•Maintenance of cellular homeostasis by lysosome-dependent mechanism of intracellular degradation
•Can be induced by diverse stimulations: reactive oxygen species, hypoxia impairments, subcellular organelle damages, protein aggregation
•Dysregulation of autophagy is closely related to a vast number of human diseases: cancer, neurodegeneration, infection, cardiovascular disorders, metabolic diseases, pulmonary diseases, aging
•Both up- and down-regulation of autophagy is protective against cancer, neurodegeneration, infectious diseases and ischaemic insult in the heart
Targets space includes ROS, VPS34, Mitophagy, AMPK, mTORC1, MAPK, BCEN1 and others.
Medicinal and Computational Chemistry Dept., ChemDiv, Inc.
12760 High Bluff Dr, San Diego, CA, 92130
Phone: + 1 916 234 0888
Fax: +1 858 794 4931
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