Autophagy-Targeted Library

17,000 Compounds

•Maintenance of cellular homeostasis by lysosome-dependent mechanism of intracellular degradation
•Can be induced by diverse stimulations:
reactive oxygen species, hypoxia impairments, subcellular organelle damages, protein aggregation
•Dysregulation of authophagy is closely related to a vast number of human diseases:
cancer, neurodegeneration, infection, cardiovascular disorders,
metabolic diseases, pulmonary diseases, aging
•Both up- and down-regulation of autophagy is protective against cancer, neurodegeneration, infectious diseases and ischaemic insult in the heart*

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