Mechanism of action
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Small-molecule compounds that can be used in GPCR drug discovery. Dysregulation of these receptors causes diabetes, CNS disorders.
PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.
Carbonic anhydrase II library is a set of compounds belonging to the sulfonamides, mercaptans and phenols aimed at modulating of Carbonic anhydrase II activity
Set of RAR receptor antagonists. The retinoic acid receptor is a type of nuclear receptor which can also act as a transcription factor.
Small molecules that can inhibit NOTUM thus potentially treating diseases caused by dysregulation of Wnt signaling.
Molecules from c-Met Library target receptor tyrosine kinase. It prevents binding hepatocyte growth factor with c-Met which can lead to cancer.
PRMT Library is set of small-molecule compounds with reported affinity against cancer-assosiated PRMTs.
Androgen Receptor Antagonists Library is a set of non-steroidal small molecules for prostate cancer treatment.
RPTP Targeted Library is small-molecule inhibitors. Disruption of protein tyrosine phosphorylation contributes to a variety of human diseases.
Set of small-molecule HDAC inhibitors. HDAC regulate gene expression and its inhibitors act against cancers, neurodegenerative and inflammatory diseases.
Small-molecule compounds that mimic the action of protein and modulates PPI.
Glucocorticoid Receptors Library is small-molecule selective modulators of GR which regulates gene transcription.
Epitranscriptome Focused Small Molecule Library modulates the activity of proteins involving in aberrant RNA modification.
Adenosine Receptors Targeted Library is a set of small-molecule ligands. They can be used for treating neurodegeneration diseases.
Small molecules that mimic the action of peptides thus modulating PPI. Protein secondary structures are targets for mimicry.
Set of GABA receptor antagonists. These drug-like compounds inhibit the action of GABA and produce stimulant and convulsant effects.
MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.
Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.
Purinergic Library is a set of purinergic receptor antagonists. Such antagonists are used for thrombosis and stroke treatment.
TLR-8 Ligands Library is a set of small-molecule TLR-8 agonists. They can be used in adjuvantation research and for the treatment of ovarian cancer.
Library contains nonpeptide small-molecules that inhibit PPI. They are structural mimetics to target proteins.
Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.
Bromodomain Modulators Library is a set of drug-like compounds aimed at modulating PPI of bromodomain-containing proteins with other vital proteins.
MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.
PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.
Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.
Anti-Aging Library is small molecules targeting cellular pathways and biological targets that are implicated in aging.
SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.
Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.
Neuropeptide S Library is a set of small-molecule NPSR ligands. They can be used in psychiatric disorders treatment as anxiolytics and analgesics.
Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.
PPI Tripeptide Mimetics Library is small-molecule PPI inhibitors that mimic significant endogenous tripeptides.
Focused Epigenetics Library is a set of small-molecule modulators that target epigenetic proteins.
SH2 Domain Library is a set of inhibitors. SH2 are modular units, which bind to tyrosyl-phosphorylated peptide on their target protein mediating PPI.
Chemokine Receptor Targeted Library is a set of small-molecule ligands. Modulation of chemokine receptor is used in the treatment of inflammatory diseases.
Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.
Eccentric PPI Library is a set of unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems.
Selective small-molecule PDZ inhibitors. They help to overcome drawbacks of PPI.