•Maintenance of cellular homeostasis by lysosome-dependent mechanism of intracellular degradation
•Can be induced by diverse stimulations:
reactive oxygen species, hypoxia impairments, subcellular organelle damages, protein aggregation
•Dysregulation of authophagy is closely related to a vast number of human diseases:
cancer, neurodegeneration, infection, cardiovascular disorders,
metabolic diseases, pulmonary diseases, aging
•Both up- and down-regulation of autophagy is protective against cancer, neurodegeneration, infectious diseases and ischaemic insult in the heart*
Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
12760 High Bluff Dr, San Diego, CA, 92130
Phone: + 1 916 234 0888
Fax: +1 858 794 4931
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