score: 7.592094 | Text size: 433990 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

External link


Cellular discovery platform for neurodegenerative diseases

Susan L. Lindquist [US]Vikram Khurana [US]Chee-Yeun Chung [US]

Publication date: 2021-06-29 | Patent publication No.: US-11047848-B2 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: G01N33/50; G01N33/68; C12Q1/6883 | Oldest priority date: 2013-03-15 | Publication date: 2021-06-29

Score: 7.1699963 | Text size: 565577 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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SELECTIVE CALCIUM CHANNEL ANTAGONISTS

Dalton J. Surmeier, Jr. [US]Richard B. Silverman [US]Soo Sung Kang [US]Garry Cooper [US]

Publication date: 2021-06-24 | Patent publication No.: US-20210186970-A1 | Assignees: Northwestern University [US] | IPC: A61K31/515; C07D239/62 | Oldest priority date: 2011-01-19 | Publication date: 2021-06-24

Score: 13.245268 | Text size: 99718 | Find: similar documents

to screen 60,480 commercial compounds (ADSI set 6,800; ChemBridge diverse/lead like set 20,000; ChemDiv diverse set 30,000; NIH clinical trial set 480, NCl/DTP set 3,200).


COMPOSITIONS FOR TREATMENT OF FIBROSIS

TWEARDY, David, J. [US]KASEMBELI, Moses, M. [US]XU, Marvin, X. [CN]AGARWAL, Sandeep, K. [US]PEDROZA, Mesias [US]

Publication date: 2021-06-23 | Patent publication No.: EP-3021839-B1 | Assignees: Baylor College Of Medicine [US] | IPC: A61K31/18; A61K31/05; A61K31/4196; A61K45/06; A61P17/02; A61P35/00; A61K31/343; A61K31/39; A61P19/04 | Oldest priority date: 2013-07-18 | Publication date: 2021-06-23

Score: 15.999366 | Text size: 142511 | Find: similar documents

Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.

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ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY

CHATTOPADHYAY, Shrikanta [US]YUSUF, Rushdia [US]VAN GASTEL, Nick [BE]SHARDA, Azeem, S. [US]SAEZ, Borja [ES]VISWANATHAN, Vasanthi, S. [US]SCADDEN, David, T. [US]

Publication date: 2021-06-17 | Patent publication No.: WO-2021119215-A1 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]; THE BROAD INSTITUTE, INC. [US]; THE GENERAL HOSPITAL CORPORATION [US] | IPC: A61P35/00; C12N9/04; A61K45/06 | Oldest priority date: 2019-12-09 | Publication date: 2021-06-17

Score: 10.988179 | Text size: 199135 | Find: similar documents

The initial screen will be performed on the ChemDiv 6 library, a select set of 44,000 public domain compounds.


AGONISTS OF RNA ADENOSINE N-6 METHYLATION FOR USE IN SUPPRESSING HIV-1 LATENT PROVIRUS ACTIVATION AND REPLICATION

SELBERG, Simona [EE]ŽUSINAITE, Eva [EE]MERITS, Andres [EE]SELI, Neinar [EE]KARELSON, Mati [EE]

Publication date: 2021-06-17 | Patent publication No.: WO-2021116476-A1 | Assignees: CHEMESTMED LTD. [EE] | IPC: A61K31/435; A61K31/495; A61P31/18 | Oldest priority date: 2019-12-12 | Publication date: 2021-06-17

Score: 14.9756 | Text size: 35975 | Find: similar documents

Methyl piperazine-2-carboxylate (IX) (ChemDiv, Inc., Catalog Number: FF20-0374, Purity > 90%). Ethyl 2-oxopiperidine-3-carboxylate (X) (Enamine, Ltd.


COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

RAMSDEN, Dr. Nigel [GB]FOX, Dr. David John [GB]HUNTINGTON, Prof. James Andrew [GB]TOMLINSON, Dr. James Michael [GB]

Publication date: 2021-06-17 | Patent publication No.: WO-2021116703-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D207/48; C07D211/96; C07D401/12; A61K31/40; A61K31/445; A61K31/4709 | Oldest priority date: 2019-12-13 | Publication date: 2021-06-17

Score: 15.196177 | Text size: 41754 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.


ALPHA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

Iwao Ojima [US]Dale Deutsch [US]Martin Kaczocha [US]Kongzhen Hu [US]Simon Tong [US]Matthew Elmes [US]Su Yan [US]

Publication date: 2021-06-17 | Patent publication No.: US-20210179535-A1 | Assignees: The Research Foundation for The State University of New York [US] | IPC: C07C69/753; C07C69/757; C07C205/55; C07D249/06; C07D309/06; C07C233/25; C07C61/04; C07D215/06 | Oldest priority date: 2016-03-11 | Publication date: 2021-06-17

Score: 13.077378 | Text size: 120610 | Find: similar documents

Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49.


SMALL MOLECULE INHIBITORS OF VOLTAGE-GATED SODIUM CHANNEL 1.7 AND METHODS OF USING SAME

BORTSOV, Andrey [US]CHANDRA, Sharat [US]JI, Ru-Rong [US]

Publication date: 2021-06-17 | Patent publication No.: WO-2021119157-A1 | Assignees: DUKE UNIVERSITY [US] | IPC: C07D209/08; C07D401/12; C07D401/14 | Oldest priority date: 2019-12-11 | Publication date: 2021-06-17

Score: 19.189526 | Text size: 136261 | Find: similar documents

For virtual screening, a database of 1.5 million compounds was downloaded from the Chemdiv website (chemdiv.com, ChemDiv Inc., San Diego, CA). ... A similarity threshold value of 0.5 against the compounds from the Chemdiv database was used to screen for potential Navi.7 inhibitors. ... Similarity search of the ChemDiv database (ChemDiv Inc, San Diego, CA) containing 1.5 million pre- synthetized compounds yielded a set of 2000 compounds ... and sufficient quantity (1 mg or more) available in stock were selected and purchased from ChemDiv for in vitro and in vivo activity assessment. [0139] Patch-clamp recordings of Navl.


SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION

Pearlie Burnette [US]Harshani Lawrence [US]Nicholas J. Lawrence [US]

Publication date: 2021-06-17 | Patent publication No.: US-20210177825-A1 | Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: A61K31/4545; A61K31/454; A61K31/517; A61K31/513; A61K31/404; A61K31/45; A61K31/4725; A61K31/4525; A61K31/4015; A61K31/5377; A61K31/50; A61K31/4523 | Oldest priority date: 2016-03-16 | Publication date: 2021-06-17

Score: 8.605278 | Text size: 476034 | Find: similar documents

32,000 compounds LifeChemicals 6000 compounds NCl fucused collections 4,000 compounds ChemDiv 30,000 compounds Chembridge 60,000 compounds Kinase libraries.


Methods and compositions for treating mesothelioma and small lung cancer that express midkine

Jeffrey A. Whitsett [US]Yutaka Maeda [US]Takuya Fukazawa [JP]

Publication date: 2021-06-08 | Patent publication No.: US-11026950-B2 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2021-06-08

Score: 14.656486 | Text size: 56241 | Find: similar documents

(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.

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α- and γ-truxillic acid derivatives and pharmaceutical compositions thereof

Iwao Ojima [US]Dale Deutsch [US]Martin Kaczocha [US]William T. Berger [US]Robert Rizzo [US]Trent E. Balius [US]

Publication date: 2021-06-08 | Patent publication No.: US-11026910-B2 | Assignees: The Research Foundation for The State University of New York [US] | IPC: A61K31/216; C07C67/08; C07C211/58; C07C233/11; C07C233/58; C07C235/38; C07C235/40; C07C69/753; C07C69/76; C07C67/48; C07C69/757; G01N33/566; A61K31/194; G01N33/68 | Oldest priority date: 2012-07-20 | Publication date: 2021-06-08

Score: 19.70499 | Text size: 144954 | Find: similar documents

Energetically DOCK selected ligands from the ChemDiv library that did not have unfavorable interaction, both VDW and ES, intrinsically selecting ... The following compounds are available from ChemDiv (San Diego, Calif., USA): StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334 [[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from Cayman Chemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv, Inc. (Moscow, Russia). ... Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49. ... Virtual Screening A high-throughput virtual screening of over one million molecules from the ChemDiv subset of the ZINC database (http://zinc.docking.

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RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHODS OF USING SAME

PYLE, Anna, Marie [US]RAWLING, David [US]JAGDMANN, G., Erik [US]POTAPOVA, Olga [US]

Publication date: 2021-05-14 | Patent publication No.: WO-2021091958-A1 | Assignees: YALE UNIVERSITY [US] | IPC: A61K31/403; A61K31/712; A61P35/00 | Oldest priority date: 2019-11-04 | Publication date: 2021-05-14

Score: 13.077378 | Text size: 123000 | Find: similar documents

11 libraries, including the ChemBridge, Enzo Kinase Inhibitor, Enzo Phosphatase Inhibitor, ChemDiv and Nuclear Receptor Libraries, was screened.


LYMPHOCYTE ANTIGEN CD5-LIKE (CD5L) MONOMER, HOMODIMER, AND INTERLEUKIN 12B (P40) HETERODIMER AGONISTS AND METHODS OF USE THEREOF

Vijay K. Kuchroo [US]Chao Wang [US]Aviv Regev [US]

Publication date: 2021-05-13 | Patent publication No.: US-20210139601-A1 | Assignees: The Broad Institute, Inc. [US]; The Brigham and Women's Hospital, Inc. [US]; Massachusetts Institute of Technology [US] | IPC: C07K16/28; C07K14/705; A61K38/17; A61K39/395; A61K45/06; A61P35/00 | Oldest priority date: 2017-05-25 | Publication date: 2021-05-13

Score: 6.7923617 | Text size: 634947 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM AsisChemTM, and Princeton Biomolecular ResearchTM, among others.


COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA

Anna Pyle [US]Olga Fedorova [US]Erik Gunnar Jagdmann [US]Michael Van Zandt [US]Lin Yuan [US]Albert DeBerardinis [US]

Publication date: 2021-05-13 | Patent publication No.: US-20210139512-A1 | Assignees: YALE UNIVERSITY [US] | IPC: C07F5/02; C07D307/83; C07D307/80; C07C233/73; C07D405/04; C07D277/26; C07D405/12; C07C243/38; C07D307/52; C07D239/26; C07C49/84; C07C233/65; C07D217/04; C07D207/08; C07D211/16; C07D413/04; C07D233/64; C07D277/24; C07D295/192; C07D277/66; C07D295/215; A61P31/10 | Oldest priority date: 2018-01-26 | Publication date: 2021-05-13

Score: 10.328181 | Text size: 285136 | Find: similar documents

(76 compounds), protease inhibitors (53 compounds) and additional compounds from ChemBridge MW and ChemDiv to bring the total number of compounds to 10000. The D135 ribozyme (Su et al.


INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

Sanjay A. Desai [US]Ajay D. Pillai [IN]

Publication date: 2021-04-29 | Patent publication No.: US-20210121476-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: A61K31/553; A61K31/165; A61K31/4155; A61K31/423; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741; A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D403/08; C07D498/04; C07D263/57; C07D281/16; C07D413/14; C07D417/06; C07D491/048; C07D513/04; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2021-04-29

Score: 14.451191 | Text size: 51257 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England.


FERROCHELATASE INHIBITORS AND METHODS OF USE

Timothy W. CORSON [US]Kamakshi SISHTLA [US]Seung-Yong SEO [KR]Bit LEE [KR]

Publication date: 2021-04-29 | Patent publication No.: US-20210121465-A1 | Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US]; Gachon University of Industry-Academic Cooperation [KR] | IPC: A61K31/519; A61K41/00; A61K38/17; A61K39/395; A61K31/4025; A61K31/4706; A61K31/49; A61K31/37; A61K31/4709; A61K31/122; A61K31/155; A61K31/409; A61K31/343; C12N15/113; A61K45/06; C07D487/04; C07D249/14; A61P27/02; A61K31/4196; C07K16/22 | Oldest priority date: 2018-04-30 | Publication date: 2021-04-29

Score: 15.999366 | Text size: 141607 | Find: similar documents

at the Indiana University School of Medicine Chemical Genomics Core Facility (CGCF) using the ChemDiv 10K and a portion (10,000 compounds) of the ChemBridge 50K libraries of chemical compounds. ... IC50 Determination Compounds, reordered from ChemDiv or synthesized as described above, were made to 10 mM in DMSO and tested in the FECH enzymatic


REACTIVE AFFINITY PROBE-INTERACTION DISCOVERY PLATFORM

LABENSKI, Matthew, T. [US]RETTENMAIER, Terry, J. [US]JONES, Lyn, H. [US]MUNCIPINTO, Giovanni [US]

Publication date: 2021-04-22 | Patent publication No.: WO-2021076680-A1 | Assignees: JNANA THERAPEUTICS, INC. [US] | IPC: G01N33/68; G01N33/561; C08G65/32; G01N33/58; C07K7/06 | Oldest priority date: 2019-10-15 | Publication date: 2021-04-22

Score: 14.656486 | Text size: 52535 | Find: similar documents

for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.


RESPIRATORY AND SWEAT GLAND IONOCYTES

Jayaraj Rajagopal [US]Aviv Regev [US]Moshe Biton [US]Adam Haber [US]Daniel Montoro [US]Orit Rozenblatt-Rosen [US]

Publication date: 2021-04-22 | Patent publication No.: US-20210115407-A1 | Assignees: The Broad Institute, Inc. [US]; The General Hospital Corporation [US]; Massachusetts Institute of Technology [US] | IPC: C12N5/071; A61K35/42; A61P11/00; G01N33/50 | Oldest priority date: 2017-04-12 | Publication date: 2021-04-22

Score: 7.592094 | Text size: 511847 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM among others.


INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION

Mark D. Andrake [US]Anna Marie Skalka [US]George W. Merkel [US]

Publication date: 2021-04-22 | Patent publication No.: US-20210113570-A1 | Assignees: Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center [US] | IPC: A61K31/53; A61K31/4245; A61K31/454 | Oldest priority date: 2017-01-26 | Publication date: 2021-04-22

Score: 17.199627 | Text size: 51249 | Find: similar documents

formation (see FIG. 1B), and used it to screen the 50,000 compound chemical diversity library of ChemDiv, ltd. at 10 uM concentration. ... day were performed to screen the entire Chemical Diversity set of 50,000 compounds obtained from ChemDiv, Ltd.


NATURAL SWEETENER COMPOSITIONS

Anandasankar RAY [US]Sean Michael BOYLE [US]

Publication date: 2021-04-22 | Patent publication No.: US-20210112839-A1 | Assignees: Sensorygen, Inc. [US] | IPC: A23L27/30; A23L33/125; A23L33/17; A23L2/60 | Oldest priority date: 2016-11-16 | Publication date: 2021-04-22

Score: 12.913692 | Text size: 221423 | Find: similar documents

other well-known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.


METHODS FOR DETECTING PROTEIN-PROTEIN INTERACTIONS

CABANTOUS, Stéphanie [FR]KORAÏCHI, Faten [FR]FAVRE, Gilles [FR]

Publication date: 2021-04-21 | Patent publication No.: EP-3314260-B1 | Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale) [FR]; Université Paul Sabatier Toulouse III [FR] | IPC: G01N33/542; G01N33/68 | Oldest priority date: 2015-09-30 | Publication date: 2021-04-21

Score: 13.077378 | Text size: 128423 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.

