Pop-Science

Gamma-aminobutyric acid (GABA) is familiar to neurophysiologists as an inhibitory neurotransmitter in the central nervous system.

Protein kinase inhibitors are an important class of drugs. The FDA has approved over 70 small molecules with this type of action [1, 2]. Approved kinase inhib...

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the adult brain. And since everyone, including our brain, needs to relax from time to time for normal work, GABA maintains the...

Combinatorial libraries: from ligand-receptor recognition to machine-learning

In people with sickle cell disease, the structure of hemoglobin, a protein of red blood cells that carries oxygen, is disrupted. Due to a hereditary mutation in such people, hemoglobin does not assemb...

Diabetes mellitus was a fatal disease for humans 100 years ago. Its development of begins with the fact that the child’s immunity after some trigger (stress, illness) starts to damage his beta-c...

The obesity epidemic is growing every year, and science has long been trying to find a way to treat obesity. At the same time, the functioning of adipose tissue is strongly influenced by the immun...

Dimethyl sulfoxide (DMSO) is an organic chemical polar compound in a liquid state under normal conditions. It is the aprotic solvent or the solvent which, when decomposed in solution, does not...

GPCR and their allosteric regulation

Aurora kinases: classification, functions and inhibitor design

This short piece covers some of the more widespread opportunistic pathogens (sometimes referred to as ‘OP’ for short) and the broad picture on the impact and implications they have on soci...

Allosteric inhibitors and possibilities of their application