J&J's Stelara succeeds in chronic bowel disease study
(Reuters) - Johnson & Johnson said on Tuesday its blockbuster drug Stelara was found to be effective in treating a chronic bowel disease in a late-stage trial.
Two doses of Stelara, already approved for psoriasis, psoriatic arthritis and Crohn’s disease, was tested in 961 patients with moderate-to-severe ulcerative colitis (UC) who had failed prior therapy.
The treatment and the placebo arms reported similar proportion of side effects, with one patient on the 6 mg/kg dose dying following excessive bleeding, J&J said.
The patient had no prior history of high blood pressure or cirrhosis, the drugmaker said.
Stelara, which brought in sales of $1.34 billion in the second quarter of 2018, is also being tested in autoimmune disease lupus.
Ulcerative colitis, which affects about 38,000 people in the United States annually, is a chronic condition causing abdominal pain, intestinal ulcers, bloody diarrhea and weight loss.