External link


SMALL MOLECULE INHIBITORS OF Id PROTEINS

BENEZRA, Robert [US]OUERFELLI, Ouathek [US]

Publication date: 2021-04-08 | Patent publication No.: WO-2021067393-A1 | Assignees: MEMORIAL SLOAN KETTERING CANCER CENTER [US] | IPC: A61K31/131; A61K31/135; A61K31/137; C07C211/01; C07C211/03; C07C211/08 | Oldest priority date: 2019-10-01 | Publication date: 2021-04-08

Score: 10.759004 | Text size: 240527 | Find: similar documents

Compiled lists of commercially available compounds (libraries available from ChemBridge, ChemDiv, Maybridge, and Salor) were screened using a beta release of Autodock 4.0 (The Scripps Research


Substituted thiazoles for preventing and/or treating cell or tissue necrosis

Ilana Nathan [IL]Boris Khalfin [IL]

Publication date: 2021-04-06 | Patent publication No.: US-10968185-B2 | Assignees: ELA PHARMA LTD. [IL] | IPC: A61K31/427; C07D277/20; C07D265/22; A61K31/4178; A61K31/426; A61K31/454; C07D277/42; C12N15/113; A61K31/00; A61K31/496; A61K31/415; C07D405/06; C07D277/56; A61K31/4439; C07D233/44; C07D417/12; A61K31/4196; A61K31/4045; A61P25/00; A61K31/167; A61K31/428; A61K31/536; A61K45/06; C07C233/24; C07D233/48; C07D275/06; C12N5/077 | Oldest priority date: 2015-04-07 | Publication date: 2021-04-06

Score: 15.95058 | Text size: 246336 | Find: similar documents

All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, Calif. ... 3D Structure Similarities and Topological Analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.

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Alpha-truxillic acid derivatives and pharmaceutical compositions thereof

Iwao Ojima [US]Dale Deutsch [US]Martin Kaczocha [US]Kongzhen Hu [US]Simon Tong [US]Matthew Elmes [US]Su Yan [US]

Publication date: 2021-04-06 | Patent publication No.: US-10968163-B2 | Assignees: The Research Foundation for the State University of New York [US] | IPC: C07C69/753; C07C61/04; C07C69/757; C07C205/55; C07D249/06; C07D309/06; C07C233/25; C07D215/06 | Oldest priority date: 2016-03-11 | Publication date: 2021-04-06

Score: 13.077378 | Text size: 127287 | Find: similar documents

Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49.

External link


SMALL MOLECULES FOR DISRUPTING THE SUPER ELONGATION COMPLEX AND INHIBITING TRANSCRIPTION ELONGATION FOR CANCER THERAPY


Ali Shilatifard [US]Kaivvei Liang [US]Edwin R. Smith [US]Gary E. Schiitz [US]Rama K. Mishra [US]Kristen Stoltz [US]

Publication date: 2021-04-01 | Patent publication No.: US-20210094907-A1 | Assignees: NORTHWESTERN UNIVERSITY [US] | IPC: C07C235/74; C07C235/78; C07D241/20; C07D213/40; C07D257/06; C07D271/07; C07D277/46; C07D213/75; C07D239/42; C07D261/18; C07D231/14; C07D239/36; A61P35/00 | Oldest priority date: 2018-03-21 | Publication date: 2021-04-01

Score: 15.288118 | Text size: 192069 | Find: similar documents

Based on the structure of KL-1 (FIG. 1C), we performed a KL-1 similarity search with ChemDiv compounds and tested the top 32 most similar compounds. ... The candidate chemicals from the in silico screening were purchased from the vendors ChemDiv, ChemBridge and Enamine. MDA231-LM2 Tumor Model.


PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA

Sanjay A. Desai [US]

Publication date: 2021-03-25 | Patent publication No.: US-20210085679-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: A61K31/501; A61K31/496; A61K45/06; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K31/423; A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date: 2011-04-12 | Publication date: 2021-03-25

Score: 15.755042 | Text size: 131078 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England. ... room temperature using a commercial library of 50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at


USE OF THIAZOLE AMIDE COMPOUNDS FOR MODULATING HUMAN IMMUNE RESPONSE

DOWLING, David J. [US]LEVY, Ofer [US]BORRIELLO, Francesco [US]

Publication date: 2021-03-25 | Patent publication No.: WO-2021055386-A1 | Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A23L1/30; A23L2/52; A61K36/14 | Oldest priority date: 2019-09-17 | Publication date: 2021-03-25

Score: 12.507937 | Text size: 351345 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).


Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases

Philippe Guedat [FR]Anne Bertolotti [GB]

Publication date: 2021-03-23 | Patent publication No.: US-10954198-B2 | Assignees: United Kingdom Research and Innovation [GB]; Inflectis Bioscience [FR] | IPC: C07D253/075; A61K31/155; A61K31/44; A61K31/53; C07C281/18; C07D213/61; A61K45/06; A61K31/165; A61K31/216; C07C281/16 | Oldest priority date: 2013-01-10 | Publication date: 2021-03-23

Score: 16.251385 | Text size: 109228 | Find: similar documents

EXAMPLES Methods & Materials Example 1 was purchased from Chemdiv ref: 1683-6588 Example 2 was purchased from Chembridge ref: 5173161 Example 4 was purchased from Enamine ref: Z49562642 Example 6 was purchased from Chemdiv ref: 1683-6502 Preparation of the Compounds According to the Present Invention The reactants and

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Compounds useful as modulators of TRPM8

Chad Priest [US]Alain Noncovich [US]Andrew Patron [US]Jane Ung [US]

Publication date: 2021-03-23 | Patent publication No.: US-10953007-B2 | Assignees: Firmenich Incorporated [US] | IPC: A61K31/381; A61K31/4155; A61K31/497; A23L27/00; C07C233/11; C07C235/20; C07C235/24; C07C235/34; C07D213/40; C07D213/75; C07D231/40; C07D277/28; C07D307/52; C07D333/20; C07D333/24; C07D333/32; C07D405/12; C07D407/12; C07D409/14; C07D413/12; C07D417/12; C07D471/04; A61K8/42; A61K8/49; A61K8/69; A61Q19/00; C07D409/12; A01N43/10; A01N43/40; A01N43/56; A01N43/60; A01N43/76; A01N43/80; A01N43/90; A23L33/10; A01N37/18; A01N43/78; A61K31/165; A61K31/415; A61K31/422; A61K31/426; A61K31/437; A61K31/4409; A61K31/4436; A61Q1/02; A61Q5/02; A61Q5/12; A61Q9/02; A61Q11/00; A61Q15/00; A61Q17/02; A61Q17/04; A61Q19/10 | Oldest priority date: 2010-11-05 | Publication date: 2021-03-23

Score: 19.40844 | Text size: 247612 | Find: similar documents

93 This compound was purchased from Chemdiv. ... 96 This compound was purchased from Chemdiv. ... 109 This compound was purchased from Chemdiv. ... 116 This compound was purchased from Chemdiv. ... 123 This compound was purchased from Chemdiv. ... 128 This compound was purchased from Chemdiv. ... 132 This compound was purchased from Chemdiv. ... 163 This compound was purchased from Chemdiv. ... 166 This compound was purchased from Chemdiv. ... 169 This compound was purchased from Chemdiv.

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NOVEL GENETIC MARKERS FOR POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF THE SAME

HAKONARSON, Hakon [US]QU, Huiqi [US]

Publication date: 2021-03-18 | Patent publication No.: WO-2021050608-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: A01H1/00; A01H5/00; C07K14/415; C07K16/16; C12N1/21; C12N5/10; C12N15/63 | Oldest priority date: 2019-09-09 | Publication date: 2021-03-18

Score: 13.775837 | Text size: 86074 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


COMPOSITIONS COMPRISING RARE GENETIC SEQUENCE VARIANTS ASSOCIATED WITH PULMONARY FUNCTION AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF ASTHMA IN AFRICAN AMERICAN PATIENTS

HAKONARSON, Hakon [US]SLEIMAN, Patrick [US]

Publication date: 2021-03-18 | Patent publication No.: WO-2021050445-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: A61P11/06; C12Q1/6827; C12Q1/6883 | Oldest priority date: 2019-09-09 | Publication date: 2021-03-18

Score: 13.594319 | Text size: 86771 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


VACUOLIN-1 AS AN INHIBITOR OF AUTOPHAGYAND ENDOSOMAL TRAFFICKING AND THE USE THEREOF FOR INHIBITING TUMOR PROGRESSION

YUE, Jianbo [CN]LU, Yingying [CN]

Publication date: 2021-01-13 | Patent publication No.: EP-3107543-B1 | Assignees: Versitech Limited [CN] | IPC: A61K31/5377; A61P35/00; A61P33/06; A61K31/337; A61K31/436; A61K31/513 | Oldest priority date: 2014-02-19 | Publication date: 2021-01-13

Score: 14.656486 | Text size: 53377 | Find: similar documents

Figure 14 shows a virtual screening strategy for vacuolin-1 analogue identification using ChemDiv.

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Inhibitors of HIV-1 integrase multimerization

Mark D. Andrake [US]Anna Marie Skalka [US]George W. Merkel [US]

Publication date: 2021-01-12 | Patent publication No.: US-10888564-B2 | Assignees: Institute for Cancer Research [US] | IPC: A61K31/4245; A61K31/454; A61K31/53 | Oldest priority date: 2017-01-26 | Publication date: 2021-01-12

Score: 17.199627 | Text size: 54983 | Find: similar documents

formation (see FIG. 1B), and used it to screen the 50,000 compound chemical diversity library of ChemDiv, ltd. at 10 uM concentration. ... day were performed to screen the entire Chemical Diversity set of 50,000 compounds obtained from ChemDiv, Ltd.

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PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY

Vladimir L. Katanaev [CH]Alexey Koval [CH]

Publication date: 2021-01-07 | Patent publication No.: US-20210002265-A1 | Assignees: Université de Lausanne [CH] | IPC: C07D405/14; A61P35/00; C07D405/10; C07D401/04 | Oldest priority date: 2018-03-02 | Publication date: 2021-01-07

Score: 19.328047 | Text size: 81564 | Find: similar documents

Compound Identification A commercial (ChemDiv Inc., San Diego, Calif., US) small molecule library (high-diversity GPCR-targeted compound library containing 1000 compounds selected by ChemDiv focusing on maximizing chemical diversity from the 40′000 GPCR-targeted compound library [see http://www.chemdiv.com, particularly http://www.chemdiv. ... overall chemical (Tanimoto) and substructural (via generalized structure search) similarity in the ChemDiv collection (ca. 1.5 mio compounds). The overall set of similars (ca. ... (106, F2-99) V006-4971 24.1 85.2 26 (108) V012-3790 16.5 72.7 27 (109) V008-3606 14.3 86.5 *ChemDiv library catalogue number Example 2: Structure of Identified Wnt Pathway Inhibitors TABLE 2:


Inhibitors of the plasmodial surface anion channel as antimalarials

Sanjay A. Desai [US]Ajay D. Pillai [IN]

Publication date: 2021-01-05 | Patent publication No.: US-10881669-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/00; A61K31/553; A61K31/165; A61K31/4155; A61K31/423; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741; A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D403/08; C07D498/04; C07D263/57; C07D281/16; C07D413/14; C07D417/06; C07D491/048; C07D513/04; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2021-01-05

Score: 14.553114 | Text size: 52320 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England.

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Method to detect activity of a polymerase

Tim Bergbrede [DE]Nils-Göran Larsson [DE]Claes Gustafsson [SE]Maria Falkenberg-Gustafsson [SE]

Publication date: 2021-01-05 | Patent publication No.: US-10883137-B2 | Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE]; LEAD DISCOVERY CENTER GMBH [DE] | IPC: C12Q1/6818; C12Q1/68; C12Q1/6825; G01N33/542; G01N33/58; C12Q1/48 | Oldest priority date: 2015-05-29 | Publication date: 2021-01-05

Score: 13.077378 | Text size: 111794 | Find: similar documents

in the assay was 4-methyl-5-[2-(pyrimidin-2-ylamino)thiazol-4yl]thiazol-2-amine (available at ChemDiv) and is applied using contact-free acoustic droplet-dispensing (Labcyte Echo®) from 10 mM compound

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AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR

HAQUE, Aftabul [US]LINDQUIST, Susan L. [US]

Publication date: 2020-12-30 | Patent publication No.: EP-3155003-B9 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C07K14/47; C12N15/81; C12N15/85; G01N33/50 | Oldest priority date: 2014-06-13 | Publication date: 2020-12-30

Score: 12.913692 | Text size: 134804 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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TARGETING MELANOCORTIN 3 RECEPTOR FOR TREATMENT/PREVENTION OF EATING, METABOLISM, AND/OR EMOTIONAL DISORDERS

CONE, Roger [US]SWEENEY, Patrick [US]

Publication date: 2020-12-24 | Patent publication No.: WO-2020257662-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US] | IPC: A61P3/04; C07K7/06; A61K38/00 | Oldest priority date: 2019-06-19 | Publication date: 2020-12-24

Score: 11.738287 | Text size: 165775 | Find: similar documents

A screen was performed with a series of 4160 samples from the ChemDiv 100,000 compound diversity set maintained at CCG (Fig. 2D-F).


IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE

Phillip C. Liu [US]Alla Volgina [US]Richard Wynn [US]Nina Zolotarjova [US]Liangxing Wu [US]Kaijiong Xiao [US]Song Mei [US]Liang Lu [US]Wenyu Zhu [US]Yingda Ye [US]Haisheng Wang [US]Ding-Quan Qian [US]Wenqing Yao [US]

Publication date: 2020-12-24 | Patent publication No.: US-20200397893-A1 | Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61P37/00; A61P37/04; A61P35/00; A61K45/06; C07D213/81; C07D263/57; C07D413/06; C07D413/14; C07D471/04; C07D519/00; G01N33/50 | Oldest priority date: 2016-12-22 | Publication date: 2020-12-24

Score: 8.327448 | Text size: 635928 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


PHOSPHATIDYLSERINE DECARBOXYLASE INHIBITORS

BEN MAMOUN, Choukri [US]HOYER, Denton [US]PLUMMER, Mark [US]THEKKINIATH, Jose [US]VOELKER, Dennis R. [US]CHOI, Jae-Yeon [US]

Publication date: 2020-12-24 | Patent publication No.: WO-2020257753-A1 | Assignees: YALE UNIVERSITY [US]; NATIONAL JEWISH HEALTH [US] | IPC: G01N21/64; A61K49/00; C12Q1/527; G01N21/63; G01N33/50 | Oldest priority date: 2019-06-20 | Publication date: 2020-12-24

Score: 12.59831 | Text size: 130889 | Find: similar documents

in Humans” Collection (Yale Center for Molecular Discovery), and bioactive collections from ChemDiv, ChemBridge, and Analyticon.


Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria

Sanjay A. Desai [US]

Publication date: 2020-12-22 | Patent publication No.: US-10869865-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Serv [US] | IPC: A61K31/506; A61K31/496; A61K31/501; A61K45/06; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K31/423; A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date: 2011-04-12 | Publication date: 2020-12-22

Score: 15.999366 | Text size: 142367 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England. ... room temperature using a commercial library of 50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at

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METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING MICROBIOME DYSREGULATIONS ASSOCIATED WITH CIRCADIAN CLOCK DISRUPTION

Mathias CHAMAILLARD [FR]

Publication date: 2020-12-17 | Patent publication No.: US-20200390740-A1 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]; UNIVERSITE DE LILLE [FR]; INSTITUT PASTEUR DE LILLE [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - [FR] | IPC: A61K31/353; A61K31/277; A61P1/00 | Oldest priority date: 2016-05-20 | Publication date: 2020-12-17

Score: 13.775837 | Text size: 87730 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (San Diego, Calif.), ChemDiv (San Diego, Calif.), SPECS (Delft, The Netherlands), Timtec (Newark, Del.


