Scale up synthesis

Scale up

Method development and chemical synthesis

 Development and validation of new methods for the synthesis of compounds (series from 100 mg to 100 g):

• Synthesis of individual innovative and well-known small molecules, active substances and impurities with a purity of up to 90-99%

• Synthesis of libraries of chemical compounds for in vitro research (10-100 compounds per scaffold)

Scaling and optimization of synthesis methods and technologies (batch up to 1-100 kg):

• Scaling and development of laboratory regulations for the production of substances obtained by chemical synthesis methods

• Chemical reactions with a large volume of reagents (up to 30 liters), using both laboratory and pilot-industrial systems for synthesis

• Purification of large reaction volumes by laboratory and high-tech methods - distillation at low pressure, chromatography, recrystallization, etc.

• Ability to develop synthesis methods with subsequent staging of technology and validation of analytical methods and development of GMP production technology

Development and validation of analytical quality control procedures:

• Analysis of synthesized compounds by HPLC, LCMS, NMR

• High performance automated analysis and cleaning

Chemical analytics capabilities:

HPLC LCMS                                                                                           NMR

UPLS/MS Shimadzu 2020                                                     Bruker DPX-300

PE Sciex API 150EX LC-MS/MS                                           Bruker DPX-400

LCMS system Shimadzu 2010 EV

Preparative LCMS/PREP system Shimadzu 2020

 Methods and technologies

• Heterocyclic chemistry

• Organometallic chemistry

• Cascade assembly of structures

• Microwave synthesis

• Synthesis, separation of stereoisomers and enantiomers

• High pressure reactions

• Parallel and asymmetric synthesis and others

Scale up Synthesis

Development and validation of new methods for the synthesis of compounds:

• Synthesis of individual innovative and well-known small molecules, active substances and impurities with a purity of up to 90-99%
• Synthesis of libraries of chemical compounds for in vitro research (10-100 compounds per scaffold)
• Scaling and development of laboratory regulations for the production of substances obtained by chemical synthesis methods
• Chemical reactions with a large volume of reagents (up to 30 liters), using both laboratory and pilot-industrial systems for synthesis
• Purification of large reaction volumes by laboratory and high-tech methods - distillation at low pressure, chromatography, recrystallization, etc.
• Ability to develop synthesis methods with subsequent staging of technology and validation of analytical methods and development of GMP production technology
• Development and validation of analytical quality control procedures:
• Analysis of synthesized compounds by HPLC, LCMS, NMR, High performance automated analysis and cleaning

ChemDiv’s methods and technologies for scale-up synthesis include:

• Heterocyclic chemistry
• Organometallic chemistry
• Cascade assembly of structures
• Microwave synthesis
• Synthesis, separation of stereoisomers and enantiomers
• High pressure reactions
• Parallel and asymmetric synthesis and others