Growing interest towards medium- and large-sized macrocycles closely linked with the field of protein-protein interactions (PPI) as promising therapeutics targets.
ChemDiv used two methodologies for design and synthesis of macrocyclic peptidomimetic library.
One of them includes ring expansion employing Bormann-Wasserman strategy (BWS) and allows synthesising 10-12-membered lactams. This gives us access to unique functionally enriched , spiro and fused scaffolds.
The other one is based on click-macrocyclization of linear peptidomimetics bearing acetylene and azide functionalities at the ends to provide 14-22 membered macrocyclic peptidomimetics.
That allowed us to obtain novel, diverse set of macrocyclic scaffolds and over 3000 stock available molecules, potential PPI modulators.
Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
12760 High Bluff Dr, San Diego, CA, 92130
Phone: + 1 916 234 0888
Fax: +1 858 794 4931
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