METHODS TO IDENTIFY MODULATORS OF ACTIN-BINDING PROTEINS

Adam William Avery [US]Thomas S. Hays [US]David D. Thomas [US]Michael E. Fealey [US]Robyn T. Rebbeck [US]

Publication date: 2020-12-17 | Patent publication No.: US-20200393445-A1 | Assignees: Regents of the University of Minnesota [US] | IPC: G01N33/50; G01N21/64 | Oldest priority date: 2019-06-11 | Publication date: 2020-12-17

Score: 13.245268 | Text size: 112512 | Find: similar documents

and include AM:RI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,


Molecules, compositions and methods for modulation of SIRT6

Haim Yosef Cohen [IL]Yariv Kanfi [IL]

Publication date: 2020-12-08 | Patent publication No.: US-10857170-B1 | Assignees: SirTLab Corporation [IL] | IPC: A61K31/7048; A61K31/428 | Oldest priority date: 2015-12-31 | Publication date: 2020-12-08

Score: 19.510805 | Text size: 61276 | Find: similar documents

High Throughput Screening In the primary screening, compounds from a library (ChemDiv Inc.) were tested at a single concentration of 20 micromolar for their potential to modulate SIRT6 ... an internal identifier; column 2 gives the CAS number for the molecule while column 3 shows its ChemDiv ID; column 4 gives the molecular structure; and column 5 shows percent activity of the molecule in ... TABLE 1 # CAS number ChemDiv ID Structure% activity 20 uM% activity Max. conc. ... stereoisomer of molecule 768382-41-8 D715-0284 [[image:EMI-C00003]] 70 195 TABLE 2 # CAS numberChemDiv ID Structure% activity 20 uM% activity 100 uM 1 332173-46-3 2803-0068 [[image:EMI-C00004]] 88 428 2

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Methods for treatment of retinal disease by photoreceptor gene expression modulation

Thomas A. Reh [US]Paul Nakamura [US]Sheng Ding [US]

Publication date: 2020-12-01 | Patent publication No.: US-10849904-B2 | Assignees: University of Washington [US]; The J. David Gladstone Institutes, a Teatamentary Trust Established Under the Will of J. David. Gladstone [US] | IPC: A61K31/519; C07D495/04; A61K31/426; A61K9/00; A61P27/02 | Oldest priority date: 2015-03-27 | Publication date: 2020-12-01

Score: 18.309502 | Text size: 64672 | Find: similar documents

(I) is CA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commercially available from ChemDiv (San Diego, Calif. ... (II) is CA9513: [[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially available from ChemDiv (San Diego, Calif. ... Nr2e3 interacting molecules specifically identified herein were obtained commercially from ChemDiv (San Diego, Calif.

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AUTOPHAGY MODULATORS FOR USE IN TREATING CANCER

Melvin L. DePamphilis [US]Gaurav Sharma [IN]Juan Jose Marugan [US]Marc Ferrer [US]Ajit Roy [US]

Publication date: 2020-11-26 | Patent publication No.: US-20200369649-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: C07D403/12; C07D251/54; C07D239/50; A61P35/00 | Oldest priority date: 2017-12-01 | Publication date: 2020-11-26

Score: 12.913692 | Text size: 129680 | Find: similar documents

Materials and Methods Reagents Compounds 1, 4, 5, 3, and 2 (Specs, ChemDiv, Life Chemicals) and Rapamycin (S1039, Selleck Chemicals) were dissolved in dimethyl sulfoxide


PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR TREATMENT OF RETINAL DISEASE

Thomas A. Reh [US]Paul Nakamura [US]Andy Shimchuk [US]Shibing Tang [CN]Sheng Ding [US]

Publication date: 2020-11-26 | Patent publication No.: US-20200368234-A1 | Assignees: University of Washington [US]; The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J David Gladst [US] | IPC: A61K31/517; A61K9/00 | Oldest priority date: 2017-08-10 | Publication date: 2020-11-26

Score: 14.867696 | Text size: 40027 | Find: similar documents

It was initially obtained from ChemDiv and then synthesized and purified in large quantities in the lab after initial screening.


Methods to diagnose and treat attention-deficit, hyperactivity disorder (ADHD)


Joseph Glessner [US]Josephine Elia [US]Hakon Hakonarson [US]

Publication date: 2020-11-24 | Patent publication No.: US-10844434-B2 | Assignees: The Children's Hospital of Philadelphia [US] | IPC: C12Q1/6883; C12Q1/6876; A61K31/454 | Oldest priority date: 2010-08-24 | Publication date: 2020-11-24

Score: 10.759004 | Text size: 259413 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven Albert Everett [US]Saraj Ulhaq [GB]

Publication date: 2020-11-19 | Patent publication No.: US-20200360521-A1 | Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54; A61K31/343; A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16; C07D311/18; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; C07D487/04; C07D491/22; A61K31/37; A61K31/381; A61K31/513; A61K31/52; A61K31/665 | Oldest priority date: 2009-05-01 | Publication date: 2020-11-19

Score: 16.116692 | Text size: 221424 | Find: similar documents

for CYP181 The target enzyme CYP1B1 was screened against two commercial libraries including the ChemDiv Diversity 50,000 test compound collection and the ChemDiv Kinase Targeted 10,000 test compound collection with a view to identifying activity differentiating ... cross validation on a training set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverse and Kinase libraries.


COMPOUNDS FOR TREATING DENGUE VIRUS INFECTION AND OTHER VIRAL INFECTIONS

Priscilla L. Yang [US]Wenlong Lian [US]Nathanael S. Gray [US]Nicholas Paul Kwiatkowski [US]Jinhua Wang [US]Jaebong Jang [KR]

Publication date: 2020-11-19 | Patent publication No.: US-20200360381-A1 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; President and Fellows of Harvard College [US] | IPC: A61K31/5025; A61K31/4045; A61K31/416; A61K31/47; A61K31/277; A61K31/167; A61K31/53; A61P31/16 | Oldest priority date: 2017-05-15 | Publication date: 2020-11-19

Score: 10.759004 | Text size: 297179 | Find: similar documents

about 20,000 compounds at the concentration of 10 μM (Selleck Known Bioactive library) or 5 μg/ml (ChemDiv library) in duplicate were applied in the AlphaScreen based competition assay using automation


LIN28/LET-7 CRYSTAL STRUCTURES, PURIFICATION PROTOCOLS, AND MOLECULAR PROBES SUITABLE FOR SCREENING ASSAYS AND THERAPEUTICS

Piotr SLIZ [US]Yunsun NAM [US]

Publication date: 2020-11-19 | Patent publication No.: US-20200362350-A1 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/113; A61K31/7105; A61K45/06; A61K31/7115; A61K31/712; A61K31/713; C07K14/47; A61K47/60; A61K47/64; C07H21/02 | Oldest priority date: 2011-11-09 | Publication date: 2020-11-19

Score: 10.328181 | Text size: 292964 | Find: similar documents

2, Prestwick 2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge 3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5. These libraries can be screened using the


Compounds and Methods for Treating or Preventing Anterior Segment Ocular Disorders and/or Retinal Degenerations

Mark Fields [US]Lucian Del Priore [US]Huey Cai [US]Denton Hoyer [US]

Publication date: 2020-10-29 | Patent publication No.: US-20200338081-A1 | Assignees: YALE UNIVERSITY [US] | IPC: A61K31/519; A61K47/40 | Oldest priority date: 2018-01-08 | Publication date: 2020-10-29

Score: 16.124392 | Text size: 102942 | Find: similar documents

As used herein, “compound 414” or “YU162779-01” refers to ChemDiv library compound number C325-0414, or a salt, solvate or hydrate thereof, having the formula: [[image:EMI-C00011]] As used herein, “compound 434” or “YU162787-01” refers to ChemDiv library compound number C325-0434, or a salt, solvate or hydrate thereof, having the


COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES

Hakonarson, Hakon [US]Yun, Rose Li [US]Keating, Brendan [US]

Publication date: 2020-10-28 | Patent publication No.: EP-3730188-A1 | Assignees: The Children's Hospital of Philadelphia [US] | IPC: A61P1/04; C12Q1/68 | Oldest priority date: 2016-04-08 | Publication date: 2020-10-28

Score: 9.22053 | Text size: 312243 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

External link


ISOLATED HUMAN LUNG PROGENITOR CELLS AND USES THEREOF

RAJAGOPAL, Jayaraj [US]MOU, Hongmei [US]

Publication date: 2020-10-28 | Patent publication No.: EP-2802647-B1 | Assignees: The General Hospital Corporation [US] | IPC: C12N5/071; C12N5/077; A61K35/42; A61P11/00; A61L27/38; A61L27/56; A61L27/58; A61K9/00; G01N33/68 | Oldest priority date: 2012-04-03 | Publication date: 2020-10-28

Score: 10.328181 | Text size: 254262 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

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PURMORPHAMINE AS A SMALL COMPOUND POSITIVE ALLOSTERIC MODULATOR OF SECRETIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION

SINGH, Kailash [CN]CHOW, Billy Kwok Chong [CN]

Publication date: 2020-10-22 | Patent publication No.: WO-2020211772-A1 | Assignees: VERSITECH LIMITED [CN] | IPC: A61K31/5377; A61P9/12 | Oldest priority date: 2019-04-16 | Publication date: 2020-10-22

Score: 13.245268 | Text size: 113705 | Find: similar documents

available small molecule libraries used include, but not limited to, PubChem, CHEMBL, MolProt, ChemDiv, ChemSpace, NCI open and ZINC.


METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA

David J. Tweardy [US]Moses M. Kasembeli [US]Marvin X. Xu [CN]Thomas Kristian Eckols [US]

Publication date: 2020-10-22 | Patent publication No.: US-20200331880-A1 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D215/36; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/21; C07C311/24; C07C311/29; C07C311/44; C07C323/49; C07C381/06; A61K45/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513 | Oldest priority date: 2013-07-18 | Publication date: 2020-10-22

Score: 14.233541 | Text size: 272534 | Find: similar documents

Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.


25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC

OHE, Munemichi [JP]INOUE, Naoki [JP]LIMBAD, Chandani [US]DOI, Ryosuke [US]

Publication date: 2020-10-22 | Patent publication No.: WO-2020214993-A1 | Assignees: BUCK INSTITUTE FOR RESEARCH ON AGING [US]; ASTELLAS PHARMA INC. [JP] | IPC: A61K31/352; A61K31/506 | Oldest priority date: 2019-04-19 | Publication date: 2020-10-22

Score: 8.902286 | Text size: 356441 | Find: similar documents

and real screening services are commercially available from a number of suppliers (see, e.g., ChemDiv (San Diego, CA), and the like).


Immunomodulator compounds and methods of use

Liang Lu [US]Wenyu Zhu [US]Ding-Quan Qian [US]Kaijiong Xiao [US]

Publication date: 2020-10-20 | Patent publication No.: US-10806785-B2 | Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61P37/00; A61P37/04; A61P35/00; A61K45/06; C07D213/81; C07D263/57; C07D413/06; C07D413/14; C07D471/04; C07D519/00; G01N33/50; A61K39/00 | Oldest priority date: 2016-12-22 | Publication date: 2020-10-20

Score: 8.605278 | Text size: 618747 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bio net (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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PAK1 INHIBITORS AND USES THEREOF

Ulrich Steidl [US]Ashley M. Eckel [US]Robert F. Stanley [US]Boris Rogovoy [US]Ilya Okun [US]

Publication date: 2020-10-15 | Patent publication No.: US-20200323855-A1 | Assignees: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. [US] | IPC: A61K31/519; A61K31/437; A61K31/496; A61P35/00 | Oldest priority date: 2016-05-06 | Publication date: 2020-10-15

Score: 14.350686 | Text size: 67504 | Find: similar documents

Compounds were screened for PAK1 inhibition using a 50,024 compound library by ChemDiv (San Diego, Calif.


NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

GUEDAT, Philippe [FR]

Publication date: 2020-10-14 | Patent publication No.: EP-3721877-A1 | Assignees: InFlectis BioScience [FR] | IPC: A61K31/155; A61K31/44; A61K31/53; A61P31/00; A61P29/00 | Oldest priority date: 2014-07-02 | Publication date: 2020-10-14

Score: 15.288118 | Text size: 154239 | Find: similar documents

& METHODS Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1 - Preparation of the compounds according to the present invention The reactants

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PLASMINOGEN ACTIVATOR-1 INHIBITORS AND METHODS OF USE THEREOF

LAWRENCE, Daniel, A. [US]EMAL, Cory [US]REINKE, Ashley [US]LI, Shih-Hon [US]WARNOCK, Mark [US]ABERNATHY, Gregory [US]

Publication date: 2020-10-14 | Patent publication No.: EP-2914575-B1 | Assignees: The Regents of The University of Michigan [US]; Eastern Michigan University [US] | IPC: C07C233/08; C07C233/05; A61K31/16; A61K31/165; C07C259/06; C07C271/16; C07C275/64; C07C69/84; C07C311/17; C07C311/29; C07D417/04; C07C323/60; C07D261/18; C07C235/34; C07D271/113; C07D277/34; C07C243/26; C07D207/48; C07C251/76; C07D209/08 | Oldest priority date: 2012-10-31 | Publication date: 2020-10-14

Score: 12.297968 | Text size: 143816 | Find: similar documents

Chemical Methodologies Libraries Development (Boston University), Maybridge, Chembridge, ChemDiv, National Cancer Institute-Development Therapeutics Program Library, the Cayman Cannabinoid and

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High-throughput, high-precision methods for detecting protein structural changes in living cells

David D. Thomas [US]Simon Joseph Gruber [US]Razvan L. Cornea [US]Gregory David Gillispie [US]Kurt C. Peterson [US]Seth Louis Robia [US]

Publication date: 2020-10-06 | Patent publication No.: US-10794898-B2 | Assignees: Regents of the University of Minnesota [US]; Loyola University Chicago [US] | IPC: G01N33/50; G01N21/64; G01N33/58 | Oldest priority date: 2014-01-17 | Publication date: 2020-10-06

Score: 12.913692 | Text size: 131545 | Find: similar documents

and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,

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MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE

John Schneekloth, JR. [US]John Simmons [US]Kenneth Felsenstein [US]Beverly Mock [US]Lindsey Saunders [US]David Calabrese [US]Elena Leon [US]

Publication date: 2020-10-01 | Patent publication No.: US-20200308128-A1 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Servic [US] | IPC: C07D307/84; A61K31/343; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496; A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 | Publication date: 2020-10-01

Score: 17.89937 | Text size: 186723 | Find: similar documents

20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... No.Peggy (% c-Myc expression compared to untreated) IC50 1 [[image:EMI-C00030]] Commercial: ChemDiv No. D089-0563 50% (at 10 μM) 7.6 μM 2 [[image:EMI-C00031]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:EMI-C00032]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:EMI-C00033]] Commercial: ChemDiv No. ... ChemBridge No. 6238398 69% (at 10 μM) 89% viability (at 10 μM) 12 [[image:EMI-C00041]] Commercial: ChemDiv No. D089-0350 43% (at 10 μM) 3.4 μM 13 [[image:EMI-C00042]] Commercial: Otava Chemical No.


TARGETING THE TLK1/NEK1 AXIS IN PROSTATE CANCER

Arrigo DeBENEDETTI [US]Siddhant BHOIR [IN]Vibha SINGH [US]Javeena HUSSAIN [IN]Rupesh CHIKHALE [GB]Richard BRYCE [GB]Sivapriya KIRUBAKARAN [IN]

Publication date: 2020-10-01 | Patent publication No.: US-20200306258-A1 | Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College [US] | IPC: A61K31/5415; A61K31/167; A61P35/00 | Oldest priority date: 2019-03-29 | Publication date: 2020-10-01

Score: 12.913692 | Text size: 104561 | Find: similar documents

The inventors have screened the Prestwick Library, partially the ChemDiv, and two proprietary libraries (10,000 compounds) for inhibitors of TLK with a high throughput


METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS

MURRY, Charles E. [US]YANG, Xiulan [US]

Publication date: 2020-09-24 | Patent publication No.: WO-2020190939-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: A61K35/34; A61P9/00; A61P3/10; A61P3/04; A61P3/00 | Oldest priority date: 2019-03-18 | Publication date: 2020-09-24

Score: 10.759004 | Text size: 227455 | Find: similar documents

for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.


