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Macrocyclic Peptidomimetics: Library Design And Synthesis

Growing interest towards medium- and large-sized macrocycles closely linked with the field of protein-protein interactions (PPI) as promising therapeutics targets.

ChemDiv used two methodologies for design and synthesis of macrocyclic peptidomimetic library. One of them includes ring expansion employing Bormann-Wasserman strategy (BWS) and allows synthesising 10-12-membered lactams. This gives us access to unique functionally enriched , spiro and fused scaffolds. The other one is based on click-macrocyclization of linear peptidomimetics bearing acetylene and azide functionalities at the ends to provide 14-22 membered macrocyclic peptidomimetics.

That allowed us to obtain novel, diverse set of macrocyclic scaffolds and over 3000 stock available molecules, potential PPI modulators.

You can see more details on our scientific poster


and send a request to download stock available library of macrocycles on our website: http://www.chemdiv.com/macrocycles-library/


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