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Deacetylases

Deacetylases

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Deacetylases

ChemDiv offers high throughput screening (HTS) service
Deacetylases research platform


  • HDAC and SIRT protein assays 

  • FRET/fluorescence HTS assays.

  • 2 deacetylase-focused libraries: Histone Deacetylases (HDAC) Targeted Library, MEF2-HDAC (class II) Modulators Library,  15K compounds in total

  • Our support in compound selection based on your research project

  • Screening from 10000 compound sets up to 300000 and more

  • A quick start of your research project

  • 25 years of experience

More details on prices, time, or research specificity - please contact chemdiv@chemdiv.com


Many drugs exist that target HDACs – Vorinostat and Romidepsin for lymphoma treatment or panobinostat for skin cancer treatment, for example. While, due to limited capability and toxicity, it is uncommon to solely use HDAC inhibitors, combinatorial therapies are more effective. And, although selectivity remains an issue for the small molecules developed (and, for some, like SRT501, which was poised to treat some forms of cancer, fail due to toxicity), there are some drug candidates at the trial stage for sirtuins as well. SRT2104, which, like SRT501, targets SIRT1, was poised to treat diabetes, but the development was stopped at phase II stage. Selisistat, an SIRT1 inhibitor, is still in the development. 

HDAC assay scheme, from ‘Purification and enzymatic assay of class I histone deacetylase enzymes’ by Adams et al. Both the protein preparation stage and the assay itself are shown.

 Research tends to involve a fluorescence assay: either a standard one of FRET. Core of it can be condensed into four key points:

●      a donor fluorophore gets energy

●      this energy is then passed on to an acceptor fluorophore

●      acceptor emits a measurable signal

●      suited for HTS due to being easy to automate

ChemDiv offers quality HTS deacetylase assays both for HDAC and SIRT series, all developed within a competitive time-frame and at an affordable price. 

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