PROTEOSTASIS REGULATORS

Megan Foley [US]Bradley Tait [US]Matthew Cullen [US]

Publication date: 2020-09-24 | Patent publication No.: US-20200299270-A1 | Assignees: Proteostasis Therapeutics, Inc. [US] | IPC: C07D403/06; C07D207/333; C07D207/337; C07D231/12; C07D249/06; C07D263/32; C07D275/02; C07D295/185; C07D333/20; C07D401/06; C07D405/06; C07D471/04; C07D333/22 | Oldest priority date: 2011-05-12 | Publication date: 2020-09-24

Score: 11.738287 | Text size: 208821 | Find: similar documents

Compound A47 (also shown below) was purchased from ChemDiv, San Diego, Calif.


SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

LIST, Alan F. [US]WEI, Sheng [US]

Publication date: 2020-09-23 | Patent publication No.: EP-3711484-A1 | Assignees: H. Lee Moffitt Cancer Center And Research Institute, Inc. [US] | IPC: A01N25/00; A61K39/00; C12P21/04 | Oldest priority date: 2014-04-10 | Publication date: 2020-09-23

Score: 11.477125 | Text size: 168410 | Find: similar documents

ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,

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Methods for detecting protein-protein interactions

Stéphanie Cabantous [FR]Faten Koraïchi [FR]Gilles Favre [FR]

Publication date: 2020-09-22 | Patent publication No.: US-10782304-B2 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]; UNIVERSITÉ PAUL SABATIER TOULOUSE III [FR] | IPC: G01N33/68; G01N33/542; C07K16/18; C40B30/04; G01N33/50; G01N33/533 | Oldest priority date: 2015-06-24 | Publication date: 2020-09-22

Score: 13.417523 | Text size: 112605 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.

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CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF

SAVVIDES, Savvas [BE]VERSTRAETE, Kenneth [BE]

Publication date: 2020-09-17 | Patent publication No.: WO-2020182615-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE] | IPC: C12N9/88; C30B29/58 | Oldest priority date: 2019-03-08 | Publication date: 2020-09-17

Score: 13.594319 | Text size: 106637 | Find: similar documents

from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands).


NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

Philippe GUEDAT [FR]

Publication date: 2020-09-17 | Patent publication No.: US-20200289436-A1 | Assignees: InFlectis BioScience [FR] | IPC: A61K31/155; A61K31/44; A61K31/53 | Oldest priority date: 2014-07-02 | Publication date: 2020-09-17

Score: 15.288118 | Text size: 155351 | Find: similar documents

& Methods Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1—Preparation of the Compounds According to the Present Invention The reactants


Materials and method for inhibiting replication protein A and uses thereof

John J. Turchi [US]

Publication date: 2020-09-15 | Patent publication No.: US-10774063-B2 | Assignees: Indiana University Research and Technology Corporation [US] | IPC: C07D401/04; A61P35/00; C07D403/04; C07D231/06; A61K45/06; A61K47/26; A61K47/38; C07D401/14; C07D413/14; A61K9/00 | Oldest priority date: 2014-11-13 | Publication date: 2020-09-15

Score: 13.775837 | Text size: 80367 | Find: similar documents

Chemical compounds, either purchased from ChemDiv or synthesized in the laboratory, were suspended in DMSO and titrated as detailed in each figure.

External link


ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME

Dan THEODORESCU [US]Michael Fitzpatrick WEMPE [US]David ROSS [US]Chao YAN [US]Phillip REIGAN [US]

Publication date: 2020-08-13 | Patent publication No.: US-20200255442-A1 | Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61P35/04; A61K45/06 | Oldest priority date: 2014-07-10 | Publication date: 2020-08-13

Score: 12.297968 | Text size: 143369 | Find: similar documents

The ChemDiv library [v2006.


BENZYLIDENEGUANIDINE DERIVATIVES AND THERAPEUTIC USE FOR THE TREATMENT OF PROTEIN MISFOLDING DISEASES

GUEDAT, Philippe [FR]BERTOLOTTI, Anne [GB]

Publication date: 2020-08-12 | Patent publication No.: EP-3115357-B1 | Assignees: United Kingdom Research and Innovation [GB]; InFlectis BioScience [FR] | IPC: C07C281/18; C07D253/075; C07D213/61; A61K31/155; A61K31/165; A61K31/216; A61K31/44; A61K31/53; A61K45/06; A61P3/10; A61P25/00; A61P25/16; A61P25/28; A61P35/00 | Oldest priority date: 2013-01-10 | Publication date: 2020-08-12

Score: 16.251385 | Text size: 108206 | Find: similar documents

EXAMPLES Methods & Materials Example 1 was purchased from Chemdiv ref: 1683-6588 Example 2 was purchased from Chembridge ref: 5173161 Example 4 was purchased from Enamine ref: Z49562642 Example 6 was purchased from Chemdiv ref: 1683-6502 Preparation of the compounds : used in the present invention The reactants and

External link


Inhibitors of RAD52 recombination protein and methods using same

Alexander V. Mazin [US]

Publication date: 2020-08-11 | Patent publication No.: US-10738061-B2 | Assignees: Drexel University [US] | IPC: A61P35/00; A61K31/4188; A61K31/5377; A61K31/4741; A61K45/06; A61K31/55; A61K31/47; A61K31/4525; A61K31/496; A61K31/517; C07D491/056; C07D491/048; C07D471/04; C07D307/82; C07D495/04; C07D405/12; C07D239/95; C07D215/38 | Oldest priority date: 2015-06-04 | Publication date: 2020-08-11

Score: 12.59831 | Text size: 134936 | Find: similar documents

The compounds for confirmation analysis were purchased from Asinex Ltd., ChemBridge Co., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific Services Inc., InterBioScreen Ltd., Life Chemicals Inc.

External link


PHARMACEUTICAL COMPOSITION FOR TREATING THYROID CANCER COMPRISING TYROSINE KINASE ACTIVITY INHIBITOR AS ACTIVE INGREDIENT

Byeong Cheol AHN [KR]Ji Min OH [KR]

Publication date: 2020-08-06 | Patent publication No.: US-20200246341-A1 | Assignees: Kyungpook National University Industry-Academic Cooperation Foundation [KR] | IPC: A61K31/519; A61P35/04 | Oldest priority date: 2017-10-20 | Publication date: 2020-08-06

Score: 14.9756 | Text size: 40797 | Find: similar documents

Among the TKI candidates, TKI-0266 was selected, purchased from Chemdiv (USA), dissolved in DMSO, and then stored at −80° C. 5. Protein Isolation and Western


COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL KILLER CELL ACTIVATION AND FUNCTION

BARDA-SAAD, Mira [IL]

Publication date: 2020-08-06 | Patent publication No.: WO-2020157750-A1 | Assignees: BAR ILAN UNIVERSITY [IL] | IPC: A61K31/7105; A61K35/17; A61K9/14; A61P35/00 | Oldest priority date: 2019-01-28 | Publication date: 2020-08-06

Score: 8.902286 | Text size: 338346 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Ft, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive


PYRAZOLOPYRIMIDINE MODULATORS OF RAS GTPASE

GARLAND, William A. [US]UNGASHE, Solomon B. [US]YANOFSKY, Stephen D. [US]LIAW, Philip [US]LENNEK, Annie L. [US]

Publication date: 2020-08-06 | Patent publication No.: WO-2020159942-A1 | Assignees: TOSK, INC. [US] | IPC: C07D487/04; A61K31/519; A61P35/00 | Oldest priority date: 2019-01-29 | Publication date: 2020-08-06

Score: 12.59831 | Text size: 144424 | Find: similar documents

A library of over 16,000 distinct chemicals was purchased from ChemDiv, San Diego, CA.


AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR

HAQUE, Aftabul [US]LINDQUIST, Susan L. [US]

Publication date: 2020-08-05 | Patent publication No.: EP-3155003-B1 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C07K14/47; C12N15/81; C12N15/85; G01N33/50 | Oldest priority date: 2014-06-13 | Publication date: 2020-08-05

Score: 12.913692 | Text size: 134796 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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Use of aldehyde dehydrogenase as biomarker for beta-cell dysfunction and loss

Domenico Accili [US]Ja Young Kim-Muller [US]

Publication date: 2020-08-04 | Patent publication No.: US-10732173-B2 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: G01N33/50; C12N5/071 | Oldest priority date: 2015-09-15 | Publication date: 2020-08-04

Score: 12.011612 | Text size: 258055 | Find: similar documents

Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed

External link


Pyrazolopyrimidine Modulators of RAS GTPase

William A. Garland [US]Solomon B. Ungashe [US]Stephen D. Yanofsky [US]Philip Liaw [US]Annie L. Lennek [US]

Publication date: 2020-07-30 | Patent publication No.: US-20200239479-A1 | Assignees: Tosk, Inc. [US] | IPC: C07D487/04; A61P35/00 | Oldest priority date: 2019-01-29 | Publication date: 2020-07-30

Score: 12.59831 | Text size: 130836 | Find: similar documents

3 Identification of Structure 1 A library of over 16,000 distinct chemicals was purchased from ChemDiv, San Diego, Calif.


6-AMINO-1,3-DIMETHYL-4-(4-(TRIFLUOROMETHYL)PHENYL)-1,4-DIHYDROPYRANO [2,3-C]PYRAZOLE-5-CARBONITRILE AND RELATED COMPOUNDS AS RAL GTPASE INHIBITORS FOR TREATING CANCER METASTASIS

THEODORESCU, Dan [US]WEMPE, Michael [US]ROSS, David [US]YAN, Chao [US]REIGAN, Philip [US]

Publication date: 2020-07-29 | Patent publication No.: EP-3686202-A1 | Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61P35/00; A61P35/04 | Oldest priority date: 2014-07-10 | Publication date: 2020-07-29

Score: 12.297968 | Text size: 150328 | Find: similar documents

The ChemDiv library [v2006.

External link


HUMAN PLURIPOTENT STEM CELL DERIVED ENDOCARDIAL ENDOTHELIUM

Charles E. Murry [US]Lil Pabon [US]Nathan Palpant [US]

Publication date: 2020-07-23 | Patent publication No.: US-20200231933-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: C12N5/077; A61K35/545 | Oldest priority date: 2016-02-19 | Publication date: 2020-07-23

Score: 10.759004 | Text size: 207588 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.


NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND

Okuyama, Masahiro [JP]Fukunaga, Kenji [JP]Usui, Kenji [JP]Hayashi, Norimitsu [JP]Iijima, Daisuke [JP]Horiuchi, Hideki [JP]Itagaki, Noriaki [JP]

Publication date: 2020-07-22 | Patent publication No.: EP-3683222-A1 | Assignees: Mitsubishi Tanabe Pharma Corporation [JP] | IPC: C07D513/04; C07D471/04; C07D487/04; C07D513/14; A61K31/437; A61K31/5025; A61K31/519; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00 | Oldest priority date: 2014-04-23 | Publication date: 2020-07-22

Score: 6.4525156 | Text size: 1029257 | Find: similar documents

sold by plural companies (e.g., AKos Consulting & Solutions GmbH, Ambinter, Aurora Fine Chemicals, ChemDiv, Inc.). However, a KAT-II inhibitory action and other pharmacological activities of these compounds have

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NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

Catherine TACHDJIAN [US]Andrew P. PATRON [US]Sara L. ADAMSKI-WERNER [US]Farid BAKIR [US]Qing CHEN [US]Vincent DARMOHUSODO [US]Stephen Terrence HOBSON [US]Xiaodong LI [US]Ming QI [CN]Daniel H. ROGERS [US]Marketa RINNOVA [US]Guy SERVANT [US]Xiao-Qing TANG [US]Mark ZOLLER [US]David WALLACE [US]Amy XING [US]Klaus GUBERNATOR [US]

Publication date: 2020-07-16 | Patent publication No.: US-20200225217-A1 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; A23L27/00; C07F9/655; C07D405/12; A61K47/24; A61K47/22; A61K8/55; A61K8/49; A23L2/56; G01N33/50; C07D307/82; C07D307/79; C07D307/68; C07D307/52; C07D213/40; C07D285/135; C07D209/42; C07D277/64; C07D209/08; C07D275/03; C07D271/12; C07D261/18; C07D417/12; C07D409/12; C07D401/04; C07D333/38; C07D333/24; C07D231/14; C07D217/06; C07D215/48; C07D213/85; C07D213/81; C07D263/56; A23L27/20; G01N33/74; G01N33/566; C07D317/68; C07D307/84; C07C275/34; C07C275/30; C07C235/54; C07C233/65 | Oldest priority date: 2003-08-06 | Publication date: 2020-07-16

Score: 9.562369 | Text size: 325239 | Find: similar documents

offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego CA, Chembridge of San Diego Calif.


XPA INHIBITOR COMPOUNDS AND THEIR USE

John J. TURCHI [US]Navath GAVANDE [US]Pamela S. VANDERVERE-CAROZZA [US]

Publication date: 2020-07-16 | Patent publication No.: US-20200222367-A1 | Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: A61K31/4155 | Oldest priority date: 2017-09-19 | Publication date: 2020-07-16

Score: 15.518069 | Text size: 174633 | Find: similar documents

Compound X80 (1) (FIG. 2A) and its commercially available analogs 2-24 were purchased from ChemDiv (San Diego, USA) and AKos GmbH (Steinen, Germany) library with highest purity (≥95%) and prepared ... binding pockets and identify inhibitors with improved potency, we first searched the virtual Chemdiv (San Diego, USA) and AKos GmbH (Steinen, Germany) library for X80 analogs with a criterion of


Therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies

Philippe Guedat [FR]

Publication date: 2020-07-14 | Patent publication No.: US-10709677-B2 | Assignees: INFLECTIS BIOSCIENCE [FR] | IPC: A61K31/155; A61K31/44; A61K31/53 | Oldest priority date: 2014-07-02 | Publication date: 2020-07-14

Score: 15.288118 | Text size: 153760 | Find: similar documents

& Methods Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1—Preparation of the Compounds According to the Present Invention The reactants

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METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS

CHEN, Beibei [US]FINKEL, Toren [US]LIU, Yuan [US]

Publication date: 2020-07-09 | Patent publication No.: WO-2020142748-A1 | Assignees: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US] | IPC: A61K31/519; C07D239/72; A61P25/00 | Oldest priority date: 2019-01-03 | Publication date: 2020-07-09

Score: 14.432653 | Text size: 245570 | Find: similar documents

The following compounds (free base) provided in Table 2 were obtained from commercial sources (ChemDIV, Inc. and Molport, Inc. ... The following compounds shown in Table 4 were purchased from ChemDIV, Inc.


COMPOSITIONS AND METHODS OF TREATMENT USING NICOTINAMIDE MONONUCLEOTIDE

Shin-ichiro Imai [US]Alessia Grozio [US]

Publication date: 2020-07-09 | Patent publication No.: US-20200215087-A1 | Assignees: Washington University [US] | IPC: A61K31/706; A61K45/06; A61K48/00; A61P3/04; C12N15/86; G01N33/50; G01N33/68 | Oldest priority date: 2017-08-10 | Publication date: 2020-07-09

Score: 11.738287 | Text size: 160101 | Find: similar documents

media contending 0.2% DMSO (vehicle), 20 M EX527 (Cayman chemical, MI) or 20 M STK665401 (ChemDiv, cat #8018-9378; Sociali, G. et al., Eur. J. Med. Chem., 2015, 102, 530-539).


