PROTAC. Protein degradation (PROTAC and beyond)

Are you looking for a reliable and efficient partner to accelerate your research in targeted protein degradation? Look no further than ChemDiv's integrated Targeted Protein Degradation Services.

Our team of experts has extensive experience in designing and optimizing small molecule degraders using a variety of strategies, including PROTACs, molecular glues, and LYTACs. We offer a comprehensive suite of services, including hit identification, lead optimization, and preclinical evaluation, to support your drug discovery efforts.

At ChemDiv, we understand that every project is unique, and we work closely with our clients to tailor our services to meet their specific needs. Whether you require a complete drug discovery program or targeted support in specific areas, we have the expertise and flexibility to help you achieve your research goals.

Don't let the challenges of targeted protein degradation slow down your research progress. Partner with ChemDiv and accelerate your drug discovery today.

To learn more about our Targeted Protein Degradation Services, visit our website or contact us directly at LT@chemdiv.com

Extensive experience in the synthesis of active PROTAC molecules for wide range of biological targets, from kinases to nuclear hormone receptors.
Active anchors could be selected from the literature or discovered through HTS and optimization discovery program

Hands on experience in synthesis and selection of E3 ligase recruiters, e.g. VHL, CRBN, IAP, and others.
Large selection of pre-synthesized ligase recruiters is in stock and available for development program.

Hands on experience in synthesis and selection of active small molecule anchor and E3 ligase recruiter linkers.
Small molecule library is available for CADD evaluation against selected target and for further screening and discovery program.

Hands on experience in synthesis and selection of anchor-recruiter linkers.
Large selection of pre-synthesized linkers is in stock and available for development program.

Discovery and optimization of active small molecules anchors for PROTAC’s:
Protein or ligand based CADD design of active molecules
Small molecules library selection and screening
Computer based modeling studies for PROTAC active anchor exit vector selection
Computer based modeling studies for PROTAC linker selection
Chemistry optimization for linker type and size, linker-anchor or linker-recruiter connection

In vitro biology platform for PROTAC evaluation
Biochemical or cell-based assays for target active small molecules discovery
Protein Simple Jess high throughput capillary Wester blotting system for PROTAC induced protein degradation

• Multiple readouts
• Up to 24 runs in parallel

Selection of suitable cell-based biology platform for PROTAC evaluation:

• Selected ligases expression levels
• Target expression level

Downstream targets or substrates expression levels
In house capabilities for ADME properties of synthesized PROTAC’s evaluation, including animal studies.