miRNA targeted small molecule library

Description

MicroRNAs (miRs) are small (~18e25 nucleotides), noncoding RNAs, involved in regulation of cell division, proliferation, and death.

MiRs can have a role in a wide range of diseases including cancer, neurologic disorders, autoimmune diseases, metabolic diseases, and cardiovascular diseases.

Since their discovery in 1993, over 2500 human mature miRs have been found; their mechanism of action and functions are focus for the ongoing research [1, 2].

Despite the fact that numerous small molecules have been discovered over the last decade, research into miR targeted small molecules has just started. We share CheDiv's miR-targeted library in hope to help this field continue to thrive. 

Publications

1. Alles J, Fehlmann T, Fischer U, Backes C, Galata V, Minet M, Hart M, Abu-Halima M, Grässer FA, Lenhof HP, Keller A, Meese E. An estimate of the total number of true human miRNAs. Nucleic Acids Res. 2019 Apr 23;47(7):3353-3364. doi: 10.1093/nar/gkz097




2. Van Meter EN, Onyango JA, Teske KA. A review of currently identified small molecule modulators of microRNA function. Eur J Med Chem. 2020 Feb 15;188:112008. doi: 10.1016/j.ejmech.2019.112008