Materials for cathepsin B enhancement and methods of use

Ben A. Bahr [US]

Publication date: 2020-07-07 | Patent publication No.: US-10702571-B2 | Assignees: The University of North Carolina at Pembroke [US] | IPC: A61K31/70; A61K31/27; A61K38/05; A61K31/352; C07K5/065; A61K45/06; A61P25/28; A61K9/00 | Oldest priority date: 2015-12-03 | Publication date: 2020-07-07

Score: 12.913692 | Text size: 106619 | Find: similar documents

Z-Phe-Pro-OH is commercially available from ChemDiv Inc. (San Diego, Calif., USA).

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Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics

Piotr Sliz [US]Yunsun Nam [US]

Publication date: 2020-07-07 | Patent publication No.: US-10704049-B2 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/113; A61K45/06; A61K47/60; C07K14/47; A61K47/64; C07H21/02; A61K48/00; A61K31/7105; A61K31/7115; A61K31/712; A61K31/713 | Oldest priority date: 2011-11-09 | Publication date: 2020-07-07

Score: 10.328181 | Text size: 297420 | Find: similar documents

2, Prestwick 2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge 3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5. These libraries can be screened using the

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TAF1 inhibitors for the therapy of cancer

Sara Sdelci [AT]Stefan Kubicek [AT]

Publication date: 2020-07-07 | Patent publication No.: US-10702518-B2 | Assignees: CeMM—Forschungszentrum für Molekulare Medizin GmbH [AT] | IPC: A61K31/4725; A61K31/5517; A61P35/00; C07D413/12; C07D217/26; C07D407/12; C07D401/12; A61K45/06; A61K31/44; A61K31/513; G01N33/50; G01N33/68; G01N33/574; A61K31/4433; A61K31/472; A61K31/22; A61K31/517 | Oldest priority date: 2016-02-15 | Publication date: 2020-07-07

Score: 10.759004 | Text size: 232763 | Find: similar documents

Compounds A2, A3, A4 and A5 were purchased from ChemDiv (San Diego, USA). Synthesis of all other analogs was carried out by Enamine Ltd.

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Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia

David J. Tweardy [US]Moses M. Kasembeli [US]Marvin X. Xu [CN]Thomas Kristian Eckols [US]

Publication date: 2020-06-09 | Patent publication No.: US-10676455-B2 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/44; A61K31/194; C07C311/21; C07D215/36; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/24; C07C311/29; C07C311/44; C07C323/49; C07C381/06; A61K45/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513 | Oldest priority date: 2013-07-18 | Publication date: 2020-06-09

Score: 14.233541 | Text size: 273813 | Find: similar documents

Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.

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Anti-cancer compounds targeting Ral GTPases and methods of using the same

Dan Theodorescu [US]Michael Fitzpatrick Wempe [US]David Ross [US]Chao Yan [US]Phillip Reigan [US]

Publication date: 2020-06-09 | Patent publication No.: US-10676480-B2 | Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61K45/06; A61P35/04 | Oldest priority date: 2014-07-10 | Publication date: 2020-06-09

Score: 12.59831 | Text size: 162784 | Find: similar documents

The ChemDiv library [v2006.

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Methods and compositions for treating mesothelioma and small lung cancer that express midkine


Takuya Fukazawa [JP]Jeffrey A. Whitsett [US]Yutaka Maeda [US]

Publication date: 2020-06-02 | Patent publication No.: US-10668078-B2 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2020-06-02

Score: 14.656486 | Text size: 55756 | Find: similar documents

(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.

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NETRIN- 1 AND DEPENDENCE RECEPTOR PROTEINS AND METHOD OF USE

Jorg Stetefeld [CA]

Publication date: 2020-05-28 | Patent publication No.: US-20200165308-A1 | Assignees: UNIVERSITY OF MANITOBA [CA] | IPC: C07K14/475; C07K16/18; A61K39/395; C07K14/705; C07K14/47 | Oldest priority date: 2014-02-10 | Publication date: 2020-05-28

Score: 12.913692 | Text size: 130967 | Find: similar documents

and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,


Non-beta lactam antibiotics

Mayland Chang [US]Shahriar Mobashery [US]Edward Spink [GB]Derong Ding [US]Sebastian Testero [AR]Erika Leemans [BE]Marc Boudreau [US]

Publication date: 2020-05-26 | Patent publication No.: US-10662164-B2 | Assignees: University of Notre Dame du Lac [US] | IPC: A61K31/4245; C07D271/107; C07D413/04; C07D471/04; C07D271/06; C07F9/653 | Oldest priority date: 2014-09-25 | Publication date: 2020-05-26

Score: 15.288118 | Text size: 174083 | Find: similar documents

A library of 1.2 million drug-like compounds from the ChemDiv subset of the ZINC database (Irwin et al., J. Chem. Inf. Model. ... From these, 29 compounds were selected and purchased from ChemDiv for in vitro activity experiments. Syntheses.

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LYMPHOCYTE ANTIGEN CD5LIKE (CD5L) MONOMER, HOMODIMER, AND INTERLEUKIN 12B (P40) HETERODIMER ANTAGONISTS AND METHODS OF USE THEREOF

Aviv Regev [US]Vijay K. Kuchroo [US]Chao Wang [US]

Publication date: 2020-05-21 | Patent publication No.: US-20200157237-A1 | Assignees: The Broad Institute, Inc. [US]; Massachusetts Institute of Technology [US]; The Brigham and Women's Hospital, Inc. [US] | IPC: C07K16/28; C07K16/30; C12N15/113; G01N33/50; G01N33/574; G16B50/30; G16H50/70 | Oldest priority date: 2017-05-25 | Publication date: 2020-05-21

Score: 6.7923617 | Text size: 644529 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.


NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

GUEDAT, Philippe [FR]

Publication date: 2020-05-20 | Patent publication No.: EP-3164123-B1 | Assignees: InFlectis BioScience [FR] | IPC: A61K31/155; A61K31/44; A61K31/53; A61P9/10; A61P9/12; A61P3/04; A61P19/10 | Oldest priority date: 2014-07-02 | Publication date: 2020-05-20

Score: 15.288118 | Text size: 168703 | Find: similar documents

& METHODS Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1 - Preparation of the compounds according to the present invention The reactants

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COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES

WU, Jay Jie-Qiang [US]

Publication date: 2020-05-20 | Patent publication No.: EP-3135672-B9 | Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36; C07D498/04; A61K31/4162; A61P35/00 | Oldest priority date: 2008-10-10 | Publication date: 2020-05-20

Score: 11.738287 | Text size: 207681 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE) or can be synthesized.

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Small molecule inhibitors of USP1 deubiquitinating enzyme activity

Alan D. D'Andrea [US]Gregory D. Cuny [US]Ross L. Stein [US]Marcie Glicksman [US]April Case [US]Jun Xian [US]David Wilson [US]Min Huang [CN]

Publication date: 2020-05-19 | Patent publication No.: US-10653676-B2 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; The Brigham and Women's Hospital, Inc. [US] | IPC: A61K31/423; C07D405/06; C07D263/60; A61K31/136; A61K31/472; A61K31/4725; A61K45/06; C07C225/30; C07D217/24 | Oldest priority date: 2010-04-30 | Publication date: 2020-05-19

Score: 11.738287 | Text size: 199526 | Find: similar documents

consists of known bioactive libraries, natural product libraries, and commercial libraries such as ChemDiv, ChemBridge, etc.

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COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH MUTANT KCNJ5

Richard Lifton [US]Ute Scholl [DE]

Publication date: 2020-05-14 | Patent publication No.: US-20200147113-A1 | Assignees: The Rockefeller University [US] | IPC: A61K31/7048; G01N33/74 | Oldest priority date: 2017-05-18 | Publication date: 2020-05-14

Score: 20.795069 | Text size: 190171 | Find: similar documents

70.1 75.5 72.8 YU039827 Microsource 2300165 Amiodarone hydrochloride 77.8 65.9 71.8 YU200116 ChemDiv G281-2440 54.5 87.7 71.1 YU164429 ChemDiv D089-0725 65.8 75.6 70.7 YU182169 ChemDiv D393-0253 63.3 77.5 70.4 YU163288 ChemDiv C620-0363 70.5 68.6 69.5 YU164416 ChemDiv D089-0533 53.7 82.7 68.2 YU214875 ChemDiv L491-0661 84.0 52.1 68.1 YU165270 ChemDiv D297-0001 94.9 40.9 67.9 YU164350 ChemDiv D089-0310 81.9 50.4 66.1 YU039449 NCC SAM001246981 Indatraline 70.6 61.3 65.9 YU171244 ChemDiv 5340-0013 58.6 73.1 65.8 YU155938 ChemDiv 2434-0134 83.4 47.9 65.7 YU195274 ChemDiv F580-1522 74.6 49.9 62.3 YU156667 ChemDiv 3534-0434 68.1 56.0 62.0 YU164338 ChemDiv D089-0264 54.7 69.0 61.9 YU164351 ChemDiv D089-0311 77.7 44.0 60.8 YU164423 ChemDiv D089-0559 66.6 54.9 60.8 YU200600 ChemDiv G345-0648 84.


CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. VERKMAN [US]Marc H. LEVIN [US]Onur Cil [US]

Publication date: 2020-05-07 | Patent publication No.: US-20200140402-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C07D285/135; A61P27/04; A61P1/10; C07D417/12 | Oldest priority date: 2015-12-24 | Publication date: 2020-05-07

Score: 15.926296 | Text size: 420283 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.


1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER

BASTIAN, Jolie Anne [US]CHEN, Jiehao [US]COHEN, Jeffrey Daniel [US]HENRY, James Robert [US]MCMILLEN, William Thomas [US]REAMAN, Bradley Earl [US]RUBIO, Almudena [US]SALL, Daniel Jon [US]ZHAO, Gaiying [US]

Publication date: 2020-04-29 | Patent publication No.: EP-3468965-B1 | Assignees: Eli Lilly and Company [US] | IPC: C07D405/06; A61K31/4045; A61P35/00 | Oldest priority date: 2016-06-10 | Publication date: 2020-04-29

Score: 12.59831 | Text size: 133158 | Find: similar documents

of unlabeled 1-(2,4-difluorophenyl)-3-{[1-(phenylcarbonyl)-2,3-dihydro-1H-indol-5-yl]methyl}urea (ChemDiv, Cat# G714-0242) )100 μM to 50 nM

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COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING A GROWTH RELATED DISEASE AND/OR A CLINICAL CONDITION THEREOF

CHOI, Kang-Yell [KR]CHOI, Sehee [KR]SEO, Seol Hwa [KR]KIM, Eunhwan [KR]

Publication date: 2020-04-23 | Patent publication No.: WO-2020079570-A1 | Assignees: CK BIOTECHNOLOGY CO. [KR] | IPC: A61K31/404; A61K9/107; A61K47/40; A61P3/00; A61P3/04; A61P3/10; A23L33/10 | Oldest priority date: 2018-10-15 | Publication date: 2020-04-23

Score: 15.755042 | Text size: 118797 | Find: similar documents

that inhibited the CXXC5–DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described ... delay growth plate senescence, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5–DVL interaction


COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION

MOELLERING, Raymond [US]COUKOS, John [US]LEE, Gihoon [US]CHANG, Jae Won [US]MUTLU, Gokhan [US]

Publication date: 2020-04-23 | Patent publication No.: WO-2020081446-A1 | Assignees: THE UNIVERSITY OF CHICAGO [US] | IPC: A61P35/04; C07D333/48 | Oldest priority date: 2018-10-14 | Publication date: 2020-04-23

Score: 15.518069 | Text size: 138489 | Find: similar documents

CBR-470-0 and CBR-581-9 were from ChemDiv. CBR-470- 1 (initially from ChemDiv as D470-2172) and related analogs were synthesized in house according to full methods described in


COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING METABOLIC DISEASES AND/OR A CLINICAL CONDITION THEREOF

CHOI, Kang-Yell [KR]SEO, Seol Hwa [KR]KIM, Eunhwan [KR]

Publication date: 2020-04-23 | Patent publication No.: WO-2020079569-A1 | Assignees: CK BIOTECHNOLOGY CO. [KR] | IPC: A61K31/404; A61K9/107; A61K47/40; A61P3/00; A61P3/04; A61P3/10; A23L33/10 | Oldest priority date: 2018-10-15 | Publication date: 2020-04-23

Score: 15.628418 | Text size: 228572 | Find: similar documents

that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... Library size single compounds at 10 mM in DMSO Library composition Small molecules Source ChemDiv and Sigma LOP AC 1280 Screen Format 96-well black polystyrene plates Coneentration(s) tested ... of the CXXC5-DVL interface, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction


RNF41 as a biomarker predicting response to lenalidomide in non-del(5q) MDS

Alan List [US]

Publication date: 2020-04-07 | Patent publication No.: US-10612097-B2 | Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc. [US] | IPC: C12Q1/68; G01N33/574; C12Q1/6883; G01N33/573; A61K45/06; A61K31/454 | Oldest priority date: 2012-12-05 | Publication date: 2020-04-07

Score: 14.656486 | Text size: 45103 | Find: similar documents

Corporation (16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, Calif.

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Human pluripotent stem cell derived endocardial endothelium

Charles E. Murry [US]Lil Pabon [US]Nathan Palpant [US]

Publication date: 2020-04-07 | Patent publication No.: US-10612002-B2 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: C12N5/00; C12N5/02; C12N5/077; A61K35/545 | Oldest priority date: 2016-02-19 | Publication date: 2020-04-07

Score: 10.759004 | Text size: 222748 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

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CFTR regulators and methods of use thereof

Alan S. Verkman [US]Marc H. Levin [US]Onur Cil [US]Sujin Lee [US]

Publication date: 2020-03-31 | Patent publication No.: US-10604492-B2 | Assignees: THE REGENTS OF THE UNIVERSTIY OF CALIFORNIA [US] | IPC: C07D251/52; C07D251/46; C07D403/04; A61K45/06; A61K31/53; A61K31/5377; A61K31/496; A61P27/04; A61P1/10; A61K31/55; C07D413/12 | Oldest priority date: 2015-12-24 | Publication date: 2020-03-31

Score: 15.221389 | Text size: 548871 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.

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MYC G-quadruplex stabilizing small molecules and their use

John Schneekloth, Jr. [US]John Simmons [US]Kenneth Felsenstein [US]Beverly Mock [US]Lindsey Saunders [US]David Calabrese [US]Elena Leon [US]

Publication date: 2020-03-31 | Patent publication No.: US-10604499-B2 | Assignees: The United States of America as represented by the Secretary, Department of Health and Human Service [US] | IPC: C07D307/84; A61K31/343; A61P35/00; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496; A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 | Publication date: 2020-03-31

Score: 17.89937 | Text size: 191734 | Find: similar documents

20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... Catalog No.Peggy (% c-Myc expression compared to untreated IC50 1 [[image:EMI-C00029]] Commercial: ChemDiv No. D089-563 50% (at 10 μM) 7.6 μM 2 [[image:EMI-C00030]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:EMI-C00031]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:EMI-C00032]] Commercial: ChemDiv No. ... No. 6238398 69% (at 10 μM) 89% viability (at 10 μM) 12 [[image:EMI-C00040]] Commercial: ChemDiv No. D089-0350 43% (at 10 μM) 3.4 μM 13 [[image:EMI-C00041]] Commercial: Otava Chemical No.

