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Leave your request for services (Custom chemistry, HTS, CADD, Integrated Drug Discovery, ADME, PK)

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ChemDiv offers high throughput screening (HTS) service
Phosphatases research platform

  • 23 protein assays depending on groups available

  • LANCE TR-FRET as a platform.

  • 4 phosphatase-focused libraries (Human Phosphatases Annotated Library, Receptor protein tyrosine phosphatases, Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library, Phosphatases library), 52K compounds in total

  • Our support in compound selection based on your research project

  • Screening from 10000 compound sets up to 300000 and more

  • A quick start of your research project

  • 25 years of experience

More details on prices, time, or research specificity - please contact chemdiv@chemdiv.com

Although phosphatases have the reputation of notoriously difficult therapy targets, there are several drugs going through their clinical trials that target them: TNO155, an allosteric SHP2 inhibitor; trodusquemine, an allosteric PTP1B inhibitor; IFB-088, a PPP1R15A/PP1c inhibitor. Additionally, there are other ways in which they are clinically relevant: levels of acid phosphatase are monitored during prostate cancer treatment in order to evaluate its success, determining the presence level of alkaline phosphatase in the blood is a way of checking for liver inflammation. Possible future drug targets include PP2a and PTEN, mutations in which are signatures in a number of tumor groups.

SHP2 structure, sequence from the PDB

One of the standard methods for measuring phosphatase activity is LANCE TR-FRET:

  • Eu antibodies with phosphorylated peptides participate in TR-FRET
  • Phosphatase dephosphorylates peptides
  • The TR-FRET signal weakens
  • The loss of the signal is a measure of phosphatase activity

As part of our target-to-clinic approach, ChemDiv offers assays for all common phosphatase assays, which you can add into your shopping cart: acid phosphatase, alkaline phosphatase, protein tyrosine phosphatase and serine/threonine phosphatase, just pick from the list below:

  • DUSP22
  • PP1A, PP1B
  • PP2alpha
  • PP2Calpha, PP2Cgamma
  • PTEN
  • PTPN1 and other PTPNXs, like PTPN7
  • PTPRA and other PTPRXs, like PTPRF
  • SHIP1, SHIP2
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