Scale up Synthesis
Scale up
Method development and chemical synthesis
Development and validation of new methods for the synthesis of compounds (series from 100 mg to 100 g):
-
Synthesis of individual innovative and well-known small molecules, active substances and impurities with a purity of up to 90-99%
-
Synthesis of libraries of chemical compounds for in vitro research (10-100 compounds per scaffold)
Scaling and optimization of synthesis methods and technologies (batch up to 1-100 kg):
-
Scaling and development of laboratory regulations for the production of substances obtained by chemical synthesis methods
-
Chemical reactions with a large volume of reagents (up to 30 liters), using both laboratory and pilot-industrial systems for synthesis
-
Purification of large reaction volumes by laboratory and high-tech methods - distillation at low pressure, chromatography, recrystallization, etc.
-
Ability to develop synthesis methods with subsequent staging of technology and validation of analytical methods and development of GMP production technology
Development and validation of analytical quality control procedures:
-
Analysis of synthesized compounds by HPLC, LCMS, NMR
-
High performance automated analysis and cleaning
Chemical analytics capabilities:
HPLC LCMS NMR
UPLS/MS Shimadzu 2020 Bruker DPX-300
PE Sciex API 150EX LC-MS/MS Bruker DPX-400
LCMS system Shimadzu 2010 EV
Preparative LCMS/PREP system Shimadzu 2020
Methods and technologies
-
Heterocyclic chemistry
-
Organometallic chemistry
-
Cascade assembly of structures
-
Microwave synthesis
-
Synthesis, separation of stereoisomers and enantiomers
-
High pressure reactions
-
Parallel and asymmetric synthesis and others