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GENERATION OF LUNG BUD ORGANOIDS WITH BRANCHING STRUCTURES AND USES THEREOF FOR LUNG DISEASE MODELING

Hans-Willem SNOECK [US]Ya-Wen CHEN [US]

Publication date: 2020-03-26 | Patent publication No.: US-20200093959-A1 | Assignees: Hans-Willem SNOECK [US]; Ya-Wen CHEN [US] | IPC: A61L27/36; A61L27/38; G01N33/50; A61L27/52 | Oldest priority date: 2017-03-24 | Publication date: 2020-03-26

Score: 12.913692 | Text size: 154155 | Find: similar documents

(A division of Key Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego, Calif.; ChemDiv Inc, San Diego, Calif.; ChemRx Advanced Technologies, South San Francisco, Calif.; ComGenex Inc.


BRAIN OSTEOCALCIN RECEPTOR AND COGNITIVE DISORDERS

Gerard KARSENTY [US]Arnaud OBRI [US]Lori KHRIMIAN [US]

Publication date: 2020-03-05 | Patent publication No.: US-20200069775-A1 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: A61K38/23; A61P25/28; G01N33/68 | Oldest priority date: 2017-02-15 | Publication date: 2020-03-05

Score: 10.759004 | Text size: 254322 | Find: similar documents

Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed


COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES

BARBOUR, Jason [US]OTT, David [US]

Publication date: 2020-02-27 | Patent publication No.: WO-2020041533-A1 | Assignees: SF17 THERAPEUTICS, INC. [US] | IPC: A61K31/135; A61K31/137; A61K31/165; A61P29/00 | Oldest priority date: 2018-08-21 | Publication date: 2020-02-27

Score: 13.245268 | Text size: 93189 | Find: similar documents

Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state.


COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS

Hakon Hakonarson [US]Dong Li [US]Lifeng Tian [US]Kenny Nguyen [US]Patrick Sleiman [US]

Publication date: 2020-02-20 | Patent publication No.: US-20200056238-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61K31/4184; A61K31/4427; A61K31/4709; A61K31/501; A61K31/436; A61K31/519; A61K31/5377; A61P43/00 | Oldest priority date: 2016-08-31 | Publication date: 2020-02-20

Score: 12.011612 | Text size: 151277 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.


SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

Alan F. List [US]Sheng Wei [US]

Publication date: 2020-02-20 | Patent publication No.: US-20200055916-A1 | Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: C07K14/705; G01N33/68; A61K47/69; C07K19/00; A61K38/17 | Oldest priority date: 2013-07-05 | Publication date: 2020-02-20

Score: 11.477125 | Text size: 161706 | Find: similar documents

Corporation (16981 Via Taxon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, Calif.


COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES

WU, Jay Jie-Qiang [US]

Publication date: 2020-02-19 | Patent publication No.: EP-3135672-B1 | Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36; C07D498/04; A61K31/4162; A61P35/00 | Oldest priority date: 2008-10-10 | Publication date: 2020-02-19

Score: 11.738287 | Text size: 207682 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE) or can be synthesized.

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SMALL MOLECULE-INHIBITORS OF 6-PHOSPHOFRUCTO-1-KINASE FOR REDUCING LACTATE GENERATION BY CANCER CELLS

LEGISA, Matic [SI]LESNIK, Samo [SI]KONC, Janez [SI]SOLMAJER, Tomaz [SI]VODOPIVEC, Tina [SI]CAMERNIK, Katja [SI]K POTOKAR, Urska [SI]KAVCIC, Luka [SI]

Publication date: 2020-02-13 | Patent publication No.: WO-2020030613-A1 | Assignees: KEMIJSKI INSTITUT [SI] | IPC: A61K31/427; A61P35/00 | Oldest priority date: 2018-08-07 | Publication date: 2020-02-13

Score: 14.153812 | Text size: 66099 | Find: similar documents

and 18 potential PFK-P inhibitors were purchased from Enamine (1 -8), Chembridge (9-16) and ChemDiv (17 and 18) for in-depth testing (1 st generation of Inhibitors).


NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS

PHANSTIEL IV, Otto [US]MOOTS, Holly [US]MALONEY, Patrick [US]HERSHBERGER, Paul [US]PEDDIBHOTLA, Satyamaheshwar [US]

Publication date: 2020-02-13 | Patent publication No.: WO-2020033944-A2 | Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US]; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US] | IPC: A61K31/496 | Oldest priority date: 2018-08-10 | Publication date: 2020-02-13

Score: 17.002005 | Text size: 190919 | Find: similar documents

round of SAR was primarily fueled by 38 compounds, which were purchased from commercial vendors (ChemDiv) while a robust synthetic route was under development. ... In terms of toxicity profiles, compounds ChemDiv F687-0882 and ChemDiv F687-0884 and compounds 50 and 64 gave IC50 values >38 mM and were deemed relatively non-toxic.


Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof


Catherine Tachdjian [US]Andrew P. Patron [US]Sara L. Adamski-Werner [US]Farid Bakir [US]Qing Chen [US]Vincent Darmohusodo [US]Stephen Terrence Hobson [US]Xiaodong Li [US]Ming Qi [CN]Daniel H. Rogers [US]Marketa Rinnova [US]Guy Servant [US]Xiao-Qing Tang [US]Mark Zoller [US]David Wallace [US]Amy Xing [US]Klaus Gubernator [US]

Publication date: 2020-02-11 | Patent publication No.: US-10557845-B2 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82 | Oldest priority date: 2003-08-06 | Publication date: 2020-02-11

Score: 9.562369 | Text size: 375177 | Find: similar documents

offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif.

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COMPOSITIONS AND METHODS FOR TARGETING A VIRAL INFECTION

CHEN, Bing [US]FREY, Gary [US]XIAO, Tianshu [US]

Publication date: 2020-01-30 | Patent publication No.: WO-2020023849-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4709 | Oldest priority date: 2018-07-27 | Publication date: 2020-01-30

Score: 13.489152 | Text size: 307779 | Find: similar documents

Asinex 1 (Winston-Salem, NC), Bionet (Ryan Scientific, Mount Pleasant, SC), CEREP (Redmond, WA), ChemDiv (San Diego, CA), and ChemBridge (San Diego, CA), ENAMINE (Ukraine), Life Chemicals (Burlington, ON, ... Asinex 1 (Winston-Salem, NC), Bionet (Ryan Scientific, Mount Pleasant, SC), CEREP (Redmond, WA), ChemDiv (San Diego, CA), and ChemBridge (San Diego, CA), ENAMINE (Ukraine), Life Chemicals (Burlington, ON,


USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

DOWLING, David, J. [US]LEVY, Ofer [US]BORRIELLO, Francesco [US]SCOTT, David, A. [US]BRIGHTMAN, Spencer, E. [US]

Publication date: 2020-01-30 | Patent publication No.: WO-2020023872-A1 | Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE, INC. [US] | IPC: A01N43/04; A61K31/70 | Oldest priority date: 2018-07-27 | Publication date: 2020-01-30

Score: 12.211837 | Text size: 387085 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).


Methods for producing enteroendocrine cells that make and secrete insulin

Chutima Talchai [US]Domenico Accili [US]

Publication date: 2020-01-28 | Patent publication No.: US-10544415-B2 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: C12N15/113; G01N33/50; A61K31/7088; A61K39/395; C12N5/071 | Oldest priority date: 2010-05-12 | Publication date: 2020-01-28

Score: 11.477125 | Text size: 206394 | Find: similar documents

Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed

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MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE

SCHNEEKLOTH, John, Jr. [US]SIMMONS, John [US]FELSENSTEIN, Kenneth [US]MOCK, Beverly [US]SAUNDERS, Lindsey [US]GAREISS, Peter [US]CALABRESE, David [US]LEON, Elena [US]

Publication date: 2020-01-22 | Patent publication No.: EP-3597186-A1 | Assignees: The U.S.A. as represented by the Secretary, Department of Health and Human Services [US]; Yale University, Inc. [US] | IPC: A61K31/343; A61P35/00; C07D307/84 | Oldest priority date: 2015-01-05 | Publication date: 2020-01-22

Score: 18.024454 | Text size: 182184 | Find: similar documents

20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... No.Peggy (% c-Myc expression compared to untreated)IC50 1 [[image:ib0038]] Commercial: ChemDiv No. D089-0563 50% (at 10 μM) 7.6 μM 2 [[image:ib0039]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:ib0040]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:ib0041]] Commercial: ChemDiv No. D089-0559 73% (at 10 μM) 75% viability (at 10 μM) 5 [[image:ib0042]] Commercial: ChemBridge No.

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Methods of treating muscular dystrophy

Dean Burkin [US]Ryan Wuebbles [US]

Publication date: 2020-01-21 | Patent publication No.: US-10537553-B2 | Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; A61K45/06 | Oldest priority date: 2013-03-15 | Publication date: 2020-01-21

Score: 10.328181 | Text size: 367834 | Find: similar documents

et al., 2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds from the ChemDiv library. 3) LOPAC library (Sigma-RPI) consists of 1280 pharmaceutically active compounds.

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Oxadiazole derivative and pharmaceutical containing same

Katsuhiko Yanagisawa [JP]Akiyoshi Kawai [JP]

Publication date: 2020-01-21 | Patent publication No.: US-10538516-B2 | Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: C07D413/04; C07D413/14; C07D413/12; C07D413/06; C07D285/08; C07D285/12; C07D271/06; C07D271/10; A61K31/4196; A61K31/4709; A61K31/5377; A61K31/41; A61K31/4245; A61K31/4178 | Oldest priority date: 2015-03-25 | Publication date: 2020-01-21

Score: 11.227331 | Text size: 311357 | Find: similar documents

UORSY Ltd., Vitas-M Laboratory Ltd., Interbioscreen Ltd., Interchim Inc., Ryan Scientific Inc., ChemDiv Inc., through Namiki Shoji Co., Ltd. or Kishida Chemical Co., Ltd., when purchased in Japan.

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SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS

Alan S. Verkman [US]Cristina Esteva-Font [US]

Publication date: 2020-01-16 | Patent publication No.: US-20200016147-A1 | Assignees: The Regents of the University of California [US] | IPC: A61K31/4709; A61K31/425; A61K31/426 | Oldest priority date: 2014-05-09 | Publication date: 2020-01-16

Score: 15.518069 | Text size: 143763 | Find: similar documents

screening was done using a collection of 50,000 chemically diverse, drug-like compounds from ChemDiv (San Diego, Calif.). For analysis of structure-activity relationships, >300 commercially available analogs (ChemDiv and Asinex, Winston-Salem, N.C.) were tested.


Identification of Stabilizers of Multimeric Proteins

Isabella A. Graef [US]Mamoun M. Alhamadsheh [US]

Publication date: 2020-01-16 | Patent publication No.: US-20200016098-A1 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; A61K31/4196; A61K31/428; A61K31/433; C07D231/12; C07D487/04; A61K31/519; A61K31/166 | Oldest priority date: 2010-05-07 | Publication date: 2020-01-16

Score: 12.011612 | Text size: 137828 | Find: similar documents

120,000 compounds from the Stanford IITBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS, and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from


SWEET FLAVOR MODIFIER

TACHDJIAN, Catherine [US]KARANEWSKY, Donald [US]WERNER, Sara [US]DARMOHUSODO, Vincent [US]YAMAMOTO, Jeff [US]

Publication date: 2020-01-15 | Patent publication No.: EP-3593648-A1 | Assignees: Firmenich Incorporated [US] | IPC: A23L27/00; A23L2/60; A23L2/56; C07D417/12; C07D417/14; A23L29/30 | Oldest priority date: 2013-03-13 | Publication date: 2020-01-15

Score: 10.759004 | Text size: 249393 | Find: similar documents

other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, PA, ChemDiv of San Diego, CA, Chembridge of San Diego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

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Proteostasis regulators

Megan Foley [US]Bradley Tait [US]Matthew Cullen [US]

Publication date: 2020-01-14 | Patent publication No.: US-10532996-B2 | Assignees: Proteostasis Therapeutics, Inc. [US] | IPC: C07D403/06; C07D405/06; C07D401/06; C07D249/06; C07D207/333; C07D207/337; C07D231/12; C07D263/32; C07D275/02; C07D295/185; C07D333/20; C07D471/04; C07D333/22 | Oldest priority date: 2011-05-12 | Publication date: 2020-01-14

Score: 12.011612 | Text size: 219476 | Find: similar documents

Compound A47 (also shown below) was purchased from ChemDiv, San Diego, Calif.

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METHOD TO DETECT ACTIVITY OF A POLYMERASE

BERGBREDE, Tim [DE]LARSSON, Nils-Göran [DE]GUSTAFSSON, Claes [SE]FALKENBERG-GUSTAFSSON, Maria [SE]

Publication date: 2020-01-08 | Patent publication No.: EP-3303613-B1 | Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE]; Lead Discovery Center GmbH [DE] | IPC: C12Q1/68 | Oldest priority date: 2015-05-29 | Publication date: 2020-01-08

Score: 12.913692 | Text size: 122895 | Find: similar documents

in the assay was 4-methyl-5-[2-(pyrimidin-2-ylamino)thiazol-4yl]thiazol-2-amine (available at ChemDiv) and is applied using contact-free acoustic droplet-dispensing (Labcyte Echo®) from 10 mM compound

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SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

LIST, Alan F. [US]WEI, Sheng [US]

Publication date: 2020-01-08 | Patent publication No.: EP-3016512-B1 | Assignees: H. Lee Moffitt Cancer Center And Research Institute, Inc. [US] | IPC: A01N25/00; A61K39/00; C12P21/04 | Oldest priority date: 2014-04-10 | Publication date: 2020-01-08

Score: 11.477125 | Text size: 173774 | Find: similar documents

ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,

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Anti-oral Squamous Cell Carcinoma Effects of a Potent TAZ Inhibitor AR-42

Lingyu SuSi WangTing YuanXudong XieXiaoming FuPing JiLei ZhongWenzhao Liu

PMC ID: PMC6930442 | DOI: 10.7150/jca.32436 |Journal: Journal of Cancer, 11(1) pp. 364-373 | Publisher: IvyspringInternational Publisher |Publication date: 2020-01-01

Originaldocument: PMC | Score: 16.650314 | Text size: 33910 | Find: similardocuments

In brief, HEK293-TAZ cells were seeded in 96-well plates, and treated with small molecules from ChemDiv compound library and an in-house focused library for 24 h at 37 °C. ... reporter assay on HEK293-TAZ cells to screen TAZinhibitor in an in-house focused library and ChemDiv compound library, and found that the HDAC inhibitor AR-42 (Fig.

Identification of Plasmodium dipeptidyl aminopeptidase allostericinhibitors by high throughput screening

Mateo I. SanchezLaura E. deVriesChristine LehmannJeong T. LeeKenny K. AngChristopher WilsonSteven ChenMichelle R.ArkinMatthew BogyoEdgar DeuLuzia Helena Carvalho

PMC ID: PMC6919601 | DOI: 10.1371/journal.pone.0226270 |Journal: PLoS ONE, 14(1) Publisher: PublicLibrary of Science | Publication date: 2019-12-18

Original document: PMC | Score: 13.996932 | Text size: 57294 | Find: similardocuments

is composedof 104,121 compounds and was assembled from numerous commercial vendors (ChemBridge,ChemDiv and SPECS), and the Celera Protease Inhibitor Collection of 1,817 compounds, which is unique and

Discovery of Non-peptide Small Molecule Allosteric Modulators of theSrc-family Kinase, Hck

Heather R.DormanDavid CloseBentley M.WingertCarlos J.CamachoPaul A. JohnstonThomas E.Smithgall

PMC ID: PMC6893557 | DOI: 10.3389/fchem.2019.00822 |Journal: Frontiers in Chemistry, 7(1) | Publisher: Frontiers Media S.A. |Publication date: 2019-11-28

Originaldocument: PMC | Score: 13.996932 | Text size: 48193 | Find: similardocuments

Screeninglibraries were purchased from ChemDiv (10,000 non-peptidepeptidomimetic library) and ChemBridge (50,000 compound diversity library).

Nanomolar-potency ‘co-potentiator’ therapy for cystic fibrosis caused bya defined subset of minimal function CFTR mutants

Puay-Wah PhuanJoseph-AnthonyTan;Amber A. RiveraLorna ZlockDennis W.Nielson;Walter E.Finkbeiner;Peter M. HaggieAlan S. Verkman

PMC ID: PMC6881293 | DOI: 10.1038/s41598-019-54158-2 |Journal: Scientific Reports, 9(1) Publisher: NaturePublishing Group UK |Publication date: 2019-11-27

Originaldocument: PMC | Score: 14.2392435 | Text size: 45168 | Find: similar documents

Forscreening, 120,000 diverse drug-like synthetic compounds (ChemDiv Inc.,San Diego, CA) were tested. Other chemicals were purchased from Sigma unlessotherwise stated.

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2inhibitors

Irina KufarevaBenoit BestgenPaul BrearRenaud PrudentBéatriceLaudet;VirginieMoucadel;MohamedEttaoussi;Celine F. SautelIsabelle KrimmMatthias EngelOdile FilholMarc Le BorgneThierryLomberget;Claude CochetRuben Abagyan

PMC ID: PMC6828666 | DOI: 10.1038/s41598-019-52141-5 |Journal: Scientific Reports, 9(1) Publisher: NaturePublishing Group UK |Publication date: 2019-11-04

Originaldocument: PMC | Score: 13.536236 | Text size: 82786 | Find: similardocuments

reagent gradeor better and were supplied by the following companies: Chembridge (San Diego,CA), ChemDiv(San Diego, CA), Enamine (Kiev, Ukraine),InterBioScreen (Moscow, Russia), LifeChemicals (Kiev,

Novel Hit Compounds as Putative Antifungals: The Case of Aspergillusfumigatus

Eftichia KritsiMinos-TimotheosMatsoukas;ConstantinosPotamitis;Anastasia DetsiMarija IvanovMarina SokovicPanagiotis Zoumpoulakis;AthinaGeronikaki;Rino Ragno

PMC ID: PMC6864791 | DOI: 10.3390/molecules24213853 |Journal: Molecules, 24(1) Publisher: MDPI | Publication date: 2019-10-25

Original document: PMC | Score: 14.363574 | Text size: 49217 | Find: similardocuments

Sample Availability:Samples of the compounds 1–2, 3–5 and 6–8 were purchased from ChemDiv,Mcule and eMolecules, respectively. Supplementary Materials The following areavailable online.

A Chemosensory GPCR as a Potential Target to Control the Root-KnotNematode Meloidogyne incognita Parasitism in Plants

Emmanuel BressoDiana FernandezDeisy X. AmoraPhilippe NoelAnne-SophiePetitot;Maria-EugêniaLisei de Sa;Erika V. S.Albuquerque;Etienne G. J.Danchin;Bernard MaigretNatáliaF. Martins

PMC ID: PMC6832152 | DOI: 10.3390/molecules24203798 |Journal: Molecules, 24(1) Publisher: MDPI | Publication date: 2019-10-22

Originaldocument: PMC | Score: 17.646307 | Text size: 62242 | Find: similardocuments

selectedmolecules allowed the identification of an active compound, namely C260-2124,from the ChemDivprovider, which can serve as a starting point forfurther investigations. ... From this list, it appeared that 85 compounds camefrom the ChemDiv provider’s library. ... the GPCR-centredlibraries encompassing six compounds providers: Asinex [73], Chembridge[74], ChemDiv [75], LifeChemicals [76], Otava [77] andSelleckchem [78], representing 112,951 molecules.

Design and Selection of Novel C1s Inhibitors by In Silico and In VitroApproaches

KatalinSzilágyiIstvánHajdúBeátaFlachner;ZsoltLőrinczJúliaBalczer;PéterGál;PéterZávodszkyChiara PirliBalázsBalogh;István M.Mándity;SándorCseh;GyörgyDormán

PMC ID: PMC6832932 | DOI: 10.3390/molecules24203641 |Journal: Molecules, 24(1) Publisher: MDPI | Publication date: 2019-10-09

Originaldocument: PMC | Score: 16.44229 | Text size: 76556 | Find: similardocuments

removal ofthe duplicated structures resulted in 445,457 compounds (Enamine (71,311compounds), ChemDiv(258,797 compounds), Chembridge (60,052 compounds),Interbioscreen (31,255 compounds) and Life ... from the actual edition of thetop vendor databases (~5 million compounds): Asinex, ChemBridge, ChemDiv,Enamine, Interbioscreen, Life Chemicals, Specs, UkrOrg, etc.[21,22,23,24,25,26,27,28].

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic OcularNeovascularization

Paulina M.Wojnarowicz;Raquel Lima eSilva;Masayuki OhnakaSang Bae LeeYvette ChinAnita KulukianSung-Hee ChangBina DesaiMarta GarciaEscolano;Riddhi ShahMarta Garcia-CaoSijia XuRashmi KadamYehuda GoldgurMeredith A.Miller;OuathekOuerfelli;Guangli Yang;Tsutomu ArakawaSteven K.Albanese;William A.Garland;Glenn StollerJaideepChaudhary;Larry NortonRajesh KumarSoni;John PhilipRonald C.Hendrickson;Antonio IavaroneAndrew J.Dannenberg;John D. ChoderaNikola PavletichAnna LasorellaPeter A.Campochiaro;Robert Benezra

PMC ID: PMC6896334 | DOI: 10.1016/j.celrep.2019.08.073 |Journal: Cell reports, 29(1) pp. 62-75.e7 |Publicationdate: 2019-10-01 | Print publication date: 2019-10-01

Originaldocument: PMC | Score: 13.104898 | Text size: 96574 | Find: similardocuments

Compiledlists of commercially available compounds (libraries available fromChemBridge, ChemDiv, Maybridge, and Salor) were screened using abeta release of Autodock 4.0 (The Scripps Research

Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-BasedScreening

Yuchen ZhouMatthew W. ElmesJoseph M.Sweeney;Olivia M. JosephJoyce CheHao-Chi HsuHuilin LiDale G. DeutschIwao OjimaMartin KaczochaRobert C. Rizzo

PMC ID: PMC6812325 | DOI: 10.1021/acs.biochem.9b00625 |ISSN: 0006-2960 | Journal: Biochemistry, 58(1) pp. 4304-4316 |Publisher:AmericanChemical Society | Publicationdate: 2019-09-20 | Print publication date: 2019-10-22

Originaldocument: PMC | Score: 14.2392435 | Text size: 67063 | Find: similardocuments

in thebinding site from different rank-ordered lists, 78 compounds were ultimatelypurchased (ChemDivvendor) for experimental testing.

Predictive Power of In Silico Approach to Evaluate Chemicals against M.tuberculosis: A Systematic Review

Giulia OliveiraTimo;Rodrigo SouzaSilva Valle dos ReisAdrianaFrançozo de MeloThales VianaLabourdette CostaPérola deOliveira Magalhães;MauricioHomem-de-Mello

PMC ID: PMC6789803 | DOI: 10.3390/ph12030135 |Journal: Pharmaceuticals, 12(1) Publisher: MDPI | Publication date: 2019-09-16

Original document: PMC | Score: 14.490094 | Text size: 58450 | Find: similardocuments

CollaborativeDrug Discovery Database [49,50]; Other (CDRI [60], FDA approved drugs[67], ChemDiv [6], ChemSpider [59], TAACF [16], GSK [16],Enamine REAL [61], NCI [21] and Specs [70]).

Leishmania mexicana Trypanothione Reductase Inhibitors: Computational andBiological Studies

Félix Matadamas-MartínezAliciaHernández-CamposAlfredoTéllez-ValenciaAlejandraVázquez-RaygozaSandraComparán-AlarcónLiliánYépez-MuliaRafael Castillo

PMC ID: PMC6767256 | DOI: 10.3390/molecules24183216 |Journal: Molecules, 24(1) Publisher: MDPI | Publication date: 2019-09-04

Originaldocument: PMC | Score: 14.301138 | Text size: 52177 | Find: similardocuments

GeneralInformation Compounds ZINC04684558 and ZINC09642432 were purchased from ChemDiv (SanDiego, CA, USA), and compounds ZINC12151998, ZINC14970552, and ZINC11841871were purchased

Identification of Novel Antibacterials Using Machine Learning Techniques

Yan A. IvanenkovAlex ZhavoronkovRenat S.Yamidanov;Ilya A. OstermanPetr V. SergievVladimir A.Aladinskiy;Anastasia V.Aladinskaya;Victor A.Terentiev;Mark S. VeselovAndrey A.Ayginin;Victor G.Kartsev;Dmitry A.Skvortsov;Alexey V.Chemeris;Alexey Kh.Baimiev;Alina A.Sofronova;Alexander S.Malyshev;Gleb I. FilkovDmitry S.Bezrukov;Bogdan A.Zagribelnyy;Evgeny O. PutinMaria M.Puchinina;Olga A. Dontsova

PMC ID: PMC6719509 | DOI: 10.3389/fphar.2019.00913 |Journal: Frontiers in Pharmacology, 10(1) | Publisher: Frontiers Media S.A. |Publication date: 2019-08-27

Originaldocument: PMC | Score: 17.583435 | Text size: 67557 | Find: similardocuments

In general,we used two collections of commercially available compounds by ChemDiv andIBS. WhileChemDiv stock mainly contains organic compounds ofsynthetic origin, IBS basically focuses on nature-based ... These moleculeswere randomly selected and purchased from ChemDiv and IBScollections.

HighThroughputApproaches in CarbohydrateActive Enzymology: Glycosidase and GlycosylTransferase Inhibitors, Evolution, and Discovery

Lemeng ChaoSeino Jongkees

PMC ID: PMC6771893 | DOI: 10.1002/anie.201900055 |ISSN: 1433-7851 | Journal: Angewandte Chemie (International Ed. in English),58(1) pp. 12750-12760 | Publisher: John Wileyand Sons Inc. | Publicationdate: 2019-07-17 | Print publication date: 2019-09-09

Originaldocument: PMC | Score: 14.426556 | Text size: 49031 | Find: similardocuments

group,initial hits against OGlcNAc transferase from an expanded version of the the commercial ChemDivlibrary21were diversified through combinatorial chemistry based on a conserved

A Ligand-Based Virtual Screening Method Using Direct Quantification ofGeneralization Ability

Weixing DaiDianjing Guo

PMC ID: PMC6651094 | DOI: 10.3390/molecules24132414 |Journal: Molecules, 24(1) Publisher: MDPI | Publication date: 2019-06-30

Originaldocument: PMC | Score: 14.74994 | Text size: 37243 | Find: similardocuments

All the testcompounds were bought from ChemDiv (San Diego, CA, USA).

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization tomaintain nuclear genome integrity

Yuan MengChangwei LiuLei ShenMian ZhouWenpeng LiuClaudia KowolikJudith LCampbell;Li ZhengBinghui Shen

PMC ID: PMC6698806 | DOI: 10.1093/nar/gkz537 |ISSN: 0305-1048 | Journal: Nucleic Acids Research, 47(1) pp. 7564-7579 |Publisher:OxfordUniversity Press | Publicationdate: 2019-06-19 | Print publication date: 2019-08-22

Originaldocument: PMC | Score: 13.76273 | Text size: 62685 | Find: similardocuments

The TRAF6 E3ligase inhibitor C25–140 (ChemDiv, Catalog #G827–0140) was added for 48h at a final concentration of 30 μM.

Development and optimization of a high-throughput screening methodutilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics

Laura AbriolaDenton HoyerConor R. CaffreyDavid L.Williams;Timothy P.Yoshino;Jon J. VermeireJosué deMoraes

PMC ID: PMC6546214 | DOI: 10.1371/journal.pone.0217019 |Journal: PLoS ONE, 14(1) Publisher: PublicLibrary of Science | Publicationdate: 2019-06-03

Originaldocument: PMC | Score: 14.618862 | Text size: 29332 | Find: similardocuments

Small MW,ChemBridge DiverSet, Enzo kinase inhibitor, Yale Compounds, MicroSourcePharmakon 1600,ChemDiv Diversity, Rainforest Endophyte Extracts)were screened against A. ceylanicum eggs in our egg hatch

Leveraging heterogeneous data from GHS toxicity annotations, molecularand protein target descriptors and Tox21 assay readouts to predict andrationalise acute toxicity

Chad H. G. AllenLewis H. MervinSamar Y. MahmoudAndreas Bender

PMC ID: PMC6544914 | DOI: 10.1186/s13321-019-0356-5 |Journal: Journal of Cheminformatics, 11(1) Publisher: SpringerInternational Publishing | Publicationdate: 2019-05-31

Originaldocument: PMC | Score: 16.524874 | Text size: 84316 | Find: similardocuments

with the“reactive, unstable, toxic” endpoint, which includes structural alerts definedby ChemDiv, LifeChemicals and Enamine used for their internalcompound selection purposes, which was also ... propane and cyclopropane 25.13.1 × 10−5 Life chemicals TA567 Thioureas 25.1 3.1 ×10−5 ChemDiv TA885 Life chemicals TA1075 Ontarioinstitute for cancer research TA914 Nitrosos 16.

Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapyresponse in vitro and in vivo mouse model of human non-small-cell lung cancer

Akiko SuzukiSachin PuriPamela LelandAnkit PuriTarsem MoudgilBernard A. FoxRaj K. PuriBharat H. JoshiAamir Ahmad

PMC ID: PMC6532891 | DOI: 10.1371/journal.pone.0217131 |Journal: PLoS ONE, 14(1) Publisher: PublicLibrary of Science | Publicationdate: 2019-05-23

Originaldocument: PMC | Score: 13.878843 | Text size: 55081 | Find: similardocuments

(SMI-Compound2825–0090, N-(3-carboxy-4-hydroxy) phenyl 1–2,5,-dimethylpyrole) was purchasedfromChemDiv (San Diego, CA) and dissolved in PBS for treating theNSCLC and normal lung cell lines.

Novel chemical starting points for drug discovery in leishmaniasis andChagas disease

Irene RoqueroJuan CantizaniIgnacio CotilloM. Pilar ManzanoAlbane KesslerJ. JulioMartínCase W. McNamara

PMC ID: PMC6545338 | DOI: 10.1016/j.ijpddr.2019.05.002 |Journal: International Journal for Parasitology: Drugs and DrugResistance, 10(1) pp. 58-68 | Publisher: Elsevier | Publication date: 2019-05-22

Originaldocument: PMC | Score: 13.76273 | Text size: 72868 | Find: similardocuments

the screencompounds. 76 T. cruzi hits and 63 L. donovani hits were available for resupplyfrom ChemDiv and Life Chemicals.

Advancement of the5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarmthe Bacterial SOS Response

Trevor SelwoodBrian J. LarsenCharlie Y. MoMatthew J.Culyba;Zachary M.Hostetler;Rahul M. KohliAllen B. ReitzSimon D. P. Baugh

PMC ID: PMC6305444 | DOI: 10.3389/fmicb.2018.02961 |Journal: Frontiers in Microbiology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-12-18

Originaldocument: PMC | Score: 14.2392435 | Text size: 51939 | Find: similardocuments

Analogswhich were not synthesized were obtained from commercial vendors ChemDiv (SanDiego, CA, United States) and Vitas-M Laboratory (Champagne, IL).

Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoicacid/HIF-1α/VEGF signalling in MCF-7 breastcancer cells

Valerio CicconeErika TerzuoliSandra DonniniAntonioGiachetti;Lucia MorbidelliMarina Ziche

PMC ID: PMC6291966 | DOI: 10.1186/s13046-018-0975-0 |ISSN: 0392-9078 | Journal: Journal of Experimental & Clinical Cancer Research: CR, 37(1) Publisher: BioMedCentral | Publicationdate: 2018-12-12

Originaldocument: PMC | Score: 13.536236 | Text size: 64085 | Find: similardocuments

MethodsChemicals and reagents The ALDH1A1 selective inhibitor CM037 was from ChemDivInc. (San Diego, CA, USA).

Inhibition of CPAP–tubulin interaction prevents proliferation ofcentrosomeamplified cancercells

AruljothiMariappan;Komal SoniKenji SchorppFan ZhaoAmin MinakarXiangdong ZhengSunit MandadIris MacheleidtAnand RamaniTomášKubelka;MaciejDawidowski;KristinaGolfmann;Arpit WasonChunhua YangJudith SimonsHans‐Günther Schmalz; Anthony A HymanRitu Aneja;Roland UllrichHenning UrlaubMargareteOdenthal;ReinhardtBüttnerHaitao LiMichael SattlerKamyar HadianJayGopalakrishnan

PMC ID: PMC6331730 | DOI: 10.15252/embj.201899876 |ISSN: 0261-4189 | Journal: The EMBO Journal, 38(1) Publisher: John Wileyand Sons Inc. | Publicationdate: 2018-12-10 | Print publication date: 2019-01-15

Originaldocument: PMC | Score: 12.700202 | Text size: 117793 | Find: similardocuments

in the CPAPtubulin HTScampaign was composed of compounds acquired from three providers, namelyChemDiv,Inc. (10,000 compounds), Enamine, Ltd. (10,000 compounds), andChemBridge, Corp. (5,000 compounds).

An Experimental Pipeline for Initial Characterization of Bacterial TypeIII Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

Jessica M.Morgan;Hanh N. LamJocelyn DelgadoJustin LuuSina MohammadiRalph R. IsbergHelen WangVictoriaAuerbuch

PMC ID: PMC6262202 | DOI: 10.3389/fcimb.2018.00404 |Journal: Frontiers in Cellular and Infection Microbiology, 8(1) | Publisher: FrontiersMedia S.A. | Publicationdate: 2018-11-22

Originaldocument: PMC | Score: 13.996932 | Text size: 65275 | Find: similardocuments

INP0010(CAS# 68639-26-9) was obtained from ChemDiv.

QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery

Bruno J. NevesRodolpho C.Braga;Cleber C.Melo-Filho;JoséTeófilo Moreira-FilhoEugene N.Muratov;Carolina HortaAndrade

PMC ID: PMC6262347 | DOI: 10.3389/fphar.2018.01275 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-11-13

Originaldocument: PMC | Score: 14.74994 | Text size: 33091 | Find: similardocuments

data wereused to develop QSAR models and, then, applied to screen near 700,000 compoundsfromChemDiv database.

Discovery of a Novel Microtubule Targeting Agent as an Adjuvant forCancer Immunotherapy

Fumi Sato-KanekoXiaodong WangShiyin YaoTadashi HosoyaFitzgerald S.Lao;Karen MesserMinya PuNikunj M. ShuklaHoward B. Cottam;Michael ChanDennis A. CarsonMaripat CorrTomoko Hayashi

PMC ID: PMC6199861 | DOI: 10.1155/2018/8091283 |ISSN: 2314-6133 | Journal: BioMed Research International, 2018(1) | Publisher:Hindawi | Publication date: 2018-10-10

Originaldocument: PMC | Score: 13.996932 | Text size: 52535 | Find: similardocuments

Othercompounds were purchased from ChemBridge Corporation and ChemDiv andwere verified for purity (>98%) by LC-MS.

Correcting glucose-6-phosphate dehydrogenase deficiency with asmall-molecule activator

Sunhee HwangKaren MrukSimin RahighiAndrew G. RaubChe-Hong ChenLisa E. DornNaoki HorikoshiSoichi WakatsukiJames K. Chen;DariaMochly-Rosen

PMC ID: PMC6168459 | DOI: 10.1038/s41467-018-06447-z |Journal: Nature Communications, 9(1) Publisher: NaturePublishing Group UK |Publication date: 2018-10-02

Originaldocument: PMC | Score: 13.536236 | Text size: 71259 | Find: similardocuments

All thecompounds purchased from SPECS, Chembridge, ChemDiv Kinase,LOPAC, Microsource Spectrum, Biomol FDA, Biomol ICCB, and NIH ClinicalCollection were

Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STATTargeting Compounds as a Novel Treatment Strategy of CVDs

MartynaPlens-GalaskaMalgorzataSzelag;Aida ColladoPatrice MarquesSusana VallejoMariellaRamos-GonzálezJoanna WesolyMaríaJesus Sanz;ConcepciónPeiróHans A. R.Bluyssen

PMC ID: PMC6156247 | DOI: 10.3389/fimmu.2018.02141 |Journal: Frontiers in Immunology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-09-19

Originaldocument: PMC | Score: 12.700202 | Text size: 108167 | Find: similardocuments

C01 andC01L_A03-C01L_F03 were purchased from Enamine; E01 from Asinex; F01 from ChemDiv;STX-0119 from Merck and STATTIC from Sigma-Aldrich.

Small molecules that target group II introns are potent antifungal agents

Olga FedorovaG. Erik JagdmannRebecca L. AdamsLin YuanMichael C. VanZandt;Anna Marie Pyle

PMC ID: PMC6239893 | DOI: 10.1038/s41589-018-0142-0 |ISSN: 1552-4450 | Journal: Nature chemical biology, 14(1) pp. 1073-1078 |Publication date: 2018-09-07 | Print publication date: 2018-12

Originaldocument: PMC | Score: 13.878843 | Text size: 58425 | Find: similardocuments

(76compounds), protease inhibitors (53 compounds) and additional compounds fromChemBridge MW andChemDiv to bring the total number of compounds to 10000.

The Small-Compound Inhibitor K22 Displays Broad Antiviral Activityagainst Different Members of the Family Flaviviridae and Offers Potential as aPanviral Inhibitor

ObdulioGarcía-NicolásPhilip V'kovskiNathalie J.Vielle;Nadine EbertRoland ZüstJasmine PortmannHanspeterStalder;VéroniqueGaschen;GabrielleVieyres;Michael StoffelMatthiasSchweizer;ArturSummerfield;Olivier EnglerThomasPietschmann;Daniel TodtMarco P. Alves;Volker ThielStephaniePfaender

PMC ID: PMC6201103 | DOI: 10.1128/AAC.01206-18 |ISSN: 0066-4804 | Journal: Antimicrobial Agents and Chemotherapy, 62(1) Publisher:American Society for Microbiology | Publication date: 2018-09-04

Originaldocument: PMC | Score: 13.648543 | Text size: 65154 | Find: similardocuments

benzamide)was purchased from ChemDiv (catalog number 4295-0370; SanDiego, CA) and DMSO.

The TMEM16A channel mediates the fast polyspermy block in Xenopus laevis

Katherine L.Wozniak;Wesley A. PhelpsMaiwase TemboMiler T. LeeAnne E. Carlson

PMC ID: PMC6122928 | DOI: 10.1085/jgp.201812071 |ISSN: 0022-1295 | Journal: The Journal of General Physiology, 150(1) pp.1249-1259 |Publisher: Rockefeller University Press | Publicationdate: 2018-09-03 | Print publication date: 2018-09-03

Originaldocument: PMC | Score: 14.2392435 | Text size: 54256 | Find: similardocuments

and 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide(Ani9) from ChemDiv.

Discovery and Identification of Pyrazolopyramidine Analogs as NovelPotent Androgen Receptor Antagonists

Lingyan WangTianqing SongXin WangJiazhong Li

PMC ID: PMC6121070 | DOI: 10.3389/fphar.2018.00864 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-08-28

Originaldocument: PMC | Score: 18.165255 | Text size: 48086 | Find: similardocuments

Then the ARcrystal structure (PDB ID:1T65) and Anti-AR were both used to virtually screenthe ChemDivdatabase by using Glide standard precision (SP) dockingprogram. Glide SP, a semi flexible docking method, performs exhaustive samplingand is the recommended balance between speed and accuracy. ChemDiv isnow the recognized global leader in discovery chemistry with the industry'slargest, most ... regression (MLR) method were employed to in silico evaluatethe bioactivities of the filtered ChemDiv chemicals containedin database 2. The development and validation of QSAR models The linear MLR ...preparation Considering the diversity of the molecular structure, thecommercially available ChemDiv structural library(http://www.chemdiv.

A metabolite-derived protein modification integrates glycolysis withKEAP1-NRF2 signaling

Michael J.Bollong;Gihoon LeeJohn S. CoukosHwayoung YunClaudio ZambaldoJae Won ChangEmily N. ChinInsha AhmadArnab K.Chatterjee;Luke L. LairsonPeter G. SchultzRaymond E.Moellering

PMC ID: PMC6444936 | DOI: 10.1038/s41586-018-0622-0 |ISSN: 0028-0836 | Journal: Nature, 562(1) pp. 600-604 |Publicationdate: 2018-08-28 | Print publication date: 2018-10

Originaldocument: PMC | Score: 15.963614 | Text size: 82825 | Find: similardocuments

CBR-470-0and CBR-581-9 were from ChemDiv. CBR-470-1 (initially from ChemDiv asD470-2172) and related analogs were synthesized in house according to fullmethods described in

K284-6111 prevents the amyloid beta-induced neuroinflammation andimpairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

Ji Yeon ChoiIn Jun YeoKi Cheon KimWon Rack ChoiJae-Kyung JungSang-Bae HanJin Tae Hong

PMC ID: PMC6087013 | DOI: 10.1186/s12974-018-1269-3 |Journal: Journal of Neuroinflammation, 15(1) Publisher: BioMedCentral |Publication date: 2018-08-11

Originaldocument: PMC | Score: 13.878843 | Text size: 52408 | Find: similardocuments

(K284-6111)and other chemicals were obtained from ChemDiv, Inc. (Cat No.3292320, San Diego, CA).

Targeting the Microenvironment in High Grade Serous Ovarian Cancer

Nkechiyere G.Nwani;Livia E. SimaWilbertoNieves-NeiraDaniela Matei

PMC ID: PMC6115937 | DOI: 10.3390/cancers10080266 |Journal: Cancers, 10(1) Publisher: MDPI | Publication date: 2018-08-10

Originaldocument: PMC | Score: 13.42576 | Text size: 89735 | Find: similardocuments

efforts usedan AlphaLISA-based assay adapted to high-throughput screening and applied tothe ChemDivlibrary leading to the discovery and validation ofseveral small molecules [126].

Insights into the development of chemical probes for RNA

Brittany SMorgan;Jordan E ForteAmanda EHargrove

PMC ID: PMC6144806 | DOI: 10.1093/nar/gky718 |ISSN: 0305-1048 | Journal: Nucleic Acids Research, 46(1) pp. 8025-8037 |Publisher:OxfordUniversity Press | Publicationdate: 2018-08-08 | Print publication date: 2018-09-19

Originaldocument: PMC | Score: 14.2392435 | Text size: 66141 | Find: similardocuments

Recently,chemical companies have designed such focused libraries (ChemDiv,Nucleic Acid Ligands: http://www.chemdiv.

Biaryl sulfonamide motifs up- or down-regulate ion channel activity byactivating voltage sensors

Sara I. LiinPer-Eric LundJohan E. LarssonJohan BraskBjörnWallner;Fredrik Elinder

PMC ID: PMC6080886 | DOI: 10.1085/jgp.201711942 |ISSN: 0022-1295 | Journal: The Journal of General Physiology, 150(1) pp.1215-1230 |Publisher: Rockefeller University Press | Publicationdate: 2018-08-06 | Print publication date: 2018-08-06

Originaldocument: PMC | Score: 14.2392435 | Text size: 60672 | Find: similardocuments

ConsortiumSweden)*; Natural derivatives (TimTec); NIH Clinical Collection (NIH);Peptidomimetics (ChemDiv Inc.)*; and Tocriscreen Plus (Tocris Bioscience).

Identification of a novel c-Myc inhibitor with antitumor effects onmultiple myeloma cells

Ruosi YaoXiaoyang SunYu XieXiaoshen SunYao YaoHujun LiZhenyu LiJian GaoKailin Xu

PMC ID: PMC6146296 | DOI: 10.1042/BSR20181027 |ISSN: 0144-8463 | Journal: Bioscience Reports, 38(1) Publisher: PortlandPress Ltd. |Publication date: 2018-08-01

Originaldocument: PMC | Score: 17.709631 | Text size: 28027 | Find: similar documents

It wasidentified from the ChemDiv compound database by moleculardocking-based, high-throughput virtual screening. ... The ChemDiv database,a commercially available small molecule database from TopScience Co. ...Because only 2D-structural information was available, all compounds inthe ChemDiv database were preprocessed by using the dbtranslate module in Sybyl-X2.

Identification of a small molecule inhibitor of Ebola virus genomereplication and transcription using in silico screening

Victoria EastonMartin McPhillieIsabelGarcia-DorivalJohn N. BarrThomas A.Edwards;Richard FosterColin FishwickMark Harris

PMC ID: PMC6371959 | DOI: 10.1016/j.antiviral.2018.06.003 |ISSN: 0166-3542 | Journal: Antiviral Research, 156(1) pp. 46-54 |Publisher:Elsevier | Publication date: 2018-08-01 | Print publication date: 2018-08

Originaldocument: PMC | Score: 17.646307 | Text size: 42059 | Find: similardocuments

Dry stocksof the original compounds were later purchased from the original supplier (ChemDiv)to confirm initial biological activity. Follow-up compounds were purchased fromChemBridge or ChemDiv and shipped as dry stocks. ...structural derivatives, where particular functional groups had been modified,were purchased (from ChemDiv Inc) and a further eight ChemBridgeanalogues were identified using the programme ROCS (rapid overlay

Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in thecontext of Alzheimer's disease

Mohd. Babu KhanBhagath KumarPalaka;Tuleshwori DeviSapam;Naidu SubbaraoDinakara RaoAmpasala

PMC ID: PMC6166398 | DOI: 10.6026/97320630014414 |Journal: Bioinformation, 14(1) pp. 414-428 | Publisher: BiomedicalInformatics |Publication date: 2018-08

Originaldocument: PMC | Score: 19.113825 | Text size: 36455 | Find: similardocuments

Ligandlibrary preparation A library of 23,731 CNS_BBB compounds was obtained fromthe ChemDiv database (http://www.chemdiv.com/cns-bbblibrary/)[21]. CNS-BBB ChemDiv database compound is a known asantioxidant and anti-inflammatory nature, and the 2D structures in Sdf formatwere downloaded from theChemDiv database, and created a 3D-Phasedatabase from Phase module of the Schrodinger, phase version 3.2. ...Discussion Based on this CNS-BBB, Standard Data Format (SDF) data, provided bythe ChemDiv Data base server, finding the top three ligandinhibitors as M1, M8, and M10 shows a good ... -204.27+/-50.94 -214.40 +/12.67Table 3 ADMET Property profile of the top ten hits of CNS-BBB of ChemDiv databasecompounds Compound Ida Molecular Weight1 SASA2 QPLogS3 QPlog- HERG4 QPlog-BB5 %HOA6

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

VirginiaMurillo-GarzónIrantzuGorroño-EtxebarriaMalinÅkerfeltMikael ChristerPuustinen;Lea SistonenMatthias NeesJames Carton;Jonathan WaxmanRobert M. Kypta

PMC ID: PMC5931552 | DOI: 10.1038/s41467-018-04042-w |Journal: